Incidental Mutation 'R6005:Rgs22'
ID 479440
Institutional Source Beutler Lab
Gene Symbol Rgs22
Ensembl Gene ENSMUSG00000037627
Gene Name regulator of G-protein signalling 22
Synonyms
MMRRC Submission 044425-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6005 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 36009625-36140546 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 36010713 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Methionine at position 1125 (K1125M)
Ref Sequence ENSEMBL: ENSMUSP00000134185 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172831] [ENSMUST00000174881]
AlphaFold G3UYX5
Predicted Effect probably benign
Transcript: ENSMUST00000172831
AA Change: K1249M

PolyPhen 2 Score 0.377 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000134259
Gene: ENSMUSG00000037627
AA Change: K1249M

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
low complexity region 62 76 N/A INTRINSIC
low complexity region 173 179 N/A INTRINSIC
low complexity region 376 391 N/A INTRINSIC
RGS 845 973 3.15e-2 SMART
RGS 1014 1134 1.56e-15 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000173018
SMART Domains Protein: ENSMUSP00000133703
Gene: ENSMUSG00000037627

DomainStartEndE-ValueType
RGS 4 124 1.56e-15 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000174881
AA Change: K1125M

PolyPhen 2 Score 0.394 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000134185
Gene: ENSMUSG00000037627
AA Change: K1125M

DomainStartEndE-ValueType
low complexity region 23 37 N/A INTRINSIC
low complexity region 252 267 N/A INTRINSIC
RGS 721 849 3.15e-2 SMART
RGS 890 1010 1.56e-15 SMART
Meta Mutation Damage Score 0.1014 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.4%
  • 10x: 97.2%
  • 20x: 90.9%
Validation Efficiency 99% (79/80)
Allele List at MGI

All alleles(2) : Targeted, other(2)

Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
7530416G11Rik A T 15: 85,378,310 (GRCm39) I111N unknown Het
Adgb C T 10: 10,271,096 (GRCm39) R849H probably damaging Het
Ahnak T C 19: 8,992,525 (GRCm39) V4603A possibly damaging Het
Ank1 A G 8: 23,622,218 (GRCm39) D1589G probably damaging Het
Ankrd2 A G 19: 42,028,554 (GRCm39) D70G probably damaging Het
Arid2 T C 15: 96,268,853 (GRCm39) S989P probably benign Het
Bbs1 A T 19: 4,953,823 (GRCm39) Y113* probably null Het
Bfsp2 T G 9: 103,325,749 (GRCm39) K298T probably damaging Het
Bpi G A 2: 158,104,400 (GRCm39) V168I possibly damaging Het
Cacna2d1 T C 5: 16,566,819 (GRCm39) S921P probably damaging Het
Clec4d A C 6: 123,244,118 (GRCm39) T76P probably damaging Het
Coq8b C T 7: 26,956,750 (GRCm39) Q468* probably null Het
Dennd6b T C 15: 89,072,371 (GRCm39) E248G possibly damaging Het
Ednra A G 8: 78,401,556 (GRCm39) S245P possibly damaging Het
Epb41l4a C T 18: 33,961,196 (GRCm39) C446Y probably benign Het
Fam221a A G 6: 49,344,756 (GRCm39) probably benign Het
Fam229a T C 4: 129,385,296 (GRCm39) S76P probably benign Het
Fryl C T 5: 73,240,638 (GRCm39) D1321N probably damaging Het
Gata3os T C 2: 9,887,638 (GRCm39) probably benign Het
Gli2 C T 1: 118,769,794 (GRCm39) R586H probably damaging Het
Gm94 C T 18: 43,925,862 (GRCm39) A16T possibly damaging Het
Gorasp2 T C 2: 70,521,095 (GRCm39) V355A probably benign Het
Grid1 C A 14: 35,045,369 (GRCm39) T404N probably damaging Het
Gtf2i C A 5: 134,284,812 (GRCm39) E475* probably null Het
Gucy1a2 T C 9: 3,865,518 (GRCm39) probably null Het
Hs3st5 T A 10: 36,708,924 (GRCm39) I153N probably damaging Het
Il11ra1 T C 4: 41,763,887 (GRCm39) probably null Het
Ireb2 G A 9: 54,816,089 (GRCm39) G887S probably damaging Het
Kdsr T C 1: 106,662,311 (GRCm39) E248G probably benign Het
Lemd2 C G 17: 27,409,759 (GRCm39) R464P probably damaging Het
Lrrfip1 T C 1: 91,042,333 (GRCm39) V246A probably damaging Het
Macf1 T A 4: 123,368,068 (GRCm39) D2231V possibly damaging Het
Map2k5 C T 9: 63,188,301 (GRCm39) D283N probably damaging Het
Mfsd5 A G 15: 102,189,927 (GRCm39) D433G possibly damaging Het
Mir700 C A 4: 135,139,618 (GRCm39) probably null Het
Mroh9 A T 1: 162,903,246 (GRCm39) F52L probably damaging Het
Mtrfr G T 5: 124,478,837 (GRCm39) E153* probably null Het
Mycbp2 A C 14: 103,394,159 (GRCm39) S2691A probably benign Het
Myorg T A 4: 41,498,895 (GRCm39) H245L probably benign Het
Nktr T A 9: 121,577,460 (GRCm39) probably benign Het
Obsl1 C A 1: 75,468,859 (GRCm39) probably null Het
Or10ag60 A T 2: 87,438,424 (GRCm39) I231F probably damaging Het
Or52r1b A T 7: 102,690,853 (GRCm39) I51F probably damaging Het
Or5aq7 A G 2: 86,938,407 (GRCm39) V108A probably benign Het
Or7g35 C T 9: 19,496,181 (GRCm39) T116I probably benign Het
Or8c11 T C 9: 38,289,605 (GRCm39) S137P probably damaging Het
Pcdhb22 T A 18: 37,652,789 (GRCm39) I162N possibly damaging Het
Pde1c A T 6: 56,456,187 (GRCm39) probably null Het
Pds5b A G 5: 150,693,241 (GRCm39) probably null Het
Pkd1l1 A C 11: 8,807,113 (GRCm39) W1568G probably damaging Het
Polr3c A T 3: 96,626,784 (GRCm39) M258K possibly damaging Het
Pramel23 T A 4: 143,425,002 (GRCm39) H147L probably benign Het
Prss12 A T 3: 123,276,417 (GRCm39) I349F probably benign Het
Ptpn21 A G 12: 98,644,811 (GRCm39) *1177Q probably null Het
Rnf182 A G 13: 43,821,511 (GRCm39) K21E probably damaging Het
Rpl6 G A 5: 121,343,577 (GRCm39) probably benign Het
Samsn1 C T 16: 75,670,402 (GRCm39) V234I probably benign Het
Scrib A G 15: 75,929,600 (GRCm39) I1089T probably damaging Het
Sec31a T C 5: 100,511,737 (GRCm39) T1092A probably damaging Het
Sh3bp2 G T 5: 34,719,809 (GRCm39) R606L possibly damaging Het
