Incidental Mutation 'R6037:Olfr1034'
ID479246
Institutional Source Beutler Lab
Gene Symbol Olfr1034
Ensembl Gene ENSMUSG00000102091
Gene Nameolfactory receptor 1034
SynonymsGA_x6K02T2Q125-47521463-47522395, MOR227-8P, MOR227-8P, Olfr1533-ps1, MOR245-14P
MMRRC Submission 043258-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.416) question?
Stock #R6037 (G1)
Quality Score225.009
Status Not validated
Chromosome2
Chromosomal Location86045861-86050742 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 86046584 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Threonine at position 34 (M34T)
Ref Sequence ENSEMBL: ENSMUSP00000150150 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079298] [ENSMUST00000213496] [ENSMUST00000213865] [ENSMUST00000214546] [ENSMUST00000215682] [ENSMUST00000218397]
Predicted Effect probably benign
Transcript: ENSMUST00000079298
AA Change: M34T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000078279
Gene: ENSMUSG00000042796
AA Change: M34T

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.3e-50 PFAM
Pfam:7tm_1 39 288 9.9e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213364
Predicted Effect probably benign
Transcript: ENSMUST00000213496
AA Change: M34T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000213865
Predicted Effect probably benign
Transcript: ENSMUST00000214546
Predicted Effect probably benign
Transcript: ENSMUST00000215682
Predicted Effect probably benign
Transcript: ENSMUST00000218397
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.0%
  • 10x: 92.4%
  • 20x: 72.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930505A04Rik C T 11: 30,426,349 V173M probably damaging Het
Abi2 C A 1: 60,464,579 P212T probably damaging Het
Ano4 A G 10: 89,317,246 F68S possibly damaging Het
Art5 C A 7: 102,098,384 A63S probably benign Het
Asgr1 T A 11: 70,056,421 S96R probably benign Het
Bdp1 A T 13: 100,027,449 V2248D possibly damaging Het
Cacna1s C T 1: 136,070,967 A200V possibly damaging Het
Cacna2d2 A G 9: 107,513,539 K357E probably damaging Het
Cfap52 C T 11: 67,946,300 G212R probably benign Het
Dcun1d3 A G 7: 119,857,742 F249S probably damaging Het
Ece2 A G 16: 20,630,362 Y17C probably damaging Het
Efemp1 C T 11: 28,921,760 T425I probably damaging Het
Eprs A G 1: 185,396,109 E562G probably damaging Het
Fbn2 T C 18: 58,044,223 T2001A probably benign Het
Flt4 G A 11: 49,637,040 R940H probably damaging Het
Fry T A 5: 150,428,179 M1716K probably benign Het
Gm10684 T A 9: 45,107,741 probably benign Het
Gm281 T C 14: 13,864,282 N348S probably damaging Het
Hivep1 G A 13: 42,157,940 V1219I probably damaging Het
Hyls1 G A 9: 35,561,184 S312F probably benign Het
Il23r C T 6: 67,478,954 V177M probably damaging Het
Klf12 T C 14: 99,900,214 S299G probably benign Het
Lama5 G A 2: 180,207,013 R265C probably damaging Het
Lifr A G 15: 7,186,943 T800A probably damaging Het
Megf8 T C 7: 25,364,406 L2729P probably damaging Het
Mki67 A C 7: 135,696,803 S2167R possibly damaging Het
Mus81 T C 19: 5,484,004 K400E probably damaging Het
Nomo1 T A 7: 46,062,999 I656N possibly damaging Het
Oas3 T C 5: 120,769,319 T418A probably benign Het
Olfr1066 T A 2: 86,455,789 I161L probably benign Het
Olfr147 T A 9: 38,403,305 C144S probably benign Het
Olfr301 C T 7: 86,413,270 L303F probably benign Het
Olfr936 A G 9: 39,047,107 V104A probably damaging Het
Olr1 A G 6: 129,493,541 L221P probably damaging Het
Pih1d1 C T 7: 45,156,314 A69V probably damaging Het
Pkdrej A C 15: 85,819,766 S656R probably damaging Het
Polr3f A G 2: 144,536,023 D171G probably damaging Het
Rasal1 T C 5: 120,649,501 V11A possibly damaging Het
Rsf1 G GACGGCGGCT 7: 97,579,909 probably benign Het
Sptbn4 T A 7: 27,364,170 Y2277F probably damaging Het
St6galnac6 A G 2: 32,612,228 Q7R probably damaging Het
Thrsp T G 7: 97,417,292 D71A possibly damaging Het
Vmn2r1 C A 3: 64,081,729 Q30K probably benign Het
Vmn2r125 C A 4: 156,351,101 A258D probably benign Het
Wipf2 C T 11: 98,896,179 P345S probably benign Het
Zeb2 G T 2: 44,988,640 S1170* probably null Het
Zfp947 A G 17: 22,147,434 Y38H probably damaging Het
Other mutations in Olfr1034
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01015:Olfr1034 APN 2 86046652 missense possibly damaging 0.55
IGL01066:Olfr1034 APN 2 86047258 missense probably damaging 0.97
IGL01326:Olfr1034 APN 2 86047283 missense probably damaging 0.96
IGL02862:Olfr1034 APN 2 86047304 missense probably benign 0.07
ANU74:Olfr1034 UTSW 2 86047311 nonsense probably null
PIT4651001:Olfr1034 UTSW 2 86046518 missense probably damaging 1.00
R0415:Olfr1034 UTSW 2 86047055 missense probably benign 0.00
R0492:Olfr1034 UTSW 2 86046587 missense probably benign 0.00
R0492:Olfr1034 UTSW 2 86046934 missense possibly damaging 0.81
R0517:Olfr1034 UTSW 2 86047204 missense probably damaging 0.99
R0519:Olfr1034 UTSW 2 86047067 missense probably benign
R0619:Olfr1034 UTSW 2 86047311 nonsense probably null
R1015:Olfr1034 UTSW 2 86047082 missense possibly damaging 0.49
R1592:Olfr1034 UTSW 2 86046989 missense probably benign 0.00
R1598:Olfr1034 UTSW 2 86047313 missense probably damaging 0.99
R2062:Olfr1034 UTSW 2 86046955 missense probably damaging 1.00
R4690:Olfr1034 UTSW 2 86046898 missense probably damaging 1.00
R5757:Olfr1034 UTSW 2 86046566 missense possibly damaging 0.93
R5991:Olfr1034 UTSW 2 86046910 missense probably benign 0.05
R6037:Olfr1034 UTSW 2 86046584 missense probably benign 0.00
R6760:Olfr1034 UTSW 2 86047014 nonsense probably null
R6852:Olfr1034 UTSW 2 86046604 missense probably benign 0.28
S24628:Olfr1034 UTSW 2 86047055 missense probably benign 0.00
Predicted Primers
Posted On2017-06-26