Incidental Mutation 'IGL00432:Tgm4'
ID 4786
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tgm4
Ensembl Gene ENSMUSG00000025787
Gene Name transglutaminase 4 (prostate)
Synonyms Eapa1, 9530008N10Rik, experimental autoimmune prostatitis antigen 1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # IGL00432
Quality Score
Status
Chromosome 9
Chromosomal Location 122863806-122896623 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to T at 122891447 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000149061 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026893] [ENSMUST00000140497] [ENSMUST00000215247] [ENSMUST00000217607]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000026893
SMART Domains Protein: ENSMUSP00000026893
Gene: ENSMUSG00000025787

DomainStartEndE-ValueType
Pfam:Transglut_N 8 118 4e-26 PFAM
TGc 247 340 6.25e-42 SMART
Pfam:Transglut_C 573 670 3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000140497
SMART Domains Protein: ENSMUSP00000122604
Gene: ENSMUSG00000025786

DomainStartEndE-ValueType
low complexity region 25 35 N/A INTRINSIC
transmembrane domain 46 68 N/A INTRINSIC
transmembrane domain 73 95 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214552
Predicted Effect probably benign
Transcript: ENSMUST00000215247
Predicted Effect probably benign
Transcript: ENSMUST00000217607
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired copulatory plug formation, reduced fertilization and few litters sired. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AA986860 A T 1: 130,670,573 (GRCm39) Q265L possibly damaging Het
Akr1c18 T A 13: 4,187,232 (GRCm39) H168L probably damaging Het
Arid3b A G 9: 57,741,207 (GRCm39) S80P possibly damaging Het
Barhl2 C T 5: 106,603,365 (GRCm39) A265T possibly damaging Het
Brd1 A C 15: 88,614,361 (GRCm39) V178G probably benign Het
Brd2 C T 17: 34,333,397 (GRCm39) R26Q probably damaging Het
Ddr2 T C 1: 169,825,527 (GRCm39) M358V probably benign Het
Dnajc14 A G 10: 128,642,201 (GRCm39) D41G probably damaging Het
Erap1 T G 13: 74,821,778 (GRCm39) V711G probably benign Het
Gchfr A G 2: 119,000,229 (GRCm39) R37G probably damaging Het
Gm20518 T A 16: 17,676,362 (GRCm39) N136I probably damaging Het
Grm6 A T 11: 50,754,124 (GRCm39) probably benign Het
Hydin T A 8: 111,327,884 (GRCm39) V4797E probably damaging Het
Iws1 C A 18: 32,217,741 (GRCm39) N448K probably benign Het
Lin7c T C 2: 109,726,798 (GRCm39) probably benign Het
Lrrc40 T A 3: 157,754,087 (GRCm39) L196Q probably damaging Het
Lrrtm2 C T 18: 35,346,321 (GRCm39) G327D probably benign Het
Masp1 C T 16: 23,332,601 (GRCm39) C78Y probably damaging Het
Mmd C T 11: 90,155,360 (GRCm39) R101W probably damaging Het
Myo1d A G 11: 80,492,566 (GRCm39) Y730H probably benign Het
Pcdh15 A G 10: 74,126,914 (GRCm39) probably benign Het
Pglyrp4 G A 3: 90,646,335 (GRCm39) V290M probably damaging Het
Plxna2 G A 1: 194,326,404 (GRCm39) V113I probably benign Het
Prkch T A 12: 73,749,363 (GRCm39) probably benign Het
Rabgef1 G T 5: 130,237,565 (GRCm39) E213* probably null Het
Rdh16f2 T A 10: 127,702,533 (GRCm39) C37S probably damaging Het
Reln A G 5: 22,215,125 (GRCm39) Y1109H probably damaging Het
Scn7a A T 2: 66,572,326 (GRCm39) L215* probably null Het
Slc25a33 A T 4: 149,829,376 (GRCm39) L261H probably damaging Het
Slc28a3 A T 13: 58,717,225 (GRCm39) probably null Het
