Incidental Mutation 'R6011:Sectm1b'
ID 479763
Institutional Source Beutler Lab
Gene Symbol Sectm1b
Ensembl Gene ENSMUSG00000039364
Gene Name secreted and transmembrane 1B
Synonyms 1810003C24Rik, Sectm1, K12
MMRRC Submission 043253-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R6011 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 120944284-120954395 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 120946704 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 64 (V64I)
Ref Sequence ENSEMBL: ENSMUSP00000126486 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039309] [ENSMUST00000081499] [ENSMUST00000130786] [ENSMUST00000168459] [ENSMUST00000170381]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000039309
AA Change: V64I

PolyPhen 2 Score 0.662 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000045748
Gene: ENSMUSG00000039364
AA Change: V64I

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
IG 40 134 1.81e-1 SMART
transmembrane domain 161 183 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000081499
AA Change: V64I

PolyPhen 2 Score 0.662 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000080217
Gene: ENSMUSG00000039364
AA Change: V64I

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
IG 40 134 1.81e-1 SMART
transmembrane domain 161 183 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000130786
AA Change: V64I

PolyPhen 2 Score 0.326 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000116010
Gene: ENSMUSG00000039364
AA Change: V64I

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
IG 40 134 1.81e-1 SMART
transmembrane domain 160 182 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132117
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136500
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150577
Predicted Effect possibly damaging
Transcript: ENSMUST00000168459
AA Change: V64I

PolyPhen 2 Score 0.662 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000125965
Gene: ENSMUSG00000039364
AA Change: V64I

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
IG 40 134 1.81e-1 SMART
transmembrane domain 161 183 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000170381
AA Change: V64I

PolyPhen 2 Score 0.662 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000126486
Gene: ENSMUSG00000039364
AA Change: V64I

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
IG 40 134 1.81e-1 SMART
transmembrane domain 161 183 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.5%
  • 20x: 92.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T A 11: 84,136,570 (GRCm39) N533K probably benign Het
Adamts15 G T 9: 30,814,082 (GRCm39) H694Q probably damaging Het
Adcy5 T C 16: 34,977,598 (GRCm39) L377P probably benign Het
Add2 T C 6: 86,075,607 (GRCm39) L252P probably damaging Het
Amer1 ATTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTC ATTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTC X: 94,470,889 (GRCm39) probably benign Het
Ankrd13d A G 19: 4,331,962 (GRCm39) L39P probably damaging Het
Asic1 G T 15: 99,596,960 (GRCm39) A541S probably benign Het
Bhmt1b A G 18: 87,774,663 (GRCm39) E62G probably damaging Het
Bpifb2 A G 2: 153,731,496 (GRCm39) probably null Het
Catsper3 A G 13: 55,934,305 (GRCm39) I75M probably damaging Het
Ccser2 T C 14: 36,601,532 (GRCm39) E837G probably benign Het
Clasp2 C T 9: 113,705,315 (GRCm39) P557L probably benign Het
Clstn2 C T 9: 97,338,579 (GRCm39) R860Q probably benign Het
Cplx3 A T 9: 57,523,038 (GRCm39) D140E probably damaging Het
Cyp2c66 A G 19: 39,130,380 (GRCm39) K72E probably benign Het
Cyp3a44 A G 5: 145,738,084 (GRCm39) probably null Het
Disp2 G A 2: 118,621,301 (GRCm39) V678I possibly damaging Het
Dock4 T C 12: 40,867,756 (GRCm39) probably null Het
Eml3 T C 19: 8,916,471 (GRCm39) Y688H probably damaging Het
Fam187a A G 11: 102,776,267 (GRCm39) K24E probably damaging Het
Fhit T C 14: 9,870,068 (GRCm38) K134E probably benign Het
Foxl3 A G 5: 138,807,374 (GRCm39) *217W probably null Het
Gm16485 A T 9: 8,972,454 (GRCm39) probably benign Het
Gm7247 C T 14: 51,601,805 (GRCm39) S26F probably benign Het
Hmgxb3 G A 18: 61,296,096 (GRCm39) T304I probably damaging Het
Lgsn A G 1: 31,242,847 (GRCm39) S310G probably damaging Het
Muc21 T A 17: 35,933,074 (GRCm39) probably benign Het
Niban2 T C 2: 32,812,877 (GRCm39) Y482H probably damaging Het
Or12e13 A G 2: 87,664,259 (GRCm39) N292S probably damaging Het
Or4k42 C A 2: 111,320,192 (GRCm39) A104S probably benign Het
Or6c8b A T 10: 128,882,508 (GRCm39) H141Q probably benign Het
Or7g25 T A 9: 19,159,807 (GRCm39) E296V probably damaging Het
Or9i1b G A 19: 13,896,521 (GRCm39) V46I probably benign Het
Pelo A G 13: 115,226,302 (GRCm39) S52P probably benign Het
Prune2 A G 19: 17,096,080 (GRCm39) N528S probably benign Het
Rfc3 T A 5: 151,567,184 (GRCm39) I291L probably damaging Het
Rpl35 A T 2: 38,894,813 (GRCm39) probably null Het
Serpina12 A G 12: 104,001,993 (GRCm39) M241T probably damaging Het
Serpina1a T A 12: 103,823,728 (GRCm39) D195V probably damaging Het
Sesn2 C T 4: 132,226,708 (GRCm39) V129M probably damaging Het
Slc4a1 A C 11: 102,243,357 (GRCm39) V758G probably damaging Het
Tmx4 A T 2: 134,481,756 (GRCm39) Y56N probably damaging Het
Traj50 T C 14: 54,405,091 (GRCm39) probably benign Het
Trio T G 15: 27,735,631 (GRCm39) K2820Q probably damaging Het
Ttc28 G A 5: 111,434,309 (GRCm39) G2417S probably benign Het
Usp32 T C 11: 84,922,923 (GRCm39) D665G possibly damaging Het
Other mutations in Sectm1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00481:Sectm1b APN 11 120,946,799 (GRCm39) missense probably benign 0.02
IGL00898:Sectm1b APN 11 120,947,075 (GRCm39) missense probably damaging 1.00
IGL02071:Sectm1b APN 11 120,946,761 (GRCm39) missense probably damaging 0.96
R0243:Sectm1b UTSW 11 120,946,611 (GRCm39) missense probably damaging 1.00
R1483:Sectm1b UTSW 11 120,946,652 (GRCm39) missense probably benign 0.14
R1862:Sectm1b UTSW 11 120,945,768 (GRCm39) missense possibly damaging 0.92
R4647:Sectm1b UTSW 11 120,946,760 (GRCm39) missense probably damaging 1.00
R5927:Sectm1b UTSW 11 120,946,500 (GRCm39) missense probably benign
R7749:Sectm1b UTSW 11 120,945,768 (GRCm39) missense possibly damaging 0.92
RF018:Sectm1b UTSW 11 120,945,756 (GRCm39) missense probably benign 0.37
Predicted Primers PCR Primer
(F):5'- TGAACTCTGCCTGGAATCCAC -3'
(R):5'- TTGAACCAACTCTGAGAGTAGCTG -3'

Sequencing Primer
(F):5'- TGGAATCCACGCAGCTTC -3'
(R):5'- CCAACTCTGAGAGTAGCTGATGATG -3'
Posted On 2017-06-26