Incidental Mutation 'R6038:Olfr58'
ID479305
Institutional Source Beutler Lab
Gene Symbol Olfr58
Ensembl Gene ENSMUSG00000058659
Gene Nameolfactory receptor 58
SynonymsIG6, MOR146-7P, MOR146-3, GA_x6K02T2PVTD-13523015-13523944
MMRRC Submission 044208-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.063) question?
Stock #R6038 (G1)
Quality Score225.009
Status Not validated
Chromosome9
Chromosomal Location19780283-19785333 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 19783562 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 143 (Y143C)
Ref Sequence ENSEMBL: ENSMUSP00000150309 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079660] [ENSMUST00000212363] [ENSMUST00000215112]
Predicted Effect probably benign
Transcript: ENSMUST00000079660
AA Change: Y143C

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000078603
Gene: ENSMUSG00000063842
AA Change: Y143C

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.3e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 303 8.3e-8 PFAM
Pfam:7tm_1 41 290 4.5e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212363
Predicted Effect probably benign
Transcript: ENSMUST00000215112
AA Change: Y143C

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.1284 question?
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.1%
  • 10x: 93.7%
  • 20x: 76.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 A G 17: 46,304,360 C1327R probably damaging Het
Adcy7 A G 8: 88,322,980 T704A probably benign Het
Adgra3 A T 5: 49,999,145 Y414* probably null Het
Adgrf1 T C 17: 43,295,209 S75P probably benign Het
Antxr1 C A 6: 87,287,000 probably null Het
Arid1b A T 17: 5,336,682 Y1470F probably benign Het
Baiap3 T C 17: 25,246,334 D649G probably damaging Het
BC067074 G A 13: 113,318,619 V400M possibly damaging Het
Cabin1 A G 10: 75,739,366 V615A probably benign Het
Cntnap1 G A 11: 101,184,636 R880Q probably benign Het
Col28a1 T C 6: 8,013,140 T971A probably benign Het
Coro7 A T 16: 4,679,550 probably null Het
Defb19 T G 2: 152,576,267 probably null Het
Dnah17 T C 11: 118,055,889 D3045G probably benign Het
Dock4 A T 12: 40,733,351 probably null Het
Egln3 A G 12: 54,181,690 V210A probably damaging Het
Epb41l4a T C 18: 33,854,335 S330G probably benign Het
Epha7 G A 4: 28,821,521 E229K probably damaging Het
Fam71a C T 1: 191,162,722 E575K probably damaging Het
Fam71e1 C T 7: 44,500,295 R147W probably damaging Het
Fam71e2 T C 7: 4,753,595 probably null Het
Fetub C T 16: 22,932,331 R143C probably damaging Het
Gxylt2 T A 6: 100,804,594 L410Q probably damaging Het
H2-M10.3 C A 17: 36,368,395 C6F probably benign Het
Hecw1 G T 13: 14,346,062 Q197K probably benign Het
Hk3 T C 13: 55,006,560 M778V probably benign Het
Hydin A G 8: 110,599,031 T4691A probably benign Het
Kndc1 CT C 7: 139,923,775 probably null Het
Larp1 A G 11: 58,041,605 E204G possibly damaging Het
Lrp12 A C 15: 39,872,380 W738G probably damaging Het
March10 A G 11: 105,402,051 S72P probably damaging Het
Mdga2 A T 12: 66,630,053 D488E probably damaging Het
Mrc1 G C 2: 14,257,071 W290C probably damaging Het
Nhp2 T C 11: 51,620,085 V55A probably benign Het
Olfr1116 T A 2: 87,269,267 I141N possibly damaging Het
Olfr741 T C 14: 50,486,220 L254P probably damaging Het
Osbpl7 C T 11: 97,050,716 P22S probably benign Het
Pebp1 A T 5: 117,284,105 L124Q probably benign Het
Pfkp G T 13: 6,597,969 H524N probably benign Het
Pnmt G A 11: 98,387,768 D187N probably damaging Het
Ppl A T 16: 5,102,581 I355K possibly damaging Het
Prom1 A T 5: 44,001,793 Y836N probably damaging Het
Rubcnl T C 14: 75,031,970 S23P probably benign Het
Sap130 T A 18: 31,680,486 I532N probably damaging Het
Serpina1e A T 12: 103,946,836 probably null Het
Skiv2l2 A T 13: 112,891,290 S679T probably benign Het
Slc12a3 T G 8: 94,330,472 S124R probably benign Het
Slc24a5 A G 2: 125,085,731 T317A probably benign Het
Smarcad1 T C 6: 65,073,248 S284P possibly damaging Het
Spag9 C G 11: 94,112,092 R724G probably damaging Het
Speg T C 1: 75,418,459 probably null Het
Steap3 A G 1: 120,241,641 Y271H probably damaging Het
Syne2 C T 12: 75,878,384 Q44* probably null Het
Syt16 G A 12: 74,222,535 probably null Het
Tas2r114 A T 6: 131,689,481 C195S possibly damaging Het
Tcl1b4 T C 12: 105,202,507 M10T possibly damaging Het
Tln1 G C 4: 43,555,052 F259L probably damaging Het
Vmn2r60 C A 7: 42,194,962 A583D probably benign Het
Wdhd1 T C 14: 47,263,580 Q455R possibly damaging Het
Wdr17 A G 8: 54,632,311 probably null Het
Xbp1 T C 11: 5,524,798 L233P probably benign Het
Zbtb17 A G 4: 141,464,441 E288G probably benign Het
Other mutations in Olfr58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01461:Olfr58 APN 9 19783949 unclassified probably null
IGL01815:Olfr58 APN 9 19784015 missense probably damaging 1.00
IGL02408:Olfr58 APN 9 19783415 missense probably benign 0.31
IGL02644:Olfr58 APN 9 19783714 missense probably benign 0.30
IGL03243:Olfr58 APN 9 19783268 missense probably damaging 0.99
R0603:Olfr58 UTSW 9 19783939 missense probably damaging 1.00
R2363:Olfr58 UTSW 9 19783596 missense probably benign 0.00
R2570:Olfr58 UTSW 9 19784009 missense probably damaging 1.00
R3890:Olfr58 UTSW 9 19783715 missense probably benign 0.03
R3892:Olfr58 UTSW 9 19783715 missense probably benign 0.03
R4163:Olfr58 UTSW 9 19783790 missense possibly damaging 0.69
R4610:Olfr58 UTSW 9 19783146 nonsense probably null
R4691:Olfr58 UTSW 9 19783382 missense probably benign 0.33
R4707:Olfr58 UTSW 9 19783300 missense probably damaging 1.00
R4825:Olfr58 UTSW 9 19783576 missense possibly damaging 0.74
R4950:Olfr58 UTSW 9 19783731 missense probably benign
R5185:Olfr58 UTSW 9 19783376 missense probably damaging 1.00
R5202:Olfr58 UTSW 9 19783218 missense possibly damaging 0.46
R5439:Olfr58 UTSW 9 19783865 missense probably damaging 1.00
R5669:Olfr58 UTSW 9 19783757 missense probably benign 0.02
R5672:Olfr58 UTSW 9 19783211 missense possibly damaging 0.92
R6038:Olfr58 UTSW 9 19783562 missense probably benign
R6212:Olfr58 UTSW 9 19783289 missense probably damaging 1.00
R6415:Olfr58 UTSW 9 19783748 missense probably damaging 1.00
R7385:Olfr58 UTSW 9 19783211 missense possibly damaging 0.92
Predicted Primers
Posted On2017-06-26