Incidental Mutation 'R6009:Parn'
ID 479671
Institutional Source Beutler Lab
Gene Symbol Parn
Ensembl Gene ENSMUSG00000022685
Gene Name poly(A)-specific ribonuclease (deadenylation nuclease)
Synonyms DAN, 1200003I18Rik
MMRRC Submission 044186-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.958) question?
Stock # R6009 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 13355828-13486035 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 13485428 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Asparagine at position 23 (D23N)
Ref Sequence ENSEMBL: ENSMUSP00000155076 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023365] [ENSMUST00000035426] [ENSMUST00000058884] [ENSMUST00000069281] [ENSMUST00000127973] [ENSMUST00000229042] [ENSMUST00000231003]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000023365
SMART Domains Protein: ENSMUSP00000023365
Gene: ENSMUSG00000022684

DomainStartEndE-ValueType
RING 34 73 2.71e-6 SMART
transmembrane domain 142 164 N/A INTRINSIC
SAM 179 249 1.82e-6 SMART
transmembrane domain 361 380 N/A INTRINSIC
transmembrane domain 407 429 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000035426
SMART Domains Protein: ENSMUSP00000041742
Gene: ENSMUSG00000079737

DomainStartEndE-ValueType
low complexity region 68 78 N/A INTRINSIC
low complexity region 97 114 N/A INTRINSIC
low complexity region 162 171 N/A INTRINSIC
Pfam:Lge1 226 301 8e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000058884
AA Change: D23N

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000055969
Gene: ENSMUSG00000022685
AA Change: D23N

DomainStartEndE-ValueType
Pfam:CAF1 3 383 2.7e-86 PFAM
Pfam:R3H 172 236 2.8e-13 PFAM
Pfam:RNA_bind 430 508 2.2e-37 PFAM
low complexity region 564 578 N/A INTRINSIC
low complexity region 591 606 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000069281
SMART Domains Protein: ENSMUSP00000063371
Gene: ENSMUSG00000022684

DomainStartEndE-ValueType
RING 34 73 2.71e-6 SMART
low complexity region 86 97 N/A INTRINSIC
PDB:1V85|A 98 123 2e-8 PDB
Blast:SAM 98 124 2e-8 BLAST
transmembrane domain 236 255 N/A INTRINSIC
transmembrane domain 282 304 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000127973
SMART Domains Protein: ENSMUSP00000115585
Gene: ENSMUSG00000022684

DomainStartEndE-ValueType
RING 34 73 2.71e-6 SMART
transmembrane domain 142 161 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132349
Predicted Effect probably damaging
Transcript: ENSMUST00000229042
AA Change: D23N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000231003
AA Change: D23N

