Mutagenetix > Incidental Mutation

Incidental Mutation 'R6019:Lrp1b'

478759

Institutional Source

Beutler Lab

Gene Symbol

Lrp1b

Ensembl Gene

ENSMUSG00000049252

Gene Name

low density lipoprotein-related protein 1B (deleted in tumors)

Synonyms

9630004P12Rik

MMRRC Submission

044193-MU

Accession Numbers

Genbank: NM_053011.2

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6019 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

40595246-42653624 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 41476809 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Valine at position 485 (D485V)

Ref Sequence

ENSEMBL: ENSMUSP00000129192 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052550] [ENSMUST00000167270] [ENSMUST00000203080]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000052550
AA Change: D599V

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000054275
Gene: ENSMUSG00000049252
AA Change: D599V

Domain	Start	End	E-Value	Type
low complexity region	3	19	N/A	INTRINSIC
low complexity region	35	46	N/A	INTRINSIC
LDLa	62	102	2.97e-12	SMART
LDLa	107	146	1.31e-8	SMART
EGF	150	185	1.95e1	SMART
EGF_CA	186	225	8.37e-8	SMART
LY	256	300	4.06e1	SMART
LY	304	348	1.15e-5	SMART
LY	349	392	1.17e-11	SMART
LY	393	435	1.12e-8	SMART
LY	436	478	2.21e1	SMART
EGF	505	548	2.45e0	SMART
LY	579	621	1.32e-5	SMART
LY	622	665	1.88e-10	SMART
LY	668	717	1.47e-12	SMART
LY	718	760	5.78e-11	SMART
LY	761	802	1.45e0	SMART
EGF_like	828	865	4.55e1	SMART
LDLa	875	914	7.15e-15	SMART
LDLa	916	955	5.26e-13	SMART
LDLa	957	995	6.13e-14	SMART
LDLa	997	1035	6.47e-13	SMART
LDLa	1036	1075	1.76e-14	SMART
LDLa	1083	1121	2.29e-13	SMART
LDLa	1125	1164	3.36e-11	SMART
LDLa	1166	1206	2.57e-7	SMART
EGF	1206	1244	1.58e-3	SMART
EGF	1248	1284	4.56e0	SMART
LY	1311	1353	4.85e-4	SMART
LY	1358	1400	6.49e-14	SMART
LY	1401	1445	8.18e-11	SMART
LY	1446	1490	4.25e-9	SMART
LY	1492	1534	5.4e-2	SMART
EGF	1561	1601	9.41e-2	SMART
LY	1629	1671	3.03e-5	SMART
LY	1672	1716	1.22e-9	SMART
LY	1718	1756	1.02e-2	SMART
LY	1757	1798	8.25e-7	SMART
EGF	1868	1906	4.03e-1	SMART
LY	1933	1975	1.01e-1	SMART
LY	1976	2018	3.03e-14	SMART
LY	2019	2062	2.16e-10	SMART
LY	2063	2105	4.09e-11	SMART
LY	2107	2149	9.96e0	SMART
EGF	2177	2214	2.13e0	SMART
LY	2292	2334	6.96e-5	SMART
LY	2340	2385	1.07e-5	SMART
LY	2386	2428	1.1e-11	SMART
LY	2429	2470	4.78e-3	SMART
EGF	2498	2535	2.03e1	SMART
LDLa	2540	2580	1.1e-6	SMART
LDLa	2582	2619	1.72e-8	SMART
LDLa	2621	2658	2.45e-13	SMART
LDLa	2669	2707	6.53e-9	SMART
LDLa	2712	2749	7.97e-13	SMART
LDLa	2750	2789	1.22e-8	SMART
LDLa	2791	2832	3.07e-14	SMART
LDLa	2835	2873	7.32e-12	SMART
LDLa	2875	2917	1.85e-8	SMART
LDLa	2921	2958	4.76e-11	SMART
EGF_CA	2957	2998	1.79e-7	SMART
EGF_CA	2999	3039	1.85e-9	SMART
LY	3066	3111	2.58e-8	SMART
LY	3112	3152	1.22e-9	SMART
LY	3153	3196	8.84e-7	SMART
LY	3197	3237	3.22e-9	SMART
LY	3238	3279	1.04e-3	SMART
EGF	3307	3345	7.13e-2	SMART
LDLa	3347	3385	9.29e-14	SMART
LDLa	3387	3424	2.25e-12	SMART
LDLa	3426	3464	5.63e-13	SMART
LDLa	3466	3504	1.07e-13	SMART
LDLa	3506	3543	1.35e-15	SMART
EGF_like	3545	3581	2.8e1	SMART
LDLa	3545	3582	1.49e-12	SMART
LDLa	3583	3620	4.21e-12	SMART
LDLa	3624	3661	4.9e-13	SMART
LDLa	3662	3700	9.58e-16	SMART
LDLa	3704	3743	5.38e-10	SMART
LDLa	3745	3784	1.42e-9	SMART
LDLa	3792	3829	3.66e-12	SMART
EGF	3835	3874	3.71e0	SMART
EGF_CA	3875	3912	6.8e-8	SMART
LY	3987	4033	4.24e0	SMART
LY	4050	4093	4.46e-3	SMART
LY	4094	4136	1.73e-9	SMART
EGF	4206	4239	2.45e0	SMART
EGF	4247	4280	2.48e-1	SMART
EGF	4283	4316	1.49e-4	SMART
EGF	4319	4352	1.69e-3	SMART
EGF	4355	4388	1.18e1	SMART
EGF_like	4391	4423	6.67e1	SMART
EGF	4424	4458	1.61e0	SMART
transmembrane domain	4476	4498	N/A	INTRINSIC
low complexity region	4499	4509	N/A	INTRINSIC
low complexity region	4512	4523	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000167270
AA Change: D485V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000129192
Gene: ENSMUSG00000049252
AA Change: D485V

