Incidental Mutation 'R6036:Or2ag2b'
ID 479211
Institutional Source Beutler Lab
Gene Symbol Or2ag2b
Ensembl Gene ENSMUSG00000036744
Gene Name olfactory receptor family 2 subfamily AG member 2B
Synonyms 4933433E02Rik, Olfr701, GA_x6K02T2PBJ9-9195805-9196755, 4932441H21Rik, MOR283-1
MMRRC Submission 043257-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R6036 (G1)
Quality Score 146.008
Status Not validated
Chromosome 7
Chromosomal Location 106413336-106419916 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 106417667 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 126 (I126F)
Ref Sequence ENSEMBL: ENSMUSP00000151783 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075414] [ENSMUST00000166880] [ENSMUST00000217739]
AlphaFold Q9D3U9
Predicted Effect probably damaging
Transcript: ENSMUST00000075414
AA Change: I126F

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000074868
Gene: ENSMUSG00000036744
AA Change: I126F

Pfam:7tm_4 31 308 2.9e-46 PFAM
Pfam:7tm_1 41 290 2.3e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000166880
AA Change: I126F

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000130958
Gene: ENSMUSG00000036744
AA Change: I126F

Pfam:7tm_1 41 290 5.8e-31 PFAM
Pfam:7tm_4 139 283 1.8e-44 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209339
Predicted Effect probably damaging
Transcript: ENSMUST00000217739
AA Change: I126F

