Incidental Mutation 'R6021:Vmn1r85'
ID 478937
Institutional Source Beutler Lab
Gene Symbol Vmn1r85
Ensembl Gene ENSMUSG00000070817
Gene Name vomeronasal 1 receptor 85
Synonyms V1rj3
MMRRC Submission 044194-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R6021 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 12818216-12819142 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 12818616 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 176 (E176G)
Ref Sequence ENSEMBL: ENSMUSP00000148178 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094829] [ENSMUST00000209822]
AlphaFold Q8VIB8
Predicted Effect probably benign
Transcript: ENSMUST00000094829
AA Change: E176G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000092424
Gene: ENSMUSG00000070817
AA Change: E176G

DomainStartEndE-ValueType
Pfam:TAS2R 1 296 8.4e-18 PFAM
Pfam:V1R 24 298 2.5e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209822
AA Change: E176G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.5%
  • 20x: 92.2%
Validation Efficiency 94% (61/65)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933427I04Rik A G 4: 123,754,509 (GRCm39) D141G possibly damaging Het
A1bg T C 15: 60,791,713 (GRCm39) E241G possibly damaging Het
Abca13 G A 11: 9,240,465 (GRCm39) W776* probably null Het
Akr1b10 T A 6: 34,369,309 (GRCm39) probably null Het
Aopep A G 13: 63,208,896 (GRCm39) T338A probably damaging Het
Atf7 T C 15: 102,465,908 (GRCm39) D84G probably benign Het
AW209491 C T 13: 14,812,365 (GRCm39) A406V probably benign Het
Azi2 T A 9: 117,876,487 (GRCm39) M1K probably null Het
Boc T A 16: 44,309,017 (GRCm39) M832L probably benign Het
Brix1 C T 15: 10,476,675 (GRCm39) R267H probably benign Het
Cacna1s T C 1: 136,034,225 (GRCm39) L1050P probably benign Het
Celsr2 G T 3: 108,308,561 (GRCm39) P1789T probably benign Het
Crebbp G A 16: 3,903,282 (GRCm39) R1986C probably damaging Het
Crtam T A 9: 40,901,477 (GRCm39) I150F probably damaging Het
Crybg1 G T 10: 43,873,534 (GRCm39) S1191R probably damaging Het
D630045J12Rik T C 6: 38,167,552 (GRCm39) T1017A probably benign Het
Dnah10 A G 5: 124,814,048 (GRCm39) E396G probably damaging Het
Enpp5 A T 17: 44,396,210 (GRCm39) Y374F probably benign Het
Fzd4 G A 7: 89,056,942 (GRCm39) A330T probably benign Het
Gabra5 A G 7: 57,157,740 (GRCm39) S25P probably benign Het
Get1 T C 16: 95,946,878 (GRCm39) probably benign Het
Ggps1 T C 13: 14,228,589 (GRCm39) Y198C probably damaging Het
Gm3173 A C 14: 15,728,458 (GRCm39) D39A probably damaging Het
Grm2 T C 9: 106,527,999 (GRCm39) D295G probably damaging Het
H2-T13 T G 17: 36,392,166 (GRCm39) E182A probably damaging Het
Igfbp5 A G 1: 72,902,363 (GRCm39) M208T possibly damaging Het
Ildr2 T A 1: 166,131,173 (GRCm39) M343K possibly damaging Het
Kif19b A T 5: 140,455,434 (GRCm39) M347L probably damaging Het
Loxhd1 A T 18: 77,499,946 (GRCm39) D120V probably damaging Het
Lrp1 T C 10: 127,413,883 (GRCm39) D1175G probably damaging Het
Lrp1b C A 2: 41,234,439 (GRCm39) D1171Y probably benign Het
Lrrc9 A T 12: 72,516,005 (GRCm39) I563F probably damaging Het
Ltbp3 A T 19: 5,803,708 (GRCm39) T798S probably benign Het
Msantd4 T A 9: 4,384,063 (GRCm39) V128E probably benign Het
Mtf2 A G 5: 108,229,003 (GRCm39) I69V possibly damaging Het
Myh10 T A 11: 68,699,688 (GRCm39) S1712T possibly damaging Het
Mylk3 A G 8: 86,091,442 (GRCm39) V121A possibly damaging Het
Ndufaf4 A G 4: 24,901,760 (GRCm39) N100D probably benign Het
Notch2 T C 3: 98,029,288 (GRCm39) F1017S probably damaging Het
Or4a27 G T 2: 88,559,294 (GRCm39) Y216* probably null Het
Or4a80 A C 2: 89,582,465 (GRCm39) S236A probably benign Het
