Incidental Mutation 'R6024:Myo9a'
ID 479093
Institutional Source Beutler Lab
Gene Symbol Myo9a
Ensembl Gene ENSMUSG00000039585
Gene Name myosin IXa
Synonyms C130068I12Rik, 4732465J09Rik
MMRRC Submission 044196-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6024 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 59658179-59836149 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 59762671 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 801 (N801D)
Ref Sequence ENSEMBL: ENSMUSP00000122852 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000128341] [ENSMUST00000135298] [ENSMUST00000136740]
AlphaFold Q8C170
Predicted Effect possibly damaging
Transcript: ENSMUST00000128341
AA Change: N801D

PolyPhen 2 Score 0.638 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000119401
Gene: ENSMUSG00000039585
AA Change: N801D

DomainStartEndE-ValueType
RA 14 112 5.57e-30 SMART
low complexity region 129 137 N/A INTRINSIC
MYSc 140 1018 N/A SMART
IQ 1019 1041 1.79e1 SMART
IQ 1042 1064 4.11e0 SMART
IQ 1074 1096 1.9e-2 SMART
IQ 1115 1137 1.01e-6 SMART
IQ 1138 1160 8.71e-2 SMART
low complexity region 1161 1173 N/A INTRINSIC
coiled coil region 1265 1285 N/A INTRINSIC
low complexity region 1372 1384 N/A INTRINSIC
coiled coil region 1492 1539 N/A INTRINSIC
Blast:MYSc 1685 1938 6e-89 BLAST
low complexity region 1982 1993 N/A INTRINSIC
C1 2002 2050 2.6e-9 SMART
RhoGAP 2075 2250 3.36e-73 SMART
coiled coil region 2320 2360 N/A INTRINSIC
low complexity region 2419 2438 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000135298
AA Change: N801D

PolyPhen 2 Score 0.638 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000117432
Gene: ENSMUSG00000039585
AA Change: N801D

DomainStartEndE-ValueType
RA 14 112 5.57e-30 SMART
low complexity region 129 137 N/A INTRINSIC
MYSc 140 1018 N/A SMART
IQ 1019 1041 1.79e1 SMART
IQ 1042 1064 4.11e0 SMART
IQ 1074 1096 1.9e-2 SMART
IQ 1115 1137 1.01e-6 SMART
IQ 1138 1160 8.71e-2 SMART
low complexity region 1161 1173 N/A INTRINSIC
coiled coil region 1265 1285 N/A INTRINSIC
low complexity region 1372 1384 N/A INTRINSIC
coiled coil region 1492 1539 N/A INTRINSIC
low complexity region 1744 1759 N/A INTRINSIC
low complexity region 2053 2064 N/A INTRINSIC
C1 2073 2121 2.6e-9 SMART
RhoGAP 2146 2321 3.36e-73 SMART
coiled coil region 2391 2431 N/A INTRINSIC
low complexity region 2490 2509 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000136740
AA Change: N801D

PolyPhen 2 Score 0.679 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000122852
Gene: ENSMUSG00000039585
AA Change: N801D

DomainStartEndE-ValueType
RA 14 112 5.57e-30 SMART
low complexity region 129 137 N/A INTRINSIC
MYSc 140 1018 N/A SMART
IQ 1019 1041 1.79e1 SMART
IQ 1042 1064 4.11e0 SMART
IQ 1074 1096 1.9e-2 SMART
IQ 1115 1137 1.01e-6 SMART
IQ 1138 1160 8.71e-2 SMART
low complexity region 1161 1173 N/A INTRINSIC
coiled coil region 1265 1285 N/A INTRINSIC
low complexity region 1372 1384 N/A INTRINSIC
coiled coil region 1492 1539 N/A INTRINSIC
low complexity region 1744 1759 N/A INTRINSIC
low complexity region 2053 2064 N/A INTRINSIC
C1 2073 2121 2.6e-9 SMART
RhoGAP 2146 2321 3.36e-73 SMART
coiled coil region 2409 2449 N/A INTRINSIC
