Mutagenetix > Incidental Mutation

Incidental Mutation 'R6015:Vmn1r68'

478558

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r68

Ensembl Gene

ENSMUSG00000047031

Gene Name

vomeronasal 1 receptor 68

Synonyms

Gm6898

MMRRC Submission

043254-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

R6015 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

10261137-10262096 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 10261616 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 161 (V161M)

Ref Sequence

ENSEMBL: ENSMUSP00000050927 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000058362]

AlphaFold

E9Q0V3

Predicted Effect

probably benign
Transcript: ENSMUST00000058362
AA Change: V161M

PolyPhen 2 Score 0.313 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000050927
Gene: ENSMUSG00000047031
AA Change: V161M

Domain	Start	End	E-Value	Type
Pfam:V1R	49	306	2e-33	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.3%
20x: 95.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ano5	A	C	7: 51,224,525 (GRCm39)	S480R	probably benign	Het
Aqr	A	G	2: 114,005,646 (GRCm39)	M1T	probably null	Het
Arhgef28	A	G	13: 98,211,530 (GRCm39)	V151A	possibly damaging	Het
Atp6v1b2	T	A	8: 69,555,148 (GRCm39)	I170N	probably damaging	Het
Atxn2	T	A	5: 121,949,055 (GRCm39)	V817D	probably damaging	Het
Cdh23	A	C	10: 60,143,761 (GRCm39)	I2950S	probably damaging	Het
Ces1h	A	G	8: 94,083,691 (GRCm39)	L417P	unknown	Het
Cimap3	T	C	3: 105,906,937 (GRCm39)	D154G	possibly damaging	Het
Csf1r	A	G	18: 61,242,784 (GRCm39)	E49G	possibly damaging	Het
Eml2	G	A	7: 18,935,088 (GRCm39)	V432I	probably damaging	Het
Fat3	A	G	9: 16,287,346 (GRCm39)	S726P	possibly damaging	Het
Grik2	A	T	10: 49,399,959 (GRCm39)		probably null	Het
Il9r	A	G	11: 32,142,674 (GRCm39)	V287A	probably benign	Het
Inpp5b	T	C	4: 124,692,143 (GRCm39)	C909R	possibly damaging	Het
Kat7	G	A	11: 95,174,860 (GRCm39)	H384Y	probably damaging	Het
Lama5	A	G	2: 179,827,185 (GRCm39)	S2272P	probably benign	Het
Megf10	A	G	18: 57,386,100 (GRCm39)	H371R	probably benign	Het
Moxd2	A	T	6: 40,860,688 (GRCm39)	Y310N	probably damaging	Het
Ntrk2	A	T	13: 59,208,209 (GRCm39)	E685V	probably damaging	Het
Ogfr	G	T	2: 180,236,467 (GRCm39)	G351W	probably damaging	Het
Or52ac1	G	T	7: 104,245,915 (GRCm39)	P158T	probably damaging	Het
Parp3	C	T	9: 106,351,481 (GRCm39)	V207M	possibly damaging	Het
Pfkfb3	T	C	2: 11,486,146 (GRCm39)		probably null	Het
Pigr	T	C	1: 130,774,998 (GRCm39)	V475A	probably benign	Het
Pik3ap1	T	A	19: 41,316,640 (GRCm39)	Y250F	probably benign	Het
Ppp1r3c	A	T	19: 36,711,206 (GRCm39)	I188N	probably damaging	Het
Prmt7	T	G	8: 106,961,640 (GRCm39)		probably benign	Het
Psapl1	T	C	5: 36,361,594 (GRCm39)	V62A	probably benign	Het
Relch	T	C	1: 105,619,683 (GRCm39)	L280S	probably damaging	Het
Rpp14	G	A	14: 8,090,462 (GRCm38)	V129I	probably benign	Het
Sema4f	A	G	6: 82,916,553 (GRCm39)		probably benign	Het
Serpinb13	C	A	1: 106,928,337 (GRCm39)	A319E	probably benign	Het
Sez6l2	A	T	7: 126,552,625 (GRCm39)	S134C	probably damaging	Het
Slc4a10	T	A	2: 62,059,046 (GRCm39)	H184Q	probably benign	Het
Slc9a9	G	T	9: 94,821,602 (GRCm39)	A330S	probably benign	Het
Sord	T	C	2: 122,087,424 (GRCm39)	V176A	probably damaging	Het
Ssbp2	G	T	13: 91,817,862 (GRCm39)		probably null	Het
Stab2	G	T	10: 86,773,906 (GRCm39)	N808K	probably damaging	Het
Syne1	A	G	10: 5,296,819 (GRCm39)		probably null	Het
Tpcn2	A	G	7: 144,820,588 (GRCm39)	V341A	probably damaging	Het
Unc13b	C	A	4: 43,177,995 (GRCm39)	S2941*	probably null	Het
Utrn	T	A	10: 12,354,168 (GRCm39)	H2806L	possibly damaging	Het
Vmn1r40	C	A	6: 89,691,588 (GRCm39)	A135D	probably damaging	Het
Wiz	T	A	17: 32,606,574 (GRCm39)	I54F	probably damaging	Het