Domain	Start	End	E-Value	Type
EGF	5	40	1.95e1	SMART
EGF_CA	41	80	8.37e-8	SMART
LY	111	155	4.06e1	SMART
LY	159	203	1.15e-5	SMART
LY	204	247	1.17e-11	SMART
LY	248	290	1.12e-8	SMART
LY	291	333	2.21e1	SMART
EGF	360	403	2.45e0	SMART
LY	434	476	1.32e-5	SMART
LY	477	520	1.88e-10	SMART
LY	523	572	1.47e-12	SMART
LY	573	615	5.78e-11	SMART
LY	616	657	1.45e0	SMART
EGF_like	683	720	4.55e1	SMART
LDLa	730	769	7.15e-15	SMART
LDLa	771	810	5.26e-13	SMART
LDLa	812	850	6.13e-14	SMART
LDLa	852	890	6.47e-13	SMART
LDLa	891	930	1.76e-14	SMART
LDLa	938	976	2.29e-13	SMART
LDLa	980	1019	3.36e-11	SMART
LDLa	1021	1061	2.57e-7	SMART
EGF	1061	1099	1.58e-3	SMART
EGF	1103	1139	4.56e0	SMART
LY	1166	1208	4.85e-4	SMART
LY	1213	1255	6.49e-14	SMART
LY	1256	1300	8.18e-11	SMART
LY	1301	1345	4.25e-9	SMART
LY	1347	1389	5.4e-2	SMART
EGF	1416	1456	9.41e-2	SMART
LY	1484	1526	3.03e-5	SMART
LY	1527	1571	1.22e-9	SMART
LY	1573	1611	1.02e-2	SMART
LY	1612	1653	8.25e-7	SMART
EGF	1723	1761	4.03e-1	SMART
LY	1788	1830	1.01e-1	SMART
LY	1831	1873	3.03e-14	SMART
LY	1874	1917	2.16e-10	SMART
LY	1918	1960	4.09e-11	SMART
LY	1962	2004	9.96e0	SMART
EGF	2032	2069	2.13e0	SMART
LY	2147	2189	6.96e-5	SMART
LY	2195	2240	1.07e-5	SMART
LY	2241	2283	1.1e-11	SMART
LY	2284	2325	4.78e-3	SMART
EGF	2353	2390	2.03e1	SMART
LDLa	2395	2435	1.1e-6	SMART
LDLa	2437	2474	1.72e-8	SMART
LDLa	2476	2513	2.45e-13	SMART
LDLa	2524	2562	6.53e-9	SMART
LDLa	2567	2604	7.97e-13	SMART
LDLa	2605	2644	1.22e-8	SMART
LDLa	2646	2687	3.07e-14	SMART
LDLa	2690	2728	7.32e-12	SMART
LDLa	2730	2772	1.85e-8	SMART
LDLa	2776	2813	4.76e-11	SMART
EGF_CA	2812	2853	1.79e-7	SMART
EGF_CA	2854	2894	1.85e-9	SMART
LY	2921	2966	2.58e-8	SMART
LY	2967	3007	1.22e-9	SMART
LY	3008	3051	8.84e-7	SMART
LY	3052	3092	3.22e-9	SMART
LY	3093	3134	1.04e-3	SMART
EGF	3162	3200	7.13e-2	SMART
LDLa	3202	3240	9.29e-14	SMART
LDLa	3242	3279	2.25e-12	SMART
LDLa	3281	3319	5.63e-13	SMART
LDLa	3321	3357	5.86e-11	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000203080

SMART Domains

Protein: ENSMUSP00000145278
Gene: ENSMUSG00000049252

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
LDLa	31	70	1.4e-13	SMART
LDLa	71	109	3e-16	SMART
LDLa	111	149	3.3e-15	SMART
LDLa	150	189	8.4e-17	SMART
LDLa	197	235	1.1e-15	SMART
LDLa	239	278	1.6e-13	SMART
LDLa	280	320	1.2e-9	SMART
EGF	320	358	7.8e-6	SMART
EGF	362	398	2.3e-2	SMART
LY	425	467	2.4e-6	SMART
LY	472	514	3.3e-16	SMART
LY	515	559	4.1e-13	SMART
LY	560	604	2.1e-11	SMART
LY	606	648	2.7e-4	SMART
EGF	675	715	4.6e-4	SMART
LY	743	782	8.1e-3	SMART

Meta Mutation Damage Score

0.2657

Coding Region Coverage

1x: 99.9%
3x: 99.4%
10x: 97.2%
20x: 91.1%

Validation Efficiency

96% (81/84)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016]
PHENOTYPE: Homozygous null mice appear normal, are fertile, have normal brain histology and function, normal plasma cholesterol and fasting triglycerides, and do not develop tumors. [provided by MGI curators]

Allele List at MGI

All alleles(9) : Targeted, knock-out(3) Targeted, other(2) Gene trapped(4)

Other mutations in this stock

Total: 82 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcf3	C	T	16: 20,552,451 (GRCm38)	H436Y	possibly damaging	Het
Acad10	A	T	5: 121,634,801 (GRCm38)	H472Q	possibly damaging	Het
Ano8	G	A	8: 71,482,380 (GRCm38)	R393C	probably damaging	Het
Arhgap18	T	A	10: 26,860,650 (GRCm38)	V163E	probably damaging	Het
AW209491	C	T	13: 14,637,780 (GRCm38)	A406V	probably benign	Het
Brix1	C	T	15: 10,476,589 (GRCm38)	R267H	probably benign	Het
Cacng5	T	C	11: 107,884,388 (GRCm38)	M52V	probably benign	Het
Casz1	T	C	4: 148,947,038 (GRCm38)	C1249R	probably damaging	Het
Cenpj	C	T	14: 56,534,815 (GRCm38)	S1086N	probably benign	Het
Chil1	T	C	1: 134,189,572 (GRCm38)	F367S	probably benign	Het
Copg2	A	T	6: 30,810,933 (GRCm38)	I610N	possibly damaging	Het
Cpa6	T	C	1: 10,595,643 (GRCm38)	K57E	possibly damaging	Het
D5Ertd579e	C	T	5: 36,629,692 (GRCm38)	A111T	possibly damaging	Het
Dgat2	A	G	7: 99,154,631 (GRCm38)	M361T	probably benign	Het
Dnm3	G	T	1: 162,134,501 (GRCm38)	F46L	probably damaging	Het