low complexity region 2508 2527 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215963
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 93.0%
Validation Efficiency 100% (56/56)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. [provided by RefSeq, Dec 2011]
PHENOTYPE: Homozygous KO leads to obstructive hydrocephaly caused by blockage of the third ventricle and the rostral aqueduct caused by developmental failures of their ependymal cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A G 13: 81,624,624 (GRCm39) F3782L probably benign Het
Akr1d1 T C 6: 37,535,417 (GRCm39) I267T probably benign Het
Aoc1l1 A T 6: 48,953,030 (GRCm39) K318N possibly damaging Het
Arhgef5 T C 6: 43,252,068 (GRCm39) S940P probably benign Het
Art2b A G 7: 101,229,587 (GRCm39) I104T probably benign Het
Avpr1a A G 10: 122,285,053 (GRCm39) Y115C probably damaging Het
Cdc42bpg T A 19: 6,367,526 (GRCm39) L995Q probably damaging Het
Cenatac T C 9: 44,329,249 (GRCm39) T13A possibly damaging Het
Clip1 T C 5: 123,753,152 (GRCm39) K210E possibly damaging Het
Cog4 C T 8: 111,608,112 (GRCm39) T735I probably damaging Het
Creb3l4 G A 3: 90,146,006 (GRCm39) S206L probably damaging Het
Csf3r C A 4: 125,931,310 (GRCm39) probably null Het
Dnah11 G T 12: 117,994,007 (GRCm39) S2346R probably benign Het
Dnai2 A T 11: 114,643,734 (GRCm39) I467F possibly damaging Het
Dpy19l4 A T 4: 11,276,876 (GRCm39) M523K probably damaging Het
Ebf3 T C 7: 136,802,264 (GRCm39) D407G probably damaging Het
Fbn2 A G 18: 58,209,908 (GRCm39) I991T probably benign Het
Gcc1 T C 6: 28,419,299 (GRCm39) T345A probably benign Het
Gm1527 C T 3: 28,974,752 (GRCm39) H522Y probably benign Het
Gm4846 T A 1: 166,317,696 (GRCm39) Y240F probably benign Het
Hmgcl T C 4: 135,682,926 (GRCm39) V126A probably benign Het
Ifit1bl2 G T 19: 34,597,438 (GRCm39) S59R probably benign Het
Itga6 A G 2: 71,617,577 (GRCm39) N32S probably benign Het
Lcor C A 19: 41,572,396 (GRCm39) P384T possibly damaging Het
Macc1 T C 12: 119,414,160 (GRCm39) S779P probably benign Het
Mctp1 G T 13: 76,533,280 (GRCm39) L209F probably damaging Het
Mink1 A G 11: 70,489,915 (GRCm39) N97S possibly damaging Het
Mst1r T A 9: 107,785,350 (GRCm39) V336E probably benign Het
Muc16 A T 9: 18,557,967 (GRCm39) S2775R unknown Het
Muc6 T A 7: 141,227,841 (GRCm39) T1316S possibly damaging Het
Myh11 T A 16: 14,095,567 (GRCm39) N65I probably damaging Het
Nkain2 A T 10: 31,827,281 (GRCm39) M103K probably damaging Het
Nkx2-2 T A 2: 147,025,961 (GRCm39) Y259F probably benign Het
Nrxn1 T C 17: 90,897,526 (GRCm39) M877V possibly damaging Het
Nxf1 C T 19: 8,745,108 (GRCm39) L453F probably damaging Het
Pcnt T C 10: 76,255,871 (GRCm39) S790G possibly damaging Het
Phf3 T C 1: 30,902,307 (GRCm39) D2G probably damaging Het
Phrf1 T C 7: 140,838,898 (GRCm39) probably benign Het
Ptpn3 C A 4: 57,248,653 (GRCm39) probably null Het
Pygl T C 12: 70,243,841 (GRCm39) T625A probably benign Het
R3hdm2 T A 10: 127,295,349 (GRCm39) F239I probably damaging Het
Sesn1 A T 10: 41,772,196 (GRCm39) I242F probably damaging Het
Shank2 C T 7: 143,733,768 (GRCm39) T105I probably benign Het
Skint3 T C 4: 112,147,543 (GRCm39) F350S possibly damaging Het
Slco5a1 T C 1: 13,014,294 (GRCm39) Y320C probably damaging Het
