Incidental Mutation 'R6013:Zfand6'
ID 479852
Institutional Source Beutler Lab
Gene Symbol Zfand6
Ensembl Gene ENSMUSG00000030629
Gene Name zinc finger, AN1-type domain 6
Synonyms 3110005P07Rik, Za20d3, Awp1
MMRRC Submission 044189-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.250) question?
Stock # R6013 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 84264253-84339224 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 84281900 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 110 (V110L)
Ref Sequence ENSEMBL: ENSMUSP00000147192 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069537] [ENSMUST00000178385] [ENSMUST00000207865] [ENSMUST00000207975] [ENSMUST00000208782] [ENSMUST00000209117] [ENSMUST00000209165]
AlphaFold Q9DCH6
Predicted Effect probably benign
Transcript: ENSMUST00000069537
AA Change: V110L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000069228
Gene: ENSMUSG00000030629
AA Change: V110L

DomainStartEndE-ValueType
ZnF_A20 11 35 1.91e-10 SMART
ZnF_AN1 164 201 1.46e-15 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000178385
AA Change: V110L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000135968
Gene: ENSMUSG00000030629
AA Change: V110L

DomainStartEndE-ValueType
ZnF_A20 11 35 1.91e-10 SMART
ZnF_AN1 164 201 1.46e-15 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000207865
AA Change: V110L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000207975
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208519
Predicted Effect probably benign
Transcript: ENSMUST00000208782
AA Change: V110L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208831
Predicted Effect probably benign
Transcript: ENSMUST00000209117
AA Change: V110L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000209165
AA Change: V110L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0588 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.5%
Validation Efficiency 98% (54/55)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700008P02Rik C T 3: 6,682,310 (GRCm39) probably null Het
Aanat A T 11: 116,486,950 (GRCm39) probably null Het
Abca17 A T 17: 24,506,820 (GRCm39) V1178E possibly damaging Het
Abcf3 T A 16: 20,369,311 (GRCm39) probably null Het
Alk A G 17: 72,207,732 (GRCm39) M1001T probably benign Het
Arhgap23 C A 11: 97,391,818 (GRCm39) S1445Y probably damaging Het
Atp10a T C 7: 58,447,538 (GRCm39) I760T probably benign Het
Cadm1 C T 9: 47,768,572 (GRCm39) probably benign Het
Car10 A T 11: 93,076,105 (GRCm39) probably benign Het
Casq2 G T 3: 102,052,945 (GRCm39) probably null Het
Cemip2 G A 19: 21,809,403 (GRCm39) V928I possibly damaging Het
Clec4f T C 6: 83,632,070 (GRCm39) I55V probably benign Het
Cngb1 T C 8: 96,010,949 (GRCm39) probably benign Het
Csn1s2b A G 5: 87,972,098 (GRCm39) probably null Het
Cyp2c39 A C 19: 39,501,969 (GRCm39) R119S probably benign Het
Cyp4f16 C T 17: 32,765,652 (GRCm39) A345V probably null Het
Ddx43 T C 9: 78,321,567 (GRCm39) L412S probably damaging Het
Dnajb12 G A 10: 59,730,163 (GRCm39) probably null Het
Ephx2 A G 14: 66,347,691 (GRCm39) S56P probably benign Het
Fam83h A G 15: 75,875,849 (GRCm39) F496S probably damaging Het
Gcnt4 T C 13: 97,083,786 (GRCm39) S361P possibly damaging Het