Dph7	T	A	2: 24,963,540 (GRCm38)	C122*	probably null	Het
Dspp	A	T	5: 104,178,039 (GRCm38)	D756V	unknown	Het
Ep300	T	A	15: 81,641,382 (GRCm38)	M1469K	unknown	Het
Fsip2	T	C	2: 82,987,939 (GRCm38)	I4672T	possibly damaging	Het
Gapdh	A	T	6: 125,163,033 (GRCm38)	L67*	probably null	Het
Gm11639	T	C	11: 105,042,902 (GRCm38)		probably null	Het
Gm14025	T	C	2: 129,037,690 (GRCm38)	Q772R	probably benign	Het
Gm21994	T	A	2: 150,255,212 (GRCm38)	H99L	probably damaging	Het
Gm3259	G	A	5: 95,340,213 (GRCm38)	S2N	probably damaging	Het
Gm9495	A	T	8: 69,429,314 (GRCm38)	C337S	probably benign	Het
Gpr75	A	G	11: 30,891,640 (GRCm38)	R182G	probably benign	Het
Gsr	G	T	8: 33,693,807 (GRCm38)	A366S	probably damaging	Het
Gypc	A	G	18: 32,530,195 (GRCm38)	I33T	probably damaging	Het
Hapln1	A	G	13: 89,608,100 (GRCm38)	D341G	probably benign	Het
Hnrnpd	A	G	5: 99,967,236 (GRCm38)	S148P	probably benign	Het
Hydin	A	T	8: 110,566,620 (GRCm38)	T3450S	probably benign	Het
Kif20b	T	C	19: 34,950,464 (GRCm38)	V1002A	probably benign	Het
Kif5c	T	C	2: 49,735,509 (GRCm38)	V597A	probably benign	Het
Kntc1	A	G	5: 123,762,516 (GRCm38)	T226A	probably benign	Het
Krt75	C	A	15: 101,573,723 (GRCm38)	V37L	probably benign	Het
L3mbtl2	A	G	15: 81,686,942 (GRCm38)	I668V	probably benign	Het
Lrrc37a	T	C	11: 103,456,596 (GRCm38)	H3091R	unknown	Het
Msi1	A	G	5: 115,451,491 (GRCm38)	Y361C	probably damaging	Het
Mtus1	G	T	8: 41,083,040 (GRCm38)	N546K	probably benign	Het
Mup17	T	A	4: 61,593,699 (GRCm38)	T113S	probably benign	Het
Myh11	T	A	16: 14,206,074 (GRCm38)	D1479V	probably damaging	Het
Ncor1	C	T	11: 62,373,161 (GRCm38)	E198K	probably benign	Het
Nrde2	A	G	12: 100,132,242 (GRCm38)	V722A	probably benign	Het
Olfr206	C	T	16: 59,345,435 (GRCm38)	D89N	possibly damaging	Het
Olfr564	C	T	7: 102,804,284 (GRCm38)	R269*	probably null	Het
Olfr61	T	C	7: 140,638,012 (GRCm38)	F104L	probably benign	Het
Otog	A	G	7: 46,288,950 (GRCm38)	M2028V	probably benign	Het
Paox	T	A	7: 140,131,742 (GRCm38)	V169E	probably damaging	Het
Pcsk9	T	G	4: 106,456,876 (GRCm38)	D174A	probably benign	Het
Pde4b	A	G	4: 102,570,769 (GRCm38)	E41G	possibly damaging	Het
Pip4k2c	A	G	10: 127,199,074 (GRCm38)	I419T	probably damaging	Het
Plekhg3	G	T	12: 76,577,941 (GRCm38)	E1186*	probably null	Het
Pole	C	T	5: 110,324,515 (GRCm38)	P1548L	probably benign	Het
Pole	C	A	5: 110,324,514 (GRCm38)	P1548T	probably benign	Het
Polq	A	G	16: 37,061,764 (GRCm38)	E1430G	probably damaging	Het
Ptgr2	T	C	12: 84,298,146 (GRCm38)	S98P	probably damaging	Het
Ralgapa1	A	G	12: 55,684,042 (GRCm38)	Y1903H	possibly damaging	Het
Rasgrp1	T	C	2: 117,291,895 (GRCm38)	D338G	probably damaging	Het
Rif1	C	G	2: 52,095,844 (GRCm38)	L614V	probably damaging	Het
Rnase13	C	T	14: 51,922,403 (GRCm38)	C93Y	probably damaging	Het
Rnd2	C	T	11: 101,468,999 (GRCm38)	L57F	probably damaging	Het
S100z	T	A	13: 95,477,426 (GRCm38)	M59L	probably benign	Het
Ska1	T	A	18: 74,199,921 (GRCm38)	D142V	probably benign	Het
Slc16a3	T	C	11: 120,957,105 (GRCm38)		probably null	Het
Snd1	T	C	6: 28,880,234 (GRCm38)	V669A	probably benign	Het
Snrpd3	A	T	10: 75,532,195 (GRCm38)	T49S	probably damaging	Het
Sort1	T	C	3: 108,357,233 (GRCm38)	L856P	possibly damaging	Het
Srek1ip1	T	A	13: 104,834,322 (GRCm38)		probably null	Het
Ssrp1	T	C	2: 85,045,452 (GRCm38)	S552P	probably damaging	Het
Stab2	A	G	10: 87,003,022 (GRCm38)	V60A	probably benign	Het
Stard9	GCCC	GCC	2: 120,693,715 (GRCm38)		probably null	Het
Tll1	A	C	8: 64,041,491 (GRCm38)	H743Q	possibly damaging	Het
Tpo	G	T	12: 30,094,981 (GRCm38)	R590S	possibly damaging	Het
Trbv12-1	A	T	6: 41,113,846 (GRCm38)	T51S	probably benign	Het
Trbv30	C	T	6: 41,281,774 (GRCm38)	A40V	probably benign	Het
Tulp4	T	A	17: 6,233,215 (GRCm38)	V1173E	possibly damaging	Het
Upk1a	A	T	7: 30,612,385 (GRCm38)		probably null	Het
Vmn1r199	A	G	13: 22,382,599 (GRCm38)	D21G	possibly damaging	Het
Vmn2r7	T	C	3: 64,716,222 (GRCm38)	T317A	probably damaging	Het
Wdfy3	A	G	5: 101,849,423 (GRCm38)	V3112A	probably damaging	Het
Zbtb8os	T	C	4: 129,340,749 (GRCm38)	V40A	possibly damaging	Het
Zwint	A	G	10: 72,656,853 (GRCm38)	K108E	possibly damaging	Het