Or4c108 G T 2: 88,803,376 (GRCm39) Y286* probably null Het
P2ry2 T C 7: 100,647,607 (GRCm39) T233A probably benign Het
Paip1 T "TTA,TT" 13: 119,593,671 (GRCm39) probably null Het
Pak1 T C 7: 97,503,670 (GRCm39) S2P probably damaging Het
Pde8b A T 13: 95,162,670 (GRCm39) D817E possibly damaging Het
Pfdn2 C A 1: 171,173,338 (GRCm39) probably benign Het
Pramel28 A T 4: 143,692,336 (GRCm39) C222S probably benign Het
Raver1 A G 9: 20,987,918 (GRCm39) L606P probably damaging Het
Robo3 C T 9: 37,333,829 (GRCm39) W668* probably null Het
Rsf1 G GACGGCGGCT 7: 97,229,116 (GRCm39) probably benign Het
Rxfp2 A G 5: 149,987,202 (GRCm39) N337S possibly damaging Het
Samhd1 T C 2: 156,962,474 (GRCm39) probably null Het
Sardh A G 2: 27,079,655 (GRCm39) V879A probably benign Het
Slc4a4 A T 5: 89,188,261 (GRCm39) probably benign Het
Slc6a11 T C 6: 114,207,012 (GRCm39) L332P probably damaging Het
Tas2r135 T C 6: 42,383,321 (GRCm39) Y287H probably damaging Het
Tlr4 T A 4: 66,759,103 (GRCm39) I632N probably damaging Het
Tmem145 C T 7: 25,008,270 (GRCm39) probably null Het
Trmt61a C A 12: 111,647,411 (GRCm39) F169L probably damaging Het
Trp53tg5 T A 2: 164,313,391 (GRCm39) I95L probably benign Het
Vmn2r75 T C 7: 85,820,820 (GRCm39) D38G probably benign Het
Vmn2r99 A G 17: 19,598,210 (GRCm39) Y78C probably damaging Het
Zfp964 G T 8: 70,115,742 (GRCm39) S114I unknown Het
Other mutations in Vmn1r85
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01099:Vmn1r85 APN 7 12,818,461 (GRCm39) nonsense probably null
IGL01520:Vmn1r85 APN 7 12,819,081 (GRCm39) missense probably damaging 1.00
IGL01803:Vmn1r85 APN 7 12,818,496 (GRCm39) missense probably damaging 0.98
IGL02285:Vmn1r85 APN 7 12,818,711 (GRCm39) missense probably damaging 1.00
IGL02852:Vmn1r85 APN 7 12,819,010 (GRCm39) missense possibly damaging 0.70
IGL03012:Vmn1r85 APN 7 12,818,692 (GRCm39) missense probably benign 0.01
R0391:Vmn1r85 UTSW 7 12,818,515 (GRCm39) missense probably benign 0.01
R0655:Vmn1r85 UTSW 7 12,818,650 (GRCm39) missense probably damaging 1.00
R1142:Vmn1r85 UTSW 7 12,818,481 (GRCm39) missense probably benign 0.01
R1452:Vmn1r85 UTSW 7 12,818,808 (GRCm39) missense probably damaging 1.00
R1942:Vmn1r85 UTSW 7 12,818,668 (GRCm39) missense possibly damaging 0.83
R3760:Vmn1r85 UTSW 7 12,818,932 (GRCm39) missense probably damaging 0.96
R4783:Vmn1r85 UTSW 7 12,818,788 (GRCm39) missense probably damaging 1.00
R4785:Vmn1r85 UTSW 7 12,818,788 (GRCm39) missense probably damaging 1.00
R5373:Vmn1r85 UTSW 7 12,818,255 (GRCm39) nonsense probably null
R6035:Vmn1r85 UTSW 7 12,818,854 (GRCm39) missense probably damaging 1.00
R6035:Vmn1r85 UTSW 7 12,818,854 (GRCm39) missense probably damaging 1.00
R6834:Vmn1r85 UTSW 7 12,818,571 (GRCm39) missense probably damaging 1.00
R7340:Vmn1r85 UTSW 7 12,819,073 (GRCm39) missense probably damaging 1.00
R7346:Vmn1r85 UTSW 7 12,818,964 (GRCm39) missense probably damaging 0.99
R7836:Vmn1r85 UTSW 7 12,818,698 (GRCm39) missense probably benign 0.06
R7896:Vmn1r85 UTSW 7 12,818,448 (GRCm39) missense probably benign 0.22
R9090:Vmn1r85 UTSW 7 12,818,942 (GRCm39) nonsense probably null
R9271:Vmn1r85 UTSW 7 12,818,942 (GRCm39) nonsense probably null
R9354:Vmn1r85 UTSW 7 12,818,725 (GRCm39) missense probably damaging 1.00
R9713:Vmn1r85 UTSW 7 12,818,458 (GRCm39) missense probably damaging 1.00
R9779:Vmn1r85 UTSW 7 12,818,308 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- CAACAGGATTGTGTGAGTGGC -3'
(R):5'- TAAGCACATTCCAGGCCATC -3'

Sequencing Primer
(F):5'- CTTTGTGTTCTGGAGACTTCTGAGAG -3'
(R):5'- ACTCCCAGTAATTCTAAGTGGGCG -3'
Posted On 2017-06-26