Incidental Mutation 'R6004:Or4f60'
ID 478495
Institutional Source Beutler Lab
Gene Symbol Or4f60
Ensembl Gene ENSMUSG00000074946
Gene Name olfactory receptor family 4 subfamily F member 60
Synonyms GA_x6K02T2Q125-73119859-73118924, MOR245-23, Olfr1313
MMRRC Submission 044182-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R6004 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 111901991-111902928 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 111902371 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Isoleucine at position 186 (L186I)
Ref Sequence ENSEMBL: ENSMUSP00000148886 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099599] [ENSMUST00000213577] [ENSMUST00000216071]
AlphaFold Q7TQW8
Predicted Effect probably damaging
Transcript: ENSMUST00000099599
AA Change: L186I

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000097194
Gene: ENSMUSG00000074946
AA Change: L186I

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 2.2e-41 PFAM
Pfam:7tm_1 41 286 2.8e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213577
AA Change: L186I

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000216071
AA Change: L186I

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.4%
  • 10x: 96.8%
  • 20x: 89.1%
Validation Efficiency 98% (55/56)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp6 C T 3: 97,082,997 (GRCm39) A336V probably benign Het
Adam5 T A 8: 25,271,685 (GRCm39) Y574F probably benign Het
Arl6 A T 16: 59,444,257 (GRCm39) W80R probably damaging Het
Bmal1 A T 7: 112,879,934 (GRCm39) D22V probably damaging Het
Cars2 A G 8: 11,597,743 (GRCm39) I111T probably damaging Het
Chrd T C 16: 20,553,987 (GRCm39) L317S possibly damaging Het
Cyp4a12b A G 4: 115,290,664 (GRCm39) D262G probably benign Het
Dcaf6 A G 1: 165,216,254 (GRCm39) S450P probably benign Het
Dnah3 T C 7: 119,685,520 (GRCm39) D164G probably benign Het
Gpx6 A C 13: 21,503,239 (GRCm39) T218P probably benign Het
Htr1f T C 16: 64,746,239 (GRCm39) N351S probably damaging Het
Idua A G 5: 108,828,510 (GRCm39) E241G probably benign Het
Ighv14-2 T A 12: 113,958,255 (GRCm39) Q62L probably damaging Het
Ighv1-65 C T 12: 115,496,056 (GRCm39) noncoding transcript Het
Inpp4a T C 1: 37,411,451 (GRCm39) S372P probably damaging Het
Itgax A T 7: 127,730,624 (GRCm39) H114L probably damaging Het
Lama2 A T 10: 27,111,781 (GRCm39) F746L probably benign Het
Lrrc37a C T 11: 103,393,362 (GRCm39) V688M possibly damaging Het
Ltbp2 A G 12: 84,922,923 (GRCm39) V28A probably benign Het
Mill2 A T 7: 18,590,463 (GRCm39) D166V probably benign Het
Mroh2a G A 1: 88,176,377 (GRCm39) C982Y probably damaging Het
Msh3 T A 13: 92,478,922 (GRCm39) probably null Het
Myh15 A T 16: 48,980,062 (GRCm39) M1395L probably benign Het
Npepps T C 11: 97,113,950 (GRCm39) E642G probably benign Het
Nrg4 T C 9: 55,166,667 (GRCm39) T68A possibly damaging Het
Or10ag60 T A 2: 87,438,253 (GRCm39) F174I probably damaging Het
Or4b1d T C 2: 89,969,343 (GRCm39) N47D probably benign Het
Or6c66b T A 10: 129,376,759 (GRCm39) Y118N probably benign Het
Or8b41 A G 9: 38,055,256 (GRCm39) K270R probably damaging Het
Or9g20 A T 2: 85,629,726 (GRCm39) V296E probably damaging Het
Otogl T A 10: 107,715,390 (GRCm39) I429F probably damaging Het
Pank4 G T 4: 155,061,678 (GRCm39) G532C probably damaging Het
Plce1 A G 19: 38,710,315 (GRCm39) T1150A probably damaging Het