Sipa1 A G 19: 5,706,229 (GRCm39) V367A probably damaging Het
Slc25a44 C T 3: 88,320,153 (GRCm39) E269K probably damaging Het
Slc44a4 T A 17: 35,142,430 (GRCm39) M353K possibly damaging Het
Sorcs2 A G 5: 36,176,728 (GRCm39) S1142P probably damaging Het
Sptbn4 A G 7: 27,118,024 (GRCm39) F352L probably damaging Het
Synj1 A T 16: 90,766,174 (GRCm39) N541K probably damaging Het
Tas2r113 G A 6: 132,870,659 (GRCm39) R229K probably benign Het
Tcaf3 A T 6: 42,566,905 (GRCm39) I728K probably benign Het
Tcea1 A G 1: 4,960,996 (GRCm39) E167G probably benign Het
Timeless G A 10: 128,080,069 (GRCm39) R406H probably damaging Het
Traf6 C T 2: 101,527,029 (GRCm39) R260* probably null Het
Traj31 C T 14: 54,425,388 (GRCm39) probably benign Het
Ttn A T 2: 76,599,907 (GRCm39) V19089D probably damaging Het
Unc80 C T 1: 66,666,416 (GRCm39) S1868L possibly damaging Het
Wdr38 A T 2: 38,891,333 (GRCm39) I287F possibly damaging Het
Wnt2 G A 6: 18,030,322 (GRCm39) probably benign Het
Wnt5b G A 6: 119,410,615 (GRCm39) P288L probably benign Het
Xkr5 G T 8: 18,984,521 (GRCm39) N174K probably benign Het
Zbtb6 C T 2: 37,318,977 (GRCm39) R317Q probably damaging Het
Zcchc7 AGGGG AGGG 4: 44,931,218 (GRCm39) probably null Het
Zfp647 G A 15: 76,796,285 (GRCm39) P125L probably damaging Het
Other mutations in Rgs22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00164:Rgs22 APN 15 36,100,077 (GRCm39) missense possibly damaging 0.93
IGL00594:Rgs22 APN 15 36,083,777 (GRCm39) missense probably benign 0.00
IGL01464:Rgs22 APN 15 36,083,787 (GRCm39) missense possibly damaging 0.90
IGL01686:Rgs22 APN 15 36,103,981 (GRCm39) missense probably benign 0.00
IGL01761:Rgs22 APN 15 36,103,897 (GRCm39) missense probably damaging 0.99
IGL02045:Rgs22 APN 15 36,013,300 (GRCm39) missense probably benign 0.33
IGL02378:Rgs22 APN 15 36,103,951 (GRCm39) missense probably benign 0.00
IGL02490:Rgs22 APN 15 36,054,993 (GRCm39) missense probably damaging 1.00
IGL03219:Rgs22 APN 15 36,107,194 (GRCm39) missense probably damaging 1.00
IGL03229:Rgs22 APN 15 36,015,925 (GRCm39) splice site probably benign
IGL03328:Rgs22 APN 15 36,043,350 (GRCm39) critical splice donor site probably null
3-1:Rgs22 UTSW 15 36,100,182 (GRCm39) missense possibly damaging 0.48
R0254:Rgs22 UTSW 15 36,104,698 (GRCm39) missense probably damaging 0.99
R0463:Rgs22 UTSW 15 36,093,084 (GRCm39) missense probably damaging 1.00
R0467:Rgs22 UTSW 15 36,099,941 (GRCm39) nonsense probably null
R0486:Rgs22 UTSW 15 36,093,028 (GRCm39) missense probably damaging 0.98
R0554:Rgs22 UTSW 15 36,054,855 (GRCm39) missense probably benign 0.10
R0602:Rgs22 UTSW 15 36,140,018 (GRCm39) splice site probably benign
R0906:Rgs22 UTSW 15 36,104,048 (GRCm39) intron probably benign
R1159:Rgs22 UTSW 15 36,040,839 (GRCm39) missense probably damaging 1.00
R1300:Rgs22 UTSW 15 36,101,908 (GRCm39) missense probably benign 0.43
R1439:Rgs22 UTSW 15 36,025,939 (GRCm39) splice site probably benign
R1491:Rgs22 UTSW 15 36,093,047 (GRCm39) missense probably damaging 0.98
R1502:Rgs22 UTSW 15 36,080,997 (GRCm39) missense probably damaging 1.00
R1514:Rgs22 UTSW 15 36,013,246 (GRCm39) missense probably benign 0.00
R1538:Rgs22 UTSW 15 36,048,922 (GRCm39) missense probably damaging 1.00
R1784:Rgs22 UTSW 15 36,087,582 (GRCm39) missense probably damaging 1.00
R1938:Rgs22 UTSW 15 36,101,950 (GRCm39) missense probably benign 0.00
R1972:Rgs22 UTSW 15 36,103,982 (GRCm39) missense probably benign 0.01
R2109:Rgs22 UTSW 15 36,099,880 (GRCm39) nonsense probably null
R2208:Rgs22 UTSW 15 36,050,378 (GRCm39) missense probably benign 0.01
R3696:Rgs22 UTSW 15 36,100,038 (GRCm39) missense probably benign 0.00
R3697:Rgs22 UTSW 15 36,100,038 (GRCm39) missense probably benign 0.00