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229526
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225585
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229251
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230905
Meta Mutation Damage Score 0.4536 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.3%
  • 20x: 91.5%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr8 A G 14: 29,700,454 (GRCm39) probably benign Het
Afap1 T C 5: 36,154,904 (GRCm39) S683P probably damaging Het
Chid1 T A 7: 141,109,493 (GRCm39) D131V probably damaging Het
Clstn2 C T 9: 97,338,579 (GRCm39) R860Q probably benign Het
Crlf1 A C 8: 70,956,129 (GRCm39) K403T probably damaging Het
Ctdspl2 T G 2: 121,819,319 (GRCm39) N201K probably benign Het
Cyb561a3 G A 19: 10,564,172 (GRCm39) V171I possibly damaging Het
Dazap1 T C 10: 80,121,138 (GRCm39) probably benign Het
Dbf4 G T 5: 8,453,718 (GRCm39) Q235K probably damaging Het
Dgka C T 10: 128,559,548 (GRCm39) G471D probably damaging Het
Fam13b A T 18: 34,630,458 (GRCm39) F100Y possibly damaging Het
Flii A T 11: 60,611,583 (GRCm39) L376* probably null Het
Fnip1 G T 11: 54,393,097 (GRCm39) G487V probably damaging Het
Gm7247 C T 14: 51,601,805 (GRCm39) S26F probably benign Het
Golgb1 G T 16: 36,735,321 (GRCm39) A1523S probably damaging Het
Gstm4 A G 3: 107,950,659 (GRCm39) V114A possibly damaging Het
Gtf3c1 A G 7: 125,246,602 (GRCm39) F1569S possibly damaging Het
Gtf3c5 A T 2: 28,461,177 (GRCm39) D312E probably benign Het
Gtpbp1 G A 15: 79,596,297 (GRCm39) V149M probably damaging Het
Hoxa7 C T 6: 52,194,367 (GRCm39) V7M probably damaging Het
Il17f C T 1: 20,849,510 (GRCm39) probably null Het
Ints9 T C 14: 65,245,531 (GRCm39) V263A probably benign Het
Kansl1l C T 1: 66,774,759 (GRCm39) C689Y probably benign Het
Kctd7 G A 5: 130,174,039 (GRCm39) G39E probably damaging Het
Krt82 T A 15: 101,453,540 (GRCm39) D282V probably benign Het
Lemd1 G T 1: 132,155,990 (GRCm39) E11* probably null Het
Maml2 A G 9: 13,532,294 (GRCm39) T503A probably benign Het
Mief2 A G 11: 60,622,485 (GRCm39) T352A probably benign Het
Msantd1 C A 5: 35,075,049 (GRCm39) T37K probably benign Het
Mtus2 A G 5: 148,243,462 (GRCm39) E94G probably damaging Het
Naaa A T 5: 92,407,440 (GRCm39) L353Q probably benign Het
Nek5 T C 8: 22,610,838 (GRCm39) E55G probably benign Het
Npat T C 9: 53,474,749 (GRCm39) M847T probably damaging Het
Nus1 G A 10: 52,309,539 (GRCm39) V268I probably benign Het
Or51r1 A G 7: 102,227,801 (GRCm39) N33S possibly damaging Het
Pdgfa T C 5: 138,964,954 (GRCm39) E176G probably damaging Het
Plcl1 T A 1: 55,735,405 (GRCm39) F249I probably damaging Het
Plscr5 C T 9: 92,086,488 (GRCm39) Q153* probably null Het
Polr2b T C 5: 77,468,099 (GRCm39) I133T probably benign Het
Polr3c A G 3: 96,620,930 (GRCm39) S463P probably damaging Het
Pprc1 A T 19: 46,060,171 (GRCm39) I1530L probably damaging Het
Prex1 C T 2: 166,423,904 (GRCm39) S996N probably damaging Het
Rnf169 C A 7: 99,576,330 (GRCm39) R291S possibly damaging Het
Setd5 A G 6: 113,087,480 (GRCm39) K127R probably damaging Het
Slc25a26 G T 6: 94,487,807 (GRCm39) V89L probably benign Het
Slc4a10 A G 2: 61,877,034 (GRCm39) T16A probably benign Het
Smchd1 A T 17: 71,747,951 (GRCm39) H430Q probably damaging Het
Ttll7 A T 3: 146,640,290 (GRCm39) D503V probably damaging Het
Vav2 A T 2: 27,161,912 (GRCm39) probably null Het
Zbtb47 T C 9: 121,591,937 (GRCm39) S86P possibly damaging Het
Zfp345 A T 2: 150,314,437 (GRCm39) C367S probably damaging Het