Other mutations in Vmn1r68

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01892:Vmn1r68	APN	7	10,261,334 (GRCm39)	missense	possibly damaging	0.76
IGL02051:Vmn1r68	APN	7	10,261,948 (GRCm39)	missense	probably benign	0.00
IGL02112:Vmn1r68	APN	7	10,261,787 (GRCm39)	missense	probably damaging	0.96
IGL02619:Vmn1r68	APN	7	10,261,603 (GRCm39)	missense	probably benign	0.14
IGL03033:Vmn1r68	APN	7	10,262,074 (GRCm39)	missense	probably damaging	0.99
IGL03184:Vmn1r68	APN	7	10,261,799 (GRCm39)	missense	probably benign	0.16
PIT4354001:Vmn1r68	UTSW	7	10,261,958 (GRCm39)	missense	probably benign
R0141:Vmn1r68	UTSW	7	10,261,252 (GRCm39)	missense	possibly damaging	0.69
R0359:Vmn1r68	UTSW	7	10,261,201 (GRCm39)	missense	probably damaging	1.00
R0634:Vmn1r68	UTSW	7	10,261,162 (GRCm39)	missense	probably benign	0.00
R1731:Vmn1r68	UTSW	7	10,261,802 (GRCm39)	missense	probably damaging	1.00
R2021:Vmn1r68	UTSW	7	10,261,918 (GRCm39)	missense	probably damaging	1.00
R2022:Vmn1r68	UTSW	7	10,261,918 (GRCm39)	missense	probably damaging	1.00
R2243:Vmn1r68	UTSW	7	10,262,089 (GRCm39)	missense	probably damaging	0.98
R2262:Vmn1r68	UTSW	7	10,261,372 (GRCm39)	missense	probably damaging	1.00
R3877:Vmn1r68	UTSW	7	10,261,408 (GRCm39)	missense	probably damaging	1.00
R4470:Vmn1r68	UTSW	7	10,261,275 (GRCm39)	missense	probably benign	0.23
R4843:Vmn1r68	UTSW	7	10,261,904 (GRCm39)	missense	probably benign	0.00
R5198:Vmn1r68	UTSW	7	10,261,723 (GRCm39)	missense	probably benign	0.00
R5835:Vmn1r68	UTSW	7	10,261,747 (GRCm39)	missense	possibly damaging	0.68
R5906:Vmn1r68	UTSW	7	10,261,550 (GRCm39)	missense	probably benign	0.02
R7073:Vmn1r68	UTSW	7	10,261,778 (GRCm39)	missense	probably benign	0.00
R7614:Vmn1r68	UTSW	7	10,261,553 (GRCm39)	missense	probably benign	0.05
R7699:Vmn1r68	UTSW	7	10,261,559 (GRCm39)	missense	probably benign	0.15
R7700:Vmn1r68	UTSW	7	10,261,559 (GRCm39)	missense	probably benign	0.15
R7912:Vmn1r68	UTSW	7	10,261,237 (GRCm39)	missense	probably benign	0.01
R8166:Vmn1r68	UTSW	7	10,261,888 (GRCm39)	missense	probably benign	0.10
R8426:Vmn1r68	UTSW	7	10,261,382 (GRCm39)	missense	probably benign	0.02
R9466:Vmn1r68	UTSW	7	10,261,417 (GRCm39)	missense	probably damaging	1.00
R9466:Vmn1r68	UTSW	7	10,261,317 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- CATGAAAGCTGCGGATATGTTG -3'
(R):5'- AGAGTTGGCCGAAGTACATCC -3'

Sequencing Primer
(F):5'- TCTGTACAGGATGCCAATCATGG -3'
(R):5'- TGGCCGAAGTACATCCATTGG -3'

Posted On

2017-06-26