Incidental Mutation 'R6006:Tigd2'
ID 479476
Institutional Source Beutler Lab
Gene Symbol Tigd2
Ensembl Gene ENSMUSG00000049232
Gene Name tigger transposable element derived 2
Synonyms 3632410O17Rik
MMRRC Submission 044183-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # R6006 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 59185855-59189018 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 59187762 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 210 (I210V)
Ref Sequence ENSEMBL: ENSMUSP00000057223 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062626]
AlphaFold Q0VBL1
Predicted Effect possibly damaging
Transcript: ENSMUST00000062626
AA Change: I210V

PolyPhen 2 Score 0.453 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000057223
Gene: ENSMUSG00000049232
AA Change: I210V

DomainStartEndE-ValueType
Pfam:CENP-B_N 4 54 6e-17 PFAM
CENPB 73 139 5.78e-19 SMART
Pfam:DDE_1 206 385 2.2e-52 PFAM
low complexity region 504 519 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.3%
  • 20x: 91.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb10 A G 8: 124,694,804 (GRCm39) I296T probably benign Het
Abcb4 C A 5: 8,996,026 (GRCm39) T894K probably damaging Het
Acad12 C T 5: 121,737,299 (GRCm39) V491I possibly damaging Het
Actr8 T A 14: 29,706,099 (GRCm39) probably null Het
Adam7 A C 14: 68,748,845 (GRCm39) D467E probably damaging Het
Adamts18 A T 8: 114,433,606 (GRCm39) C1043S probably damaging Het
Adgrb3 T G 1: 25,865,612 (GRCm39) D77A possibly damaging Het
Arhgap20 T A 9: 51,761,426 (GRCm39) D1056E probably benign Het
Bco1 A G 8: 117,840,330 (GRCm39) probably null Het
Btn2a2 A T 13: 23,670,533 (GRCm39) W67R probably damaging Het
Camkmt A T 17: 85,759,666 (GRCm39) N269Y possibly damaging Het
Cand1 A G 10: 119,045,933 (GRCm39) F991L possibly damaging Het
Cchcr1 A G 17: 35,835,597 (GRCm39) K234E possibly damaging Het
Cd14 T C 18: 36,859,335 (GRCm39) D40G possibly damaging Het
Cdc73 A T 1: 143,493,177 (GRCm39) F386I probably damaging Het
Cdk14 C T 5: 5,299,211 (GRCm39) M1I probably null Het
Cnpy3 A C 17: 47,047,790 (GRCm39) S220A probably benign Het
Col22a1 A G 15: 71,845,685 (GRCm39) V359A probably damaging Het
Col6a3 C A 1: 90,696,105 (GRCm39) C2654F unknown Het
Colgalt2 A G 1: 152,348,912 (GRCm39) T186A probably damaging Het
Cpsf4l A G 11: 113,590,753 (GRCm39) V199A probably benign Het
Dhtkd1 G A 2: 5,908,836 (GRCm39) Q753* probably null Het
Ep400 A G 5: 110,852,825 (GRCm39) S1307P unknown Het
Fer1l6 T C 15: 58,518,893 (GRCm39) V1675A probably damaging Het
Glis1 T C 4: 107,425,103 (GRCm39) L238P probably damaging Het
Ift70a1 A G 2: 75,811,832 (GRCm39) Y84H probably benign Het
Iqgap3 T A 3: 87,998,854 (GRCm39) D318E probably damaging Het
Lats1 T C 10: 7,581,359 (GRCm39) F715L probably damaging Het
Mlxip T C 5: 123,583,721 (GRCm39) F428S possibly damaging Het
Morc3 T G 16: 93,663,381 (GRCm39) I528R possibly damaging Het
Mtx1 C T 3: 89,117,613 (GRCm39) G60D probably damaging Het
Mug2 G C 6: 122,060,459 (GRCm39) Q1398H probably null Het
Mup8 T C 4: 60,220,403 (GRCm39) I110V probably benign Het
Nfkb1 A T 3: 135,309,522 (GRCm39) L12* probably null Het
Numa1 G A 7: 101,641,926 (GRCm39) probably null Het
Or52e18 T G 7: 104,609,870 (GRCm39) E23A probably damaging Het
Pbk C T 14: 66,054,094 (GRCm39) P213L probably damaging Het