Zfp964 T A 8: 70,116,106 (GRCm39) H235Q possibly damaging Het
Other mutations in Parn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00987:Parn APN 16 13,485,467 (GRCm39) missense probably benign
IGL02030:Parn APN 16 13,482,514 (GRCm39) splice site probably null
IGL02179:Parn APN 16 13,485,456 (GRCm39) missense probably benign 0.00
IGL02336:Parn APN 16 13,384,567 (GRCm39) missense probably damaging 1.00
arlette UTSW 16 13,424,035 (GRCm39) missense probably damaging 1.00
PIT4453001:Parn UTSW 16 13,425,145 (GRCm39) missense probably benign 0.00
PIT4651001:Parn UTSW 16 13,449,431 (GRCm39) missense probably benign 0.25
R0388:Parn UTSW 16 13,472,340 (GRCm39) missense possibly damaging 0.72
R0485:Parn UTSW 16 13,472,299 (GRCm39) splice site probably benign
R0625:Parn UTSW 16 13,458,158 (GRCm39) missense probably benign 0.02
R1104:Parn UTSW 16 13,485,449 (GRCm39) missense probably damaging 0.99
R1299:Parn UTSW 16 13,482,593 (GRCm39) missense probably benign 0.10
R1356:Parn UTSW 16 13,468,538 (GRCm39) nonsense probably null
R2067:Parn UTSW 16 13,420,933 (GRCm39) missense probably damaging 1.00
R2111:Parn UTSW 16 13,420,933 (GRCm39) missense probably damaging 1.00
R2397:Parn UTSW 16 13,384,518 (GRCm39) missense probably benign
R4473:Parn UTSW 16 13,482,549 (GRCm39) missense probably benign 0.00
R4474:Parn UTSW 16 13,482,549 (GRCm39) missense probably benign 0.00
R4475:Parn UTSW 16 13,482,549 (GRCm39) missense probably benign 0.00
R4476:Parn UTSW 16 13,482,549 (GRCm39) missense probably benign 0.00
R4665:Parn UTSW 16 13,358,967 (GRCm39) missense probably benign 0.19
R4795:Parn UTSW 16 13,424,066 (GRCm39) missense probably benign 0.06
R5122:Parn UTSW 16 13,472,311 (GRCm39) critical splice donor site probably null
R5226:Parn UTSW 16 13,443,416 (GRCm39) missense probably benign
R5355:Parn UTSW 16 13,485,886 (GRCm39) missense possibly damaging 0.92
R5570:Parn UTSW 16 13,483,794 (GRCm39) missense probably damaging 0.98
R5979:Parn UTSW 16 13,424,035 (GRCm39) missense probably damaging 1.00
R6173:Parn UTSW 16 13,469,675 (GRCm39) missense possibly damaging 0.82
R6493:Parn UTSW 16 13,474,789 (GRCm39) missense probably damaging 1.00
R7055:Parn UTSW 16 13,443,998 (GRCm39) missense possibly damaging 0.80
R7278:Parn UTSW 16 13,443,927 (GRCm39) splice site probably null
R7391:Parn UTSW 16 13,485,870 (GRCm39) splice site probably null
R7706:Parn UTSW 16 13,425,117 (GRCm39) missense probably damaging 1.00
R8188:Parn UTSW 16 13,359,020 (GRCm39) missense probably benign 0.01
R8317:Parn UTSW 16 13,358,964 (GRCm39) missense probably damaging 0.96
R8326:Parn UTSW 16 13,483,835 (GRCm39) missense probably benign 0.00
R8419:Parn UTSW 16 13,466,338 (GRCm39) missense probably benign 0.11
R8433:Parn UTSW 16 13,485,413 (GRCm39) missense probably damaging 1.00
R8475:Parn UTSW 16 13,425,113 (GRCm39) critical splice donor site probably null
R8847:Parn UTSW 16 13,446,270 (GRCm39) nonsense probably null
R8958:Parn UTSW 16 13,466,322 (GRCm39) missense possibly damaging 0.64
R8988:Parn UTSW 16 13,466,281 (GRCm39) critical splice donor site probably null
R9277:Parn UTSW 16 13,482,519 (GRCm39) critical splice donor site probably null
R9476:Parn UTSW 16 13,358,942 (GRCm39) missense probably benign 0.10
R9510:Parn UTSW 16 13,358,942 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- TTAGTTTAAACAGCACCAGAACCAT -3'
(R):5'- TCTAGTGACCCCTGGAGGAG -3'

Sequencing Primer
(F):5'- TAATCTCTATCCAAAAATCTCACGC -3'
(R):5'- GTGTCCCTTGTGGTCCTTGAAC -3'
Posted On 2017-06-26