Incidental Mutation 'R6025:Adgre4'
ID 480003
Institutional Source Beutler Lab
Gene Symbol Adgre4
Ensembl Gene ENSMUSG00000032915
Gene Name adhesion G protein-coupled receptor E4
Synonyms EGF-TM7, Gpr127, FIRE, Emr4, D17Ertd479e
MMRRC Submission 044197-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6025 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 56056984-56160662 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 56099013 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Leucine at position 173 (S173L)
Ref Sequence ENSEMBL: ENSMUSP00000025004 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025004]
AlphaFold Q91ZE5
Predicted Effect probably benign
Transcript: ENSMUST00000025004
AA Change: S173L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000025004
Gene: ENSMUSG00000032915
AA Change: S173L

DomainStartEndE-ValueType
signal peptide 1 36 N/A INTRINSIC
Blast:EGF_like 38 76 2e-10 BLAST
Pfam:EGF_CA 77 117 3.6e-9 PFAM
GPS 288 338 4.03e-12 SMART
Pfam:7tm_2 343 588 5.7e-57 PFAM
low complexity region 613 628 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.4%
  • 20x: 92.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310033P09Rik GC G 11: 59,101,139 (GRCm39) probably null Het
Acvr1b C A 15: 101,092,856 (GRCm39) D166E probably benign Het
Adgra2 T C 8: 27,604,491 (GRCm39) I522T probably damaging Het
Akap9 A T 5: 4,082,801 (GRCm39) Q1975L probably damaging Het
Ap3d1 T A 10: 80,546,298 (GRCm39) M965L probably benign Het
Brca2 CATA CA 5: 150,465,040 (GRCm39) probably null Het
Chd6 T C 2: 160,807,502 (GRCm39) N1904S probably benign Het
Clstn3 A T 6: 124,408,623 (GRCm39) S896R possibly damaging Het
Col6a3 T A 1: 90,755,824 (GRCm39) D155V probably damaging Het
Dct T C 14: 118,273,876 (GRCm39) T344A possibly damaging Het
Dctn1 T A 6: 83,170,673 (GRCm39) probably null Het
Dgkz T C 2: 91,776,255 (GRCm39) T3A possibly damaging Het
Duoxa2 T C 2: 122,132,332 (GRCm39) S249P possibly damaging Het
Ehbp1 A T 11: 22,189,156 (GRCm39) V82E probably damaging Het
Fcho1 A T 8: 72,165,217 (GRCm39) probably null Het
Garin5b T A 7: 4,761,143 (GRCm39) D523V probably benign Het
Ifi213 T A 1: 173,422,800 (GRCm39) N22Y probably damaging Het
Kcnq1 T A 7: 142,660,170 (GRCm39) probably benign Het
Kif7 T A 7: 79,354,388 (GRCm39) Q799L probably benign Het
Lmnb1 T A 18: 56,862,456 (GRCm39) L206* probably null Het
Lonp2 G T 8: 87,440,001 (GRCm39) G247V probably damaging Het
Ly75 T C 2: 60,206,306 (GRCm39) Y121C probably damaging Het
Mboat1 C A 13: 30,408,509 (GRCm39) T224K probably benign Het
Mcm9 T C 10: 53,492,073 (GRCm39) E416G possibly damaging Het
Mtnr1b A T 9: 15,774,093 (GRCm39) I322N probably damaging Het
Nanog G A 6: 122,690,350 (GRCm39) G227R possibly damaging Het
Nbn T C 4: 15,981,347 (GRCm39) S480P probably damaging Het
Nek10 C A 14: 14,865,633 (GRCm38) L638M probably benign Het