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.0%
  • 10x: 92.6%
  • 20x: 72.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3 T C 11: 95,723,684 (GRCm39) probably benign Het
Ago1 C T 4: 126,337,021 (GRCm39) R228H probably damaging Het
Alpk3 G A 7: 80,743,005 (GRCm39) V941M probably benign Het
Ano4 A G 10: 88,818,127 (GRCm39) W588R possibly damaging Het
Atp6v1a A G 16: 43,919,194 (GRCm39) Y464H probably benign Het
Barx2 A T 9: 31,824,304 (GRCm39) D28E probably damaging Het
Cabp5 A T 7: 13,135,260 (GRCm39) M67L probably damaging Het
Col10a1 A G 10: 34,271,278 (GRCm39) T417A probably benign Het
Dnah2 C T 11: 69,349,746 (GRCm39) R2399Q probably benign Het
Eif4enif1 T C 11: 3,189,420 (GRCm39) S227P probably damaging Het
Erv3 G A 2: 131,697,925 (GRCm39) H145Y possibly damaging Het
Exoc5 T C 14: 49,251,779 (GRCm39) T591A possibly damaging Het
F5 A T 1: 164,012,565 (GRCm39) E493V probably damaging Het
Gm8444 G T 15: 81,727,794 (GRCm39) probably benign Het
Gria4 T A 9: 4,537,646 (GRCm39) I221L probably benign Het
H2bc13 A T 13: 21,900,148 (GRCm39) S56T probably damaging Het
Hc T C 2: 34,929,696 (GRCm39) T249A probably benign Het
Herc2 A G 7: 55,717,801 (GRCm39) T48A probably benign Het
Hp A G 8: 110,303,406 (GRCm39) probably null Het
Ifna15 T G 4: 88,476,310 (GRCm39) D58A possibly damaging Het
Kcnj1 A T 9: 32,308,421 (GRCm39) M262L probably benign Het
Krt87 A C 15: 101,385,412 (GRCm39) I320S possibly damaging Het
Megf10 A G 18: 57,375,799 (GRCm39) N242D probably damaging Het
Nup155 A G 15: 8,157,895 (GRCm39) T451A probably benign Het
Or4g7 T C 2: 111,309,333 (GRCm39) L68P probably damaging Het
Or4k35 C T 2: 111,099,957 (GRCm39) G252R probably damaging Het
Or51a25 T A 7: 102,373,692 (GRCm39) I2F probably benign Het
Or8d23 A G 9: 38,842,216 (GRCm39) I250V probably damaging Het
Pdzd8 G A 19: 59,293,641 (GRCm39) P403S probably damaging Het
Piezo2 G A 18: 63,248,019 (GRCm39) Q494* probably null Het
Plag1 T C 4: 3,904,618 (GRCm39) E191G possibly damaging Het
Pou4f2 A T 8: 79,162,103 (GRCm39) S167T probably damaging Het
Scd4 G A 19: 44,333,231 (GRCm39) D319N probably damaging Het
Senp2 A T 16: 21,847,308 (GRCm39) R279* probably null Het
Sh3rf3 G A 10: 58,649,806 (GRCm39) G137D probably benign Het
Simc1 C T 13: 54,672,434 (GRCm39) P261S probably benign Het
Slc26a1 T A 5: 108,821,436 (GRCm39) D151V probably damaging Het
Snx29 A G 16: 11,556,301 (GRCm39) probably null Het
Stard9 C T 2: 120,530,556 (GRCm39) A2271V probably benign Het
Stat6 A G 10: 127,491,313 (GRCm39) N485D possibly damaging Het
Tpcn2 T C 7: 144,822,606 (GRCm39) T280A possibly damaging Het
Ttc23 A G 7: 67,361,114 (GRCm39) I378V possibly damaging Het
Ttc29 A G 8: 79,052,205 (GRCm39) D362G probably benign Het
Ttll7 A G 3: 146,645,917 (GRCm39) I592V probably benign Het
Ugt3a1 A T 15: 9,306,172 (GRCm39) H107L probably benign Het
Vmn1r70 A G 7: 10,367,830 (GRCm39) Q87R probably damaging Het
Wdfy4 G T 14: 32,868,947 (GRCm39) S360R probably damaging Het
Zfp780b A G 7: 27,662,993 (GRCm39) Y521H probably damaging Het
Other mutations in Or2ag2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01476:Or2ag2b APN 7 106,417,827 (GRCm39) missense probably damaging 1.00
IGL01972:Or2ag2b APN 7 106,417,739 (GRCm39) missense probably benign 0.01
IGL02541:Or2ag2b APN 7 106,417,809 (GRCm39) missense probably benign 0.34
R0276:Or2ag2b UTSW 7 106,417,904 (GRCm39) missense probably benign 0.00
R0345:Or2ag2b UTSW 7 106,417,908 (GRCm39) missense probably benign 0.38
R0467:Or2ag2b UTSW 7 106,417,568 (GRCm39) missense possibly damaging 0.49
R1829:Or2ag2b UTSW 7 106,418,214 (GRCm39) missense probably benign
R3116:Or2ag2b UTSW 7 106,417,571 (GRCm39) missense probably damaging 0.98
R3870:Or2ag2b UTSW 7 106,418,047 (GRCm39) nonsense probably null
R5267:Or2ag2b UTSW 7 106,418,015 (GRCm39) missense probably damaging 1.00
R6036:Or2ag2b UTSW 7 106,417,667 (GRCm39) missense probably damaging 1.00
R7229:Or2ag2b UTSW 7 106,418,202 (GRCm39) missense probably damaging 0.97
R7230:Or2ag2b UTSW 7 106,417,386 (GRCm39) missense possibly damaging 0.78
R7231:Or2ag2b UTSW 7 106,417,650 (GRCm39) missense probably damaging 1.00
R7419:Or2ag2b UTSW 7 106,417,551 (GRCm39) missense possibly damaging 0.89
R7537:Or2ag2b UTSW 7 106,417,581 (GRCm39) missense probably damaging 1.00
R8468:Or2ag2b UTSW 7 106,418,046 (GRCm39) missense possibly damaging 0.66
R9246:Or2ag2b UTSW 7 106,417,938 (GRCm39) missense probably benign 0.00
R9300:Or2ag2b UTSW 7 106,418,111 (GRCm39) missense probably benign 0.01
Predicted Primers
Posted On 2017-06-26