Slc38a6 T C 12: 73,398,577 (GRCm39) I369T probably benign Het
Tnr A G 1: 159,688,815 (GRCm39) I426V probably benign Het
Vmn1r216 A G 13: 23,283,574 (GRCm39) I86V probably benign Het
Wwc1 G A 11: 35,735,029 (GRCm39) P949S possibly damaging Het
Zfp326 A T 5: 106,044,399 (GRCm39) I286F probably damaging Het
Other mutations in Tgm4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01402:Tgm4 APN 9 122,880,519 (GRCm39) missense possibly damaging 0.82
IGL02000:Tgm4 APN 9 122,885,531 (GRCm39) missense probably damaging 1.00
IGL02120:Tgm4 APN 9 122,875,594 (GRCm39) missense probably damaging 0.98
IGL03130:Tgm4 APN 9 122,885,580 (GRCm39) missense probably damaging 1.00
IGL03188:Tgm4 APN 9 122,874,101 (GRCm39) missense probably null 0.06
R0329:Tgm4 UTSW 9 122,877,622 (GRCm39) critical splice donor site probably null
R0480:Tgm4 UTSW 9 122,891,484 (GRCm39) missense probably benign
R0644:Tgm4 UTSW 9 122,880,523 (GRCm39) missense probably damaging 1.00
R0990:Tgm4 UTSW 9 122,875,576 (GRCm39) missense probably benign 0.02
R1604:Tgm4 UTSW 9 122,874,129 (GRCm39) missense probably benign 0.39
R1644:Tgm4 UTSW 9 122,880,481 (GRCm39) missense probably damaging 1.00
R2056:Tgm4 UTSW 9 122,890,835 (GRCm39) missense probably damaging 1.00
R2058:Tgm4 UTSW 9 122,890,835 (GRCm39) missense probably damaging 1.00
R2059:Tgm4 UTSW 9 122,890,835 (GRCm39) missense probably damaging 1.00
R2076:Tgm4 UTSW 9 122,880,160 (GRCm39) missense probably benign 0.24
R2437:Tgm4 UTSW 9 122,877,614 (GRCm39) nonsense probably null
R4392:Tgm4 UTSW 9 122,895,817 (GRCm39) missense probably benign 0.10
R4407:Tgm4 UTSW 9 122,885,595 (GRCm39) missense probably damaging 1.00
R4752:Tgm4 UTSW 9 122,880,451 (GRCm39) missense probably damaging 1.00
R5288:Tgm4 UTSW 9 122,885,559 (GRCm39) missense probably damaging 1.00
R5365:Tgm4 UTSW 9 122,895,866 (GRCm39) missense probably damaging 1.00
R5386:Tgm4 UTSW 9 122,885,559 (GRCm39) missense probably damaging 1.00
R5790:Tgm4 UTSW 9 122,890,808 (GRCm39) missense probably damaging 0.98
R5890:Tgm4 UTSW 9 122,890,703 (GRCm39) missense probably damaging 1.00
R6102:Tgm4 UTSW 9 122,885,600 (GRCm39) missense probably benign
R6358:Tgm4 UTSW 9 122,885,583 (GRCm39) missense probably damaging 1.00
R6956:Tgm4 UTSW 9 122,893,768 (GRCm39) missense possibly damaging 0.93
R6966:Tgm4 UTSW 9 122,880,207 (GRCm39) missense possibly damaging 0.68
R7091:Tgm4 UTSW 9 122,869,525 (GRCm39) missense probably damaging 1.00
R7258:Tgm4 UTSW 9 122,891,556 (GRCm39) missense probably benign 0.02
R7313:Tgm4 UTSW 9 122,891,556 (GRCm39) missense probably benign 0.02
R7369:Tgm4 UTSW 9 122,885,749 (GRCm39) critical splice donor site probably null
R7802:Tgm4 UTSW 9 122,880,401 (GRCm39) intron probably benign
R8219:Tgm4 UTSW 9 122,874,117 (GRCm39) missense probably benign
R8787:Tgm4 UTSW 9 122,890,910 (GRCm39) missense probably damaging 1.00
R8936:Tgm4 UTSW 9 122,869,541 (GRCm39) missense possibly damaging 0.92
R9045:Tgm4 UTSW 9 122,877,616 (GRCm39) missense possibly damaging 0.94
R9328:Tgm4 UTSW 9 122,885,697 (GRCm39) missense possibly damaging 0.93
R9359:Tgm4 UTSW 9 122,881,837 (GRCm39) missense probably damaging 1.00
R9403:Tgm4 UTSW 9 122,881,837 (GRCm39) missense probably damaging 1.00
R9471:Tgm4 UTSW 9 122,869,444 (GRCm39) missense probably benign
R9746:Tgm4 UTSW 9 122,875,634 (GRCm39) missense possibly damaging 0.95
Posted On 2012-04-20