Nelfcd T C 2: 174,268,611 (GRCm39) V538A probably damaging Het
Or1e33 A T 11: 73,738,745 (GRCm39) S69T probably benign Het
Or2b4 T G 17: 38,116,312 (GRCm39) I92S probably damaging Het
Or52a5b T C 7: 103,417,416 (GRCm39) I63V probably benign Het
Or5b97 T A 19: 12,879,034 (GRCm39) T37S probably benign Het
Phf24 G A 4: 42,938,780 (GRCm39) probably null Het
Pigz T C 16: 31,764,528 (GRCm39) S529P probably damaging Het
Pik3r5 A G 11: 68,383,144 (GRCm39) E321G probably damaging Het
Plcb3 G A 19: 6,933,547 (GRCm39) T926I probably benign Het
Pm20d2 G A 4: 33,181,833 (GRCm39) P257S probably damaging Het
Pon2 A G 6: 5,289,057 (GRCm39) V34A probably benign Het
Prkar2b A G 12: 32,110,855 (GRCm39) F76S possibly damaging Het
Prpf31 G A 7: 3,642,668 (GRCm39) E414K probably benign Het
Rsf1 CG CGACGGCGGTG 7: 97,229,115 (GRCm39) probably benign Het
Setbp1 A T 18: 78,902,455 (GRCm39) L404Q probably damaging Het
Slc26a11 C T 11: 119,265,654 (GRCm39) A389V probably damaging Het
Slc2a1 A T 4: 118,993,539 (GRCm39) T459S possibly damaging Het
Spi1 T C 2: 90,944,685 (GRCm39) L135P probably benign Het
Sspo T C 6: 48,463,720 (GRCm39) L3844P possibly damaging Het
Stxbp5 T A 10: 9,675,772 (GRCm39) T616S probably benign Het
Syde2 A G 3: 145,712,896 (GRCm39) probably null Het
Synm G T 7: 67,384,686 (GRCm39) A550D possibly damaging Het
Tanc2 T C 11: 105,787,373 (GRCm39) V891A possibly damaging Het
Tanc2 G A 11: 105,758,543 (GRCm39) R768Q probably damaging Het
Tlx1 A T 19: 45,144,413 (GRCm39) Q45L probably damaging Het
Tmem104 C A 11: 115,096,349 (GRCm39) Y191* probably null Het
Tmem17 A C 11: 22,468,659 (GRCm39) *199C probably null Het
Tns3 A T 11: 8,442,578 (GRCm39) M595K possibly damaging Het
Tyk2 A G 9: 21,027,256 (GRCm39) V538A probably benign Het
Unc80 A G 1: 66,734,727 (GRCm39) D3250G possibly damaging Het
Usp4 A G 9: 108,237,322 (GRCm39) H130R possibly damaging Het
Zfhx2 T C 14: 55,302,665 (GRCm39) Q1773R probably benign Het
Zfp790 A G 7: 29,528,970 (GRCm39) K552E possibly damaging Het
Zswim5 G A 4: 116,808,106 (GRCm39) R230Q probably damaging Het
Other mutations in Adgre4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Adgre4 APN 17 56,098,915 (GRCm39) splice site probably benign
IGL00228:Adgre4 APN 17 56,109,135 (GRCm39) missense probably damaging 1.00
IGL00572:Adgre4 APN 17 56,127,648 (GRCm39) missense probably benign 0.00
IGL01404:Adgre4 APN 17 56,104,639 (GRCm39) missense possibly damaging 0.63
IGL01420:Adgre4 APN 17 56,106,785 (GRCm39) splice site probably benign
IGL01501:Adgre4 APN 17 56,109,002 (GRCm39) splice site probably benign
IGL01510:Adgre4 APN 17 56,125,760 (GRCm39) critical splice donor site probably null
IGL01554:Adgre4 APN 17 56,124,090 (GRCm39) missense probably damaging 1.00
IGL01607:Adgre4 APN 17 56,101,748 (GRCm39) splice site probably benign