R3698:Rgs22 UTSW 15 36,100,038 (GRCm39) missense probably benign 0.00
R3879:Rgs22 UTSW 15 36,107,051 (GRCm39) missense possibly damaging 0.52
R4080:Rgs22 UTSW 15 36,107,222 (GRCm39) missense probably damaging 1.00
R4363:Rgs22 UTSW 15 36,104,020 (GRCm39) missense probably damaging 0.99
R4591:Rgs22 UTSW 15 36,100,282 (GRCm39) missense probably benign 0.01
R4673:Rgs22 UTSW 15 36,100,079 (GRCm39) missense probably benign 0.04
R4829:Rgs22 UTSW 15 36,104,034 (GRCm39) missense probably damaging 1.00
R4831:Rgs22 UTSW 15 36,050,294 (GRCm39) missense probably benign 0.00
R4865:Rgs22 UTSW 15 36,100,358 (GRCm39) missense probably damaging 1.00
R4907:Rgs22 UTSW 15 36,087,570 (GRCm39) missense possibly damaging 0.61
R4944:Rgs22 UTSW 15 36,026,088 (GRCm39) missense possibly damaging 0.83
R4975:Rgs22 UTSW 15 36,055,022 (GRCm39) nonsense probably null
R5056:Rgs22 UTSW 15 36,050,391 (GRCm39) splice site probably null
R5126:Rgs22 UTSW 15 36,040,790 (GRCm39) missense probably damaging 0.96
R5138:Rgs22 UTSW 15 36,099,934 (GRCm39) missense probably benign 0.04
R5444:Rgs22 UTSW 15 36,015,773 (GRCm39) missense possibly damaging 0.83
R5507:Rgs22 UTSW 15 36,099,798 (GRCm39) missense probably damaging 0.99
R5640:Rgs22 UTSW 15 36,107,101 (GRCm39) missense probably benign 0.00
R5969:Rgs22 UTSW 15 36,015,782 (GRCm39) missense probably benign 0.00
R6053:Rgs22 UTSW 15 36,100,153 (GRCm39) missense probably benign 0.04
R6134:Rgs22 UTSW 15 36,107,194 (GRCm39) missense probably damaging 1.00
R6230:Rgs22 UTSW 15 36,100,176 (GRCm39) missense probably benign 0.02
R6295:Rgs22 UTSW 15 36,087,520 (GRCm39) missense probably benign 0.00
R6352:Rgs22 UTSW 15 36,093,067 (GRCm39) missense probably damaging 1.00
R6809:Rgs22 UTSW 15 36,048,910 (GRCm39) missense probably damaging 1.00
R6900:Rgs22 UTSW 15 36,010,893 (GRCm39) missense possibly damaging 0.61
R6947:Rgs22 UTSW 15 36,104,036 (GRCm39) critical splice acceptor site probably null
R7102:Rgs22 UTSW 15 36,122,459 (GRCm39) missense probably damaging 1.00
R7126:Rgs22 UTSW 15 36,103,954 (GRCm39) missense probably damaging 0.97
R7263:Rgs22 UTSW 15 36,015,789 (GRCm39) missense possibly damaging 0.86
R7623:Rgs22 UTSW 15 36,040,856 (GRCm39) missense probably benign 0.08
R7732:Rgs22 UTSW 15 36,026,127 (GRCm39) missense probably damaging 1.00
R7748:Rgs22 UTSW 15 36,122,415 (GRCm39) critical splice donor site probably null
R7771:Rgs22 UTSW 15 36,050,224 (GRCm39) missense possibly damaging 0.94
R7835:Rgs22 UTSW 15 36,082,057 (GRCm39) critical splice donor site probably null
R7849:Rgs22 UTSW 15 36,099,858 (GRCm39) missense probably damaging 1.00
R7954:Rgs22 UTSW 15 36,082,148 (GRCm39) missense possibly damaging 0.75
R8384:Rgs22 UTSW 15 36,046,158 (GRCm39) critical splice donor site probably null
R8516:Rgs22 UTSW 15 36,010,481 (GRCm39) makesense probably null
R8904:Rgs22 UTSW 15 36,026,127 (GRCm39) missense probably damaging 1.00
R8923:Rgs22 UTSW 15 36,093,106 (GRCm39) missense probably damaging 1.00
R9287:Rgs22 UTSW 15 36,098,409 (GRCm39) missense probably damaging 1.00
R9324:Rgs22 UTSW 15 36,087,544 (GRCm39) missense probably benign
R9660:Rgs22 UTSW 15 36,040,856 (GRCm39) missense probably benign 0.08
R9679:Rgs22 UTSW 15 36,087,587 (GRCm39) missense probably benign 0.00
R9728:Rgs22 UTSW 15 36,040,856 (GRCm39) missense probably benign 0.08
RF035:Rgs22 UTSW 15 36,010,981 (GRCm39) critical splice acceptor site probably benign
RF043:Rgs22 UTSW 15 36,010,982 (GRCm39) critical splice acceptor site probably benign
Predicted Primers PCR Primer
(F):5'- AGCTGCTATCCTGGAAAACAAG -3'
(R):5'- TTGCCTCTTGTATACAGCGC -3'

Sequencing Primer
(F):5'- AGACATATTAGGCACGGATTCC -3'
(R):5'- GTATACAGCGCTGCTTTGC -3'
Posted On 2017-06-26