Incidental Mutation 'R6022:Trbv26'
ID 478990
Institutional Source Beutler Lab
Gene Symbol Trbv26
Ensembl Gene ENSMUSG00000076479
Gene Name T cell receptor beta, variable 26
Synonyms Gm16909, Tcrb-V3.1, Tcrb-V3
MMRRC Submission 043256-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R6022 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 41204459-41204847 bp(+) (GRCm39)
Type of Mutation critical splice donor site
DNA Base Change (assembly) T to A at 41204509 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000141897 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103280] [ENSMUST00000193064]
AlphaFold A0A075B5J0
Predicted Effect probably benign
Transcript: ENSMUST00000103280
SMART Domains Protein: ENSMUSP00000100096
Gene: ENSMUSG00000076479

DomainStartEndE-ValueType
Pfam:V-set 19 115 3.9e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000193064
SMART Domains Protein: ENSMUSP00000141897
Gene: ENSMUSG00000076479

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IG_like 37 113 2.2e-3 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 92.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T G 11: 9,240,759 (GRCm39) F874C probably damaging Het
Adam9 T C 8: 25,493,321 (GRCm39) T96A possibly damaging Het
Arhgef26 C T 3: 62,336,360 (GRCm39) T633M probably damaging Het
Atxn2l A G 7: 126,095,607 (GRCm39) probably null Het
AW209491 C T 13: 14,812,365 (GRCm39) A406V probably benign Het
Brix1 C T 15: 10,476,675 (GRCm39) R267H probably benign Het
Caskin1 T A 17: 24,715,709 (GRCm39) F158I probably benign Het
Ces1g T A 8: 94,055,085 (GRCm39) N204I probably damaging Het
Chd1 A G 17: 17,598,035 (GRCm39) I41V probably benign Het
Crybg2 A T 4: 133,801,584 (GRCm39) K915* probably null Het
Dock4 T C 12: 40,798,109 (GRCm39) V911A probably benign Het
Dok5 A G 2: 170,721,142 (GRCm39) Y302C probably damaging Het
Dpysl4 A T 7: 138,666,000 (GRCm39) probably benign Het
Dsc3 A C 18: 20,099,395 (GRCm39) V707G probably damaging Het
Endog A G 2: 30,062,921 (GRCm39) Y187C possibly damaging Het
Fcrl5 A G 3: 87,363,070 (GRCm39) T526A probably benign Het
Gcat T C 15: 78,926,478 (GRCm39) V116A probably damaging Het
Herc1 A G 9: 66,390,967 (GRCm39) D3975G probably damaging Het
Jmy G T 13: 93,590,086 (GRCm39) probably null Het
Kif1b T C 4: 149,282,989 (GRCm39) I1273V probably benign Het
Lrriq1 G T 10: 103,051,395 (GRCm39) N452K possibly damaging Het
Lrrn3 T C 12: 41,503,429 (GRCm39) E296G probably damaging Het
Marco G A 1: 120,416,294 (GRCm39) L208F probably benign Het
Mme T A 3: 63,272,218 (GRCm39) W606R probably damaging Het
Parp14 G A 16: 35,661,827 (GRCm39) P1403S probably benign Het
Phc3 A G 3: 30,984,174 (GRCm39) S647P probably damaging Het
Prx A G 7: 27,216,998 (GRCm39) K500E probably damaging Het
Ptpn22 T A 3: 103,793,421 (GRCm39) V524E probably benign Het
Ptprj A T 2: 90,301,667 (GRCm39) I155K probably benign Het
Rad51ap2 A G 12: 11,508,523 (GRCm39) E815G probably damaging Het
Rnf150 T C 8: 83,769,358 (GRCm39) V381A probably benign Het
Rnf213 A G 11: 119,376,836 (GRCm39) K5103R probably benign Het
Speer4a2 T G 5: 26,289,677 (GRCm39) E250A probably benign Het
Tecpr1 A T 5: 144,136,009 (GRCm39) W961R possibly damaging Het
Tnn A T 1: 159,937,928 (GRCm39) D932E probably benign Het
Tram2 G A 1: 21,149,361 (GRCm39) probably benign Het
Trmt11 A G 10: 30,463,497 (GRCm39) I206T possibly damaging Het
Ttk T C 9: 83,721,375 (GRCm39) Y87H probably damaging Het
Uri1 A T 7: 37,660,902 (GRCm39) probably benign Het
Vmn1r173 A G 7: 23,402,260 (GRCm39) D165G probably benign Het
Xpc A G 6: 91,476,618 (GRCm39) S494P probably damaging Het
Zfp438 T A 18: 5,213,419 (GRCm39) N513I probably damaging Het
Other mutations in Trbv26
AlleleSourceChrCoordTypePredicted EffectPPH Score
R7769:Trbv26 UTSW 6 41,204,481 (GRCm39) missense probably benign
R8685:Trbv26 UTSW 6 41,204,693 (GRCm39) missense probably damaging 1.00
R9691:Trbv26 UTSW 6 41,204,478 (GRCm39) missense probably benign 0.17
Predicted Primers PCR Primer
(F):5'- ACTGTTTCAGGGACTACATTGG -3'
(R):5'- CAGGGATACACCTCATCTTTGC -3'

Sequencing Primer
(F):5'- TTCAGGGACTACATTGGAAAGTAAC -3'
(R):5'- GGGATACACCTCATCTTTGCTTTTTG -3'
Posted On 2017-06-26