Ppp2r2b T C 18: 43,192,224 (GRCm39) probably null Het
Prkrip1 A G 5: 136,226,636 (GRCm39) M68T probably damaging Het
Psme4 T A 11: 30,806,896 (GRCm39) probably benign Het
Raet1d T A 10: 22,247,293 (GRCm39) I123N probably damaging Het
Rp1 T G 1: 4,267,808 (GRCm39) T825P unknown Het
Rttn T C 18: 89,039,816 (GRCm39) I839T probably damaging Het
Sgo2b G A 8: 64,379,707 (GRCm39) Q1042* probably null Het
Skint11 A G 4: 114,088,925 (GRCm39) T240A probably benign Het
Speg A T 1: 75,392,247 (GRCm39) K1382* probably null Het
Srsf7 A T 17: 80,513,282 (GRCm39) D68E probably damaging Het
Stag3 A T 5: 138,287,468 (GRCm39) D131V probably damaging Het
Strip2 T A 6: 29,926,570 (GRCm39) C152S probably damaging Het
Timm44 G T 8: 4,317,747 (GRCm39) D191E probably benign Het
Tlnrd1 A G 7: 83,531,987 (GRCm39) V148A probably damaging Het
Trp63 T C 16: 25,582,146 (GRCm39) probably null Het
Tusc3 G C 8: 39,538,560 (GRCm39) G200R probably damaging Het
Vmn2r10 T G 5: 109,146,944 (GRCm39) N448T probably benign Het
Vmn2r50 G A 7: 9,783,986 (GRCm39) R163C probably benign Het
Vmn2r53 T C 7: 12,316,328 (GRCm39) H497R probably benign Het
Vps39 A G 2: 120,176,131 (GRCm39) V83A possibly damaging Het
Ylpm1 A T 12: 85,075,858 (GRCm39) N861I possibly damaging Het
Zfp712 A G 13: 67,189,769 (GRCm39) C253R probably damaging Het
Zfp930 A G 8: 69,680,556 (GRCm39) T84A probably benign Het
Other mutations in Or4f60
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00895:Or4f60 APN 2 111,902,100 (GRCm39) missense probably damaging 0.98
IGL01790:Or4f60 APN 2 111,902,266 (GRCm39) missense probably benign 0.00
IGL02054:Or4f60 APN 2 111,902,269 (GRCm39) missense probably benign 0.43
IGL03387:Or4f60 APN 2 111,902,007 (GRCm39) missense probably benign 0.00
R1891:Or4f60 UTSW 2 111,902,739 (GRCm39) missense probably damaging 1.00
R2509:Or4f60 UTSW 2 111,902,837 (GRCm39) missense probably benign
R2520:Or4f60 UTSW 2 111,902,013 (GRCm39) missense probably benign 0.00
R3084:Or4f60 UTSW 2 111,902,320 (GRCm39) nonsense probably null
R3085:Or4f60 UTSW 2 111,902,320 (GRCm39) nonsense probably null
R3086:Or4f60 UTSW 2 111,902,320 (GRCm39) nonsense probably null
R4357:Or4f60 UTSW 2 111,902,583 (GRCm39) missense probably damaging 1.00
R4700:Or4f60 UTSW 2 111,902,097 (GRCm39) missense possibly damaging 0.54
R5366:Or4f60 UTSW 2 111,902,823 (GRCm39) missense possibly damaging 0.91
R5372:Or4f60 UTSW 2 111,902,454 (GRCm39) missense probably benign 0.03
R5643:Or4f60 UTSW 2 111,902,013 (GRCm39) missense probably benign 0.00
R5644:Or4f60 UTSW 2 111,902,013 (GRCm39) missense probably benign 0.00
R5681:Or4f60 UTSW 2 111,902,722 (GRCm39) missense probably benign 0.38
R6609:Or4f60 UTSW 2 111,902,509 (GRCm39) missense probably benign 0.01
R7056:Or4f60 UTSW 2 111,902,662 (GRCm39) missense probably benign
R7066:Or4f60 UTSW 2 111,902,541 (GRCm39) missense probably damaging 1.00
R7417:Or4f60 UTSW 2 111,902,445 (GRCm39) missense probably benign 0.01
R8942:Or4f60 UTSW 2 111,902,802 (GRCm39) missense probably damaging 1.00
R9261:Or4f60 UTSW 2 111,902,718 (GRCm39) missense probably damaging 1.00
R9423:Or4f60 UTSW 2 111,902,808 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- CTACAGTCACGTGAGCTGAAAGTG -3'
(R):5'- GTGCTACTCATTGCCATGGC -3'

Sequencing Primer
(F):5'- TGTAGACAGCGCTTTGTAGGAACC -3'
(R):5'- ATGTGGCCATATGTAAGCCTC -3'
Posted On 2017-06-26