Syt11 A G 3: 88,669,416 (GRCm39) S159P probably benign Het
Tanc2 G A 11: 105,758,543 (GRCm39) R768Q probably damaging Het
Tanc2 T C 11: 105,814,498 (GRCm39) S1981P probably damaging Het
Tmem200c A C 17: 69,148,722 (GRCm39) D435A possibly damaging Het
Trappc8 A G 18: 20,966,066 (GRCm39) V1125A probably damaging Het
Ttn A G 2: 76,644,487 (GRCm39) V4762A possibly damaging Het
Unc5d A G 8: 29,365,539 (GRCm39) S149P possibly damaging Het
Usf3 A T 16: 44,040,203 (GRCm39) N1561I probably damaging Het
Wdr4 A T 17: 31,720,272 (GRCm39) probably benign Het
Wdr49 T G 3: 75,209,133 (GRCm39) E612D probably benign Het
Other mutations in Myo9a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00427:Myo9a APN 9 59,750,342 (GRCm39) splice site probably benign
IGL00510:Myo9a APN 9 59,739,464 (GRCm39) splice site probably benign
IGL00710:Myo9a APN 9 59,782,594 (GRCm39) missense probably damaging 1.00
IGL00963:Myo9a APN 9 59,807,655 (GRCm39) missense probably damaging 0.98
IGL01087:Myo9a APN 9 59,697,361 (GRCm39) missense possibly damaging 0.93
IGL01145:Myo9a APN 9 59,762,658 (GRCm39) missense probably benign 0.18
IGL01403:Myo9a APN 9 59,778,846 (GRCm39) missense probably damaging 0.98
IGL01528:Myo9a APN 9 59,686,957 (GRCm39) missense probably damaging 1.00
IGL01608:Myo9a APN 9 59,778,119 (GRCm39) nonsense probably null
IGL01701:Myo9a APN 9 59,791,877 (GRCm39) critical splice donor site probably null
IGL01918:Myo9a APN 9 59,686,985 (GRCm39) missense probably damaging 1.00
IGL02026:Myo9a APN 9 59,813,245 (GRCm39) missense probably damaging 0.99
IGL02139:Myo9a APN 9 59,687,275 (GRCm39) missense probably benign 0.07
IGL02176:Myo9a APN 9 59,777,836 (GRCm39) missense probably benign 0.45
IGL02272:Myo9a APN 9 59,791,883 (GRCm39) splice site probably benign
IGL02283:Myo9a APN 9 59,778,956 (GRCm39) missense probably benign 0.00
IGL02499:Myo9a APN 9 59,722,669 (GRCm39) splice site probably benign
IGL02652:Myo9a APN 9 59,771,211 (GRCm39) missense probably damaging 1.00
IGL02666:Myo9a APN 9 59,832,187 (GRCm39) missense probably benign 0.02
IGL02878:Myo9a APN 9 59,815,583 (GRCm39) critical splice donor site probably null
IGL02982:Myo9a APN 9 59,815,491 (GRCm39) nonsense probably null
IGL03072:Myo9a APN 9 59,716,725 (GRCm39) missense possibly damaging 0.83
IGL03090:Myo9a APN 9 59,801,418 (GRCm39) splice site probably benign
IGL03111:Myo9a APN 9 59,734,526 (GRCm39) missense probably benign 0.19
IGL03389:Myo9a APN 9 59,776,890 (GRCm39) missense probably damaging 1.00
essentials UTSW 9 59,802,149 (GRCm39) missense probably benign 0.09
necessities UTSW 9 59,722,617 (GRCm39) missense probably damaging 1.00
PIT4402001:Myo9a UTSW 9 59,777,719 (GRCm39) missense possibly damaging 0.83
R0013:Myo9a UTSW 9 59,767,489 (GRCm39) splice site probably benign
R0013:Myo9a UTSW 9 59,767,489 (GRCm39) splice site probably benign
R0018:Myo9a UTSW 9 59,779,007 (GRCm39) missense probably benign 0.00
R0018:Myo9a UTSW 9 59,779,007 (GRCm39) missense probably benign 0.00
R0329:Myo9a UTSW 9 59,830,960 (GRCm39) missense probably damaging 1.00
R0423:Myo9a UTSW 9 59,802,619 (GRCm39) missense probably damaging 1.00
R0521:Myo9a UTSW 9 59,801,635 (GRCm39) missense probably damaging 1.00
R0607:Myo9a UTSW 9 59,829,076 (GRCm39) missense probably benign 0.02