Other mutations in Lrp1b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00484:Lrp1b	APN	2	41,110,861 (GRCm38)	missense	probably damaging	1.00
IGL00543:Lrp1b	APN	2	41,468,948 (GRCm38)	missense	possibly damaging	0.69
IGL00578:Lrp1b	APN	2	40,679,173 (GRCm38)	missense	unknown
IGL01020:Lrp1b	APN	2	40,998,247 (GRCm38)	missense	probably damaging	1.00
IGL01092:Lrp1b	APN	2	40,750,947 (GRCm38)	missense	probably damaging	0.97
IGL01155:Lrp1b	APN	2	41,770,935 (GRCm38)	missense	probably benign	0.17
IGL01361:Lrp1b	APN	2	41,110,751 (GRCm38)	splice site	probably benign
IGL01377:Lrp1b	APN	2	40,601,538 (GRCm38)	missense	probably damaging	1.00
IGL01459:Lrp1b	APN	2	40,860,714 (GRCm38)	missense	probably damaging	0.97
IGL01473:Lrp1b	APN	2	40,611,486 (GRCm38)	missense	probably damaging	0.97
IGL01528:Lrp1b	APN	2	40,919,182 (GRCm38)	missense	probably damaging	0.99
IGL01536:Lrp1b	APN	2	41,110,883 (GRCm38)	missense	probably benign	0.01
IGL01564:Lrp1b	APN	2	40,677,486 (GRCm38)	splice site	probably benign
IGL01747:Lrp1b	APN	2	40,860,685 (GRCm38)	missense	probably damaging	1.00
IGL01764:Lrp1b	APN	2	40,697,442 (GRCm38)	missense	unknown
IGL01783:Lrp1b	APN	2	41,312,572 (GRCm38)	missense	probably damaging	1.00
IGL01802:Lrp1b	APN	2	41,511,482 (GRCm38)	missense	probably benign	0.07
IGL01826:Lrp1b	APN	2	41,449,234 (GRCm38)	missense	probably damaging	1.00
IGL01884:Lrp1b	APN	2	41,284,213 (GRCm38)	nonsense	probably null
IGL01908:Lrp1b	APN	2	40,702,804 (GRCm38)	missense	probably benign
IGL01935:Lrp1b	APN	2	41,268,355 (GRCm38)	missense	probably damaging	1.00
IGL01959:Lrp1b	APN	2	41,312,527 (GRCm38)	missense	probably damaging	0.99
IGL02010:Lrp1b	APN	2	41,468,942 (GRCm38)	missense	probably damaging	1.00
IGL02022:Lrp1b	APN	2	41,282,160 (GRCm38)	missense	probably damaging	1.00
IGL02028:Lrp1b	APN	2	41,511,452 (GRCm38)	missense	probably damaging	1.00
IGL02034:Lrp1b	APN	2	41,268,370 (GRCm38)	nonsense	probably null
IGL02043:Lrp1b	APN	2	40,697,525 (GRCm38)	missense	probably null	0.44
IGL02066:Lrp1b	APN	2	41,111,079 (GRCm38)	nonsense	probably null
IGL02085:Lrp1b	APN	2	40,889,309 (GRCm38)	missense	probably benign
IGL02137:Lrp1b	APN	2	40,730,688 (GRCm38)	splice site	probably benign
IGL02218:Lrp1b	APN	2	41,295,672 (GRCm38)	missense	probably benign	0.11
IGL02409:Lrp1b	APN	2	41,445,196 (GRCm38)	missense	possibly damaging	0.93
IGL02513:Lrp1b	APN	2	41,110,753 (GRCm38)	critical splice donor site	probably null
IGL02543:Lrp1b	APN	2	40,870,401 (GRCm38)	missense	possibly damaging	0.89
IGL02701:Lrp1b	APN	2	41,246,017 (GRCm38)	missense	possibly damaging	0.50
IGL02728:Lrp1b	APN	2	40,801,398 (GRCm38)	missense	probably benign	0.03
IGL02739:Lrp1b	APN	2	41,498,215 (GRCm38)	missense	probably damaging	1.00
IGL02748:Lrp1b	APN	2	40,702,749 (GRCm38)	missense	probably damaging	0.99
IGL02754:Lrp1b	APN	2	40,702,794 (GRCm38)	missense	probably benign	0.02
IGL02797:Lrp1b	APN	2	41,671,057 (GRCm38)	missense
IGL02813:Lrp1b	APN	2	40,679,217 (GRCm38)	critical splice acceptor site	probably null
IGL02831:Lrp1b	APN	2	41,193,591 (GRCm38)	missense	probably damaging	1.00
IGL02869:Lrp1b	APN	2	40,701,830 (GRCm38)	missense	unknown
IGL02946:Lrp1b	APN	2	41,312,559 (GRCm38)	missense	probably damaging	1.00
IGL02952:Lrp1b	APN	2	41,506,703 (GRCm38)	missense	probably benign	0.33
IGL02958:Lrp1b	APN	2	41,302,916 (GRCm38)	missense	probably damaging	1.00
IGL02977:Lrp1b	APN	2	40,730,735 (GRCm38)	missense	probably damaging	1.00
IGL03001:Lrp1b	APN	2	40,927,889 (GRCm38)	missense	probably damaging	1.00
IGL03010:Lrp1b	APN	2	42,323,606 (GRCm38)	missense	possibly damaging	0.94
IGL03060:Lrp1b	APN	2	40,637,753 (GRCm38)	missense	probably benign	0.04
IGL03129:Lrp1b	APN	2	41,312,466 (GRCm38)	splice site	probably benign
IGL03166:Lrp1b	APN	2	41,111,038 (GRCm38)	missense	probably damaging	1.00
IGL03170:Lrp1b	APN	2	40,697,444 (GRCm38)	missense	unknown
IGL03195:Lrp1b	APN	2	41,471,122 (GRCm38)	missense	possibly damaging	0.95
IGL03224:Lrp1b	APN	2	41,471,031 (GRCm38)	missense	possibly damaging	0.92
IGL03251:Lrp1b	APN	2	40,600,267 (GRCm38)	missense	probably benign	0.20
IGL03281:Lrp1b	APN	2	40,725,514 (GRCm38)	missense	probably benign	0.01
IGL03295:Lrp1b	APN	2	40,678,987 (GRCm38)	splice site	probably null
IGL03340:Lrp1b	APN	2	41,468,969 (GRCm38)	missense	probably damaging	0.97
IGL03391:Lrp1b	APN	2	41,295,641 (GRCm38)	missense	possibly damaging	0.95
IGL03401:Lrp1b	APN	2	41,110,778 (GRCm38)	missense	probably benign	0.18
IGL03403:Lrp1b	APN	2	40,702,824 (GRCm38)	missense	probably benign	0.16
IGL03408:Lrp1b	APN	2	40,858,582 (GRCm38)	missense	probably damaging	0.97
Fetching	UTSW	2	40,879,555 (GRCm38)	missense	probably benign	0.00
Heiden	UTSW	2	40,637,775 (GRCm38)	missense	probably benign	0.00
hither	UTSW	2	40,702,848 (GRCm38)	missense	probably benign	0.00
Roeslein	UTSW	2	40,725,907 (GRCm38)	missense	probably damaging	1.00
I2288:Lrp1b	UTSW	2	41,122,932 (GRCm38)	missense	probably damaging	0.99
I2289:Lrp1b	UTSW	2	41,122,932 (GRCm38)	missense	probably damaging	0.99
LCD18:Lrp1b	UTSW	2	42,237,562 (GRCm38)	intron	probably benign
PIT4431001:Lrp1b	UTSW	2	41,004,755 (GRCm38)	missense
PIT4585001:Lrp1b	UTSW	2	41,269,204 (GRCm38)	missense
R0022:Lrp1b	UTSW	2	40,998,038 (GRCm38)	splice site	probably benign