H2-T23 G T 17: 36,341,474 (GRCm39) H332Q probably benign Het
Hrob T C 11: 102,145,859 (GRCm39) V45A probably benign Het
Ift57 G T 16: 49,519,667 (GRCm39) probably null Het
Il1rl2 A G 1: 40,391,017 (GRCm39) H320R possibly damaging Het
Kansl1 A G 11: 104,241,465 (GRCm39) V618A probably benign Het
Kctd3 T C 1: 188,728,665 (GRCm39) E157G probably benign Het
Magohb T A 6: 131,270,037 (GRCm39) D31V possibly damaging Het
Mdn1 C A 4: 32,715,713 (GRCm39) F1993L probably damaging Het
Med29 C A 7: 28,086,418 (GRCm39) C130F probably benign Het
Mtmr7 G A 8: 41,034,570 (GRCm39) R251C probably damaging Het
Ncor1 T C 11: 62,211,903 (GRCm39) I49V probably benign Het
Nfkb1 G T 3: 135,332,445 (GRCm39) T109K possibly damaging Het
Pkd1l1 A G 11: 8,819,452 (GRCm39) probably null Het
Pkp1 T A 1: 135,811,648 (GRCm39) T408S probably damaging Het
Plec A T 15: 76,073,510 (GRCm39) D501E possibly damaging Het
Prcp A C 7: 92,576,976 (GRCm39) Y335S possibly damaging Het
Reg2 T A 6: 78,384,952 (GRCm39) Y165N possibly damaging Het
Rnf7 T C 9: 96,353,787 (GRCm39) *114W probably null Het
Scg3 T C 9: 75,584,090 (GRCm39) D137G probably damaging Het
Serpinb7 T C 1: 107,377,919 (GRCm39) V204A probably benign Het
Sez6 C T 11: 77,864,623 (GRCm39) H528Y probably damaging Het
Sf3b1 A T 1: 55,039,457 (GRCm39) S723T probably damaging Het
Shtn1 T C 19: 58,963,533 (GRCm39) D594G probably damaging Het
Sptbn4 A G 7: 27,063,904 (GRCm39) L2174P probably damaging Het
Stk25 A G 1: 93,553,181 (GRCm39) probably null Het
Tep1 A T 14: 51,098,505 (GRCm39) F429I probably damaging Het
Thada T A 17: 84,580,228 (GRCm39) I1409F probably benign Het
Usp25 G A 16: 76,873,909 (GRCm39) G495E probably benign Het
Washc2 A G 6: 116,231,114 (GRCm39) S844G probably damaging Het
Xirp2 A T 2: 67,341,287 (GRCm39) H1176L possibly damaging Het
Ypel1 T C 16: 16,918,129 (GRCm39) N96D probably damaging Het
Zfp30 A G 7: 29,488,846 (GRCm39) R8G possibly damaging Het
Other mutations in Zfand6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02396:Zfand6 APN 7 84,267,111 (GRCm39) missense probably damaging 0.99
IGL03162:Zfand6 APN 7 84,283,185 (GRCm39) missense probably benign 0.01
R0780:Zfand6 UTSW 7 84,265,042 (GRCm39) missense probably damaging 1.00
R1055:Zfand6 UTSW 7 84,265,181 (GRCm39) splice site probably benign
R2427:Zfand6 UTSW 7 84,283,498 (GRCm39) nonsense probably null
R3683:Zfand6 UTSW 7 84,283,570 (GRCm39) missense probably damaging 1.00
R3685:Zfand6 UTSW 7 84,283,570 (GRCm39) missense probably damaging 1.00
R4663:Zfand6 UTSW 7 84,267,093 (GRCm39) missense probably benign 0.27
R4939:Zfand6 UTSW 7 84,265,030 (GRCm39) makesense probably null
R6867:Zfand6 UTSW 7 84,265,122 (GRCm39) missense probably damaging 1.00
R7113:Zfand6 UTSW 7 84,265,077 (GRCm39) missense probably damaging 1.00
R7692:Zfand6 UTSW 7 84,283,141 (GRCm39) missense not run
R8140:Zfand6 UTSW 7 84,281,957 (GRCm39) missense possibly damaging 0.71
R8755:Zfand6 UTSW 7 84,281,899 (GRCm39) missense probably benign
R9185:Zfand6 UTSW 7 84,283,558 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATACAAGTGGAAAGTAGATCCCAAC -3'
(R):5'- CAGCAGCACTTACCTGAAGG -3'

Sequencing Primer
(F):5'- CACATCTATGCTAGTGCC -3'
(R):5'- AGAGATTCTCTTGAGCCCAGG -3'
Posted On 2017-06-26