R0652:Myo9a UTSW 9 59,779,209 (GRCm39) missense probably benign
R0653:Myo9a UTSW 9 59,832,274 (GRCm39) missense probably damaging 1.00
R0723:Myo9a UTSW 9 59,778,383 (GRCm39) missense probably benign 0.01
R0784:Myo9a UTSW 9 59,803,828 (GRCm39) splice site probably benign
R0842:Myo9a UTSW 9 59,778,350 (GRCm39) missense probably benign 0.02
R1055:Myo9a UTSW 9 59,762,653 (GRCm39) missense probably benign 0.01
R1056:Myo9a UTSW 9 59,739,484 (GRCm39) missense possibly damaging 0.64
R1195:Myo9a UTSW 9 59,802,483 (GRCm39) missense probably damaging 1.00
R1195:Myo9a UTSW 9 59,802,483 (GRCm39) missense probably damaging 1.00
R1195:Myo9a UTSW 9 59,802,483 (GRCm39) missense probably damaging 1.00
R1615:Myo9a UTSW 9 59,695,739 (GRCm39) missense possibly damaging 0.68
R1698:Myo9a UTSW 9 59,775,464 (GRCm39) missense probably benign 0.05
R1715:Myo9a UTSW 9 59,739,583 (GRCm39) missense probably damaging 0.99
R1981:Myo9a UTSW 9 59,801,429 (GRCm39) missense probably benign
R2228:Myo9a UTSW 9 59,801,463 (GRCm39) missense probably benign 0.06
R2272:Myo9a UTSW 9 59,722,584 (GRCm39) missense probably damaging 1.00
R2327:Myo9a UTSW 9 59,687,048 (GRCm39) missense probably benign 0.11
R2990:Myo9a UTSW 9 59,832,172 (GRCm39) missense possibly damaging 0.95
R3161:Myo9a UTSW 9 59,739,598 (GRCm39) splice site probably benign
R3721:Myo9a UTSW 9 59,775,463 (GRCm39) missense probably benign
R3928:Myo9a UTSW 9 59,802,566 (GRCm39) missense probably damaging 1.00
R4197:Myo9a UTSW 9 59,802,149 (GRCm39) missense probably benign 0.09
R4212:Myo9a UTSW 9 59,813,349 (GRCm39) nonsense probably null
R4610:Myo9a UTSW 9 59,779,165 (GRCm39) missense probably benign
R4616:Myo9a UTSW 9 59,728,932 (GRCm39) missense probably damaging 1.00
R4621:Myo9a UTSW 9 59,778,355 (GRCm39) missense probably benign 0.00
R4623:Myo9a UTSW 9 59,778,355 (GRCm39) missense probably benign 0.00
R4632:Myo9a UTSW 9 59,776,947 (GRCm39) missense probably benign 0.00
R4657:Myo9a UTSW 9 59,782,699 (GRCm39) critical splice donor site probably null
R4892:Myo9a UTSW 9 59,731,525 (GRCm39) missense probably damaging 0.98
R4897:Myo9a UTSW 9 59,803,800 (GRCm39) missense probably benign 0.07
R4966:Myo9a UTSW 9 59,779,017 (GRCm39) missense probably benign 0.00
R4993:Myo9a UTSW 9 59,768,755 (GRCm39) nonsense probably null
R5160:Myo9a UTSW 9 59,779,085 (GRCm39) missense probably benign 0.24
R5233:Myo9a UTSW 9 59,817,900 (GRCm39) missense probably damaging 1.00
R5271:Myo9a UTSW 9 59,814,665 (GRCm39) missense probably damaging 1.00
R5308:Myo9a UTSW 9 59,771,244 (GRCm39) missense probably damaging 1.00
R5367:Myo9a UTSW 9 59,807,732 (GRCm39) missense probably damaging 0.96
R5432:Myo9a UTSW 9 59,772,953 (GRCm39) missense possibly damaging 0.94
R5459:Myo9a UTSW 9 59,791,803 (GRCm39) missense probably damaging 0.98
R5511:Myo9a UTSW 9 59,687,495 (GRCm39) missense probably damaging 1.00
R5568:Myo9a UTSW 9 59,781,911 (GRCm39) missense probably benign
R5573:Myo9a UTSW 9 59,778,284 (GRCm39) missense probably benign
R5589:Myo9a UTSW 9 59,802,527 (GRCm39) nonsense probably null
R5607:Myo9a UTSW 9 59,771,227 (GRCm39) missense probably damaging 1.00
R5633:Myo9a UTSW 9 59,775,467 (GRCm39) missense possibly damaging 0.60