R0022:Lrp1b	UTSW	2	40,998,038 (GRCm38)	splice site	probably benign
R0054:Lrp1b	UTSW	2	40,742,817 (GRCm38)	missense	probably benign	0.11
R0054:Lrp1b	UTSW	2	40,742,817 (GRCm38)	missense	probably benign	0.11
R0094:Lrp1b	UTSW	2	41,282,030 (GRCm38)	unclassified	probably benign
R0102:Lrp1b	UTSW	2	41,408,985 (GRCm38)	splice site	probably benign
R0123:Lrp1b	UTSW	2	40,596,983 (GRCm38)	missense	probably damaging	1.00
R0128:Lrp1b	UTSW	2	41,511,508 (GRCm38)	missense	probably damaging	1.00
R0130:Lrp1b	UTSW	2	41,511,508 (GRCm38)	missense	probably damaging	1.00
R0134:Lrp1b	UTSW	2	40,596,983 (GRCm38)	missense	probably damaging	1.00
R0135:Lrp1b	UTSW	2	41,269,239 (GRCm38)	missense	probably damaging	0.99
R0153:Lrp1b	UTSW	2	41,123,019 (GRCm38)	missense	possibly damaging	0.92
R0178:Lrp1b	UTSW	2	40,725,907 (GRCm38)	missense	probably damaging	1.00
R0225:Lrp1b	UTSW	2	40,596,983 (GRCm38)	missense	probably damaging	1.00
R0242:Lrp1b	UTSW	2	40,998,183 (GRCm38)	missense	probably benign	0.01
R0242:Lrp1b	UTSW	2	40,998,183 (GRCm38)	missense	probably benign	0.01
R0312:Lrp1b	UTSW	2	41,282,171 (GRCm38)	missense	probably damaging	1.00
R0325:Lrp1b	UTSW	2	40,851,711 (GRCm38)	missense	probably damaging	1.00
R0330:Lrp1b	UTSW	2	40,701,761 (GRCm38)	nonsense	probably null
R0372:Lrp1b	UTSW	2	40,730,798 (GRCm38)	missense	probably benign	0.30
R0400:Lrp1b	UTSW	2	40,750,914 (GRCm38)	missense	probably benign	0.40
R0408:Lrp1b	UTSW	2	40,677,591 (GRCm38)	missense	probably damaging	1.00
R0498:Lrp1b	UTSW	2	41,458,405 (GRCm38)	missense	probably benign	0.19
R0563:Lrp1b	UTSW	2	40,750,914 (GRCm38)	missense	probably benign	0.40
R0569:Lrp1b	UTSW	2	40,889,239 (GRCm38)	missense	probably benign	0.11
R0622:Lrp1b	UTSW	2	41,728,551 (GRCm38)	critical splice donor site	probably null
R0682:Lrp1b	UTSW	2	41,295,641 (GRCm38)	missense	probably benign	0.01
R0727:Lrp1b	UTSW	2	40,750,944 (GRCm38)	missense	probably benign	0.40
R0747:Lrp1b	UTSW	2	40,870,341 (GRCm38)	missense	probably damaging	1.00
R0761:Lrp1b	UTSW	2	41,185,935 (GRCm38)	missense	probably damaging	0.99
R0905:Lrp1b	UTSW	2	41,284,185 (GRCm38)	missense	probably damaging	1.00
R0959:Lrp1b	UTSW	2	41,268,354 (GRCm38)	missense	possibly damaging	0.83
R1124:Lrp1b	UTSW	2	40,875,051 (GRCm38)	missense	probably damaging	1.00
R1158:Lrp1b	UTSW	2	40,677,494 (GRCm38)	missense	unknown
R1265:Lrp1b	UTSW	2	41,476,654 (GRCm38)	missense	probably damaging	1.00
R1276:Lrp1b	UTSW	2	41,728,576 (GRCm38)	missense	probably benign	0.35
R1277:Lrp1b	UTSW	2	40,725,945 (GRCm38)	missense	probably benign
R1282:Lrp1b	UTSW	2	40,860,761 (GRCm38)	missense	probably damaging	1.00
R1291:Lrp1b	UTSW	2	41,341,895 (GRCm38)	missense	probably benign	0.05
R1316:Lrp1b	UTSW	2	40,702,804 (GRCm38)	missense	probably benign
R1340:Lrp1b	UTSW	2	40,702,794 (GRCm38)	missense	probably benign	0.02
R1371:Lrp1b	UTSW	2	40,647,153 (GRCm38)	missense	probably damaging	1.00
R1415:Lrp1b	UTSW	2	40,629,664 (GRCm38)	missense	probably damaging	1.00
R1416:Lrp1b	UTSW	2	40,998,216 (GRCm38)	missense	probably damaging	1.00
R1417:Lrp1b	UTSW	2	41,004,641 (GRCm38)	missense	probably benign	0.14
R1465:Lrp1b	UTSW	2	41,111,059 (GRCm38)	missense	probably benign	0.00
R1465:Lrp1b	UTSW	2	41,111,059 (GRCm38)	missense	probably benign	0.00
R1467:Lrp1b	UTSW	2	40,657,356 (GRCm38)	splice site	probably benign
R1468:Lrp1b	UTSW	2	40,927,829 (GRCm38)	critical splice donor site	probably null
R1468:Lrp1b	UTSW	2	40,927,829 (GRCm38)	critical splice donor site	probably null
R1480:Lrp1b	UTSW	2	40,903,389 (GRCm38)	missense	probably damaging	1.00
R1488:Lrp1b	UTSW	2	41,502,024 (GRCm38)	missense	probably benign	0.01
R1496:Lrp1b	UTSW	2	42,323,662 (GRCm38)	missense	probably damaging	0.98
R1542:Lrp1b	UTSW	2	41,123,712 (GRCm38)	missense	probably damaging	1.00
R1571:Lrp1b	UTSW	2	41,476,646 (GRCm38)	missense	probably damaging	1.00
R1598:Lrp1b	UTSW	2	41,511,478 (GRCm38)	missense	probably damaging	1.00
R1619:Lrp1b	UTSW	2	40,697,589 (GRCm38)	missense	unknown
R1697:Lrp1b	UTSW	2	40,822,683 (GRCm38)	missense	probably damaging	0.99
R1698:Lrp1b	UTSW	2	40,851,806 (GRCm38)	nonsense	probably null
R1699:Lrp1b	UTSW	2	41,185,962 (GRCm38)	missense	possibly damaging	0.91
R1715:Lrp1b	UTSW	2	41,185,981 (GRCm38)	missense	probably damaging	1.00
R1748:Lrp1b	UTSW	2	41,728,706 (GRCm38)	missense	possibly damaging	0.56
R1756:Lrp1b	UTSW	2	41,110,825 (GRCm38)	missense	probably damaging	1.00
R1889:Lrp1b	UTSW	2	40,919,167 (GRCm38)	nonsense	probably null
R1895:Lrp1b	UTSW	2	40,665,147 (GRCm38)	missense	unknown
R1902:Lrp1b	UTSW	2	40,860,661 (GRCm38)	missense	probably damaging	1.00
R1919:Lrp1b	UTSW	2	41,728,729 (GRCm38)	missense	probably benign	0.00
R1939:Lrp1b	UTSW	2	40,697,589 (GRCm38)	missense	unknown
R1946:Lrp1b	UTSW	2	40,665,147 (GRCm38)	missense	unknown
R1954:Lrp1b	UTSW	2	40,858,441 (GRCm38)	missense	probably damaging	1.00
R1970:Lrp1b	UTSW	2	40,875,069 (GRCm38)	missense	probably damaging	1.00
R1983:Lrp1b	UTSW	2	41,511,404 (GRCm38)	critical splice donor site	probably null
R2029:Lrp1b	UTSW	2	41,341,849 (GRCm38)	missense	probably benign	0.02
R2054:Lrp1b	UTSW	2	40,697,482 (GRCm38)	missense	unknown
R2108:Lrp1b	UTSW	2	41,110,757 (GRCm38)	missense	probably damaging	1.00
