Incidental Mutation 'R6011:Or9i1b'
ID 479781
Institutional Source Beutler Lab
Gene Symbol Or9i1b
Ensembl Gene ENSMUSG00000062314
Gene Name olfactory receptor family 9 subfamily I member 1B
Synonyms Olfr1505, MOR211-10_i, MOR211-4P, GA_x6K02T2RE5P-4250267-4251217
MMRRC Submission 043253-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.139) question?
Stock # R6011 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 13896386-13897336 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 13896521 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 46 (V46I)
Ref Sequence ENSEMBL: ENSMUSP00000148945 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081520] [ENSMUST00000216623] [ENSMUST00000216835]
AlphaFold Q7TQQ2
Predicted Effect probably benign
Transcript: ENSMUST00000081520
AA Change: V46I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000080235
Gene: ENSMUSG00000062314
AA Change: V46I

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 8.2e-43 PFAM
Pfam:7tm_1 41 290 2.2e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216623
AA Change: V46I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000216835
AA Change: V46I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.5%
  • 20x: 92.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T A 11: 84,136,570 (GRCm39) N533K probably benign Het
Adamts15 G T 9: 30,814,082 (GRCm39) H694Q probably damaging Het
Adcy5 T C 16: 34,977,598 (GRCm39) L377P probably benign Het
Add2 T C 6: 86,075,607 (GRCm39) L252P probably damaging Het
Amer1 ATTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTC ATTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTC X: 94,470,889 (GRCm39) probably benign Het
Ankrd13d A G 19: 4,331,962 (GRCm39) L39P probably damaging Het
Asic1 G T 15: 99,596,960 (GRCm39) A541S probably benign Het
Bhmt1b A G 18: 87,774,663 (GRCm39) E62G probably damaging Het
Bpifb2 A G 2: 153,731,496 (GRCm39) probably null Het
Catsper3 A G 13: 55,934,305 (GRCm39) I75M probably damaging Het
Ccser2 T C 14: 36,601,532 (GRCm39) E837G probably benign Het
Clasp2 C T 9: 113,705,315 (GRCm39) P557L probably benign Het
Clstn2 C T 9: 97,338,579 (GRCm39) R860Q probably benign Het
Cplx3 A T 9: 57,523,038 (GRCm39) D140E probably damaging Het
Cyp2c66 A G 19: 39,130,380 (GRCm39) K72E probably benign Het
Cyp3a44 A G 5: 145,738,084 (GRCm39) probably null Het
Disp2 G A 2: 118,621,301 (GRCm39) V678I possibly damaging Het
Dock4 T C 12: 40,867,756 (GRCm39) probably null Het
Eml3 T C 19: 8,916,471 (GRCm39) Y688H probably damaging Het
Fam187a A G 11: 102,776,267 (GRCm39) K24E probably damaging Het
Fhit T C 14: 9,870,068 (GRCm38) K134E probably benign Het
Foxl3 A G 5: 138,807,374 (GRCm39) *217W probably null Het
Gm16485 A T 9: 8,972,454 (GRCm39) probably benign Het
Gm7247 C T 14: 51,601,805 (GRCm39) S26F probably benign Het
Hmgxb3 G A 18: 61,296,096 (GRCm39) T304I probably damaging Het
Lgsn A G 1: 31,242,847 (GRCm39) S310G probably damaging Het
Muc21 T A 17: 35,933,074 (GRCm39) probably benign Het
Niban2 T C 2: 32,812,877 (GRCm39) Y482H probably damaging Het
Or12e13 A G 2: 87,664,259 (GRCm39) N292S probably damaging Het