R5885:Myo9a UTSW 9 59,778,503 (GRCm39) missense probably benign
R6086:Myo9a UTSW 9 59,697,340 (GRCm39) nonsense probably null
R6146:Myo9a UTSW 9 59,778,512 (GRCm39) missense probably benign 0.01
R6194:Myo9a UTSW 9 59,777,033 (GRCm39) missense probably benign 0.00
R6213:Myo9a UTSW 9 59,734,541 (GRCm39) missense probably damaging 1.00
R6368:Myo9a UTSW 9 59,832,231 (GRCm39) missense probably benign 0.01
R6550:Myo9a UTSW 9 59,775,482 (GRCm39) missense probably damaging 1.00
R6612:Myo9a UTSW 9 59,734,479 (GRCm39) missense probably damaging 1.00
R6665:Myo9a UTSW 9 59,779,155 (GRCm39) missense probably benign 0.09
R6951:Myo9a UTSW 9 59,802,051 (GRCm39) missense probably damaging 1.00
R7026:Myo9a UTSW 9 59,722,617 (GRCm39) missense probably damaging 1.00
R7107:Myo9a UTSW 9 59,778,098 (GRCm39) missense probably benign 0.44
R7310:Myo9a UTSW 9 59,778,436 (GRCm39) missense probably benign 0.08
R7473:Myo9a UTSW 9 59,802,527 (GRCm39) missense probably benign 0.31
R7723:Myo9a UTSW 9 59,687,141 (GRCm39) missense probably damaging 1.00
R7823:Myo9a UTSW 9 59,719,233 (GRCm39) missense probably damaging 1.00
R7824:Myo9a UTSW 9 59,767,392 (GRCm39) missense probably damaging 1.00
R7965:Myo9a UTSW 9 59,695,721 (GRCm39) missense probably damaging 1.00
R8031:Myo9a UTSW 9 59,687,374 (GRCm39) missense probably benign 0.33
R8055:Myo9a UTSW 9 59,814,743 (GRCm39) missense probably damaging 1.00
R8071:Myo9a UTSW 9 59,781,931 (GRCm39) missense probably benign
R8250:Myo9a UTSW 9 59,767,392 (GRCm39) missense probably damaging 1.00
R8260:Myo9a UTSW 9 59,817,961 (GRCm39) missense probably benign 0.08
R8355:Myo9a UTSW 9 59,817,130 (GRCm39) missense probably damaging 1.00
R8432:Myo9a UTSW 9 59,687,548 (GRCm39) missense probably damaging 1.00
R8470:Myo9a UTSW 9 59,739,573 (GRCm39) missense probably damaging 1.00
R8528:Myo9a UTSW 9 59,767,423 (GRCm39) missense probably damaging 1.00
R8681:Myo9a UTSW 9 59,775,394 (GRCm39) missense probably benign 0.16
R8690:Myo9a UTSW 9 59,782,657 (GRCm39) missense probably benign
R8793:Myo9a UTSW 9 59,791,850 (GRCm39) missense probably benign 0.03
R8812:Myo9a UTSW 9 59,687,030 (GRCm39) missense probably benign 0.14
R9016:Myo9a UTSW 9 59,775,427 (GRCm39) nonsense probably null
R9026:Myo9a UTSW 9 59,716,757 (GRCm39) missense probably damaging 0.96
R9036:Myo9a UTSW 9 59,687,584 (GRCm39) nonsense probably null
R9130:Myo9a UTSW 9 59,739,514 (GRCm39) missense probably damaging 0.98
R9131:Myo9a UTSW 9 59,768,772 (GRCm39) missense probably damaging 1.00
R9213:Myo9a UTSW 9 59,772,922 (GRCm39) missense probably benign 0.04
R9498:Myo9a UTSW 9 59,734,466 (GRCm39) missense probably damaging 1.00
R9575:Myo9a UTSW 9 59,813,190 (GRCm39) missense probably damaging 1.00
R9651:Myo9a UTSW 9 59,778,764 (GRCm39) missense probably damaging 0.96
R9672:Myo9a UTSW 9 59,687,332 (GRCm39) missense probably benign 0.16
RF018:Myo9a UTSW 9 59,776,869 (GRCm39) missense probably benign 0.00
RF019:Myo9a UTSW 9 59,829,055 (GRCm39) missense probably benign 0.00
Z1176:Myo9a UTSW 9 59,802,542 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTATACGAATGTGTCTGAATCCAC -3'
(R):5'- CCTGTCCAAGTGCTAGATCTGAAG -3'

Sequencing Primer
(F):5'- CGAATGTGTCTGAATCCACTAAAAC -3'
(R):5'- TCCAAGTGCTAGATCTGAAGAATAG -3'
Posted On 2017-06-26