R2158:Lrp1b	UTSW	2	40,879,555 (GRCm38)	missense	probably benign	0.00
R2168:Lrp1b	UTSW	2	41,375,846 (GRCm38)	missense	probably damaging	1.00
R2184:Lrp1b	UTSW	2	40,730,702 (GRCm38)	missense	probably benign
R2188:Lrp1b	UTSW	2	41,408,959 (GRCm38)	missense	probably benign	0.25
R2200:Lrp1b	UTSW	2	41,284,165 (GRCm38)	missense	probably benign	0.43
R2342:Lrp1b	UTSW	2	40,919,196 (GRCm38)	missense	possibly damaging	0.89
R2421:Lrp1b	UTSW	2	40,882,133 (GRCm38)	splice site	probably benign
R2656:Lrp1b	UTSW	2	41,511,581 (GRCm38)	missense	probably damaging	0.99
R2864:Lrp1b	UTSW	2	40,874,995 (GRCm38)	missense	possibly damaging	0.92
R2874:Lrp1b	UTSW	2	40,851,693 (GRCm38)	missense	probably damaging	1.00
R2911:Lrp1b	UTSW	2	41,506,692 (GRCm38)	missense	probably benign	0.00
R2919:Lrp1b	UTSW	2	41,770,899 (GRCm38)	missense	probably damaging	1.00
R3027:Lrp1b	UTSW	2	40,870,271 (GRCm38)	missense	probably benign	0.33
R3083:Lrp1b	UTSW	2	40,600,324 (GRCm38)	missense	probably damaging	0.99
R3545:Lrp1b	UTSW	2	40,600,288 (GRCm38)	missense	probably damaging	1.00
R3546:Lrp1b	UTSW	2	40,600,288 (GRCm38)	missense	probably damaging	1.00
R3547:Lrp1b	UTSW	2	40,600,288 (GRCm38)	missense	probably damaging	1.00
R3709:Lrp1b	UTSW	2	40,697,442 (GRCm38)	missense	unknown
R3817:Lrp1b	UTSW	2	40,876,658 (GRCm38)	missense	probably damaging	1.00
R3876:Lrp1b	UTSW	2	41,445,194 (GRCm38)	missense	probably damaging	1.00
R3877:Lrp1b	UTSW	2	41,445,194 (GRCm38)	missense	probably damaging	1.00
R3896:Lrp1b	UTSW	2	40,922,428 (GRCm38)	splice site	probably null
R3901:Lrp1b	UTSW	2	40,822,695 (GRCm38)	missense	probably damaging	1.00
R3915:Lrp1b	UTSW	2	41,449,236 (GRCm38)	missense	probably damaging	1.00
R3922:Lrp1b	UTSW	2	40,677,581 (GRCm38)	missense	unknown
R3964:Lrp1b	UTSW	2	41,312,470 (GRCm38)	splice site	probably benign
R4013:Lrp1b	UTSW	2	40,802,984 (GRCm38)	missense	possibly damaging	0.66
R4014:Lrp1b	UTSW	2	40,802,984 (GRCm38)	missense	possibly damaging	0.66
R4015:Lrp1b	UTSW	2	40,802,984 (GRCm38)	missense	possibly damaging	0.66
R4017:Lrp1b	UTSW	2	40,802,984 (GRCm38)	missense	possibly damaging	0.66
R4031:Lrp1b	UTSW	2	40,702,848 (GRCm38)	missense	probably benign	0.00
R4095:Lrp1b	UTSW	2	41,449,191 (GRCm38)	missense	probably benign	0.03
R4108:Lrp1b	UTSW	2	40,665,087 (GRCm38)	missense	unknown
R4176:Lrp1b	UTSW	2	41,408,393 (GRCm38)	missense	probably damaging	1.00
R4181:Lrp1b	UTSW	2	40,611,434 (GRCm38)	missense	probably damaging	1.00
R4359:Lrp1b	UTSW	2	40,903,065 (GRCm38)	missense	probably damaging	1.00
R4410:Lrp1b	UTSW	2	40,665,082 (GRCm38)	missense	possibly damaging	0.96
R4416:Lrp1b	UTSW	2	40,663,667 (GRCm38)	missense	unknown
R4489:Lrp1b	UTSW	2	40,661,489 (GRCm38)	unclassified	probably benign
R4577:Lrp1b	UTSW	2	40,821,719 (GRCm38)	missense	probably damaging	1.00
R4623:Lrp1b	UTSW	2	41,246,021 (GRCm38)	missense	probably damaging	1.00
R4677:Lrp1b	UTSW	2	40,801,484 (GRCm38)	missense	probably damaging	1.00
R4684:Lrp1b	UTSW	2	40,922,304 (GRCm38)	missense	probably benign	0.44
R4714:Lrp1b	UTSW	2	41,110,759 (GRCm38)	missense	possibly damaging	0.90
R4721:Lrp1b	UTSW	2	40,715,369 (GRCm38)	splice site	probably null
R4755:Lrp1b	UTSW	2	41,471,016 (GRCm38)	missense	probably benign
R4755:Lrp1b	UTSW	2	41,269,273 (GRCm38)	missense	probably benign	0.07
R4774:Lrp1b	UTSW	2	40,661,532 (GRCm38)	missense	probably null	1.00
R4854:Lrp1b	UTSW	2	41,111,077 (GRCm38)	missense	probably damaging	1.00
R4880:Lrp1b	UTSW	2	41,770,919 (GRCm38)	missense	probably benign	0.07
R4885:Lrp1b	UTSW	2	41,468,893 (GRCm38)	missense	probably benign
R4901:Lrp1b	UTSW	2	40,821,645 (GRCm38)	missense	probably damaging	1.00
R4919:Lrp1b	UTSW	2	40,647,234 (GRCm38)	missense	probably benign	0.25
R4935:Lrp1b	UTSW	2	41,498,393 (GRCm38)	missense	probably benign	0.01
R4937:Lrp1b	UTSW	2	40,802,885 (GRCm38)	splice site	probably null
R4967:Lrp1b	UTSW	2	41,788,974 (GRCm38)	missense	probably damaging	1.00
R4968:Lrp1b	UTSW	2	41,789,062 (GRCm38)	missense	probably damaging	1.00
R4968:Lrp1b	UTSW	2	40,702,707 (GRCm38)	splice site	probably null
R5155:Lrp1b	UTSW	2	41,728,622 (GRCm38)	splice site	probably null
R5221:Lrp1b	UTSW	2	41,112,982 (GRCm38)	missense	possibly damaging	0.79
R5224:Lrp1b	UTSW	2	41,110,840 (GRCm38)	missense	possibly damaging	0.61
R5227:Lrp1b	UTSW	2	40,851,793 (GRCm38)	missense	possibly damaging	0.95
R5246:Lrp1b	UTSW	2	41,470,940 (GRCm38)	critical splice donor site	probably null
R5263:Lrp1b	UTSW	2	41,960,679 (GRCm38)	missense	probably damaging	1.00
R5274:Lrp1b	UTSW	2	41,344,444 (GRCm38)	missense	probably null	1.00
R5291:Lrp1b	UTSW	2	40,903,003 (GRCm38)	missense	probably damaging	1.00
R5362:Lrp1b	UTSW	2	41,375,902 (GRCm38)	missense	probably damaging	1.00
R5365:Lrp1b	UTSW	2	40,647,125 (GRCm38)	missense	possibly damaging	0.55
R5369:Lrp1b	UTSW	2	41,004,613 (GRCm38)	nonsense	probably null
R5419:Lrp1b	UTSW	2	40,730,704 (GRCm38)	nonsense	probably null
R5434:Lrp1b	UTSW	2	41,770,868 (GRCm38)	missense	probably damaging	0.96
R5452:Lrp1b	UTSW	2	40,922,316 (GRCm38)	missense	probably damaging	1.00
R5453:Lrp1b	UTSW	2	41,282,237 (GRCm38)	missense	probably damaging	1.00
R5496:Lrp1b	UTSW	2	40,927,973 (GRCm38)	missense	probably benign	0.02
