Mutagenetix > Incidental Mutation

Incidental Mutation 'R6036:Gm8444'

479233

Institutional Source

Beutler Lab

Gene Symbol

Gm8444

Ensembl Gene

ENSMUSG00000069439

Gene Name

predicted gene 8444

Synonyms

MMRRC Submission

043257-MU

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.329) question?

Stock #

R6036 (G1)

Quality Score

100.008

Status

Not validated

Chromosome

Chromosomal Location

81843343-81843699 bp(-) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

G to T at 81843593 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000061390 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050467] [ENSMUST00000092020]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000050467

SMART Domains

Protein: ENSMUSP00000061390
Gene: ENSMUSG00000048546

Domain	Start	End	E-Value	Type
btg1	1	106	3.69e-64	SMART
Pfam:PAM2	128	145	1e-7	PFAM
low complexity region	175	189	N/A	INTRINSIC
low complexity region	194	218	N/A	INTRINSIC
low complexity region	226	243	N/A	INTRINSIC
Pfam:PAM2	249	266	5.9e-9	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000092020

SMART Domains

Protein: ENSMUSP00000089648
Gene: ENSMUSG00000069439

Domain	Start	End	E-Value	Type
Pfam:Ribosomal_L29	2	58	2.3e-22	PFAM
low complexity region	90	103	N/A	INTRINSIC

Coding Region Coverage

1x: 99.8%
3x: 99.0%
10x: 92.6%
20x: 72.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abi3	T	C	11: 95,832,858		probably benign	Het
Ago1	C	T	4: 126,443,228	R228H	probably damaging	Het
Alpk3	G	A	7: 81,093,257	V941M	probably benign	Het
Ano4	A	G	10: 88,982,265	W588R	possibly damaging	Het
Atp6v1a	A	G	16: 44,098,831	Y464H	probably benign	Het
Barx2	A	T	9: 31,913,008	D28E	probably damaging	Het
Cabp5	A	T	7: 13,401,335	M67L	probably damaging	Het
Col10a1	A	G	10: 34,395,282	T417A	probably benign	Het
Dnah2	C	T	11: 69,458,920	R2399Q	probably benign	Het
Eif4enif1	T	C	11: 3,239,420	S227P	probably damaging	Het
Erv3	G	A	2: 131,856,005	H145Y	possibly damaging	Het
Exoc5	T	C	14: 49,014,322	T591A	possibly damaging	Het
F5	A	T	1: 164,184,996	E493V	probably damaging	Het
Gria4	T	A	9: 4,537,646	I221L	probably benign	Het
Hc	T	C	2: 35,039,684	T249A	probably benign	Het
Herc2	A	G	7: 56,068,053	T48A	probably benign	Het
Hist1h2bl	A	T	13: 21,715,978	S56T	probably damaging	Het
Hp	A	G	8: 109,576,774		probably null	Het
Ifna15	T	G	4: 88,558,073	D58A	possibly damaging	Het
Kcnj1	A	T	9: 32,397,125	M262L	probably benign	Het
Krt83	A	C	15: 101,487,531	I320S	possibly damaging	Het
Megf10	A	G	18: 57,242,727	N242D	probably damaging	Het
Nup155	A	G	15: 8,128,411	T451A	probably benign	Het
Olfr1277	C	T	2: 111,269,612	G252R	probably damaging	Het
Olfr1288	T	C	2: 111,478,988	L68P	probably damaging	Het
Olfr559	T	A	7: 102,724,485	I2F	probably benign	Het
Olfr701	A	T	7: 106,818,460	I126F	probably damaging	Het
Olfr930	A	G	9: 38,930,920	I250V	probably damaging	Het
Pdzd8	G	A	19: 59,305,209	P403S	probably damaging	Het
Piezo2	G	A	18: 63,114,948	Q494*	probably null	Het
Plag1	T	C	4: 3,904,618	E191G	possibly damaging	Het
Pou4f2	A	T	8: 78,435,474	S167T	probably damaging	Het
Scd4	G	A	19: 44,344,792	D319N	probably damaging	Het
Senp2	A	T	16: 22,028,558	R279*	probably null	Het
Sh3rf3	G	A	10: 58,813,984	G137D	probably benign	Het
Simc1	C	T	13: 54,524,621	P261S	probably benign	Het
Slc26a1	T	A	5: 108,673,570	D151V	probably damaging	Het
Snx29	A	G	16: 11,738,437		probably null	Het
Stard9	C	T	2: 120,700,075	A2271V	probably benign	Het
Stat6	A	G	10: 127,655,444	N485D	possibly damaging	Het
Tpcn2	T	C	7: 145,268,869	T280A	possibly damaging	Het
Ttc23	A	G	7: 67,711,366	I378V	possibly damaging	Het
Ttc29	A	G	8: 78,325,576	D362G	probably benign	Het
Ttll7	A	G	3: 146,940,162	I592V	probably benign	Het
Ugt3a1	A	T	15: 9,306,086	H107L	probably benign	Het
Vmn1r70	A	G	7: 10,633,903	Q87R	probably damaging	Het
Wdfy4	G	T	14: 33,146,990	S360R	probably damaging	Het
Zfp780b	A	G	7: 27,963,568	Y521H	probably damaging	Het

Other mutations in Gm8444

Allele	Source	Chr	Coord	Type	Predicted Effect
R1167:Gm8444	UTSW	15	81843380	unclassified	probably benign
R2006:Gm8444	UTSW	15	81843574	unclassified	probably benign
R3054:Gm8444	UTSW	15	81843644	unclassified	probably benign
R4274:Gm8444	UTSW	15	81843533	unclassified	probably benign
R5332:Gm8444	UTSW	15	81843701	unclassified	probably benign
R5807:Gm8444	UTSW	15	81843453	unclassified	probably benign
R6036:Gm8444	UTSW	15	81843593	unclassified	probably benign
R6187:Gm8444	UTSW	15	81843606	unclassified	probably benign

Predicted Primers

Posted On

2017-06-26