Or4k42 C A 2: 111,320,192 (GRCm39) A104S probably benign Het
Or6c8b A T 10: 128,882,508 (GRCm39) H141Q probably benign Het
Or7g25 T A 9: 19,159,807 (GRCm39) E296V probably damaging Het
Pelo A G 13: 115,226,302 (GRCm39) S52P probably benign Het
Prune2 A G 19: 17,096,080 (GRCm39) N528S probably benign Het
Rfc3 T A 5: 151,567,184 (GRCm39) I291L probably damaging Het
Rpl35 A T 2: 38,894,813 (GRCm39) probably null Het
Sectm1b C T 11: 120,946,704 (GRCm39) V64I possibly damaging Het
Serpina12 A G 12: 104,001,993 (GRCm39) M241T probably damaging Het
Serpina1a T A 12: 103,823,728 (GRCm39) D195V probably damaging Het
Sesn2 C T 4: 132,226,708 (GRCm39) V129M probably damaging Het
Slc4a1 A C 11: 102,243,357 (GRCm39) V758G probably damaging Het
Tmx4 A T 2: 134,481,756 (GRCm39) Y56N probably damaging Het
Traj50 T C 14: 54,405,091 (GRCm39) probably benign Het
Trio T G 15: 27,735,631 (GRCm39) K2820Q probably damaging Het
Ttc28 G A 5: 111,434,309 (GRCm39) G2417S probably benign Het
Usp32 T C 11: 84,922,923 (GRCm39) D665G possibly damaging Het
Other mutations in Or9i1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01814:Or9i1b APN 19 13,896,892 (GRCm39) nonsense probably null
IGL03388:Or9i1b APN 19 13,896,984 (GRCm39) missense probably damaging 0.99
R0143:Or9i1b UTSW 19 13,896,614 (GRCm39) missense probably damaging 1.00
R0326:Or9i1b UTSW 19 13,896,873 (GRCm39) missense probably benign 0.13
R0602:Or9i1b UTSW 19 13,897,145 (GRCm39) missense probably benign 0.13
R0624:Or9i1b UTSW 19 13,896,808 (GRCm39) missense probably damaging 0.99
R0947:Or9i1b UTSW 19 13,896,535 (GRCm39) missense probably benign 0.00
R1472:Or9i1b UTSW 19 13,897,208 (GRCm39) missense probably damaging 1.00
R1691:Or9i1b UTSW 19 13,896,783 (GRCm39) missense probably benign 0.00
R2991:Or9i1b UTSW 19 13,896,675 (GRCm39) missense probably damaging 1.00
R4296:Or9i1b UTSW 19 13,896,717 (GRCm39) missense probably damaging 1.00
R4688:Or9i1b UTSW 19 13,896,605 (GRCm39) missense probably benign 0.01
R4814:Or9i1b UTSW 19 13,896,817 (GRCm39) missense possibly damaging 0.50
R4823:Or9i1b UTSW 19 13,897,022 (GRCm39) missense probably benign 0.02
R5038:Or9i1b UTSW 19 13,896,822 (GRCm39) missense possibly damaging 0.58
R5243:Or9i1b UTSW 19 13,897,025 (GRCm39) missense probably damaging 1.00
R5323:Or9i1b UTSW 19 13,896,980 (GRCm39) missense possibly damaging 0.95
R5542:Or9i1b UTSW 19 13,896,411 (GRCm39) missense probably benign 0.04
R5918:Or9i1b UTSW 19 13,897,139 (GRCm39) missense probably damaging 1.00
R6159:Or9i1b UTSW 19 13,897,104 (GRCm39) missense probably damaging 1.00
R7535:Or9i1b UTSW 19 13,896,449 (GRCm39) missense probably benign
R8262:Or9i1b UTSW 19 13,897,226 (GRCm39) missense probably benign 0.02
R9190:Or9i1b UTSW 19 13,896,967 (GRCm39) missense probably benign 0.23
R9459:Or9i1b UTSW 19 13,896,674 (GRCm39) missense possibly damaging 0.76
Predicted Primers PCR Primer
(F):5'- AACGACTATCCTTCAGTTGTGG -3'
(R):5'- GGAAACATTCTGTAGCTGCACAG -3'

Sequencing Primer
(F):5'- CTTCAGTTGTGGTTTCTTTACAAATC -3'
(R):5'- CAGATAGTGAAGAAGAAGAACTGGGC -3'
Posted On 2017-06-26