R5524:Lrp1b	UTSW	2	41,110,888 (GRCm38)	missense	probably damaging	1.00
R5538:Lrp1b	UTSW	2	40,697,474 (GRCm38)	missense	unknown
R5571:Lrp1b	UTSW	2	41,408,342 (GRCm38)	missense	probably damaging	0.97
R5577:Lrp1b	UTSW	2	40,875,123 (GRCm38)	missense	possibly damaging	0.70
R5609:Lrp1b	UTSW	2	41,341,795 (GRCm38)	missense	probably damaging	1.00
R5635:Lrp1b	UTSW	2	42,652,822 (GRCm38)	utr 5 prime	probably benign
R5669:Lrp1b	UTSW	2	41,111,038 (GRCm38)	missense	probably damaging	1.00
R5672:Lrp1b	UTSW	2	41,341,759 (GRCm38)	missense	probably benign	0.01
R5690:Lrp1b	UTSW	2	40,750,894 (GRCm38)	splice site	probably null
R5752:Lrp1b	UTSW	2	41,295,612 (GRCm38)	missense	probably damaging	1.00
R5853:Lrp1b	UTSW	2	40,663,726 (GRCm38)	missense	unknown
R5869:Lrp1b	UTSW	2	41,004,603 (GRCm38)	missense	probably damaging	0.98
R5880:Lrp1b	UTSW	2	41,341,814 (GRCm38)	missense	probably benign	0.23
R5887:Lrp1b	UTSW	2	40,821,707 (GRCm38)	missense	possibly damaging	0.91
R5893:Lrp1b	UTSW	2	40,601,587 (GRCm38)	missense	probably damaging	1.00
R5894:Lrp1b	UTSW	2	41,498,221 (GRCm38)	missense	probably benign	0.11
R6019:Lrp1b	UTSW	2	41,302,970 (GRCm38)	missense	probably damaging	1.00
R6021:Lrp1b	UTSW	2	41,344,427 (GRCm38)	missense	probably benign	0.02
R6045:Lrp1b	UTSW	2	40,701,813 (GRCm38)	missense	unknown
R6047:Lrp1b	UTSW	2	40,637,775 (GRCm38)	missense	probably benign	0.00
R6060:Lrp1b	UTSW	2	40,750,934 (GRCm38)	missense
R6063:Lrp1b	UTSW	2	41,284,144 (GRCm38)	nonsense	probably null
R6090:Lrp1b	UTSW	2	41,185,868 (GRCm38)	critical splice donor site	probably null
R6112:Lrp1b	UTSW	2	41,341,882 (GRCm38)	missense	probably benign	0.14
R6128:Lrp1b	UTSW	2	40,860,655 (GRCm38)	missense	probably benign
R6149:Lrp1b	UTSW	2	40,875,153 (GRCm38)	splice site	probably null
R6174:Lrp1b	UTSW	2	41,449,263 (GRCm38)	missense	probably benign
R6177:Lrp1b	UTSW	2	41,123,736 (GRCm38)	splice site	probably null
R6257:Lrp1b	UTSW	2	40,596,969 (GRCm38)	splice site	probably null
R6267:Lrp1b	UTSW	2	40,657,525 (GRCm38)	missense	probably benign	0.00
R6268:Lrp1b	UTSW	2	40,821,717 (GRCm38)	missense	probably benign	0.01
R6331:Lrp1b	UTSW	2	40,803,209 (GRCm38)	missense	probably damaging	1.00
R6334:Lrp1b	UTSW	2	41,789,033 (GRCm38)	missense	probably benign
R6359:Lrp1b	UTSW	2	41,295,596 (GRCm38)	missense	probably damaging	1.00
R6371:Lrp1b	UTSW	2	40,851,654 (GRCm38)	missense	possibly damaging	0.61
R6421:Lrp1b	UTSW	2	40,889,270 (GRCm38)	missense	probably damaging	1.00
R6524:Lrp1b	UTSW	2	40,851,804 (GRCm38)	missense	possibly damaging	0.95
R6616:Lrp1b	UTSW	2	40,699,631 (GRCm38)	missense	unknown
R6632:Lrp1b	UTSW	2	40,725,442 (GRCm38)	missense	probably benign	0.23
R6656:Lrp1b	UTSW	2	40,637,864 (GRCm38)	nonsense	probably null
R6698:Lrp1b	UTSW	2	41,302,946 (GRCm38)	missense	probably damaging	1.00
R6741:Lrp1b	UTSW	2	41,245,989 (GRCm38)	missense	possibly damaging	0.82
R6742:Lrp1b	UTSW	2	41,471,120 (GRCm38)	missense	probably benign	0.31
R6811:Lrp1b	UTSW	2	41,449,194 (GRCm38)	missense	probably benign	0.01
R6811:Lrp1b	UTSW	2	40,715,500 (GRCm38)	splice site	probably null
R6855:Lrp1b	UTSW	2	40,628,696 (GRCm38)	missense	possibly damaging	0.66
R6888:Lrp1b	UTSW	2	41,471,126 (GRCm38)	missense	probably benign	0.18
R6946:Lrp1b	UTSW	2	40,697,439 (GRCm38)	missense	probably benign
R6984:Lrp1b	UTSW	2	40,822,628 (GRCm38)	missense	probably damaging	0.97
R7026:Lrp1b	UTSW	2	41,269,222 (GRCm38)	missense	probably damaging	1.00
R7028:Lrp1b	UTSW	2	41,246,011 (GRCm38)	missense	probably benign	0.45
R7036:Lrp1b	UTSW	2	41,112,342 (GRCm38)	missense	possibly damaging	0.89
R7043:Lrp1b	UTSW	2	40,922,414 (GRCm38)	missense	possibly damaging	0.84
R7071:Lrp1b	UTSW	2	41,408,264 (GRCm38)	missense
R7077:Lrp1b	UTSW	2	41,770,846 (GRCm38)	missense
R7115:Lrp1b	UTSW	2	40,998,235 (GRCm38)	missense
R7143:Lrp1b	UTSW	2	41,312,643 (GRCm38)	missense
R7146:Lrp1b	UTSW	2	41,375,994 (GRCm38)	nonsense	probably null
R7149:Lrp1b	UTSW	2	40,637,860 (GRCm38)	missense
R7185:Lrp1b	UTSW	2	40,801,512 (GRCm38)	critical splice acceptor site	probably null
R7239:Lrp1b	UTSW	2	41,004,713 (GRCm38)	missense
R7247:Lrp1b	UTSW	2	41,269,212 (GRCm38)	missense
R7331:Lrp1b	UTSW	2	40,663,610 (GRCm38)	splice site	probably null
R7369:Lrp1b	UTSW	2	41,282,039 (GRCm38)	missense
R7378:Lrp1b	UTSW	2	41,295,669 (GRCm38)	missense
R7381:Lrp1b	UTSW	2	40,802,917 (GRCm38)	missense
R7406:Lrp1b	UTSW	2	41,376,018 (GRCm38)	critical splice acceptor site	probably null
R7437:Lrp1b	UTSW	2	40,822,646 (GRCm38)	missense
R7437:Lrp1b	UTSW	2	40,822,645 (GRCm38)	missense
R7446:Lrp1b	UTSW	2	41,671,057 (GRCm38)	missense
R7460:Lrp1b	UTSW	2	40,598,466 (GRCm38)	missense
R7462:Lrp1b	UTSW	2	41,113,029 (GRCm38)	missense
R7475:Lrp1b	UTSW	2	41,344,576 (GRCm38)	missense
R7479:Lrp1b	UTSW	2	40,801,505 (GRCm38)	missense
R7523:Lrp1b	UTSW	2	41,511,461 (GRCm38)	missense
R7525:Lrp1b	UTSW	2	40,657,416 (GRCm38)	missense
R7549:Lrp1b	UTSW	2	40,875,122 (GRCm38)	missense
R7552:Lrp1b	UTSW	2	40,677,570 (GRCm38)	missense
R7558:Lrp1b	UTSW	2	41,341,936 (GRCm38)	missense
R7587:Lrp1b	UTSW	2	40,730,717 (GRCm38)	missense
R7599:Lrp1b	UTSW	2	40,661,549 (GRCm38)	missense
R7635:Lrp1b	UTSW	2	41,123,597 (GRCm38)	critical splice donor site	probably null
R7663:Lrp1b	UTSW	2	42,653,035 (GRCm38)	unclassified	probably benign