IGL01767:Adgre4 APN 17 56,104,740 (GRCm39) missense probably benign 0.19
IGL02253:Adgre4 APN 17 56,067,573 (GRCm39) missense probably benign 0.01
IGL02358:Adgre4 APN 17 56,150,209 (GRCm39) missense probably benign 0.15
IGL02466:Adgre4 APN 17 56,121,188 (GRCm39) missense probably benign 0.42
IGL03057:Adgre4 APN 17 56,106,602 (GRCm39) splice site probably benign
R0070:Adgre4 UTSW 17 56,109,154 (GRCm39) missense probably damaging 0.98
R0070:Adgre4 UTSW 17 56,109,154 (GRCm39) missense probably damaging 0.98
R0111:Adgre4 UTSW 17 56,124,073 (GRCm39) missense possibly damaging 0.92
R0311:Adgre4 UTSW 17 56,109,010 (GRCm39) missense probably benign 0.36
R0366:Adgre4 UTSW 17 56,099,001 (GRCm39) nonsense probably null
R0415:Adgre4 UTSW 17 56,159,288 (GRCm39) missense probably benign 0.03
R0465:Adgre4 UTSW 17 56,092,137 (GRCm39) splice site probably benign
R0619:Adgre4 UTSW 17 56,127,679 (GRCm39) missense possibly damaging 0.52
R0685:Adgre4 UTSW 17 56,099,035 (GRCm39) missense probably benign 0.05
R0724:Adgre4 UTSW 17 56,159,281 (GRCm39) missense probably benign 0.00
R0835:Adgre4 UTSW 17 56,106,637 (GRCm39) missense probably damaging 1.00
R1330:Adgre4 UTSW 17 56,085,814 (GRCm39) missense probably benign 0.36
R1452:Adgre4 UTSW 17 56,091,996 (GRCm39) missense probably benign 0.35
R1960:Adgre4 UTSW 17 56,098,497 (GRCm39) missense probably benign
R1961:Adgre4 UTSW 17 56,098,497 (GRCm39) missense probably benign
R2046:Adgre4 UTSW 17 56,085,847 (GRCm39) missense possibly damaging 0.82
R2421:Adgre4 UTSW 17 56,085,872 (GRCm39) missense probably benign 0.10
R2570:Adgre4 UTSW 17 56,085,878 (GRCm39) missense possibly damaging 0.54
R3162:Adgre4 UTSW 17 56,109,218 (GRCm39) splice site probably benign
R4222:Adgre4 UTSW 17 56,092,121 (GRCm39) missense probably damaging 1.00
R4526:Adgre4 UTSW 17 56,092,016 (GRCm39) nonsense probably null
R4631:Adgre4 UTSW 17 56,121,305 (GRCm39) missense probably null 1.00
R4689:Adgre4 UTSW 17 56,109,096 (GRCm39) missense probably damaging 1.00
R4701:Adgre4 UTSW 17 56,091,971 (GRCm39) missense probably damaging 1.00
R4792:Adgre4 UTSW 17 56,098,491 (GRCm39) missense probably benign 0.00
R5205:Adgre4 UTSW 17 56,101,727 (GRCm39) nonsense probably null
R5210:Adgre4 UTSW 17 56,092,029 (GRCm39) missense probably damaging 0.97
R5358:Adgre4 UTSW 17 56,125,758 (GRCm39) missense probably benign 0.00
R5873:Adgre4 UTSW 17 56,159,282 (GRCm39) missense probably benign 0.13
R6257:Adgre4 UTSW 17 56,109,133 (GRCm39) missense possibly damaging 0.87
R6426:Adgre4 UTSW 17 56,109,196 (GRCm39) missense probably benign 0.18
R6440:Adgre4 UTSW 17 56,101,744 (GRCm39) critical splice donor site probably null
R6484:Adgre4 UTSW 17 56,109,036 (GRCm39) missense possibly damaging 0.52
R6680:Adgre4 UTSW 17 56,098,959 (GRCm39) missense probably benign 0.09
R7086:Adgre4 UTSW 17 56,127,649 (GRCm39) missense probably benign 0.00
R7442:