Pdcd1lg2 T A 19: 29,431,905 (GRCm39) H224Q possibly damaging Het
Pkp1 C G 1: 135,805,406 (GRCm39) probably null Het
Rela A G 19: 5,689,967 (GRCm39) N139S probably damaging Het
Rgs3 G A 4: 62,542,143 (GRCm39) R39Q probably damaging Het
S1pr3 A G 13: 51,573,731 (GRCm39) E304G probably damaging Het
Sertad2 G A 11: 20,597,884 (GRCm39) G27S probably benign Het
Setmar T C 6: 108,053,387 (GRCm39) S294P possibly damaging Het
Smc2 A G 4: 52,459,024 (GRCm39) N473S probably benign Het
Ssr1 TCTCTTTC T 13: 38,169,972 (GRCm39) probably null Het
Tmprss9 T A 10: 80,719,555 (GRCm39) F93L possibly damaging Het
U2surp T C 9: 95,361,360 (GRCm39) Y633C probably damaging Het
Usp18 A T 6: 121,239,781 (GRCm39) E292V possibly damaging Het
Usp32 A C 11: 84,883,277 (GRCm39) probably null Het
Utp18 T C 11: 93,776,449 (GRCm39) D12G probably benign Het
Vmn1r216 C A 13: 23,283,928 (GRCm39) H204N probably benign Het
Wdr97 T C 15: 76,241,372 (GRCm39) V626A probably damaging Het
Wwc1 A T 11: 35,761,809 (GRCm39) V619E probably null Het
Wwc1 T C 11: 35,780,100 (GRCm39) D285G probably damaging Het
Zfp3 A T 11: 70,662,590 (GRCm39) Q183L probably benign Het
Zfp955a A G 17: 33,460,660 (GRCm39) C491R probably damaging Het
Other mutations in Tigd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02304:Tigd2 APN 6 59,188,683 (GRCm39) nonsense probably null
IGL03356:Tigd2 APN 6 59,188,690 (GRCm39) missense probably benign 0.04
PIT1430001:Tigd2 UTSW 6 59,188,233 (GRCm39) missense probably damaging 1.00
R0048:Tigd2 UTSW 6 59,188,369 (GRCm39) missense possibly damaging 0.86
R0387:Tigd2 UTSW 6 59,188,143 (GRCm39) missense probably benign 0.00
R0523:Tigd2 UTSW 6 59,187,358 (GRCm39) missense probably benign 0.30
R0636:Tigd2 UTSW 6 59,188,272 (GRCm39) missense possibly damaging 0.66
R1171:Tigd2 UTSW 6 59,188,361 (GRCm39) missense possibly damaging 0.73
R2440:Tigd2 UTSW 6 59,186,980 (GRCm39) start gained probably benign
R4327:Tigd2 UTSW 6 59,187,562 (GRCm39) missense probably benign 0.36
R4731:Tigd2 UTSW 6 59,188,400 (GRCm39) missense probably benign 0.00
R4732:Tigd2 UTSW 6 59,188,400 (GRCm39) missense probably benign 0.00
R4733:Tigd2 UTSW 6 59,188,400 (GRCm39) missense probably benign 0.00
R5005:Tigd2 UTSW 6 59,188,131 (GRCm39) missense probably benign 0.06
R5028:Tigd2 UTSW 6 59,188,205 (GRCm39) nonsense probably null
R5248:Tigd2 UTSW 6 59,188,138 (GRCm39) missense probably damaging 1.00
R7099:Tigd2 UTSW 6 59,187,166 (GRCm39) missense probably damaging 1.00
R7261:Tigd2 UTSW 6 59,188,052 (GRCm39) missense probably benign 0.02
R7553:Tigd2 UTSW 6 59,188,564 (GRCm39) missense probably benign 0.04
R7688:Tigd2 UTSW 6 59,187,382 (GRCm39) missense probably damaging 1.00
R8002:Tigd2 UTSW 6 59,187,494 (GRCm39) missense probably damaging 1.00
R8734:Tigd2 UTSW 6 59,187,184 (GRCm39) missense probably damaging 1.00
R9007:Tigd2 UTSW 6 59,187,887 (GRCm39) missense probably damaging 1.00
R9095:Tigd2 UTSW 6 59,187,509 (GRCm39) nonsense probably null
R9143:Tigd2 UTSW 6 59,188,310 (GRCm39) missense probably benign 0.10
Z1177:Tigd2 UTSW 6 59,188,515 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GTATTCCAAAGGCTGCAGGG -3'
(R):5'- CTGCTCGGTAATATCTTTTGACTG -3'

Sequencing Primer
(F):5'- GGGGATGAAACTGCTGCC -3'
(R):5'- CCCTGGCTCATAGGTTGAATTAGAC -3'
Posted On 2017-06-26