R7674:Lrp1b	UTSW	2	42,652,909 (GRCm38)	start gained	probably benign
R7681:Lrp1b	UTSW	2	40,874,999 (GRCm38)	nonsense	probably null
R7703:Lrp1b	UTSW	2	41,110,786 (GRCm38)	missense
R7742:Lrp1b	UTSW	2	40,822,629 (GRCm38)	missense
R7767:Lrp1b	UTSW	2	40,801,505 (GRCm38)	missense
R7829:Lrp1b	UTSW	2	40,903,448 (GRCm38)	nonsense	probably null
R7861:Lrp1b	UTSW	2	40,697,558 (GRCm38)	missense
R7868:Lrp1b	UTSW	2	41,449,234 (GRCm38)	missense
R7883:Lrp1b	UTSW	2	40,665,129 (GRCm38)	missense
R7956:Lrp1b	UTSW	2	41,282,149 (GRCm38)	splice site	probably null
R7963:Lrp1b	UTSW	2	40,927,935 (GRCm38)	missense
R7964:Lrp1b	UTSW	2	40,598,511 (GRCm38)	missense
R8035:Lrp1b	UTSW	2	40,860,655 (GRCm38)	missense
R8046:Lrp1b	UTSW	2	41,269,187 (GRCm38)	missense
R8128:Lrp1b	UTSW	2	41,269,236 (GRCm38)	missense	probably null
R8234:Lrp1b	UTSW	2	41,312,656 (GRCm38)	missense
R8237:Lrp1b	UTSW	2	40,851,774 (GRCm38)	missense
R8244:Lrp1b	UTSW	2	41,506,782 (GRCm38)	missense
R8370:Lrp1b	UTSW	2	40,998,105 (GRCm38)	missense
R8395:Lrp1b	UTSW	2	40,657,399 (GRCm38)	missense
R8398:Lrp1b	UTSW	2	40,701,807 (GRCm38)	missense
R8421:Lrp1b	UTSW	2	40,725,423 (GRCm38)	missense
R8426:Lrp1b	UTSW	2	41,498,306 (GRCm38)	missense
R8443:Lrp1b	UTSW	2	41,375,855 (GRCm38)	nonsense	probably null
R8444:Lrp1b	UTSW	2	40,870,260 (GRCm38)	missense
R8486:Lrp1b	UTSW	2	41,728,690 (GRCm38)	missense	probably damaging	1.00
R8500:Lrp1b	UTSW	2	41,506,779 (GRCm38)	missense	probably benign	0.12
R8507:Lrp1b	UTSW	2	41,408,375 (GRCm38)	missense
R8552:Lrp1b	UTSW	2	41,408,981 (GRCm38)	missense	probably benign	0.00
R8554:Lrp1b	UTSW	2	41,344,483 (GRCm38)	missense	probably benign	0.28
R8669:Lrp1b	UTSW	2	41,282,035 (GRCm38)	critical splice donor site	probably null
R8699:Lrp1b	UTSW	2	41,282,195 (GRCm38)	missense
R8796:Lrp1b	UTSW	2	40,903,414 (GRCm38)	missense
R8815:Lrp1b	UTSW	2	40,665,159 (GRCm38)	missense
R8842:Lrp1b	UTSW	2	41,268,405 (GRCm38)	missense
R8858:Lrp1b	UTSW	2	41,670,815 (GRCm38)	intron	probably benign
R8864:Lrp1b	UTSW	2	41,112,706 (GRCm38)	missense
R8918:Lrp1b	UTSW	2	40,725,881 (GRCm38)	missense
R8920:Lrp1b	UTSW	2	42,323,598 (GRCm38)	missense
R8963:Lrp1b	UTSW	2	40,998,184 (GRCm38)	missense	probably benign	0.28
R8971:Lrp1b	UTSW	2	41,435,628 (GRCm38)	missense
R9007:Lrp1b	UTSW	2	40,697,552 (GRCm38)	missense
R9042:Lrp1b	UTSW	2	41,502,017 (GRCm38)	missense
R9053:Lrp1b	UTSW	2	40,858,489 (GRCm38)	missense
R9063:Lrp1b	UTSW	2	41,341,826 (GRCm38)	missense
R9072:Lrp1b	UTSW	2	40,725,445 (GRCm38)	nonsense	probably null
R9105:Lrp1b	UTSW	2	41,506,791 (GRCm38)	missense
R9131:Lrp1b	UTSW	2	40,699,578 (GRCm38)	nonsense	probably null
R9226:Lrp1b	UTSW	2	41,511,448 (GRCm38)	missense
R9245:Lrp1b	UTSW	2	40,598,444 (GRCm38)	missense
R9275:Lrp1b	UTSW	2	40,597,064 (GRCm38)	missense
R9278:Lrp1b	UTSW	2	40,597,064 (GRCm38)	missense
R9303:Lrp1b	UTSW	2	41,728,562 (GRCm38)	missense
R9305:Lrp1b	UTSW	2	41,728,562 (GRCm38)	missense
R9306:Lrp1b	UTSW	2	40,628,750 (GRCm38)	missense	possibly damaging	0.66
R9320:Lrp1b	UTSW	2	41,445,099 (GRCm38)	critical splice donor site	probably null
R9330:Lrp1b	UTSW	2	41,122,981 (GRCm38)	missense
R9352:Lrp1b	UTSW	2	40,858,426 (GRCm38)	missense
R9386:Lrp1b	UTSW	2	41,123,628 (GRCm38)	missense
R9397:Lrp1b	UTSW	2	40,750,910 (GRCm38)	missense
R9444:Lrp1b	UTSW	2	41,123,718 (GRCm38)	missense
R9452:Lrp1b	UTSW	2	41,960,714 (GRCm38)	nonsense	probably null
R9474:Lrp1b	UTSW	2	40,601,587 (GRCm38)	missense	probably damaging	1.00
R9501:Lrp1b	UTSW	2	41,282,235 (GRCm38)	missense
R9523:Lrp1b	UTSW	2	41,770,966 (GRCm38)	missense
R9541:Lrp1b	UTSW	2	41,344,588 (GRCm38)	missense
R9555:Lrp1b	UTSW	2	40,858,426 (GRCm38)	missense
R9555:Lrp1b	UTSW	2	40,851,681 (GRCm38)	missense
R9563:Lrp1b	UTSW	2	41,295,699 (GRCm38)	missense
R9568:Lrp1b	UTSW	2	40,679,215 (GRCm38)	missense
R9622:Lrp1b	UTSW	2	40,889,342 (GRCm38)	nonsense	probably null
R9623:Lrp1b	UTSW	2	41,476,636 (GRCm38)	missense
R9634:Lrp1b	UTSW	2	41,245,939 (GRCm38)	critical splice donor site	probably null
R9640:Lrp1b	UTSW	2	41,188,917 (GRCm38)	missense
R9664:Lrp1b	UTSW	2	40,874,992 (GRCm38)	missense
R9668:Lrp1b	UTSW	2	41,185,970 (GRCm38)	missense
R9672:Lrp1b	UTSW	2	40,889,279 (GRCm38)	missense
R9717:Lrp1b	UTSW	2	41,268,383 (GRCm38)	missense
R9741:Lrp1b	UTSW	2	41,112,288 (GRCm38)	missense
RF018:Lrp1b	UTSW	2	41,110,907 (GRCm38)	missense
RF020:Lrp1b	UTSW	2	41,770,846 (GRCm38)	missense
V1662:Lrp1b	UTSW	2	41,122,932 (GRCm38)	missense	probably damaging	0.99
X0028:Lrp1b	UTSW	2	41,471,145 (GRCm38)	missense	probably damaging	1.00
X0064:Lrp1b	UTSW	2	41,502,043 (GRCm38)	missense	probably damaging	1.00
Z1176:Lrp1b	UTSW	2	40,922,383 (GRCm38)	missense
Z1176:Lrp1b	UTSW	2	40,697,582 (GRCm38)	missense
Z1176:Lrp1b	UTSW	2	40,677,506 (GRCm38)	missense
Z1176:Lrp1b	UTSW	2	41,728,710 (GRCm38)	missense
Z1177:Lrp1b	UTSW	2	41,188,848 (GRCm38)	missense
Z1177:Lrp1b	UTSW	2	40,637,749 (GRCm38)	missense
Z1187:Lrp1b	UTSW	2	40,750,934 (GRCm38)	missense
Z1188:Lrp1b	UTSW	2	40,750,934 (GRCm38)	missense

Predicted Primers

PCR Primer
(F):5'- ACCCGTTGACTGGATCTACC -3'
(R):5'- AGTGGGTCTATCATTTGCATGAC -3'

Sequencing Primer
(F):5'- CCACAATTGCTCTTGGATGAGAC -3'
(R):5'- GTCTATCATTTGCATGACAATGTATG -3'

Posted On

2017-06-26