Mutagenetix > Incidental Mutations

Incidental Mutation 'R6008:Tas2r107'

479594

Institutional Source

Beutler Lab

Gene Symbol

Tas2r107

Ensembl Gene

ENSMUSG00000053389

Gene Name

taste receptor, type 2, member 107

Synonyms

T2R4, Tas2r7, mGR06, STC 5-1, mt2r43, T2R07

MMRRC Submission

044185-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

R6008 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

131659118-131660149 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 131659912 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 58 (V58A)

Ref Sequence

ENSEMBL: ENSMUSP00000067082 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065781]

AlphaFold

Q7M725

Predicted Effect

possibly damaging
Transcript: ENSMUST00000065781
AA Change: V58A

PolyPhen 2 Score 0.817 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000067082
Gene: ENSMUSG00000053389
AA Change: V58A

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	297	4e-106	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.8%
20x: 93.2%

Validation Efficiency

98% (55/56)

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9530077C05Rik	G	A	9: 22,424,126	W13*	probably null	Het
Abcc4	A	G	14: 118,490,566	L1268P	possibly damaging	Het
Acot3	T	A	12: 84,057,086	V223E	probably damaging	Het
Afap1	T	G	5: 35,997,551	S680A	probably damaging	Het
Aox1	C	T	1: 58,077,513	A801V	probably damaging	Het
Atp8b1	G	T	18: 64,577,616	T155K	probably damaging	Het
B230118H07Rik	A	T	2: 101,583,553	M133K	possibly damaging	Het
Bard1	C	A	1: 71,030,750	V690F	possibly damaging	Het
Btnl9	C	A	11: 49,182,965		probably null	Het
C1rl	A	G	6: 124,493,188	N13S	probably benign	Het
Cad	C	A	5: 31,069,112	T1166K	probably damaging	Het
Ckap5	T	A	2: 91,562,989	M405K	probably damaging	Het
Csn1s1	T	C	5: 87,678,085		probably null	Het
Ctnna2	A	G	6: 76,915,828	L792P	probably damaging	Het
Dennd3	T	A	15: 73,567,080	V1099D	possibly damaging	Het
Dnaic2	A	G	11: 114,752,990	N482S	probably benign	Het
Dock10	T	C	1: 80,606,173	T184A	probably damaging	Het
Ear2	T	A	14: 44,103,089	L68H	probably damaging	Het
Edn3	A	G	2: 174,779,732	T149A	probably benign	Het
Erf	C	T	7: 25,245,616	V131M	probably benign	Het
Esp34	A	G	17: 38,554,227		probably benign	Het
Gm13128	C	T	4: 144,331,207	T128I	probably benign	Het
Gm14548	G	T	7: 3,894,600	H499N	probably damaging	Het
Gm7247	C	T	14: 51,364,348	S26F	probably benign	Het
Golga1	A	G	2: 39,047,087	V161A	probably benign	Het
Gpr17	T	A	18: 31,947,477	T178S	probably benign	Het
Gsg1l2	T	A	11: 67,774,711	I35N	possibly damaging	Het
Hmgn3	T	A	9: 83,112,231	T46S	probably damaging	Het
Hydin	A	C	8: 110,599,085	I4709L	probably benign	Het
Ifna9	A	T	4: 88,592,363	L8Q	probably null	Het
Kpna4	T	C	3: 69,126,733	E125G	probably null	Het
Lrriq1	A	G	10: 103,170,464	S1267P	probably damaging	Het
Mab21l1	G	T	3: 55,783,097	C35F	possibly damaging	Het
Map3k2	A	G	18: 32,203,051	D97G	probably damaging	Het
Mdn1	T	A	4: 32,741,073	I3799N	probably damaging	Het
Mki67	G	A	7: 135,697,429	R1959C	probably damaging	Het
Mroh1	A	T	15: 76,451,357	H1400L	possibly damaging	Het
Mroh4	T	A	15: 74,625,472	K167*	probably null	Het
Mroh8	A	G	2: 157,253,064	I334T	probably benign	Het
Olfr559	T	A	7: 102,724,367	Y41F	probably damaging	Het
Phf11d	T	A	14: 59,365,449		probably benign	Het
Phf21a	C	T	2: 92,351,752	T342I	possibly damaging	Het
Plekhh3	T	C	11: 101,164,765	E483G	possibly damaging	Het
Ppp1r3b	G	A	8: 35,384,201	A65T	probably damaging	Het
Prkcq	A	G	2: 11,256,286	H383R	probably damaging	Het
Pum1	T	C	4: 130,768,847	V961A	probably damaging	Het
Scgb2b27	T	C	7: 34,012,136	E96G	probably benign	Het
Sel1l2	T	A	2: 140,244,105	E522V	probably damaging	Het
Socs4	T	G	14: 47,290,161	C184W	probably damaging	Het
Spdye4c	A	T	2: 128,596,633	I304F	probably benign	Het
Sptbn2	A	G	19: 4,739,278	I1249V	possibly damaging	Het
Sys1	T	C	2: 164,464,587	S154P	probably benign	Het
Taf6l	T	C	19: 8,778,166	Q275R	possibly damaging	Het
Thada	T	A	17: 84,436,634	I749F	probably damaging	Het
Tubb1	T	A	2: 174,457,774	H416Q	probably benign	Het
Vmn2r109	G	A	17: 20,540,719	T792I	probably damaging	Het
Zfp988	A	G	4: 147,331,802	Q231R	probably benign	Het
Zmynd8	T	C	2: 165,842,787	I182V	possibly damaging	Het
Zzz3	T	C	3: 152,428,151	V282A	probably benign	Het

Other mutations in Tas2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02749:Tas2r107	APN	6	131659954	missense	probably damaging	1.00
IGL02751:Tas2r107	APN	6	131659484	missense	probably damaging	1.00
IGL02868:Tas2r107	APN	6	131659286	missense	probably benign	0.11
IGL02943:Tas2r107	APN	6	131659406	missense	probably damaging	0.99
R1564:Tas2r107	UTSW	6	131659822	missense	probably damaging	0.96
R1905:Tas2r107	UTSW	6	131659988	missense	probably benign	0.20
R1906:Tas2r107	UTSW	6	131659988	missense	probably benign	0.20
R1907:Tas2r107	UTSW	6	131659988	missense	probably benign	0.20
R2185:Tas2r107	UTSW	6	131659603	missense	probably damaging	0.98
R3014:Tas2r107	UTSW	6	131660009	missense	probably benign	0.30
R3824:Tas2r107	UTSW	6	131659330	missense	probably benign	0.00
R4465:Tas2r107	UTSW	6	131660009	missense	probably benign	0.30
R5058:Tas2r107	UTSW	6	131659742	missense	probably damaging	1.00
R5646:Tas2r107	UTSW	6	131659708	missense	probably benign	0.02
R5975:Tas2r107	UTSW	6	131659780	missense	probably benign	0.02
R6144:Tas2r107	UTSW	6	131660003	missense	possibly damaging	0.87
R6451:Tas2r107	UTSW	6	131660014	missense	possibly damaging	0.81
R6662:Tas2r107	UTSW	6	131659489	missense	possibly damaging	0.82
R6702:Tas2r107	UTSW	6	131659384	missense	probably benign	0.12
R7032:Tas2r107	UTSW	6	131659190	missense	possibly damaging	0.62
R7635:Tas2r107	UTSW	6	131659600	missense	possibly damaging	0.92
R8303:Tas2r107	UTSW	6	131659622	missense	probably benign	0.00
R9156:Tas2r107	UTSW	6	131659459	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- TTCAGCCAGAGAAATACAGAGTTG -3'
(R):5'- TGCAGCAGAAGTAACCTTAGAGATC -3'

Sequencing Primer
(F):5'- GGTGACAAACCAGACACT -3'
(R):5'- ACCTTAGAGATCTGTAAAGATGCTG -3'

Posted On

2017-06-26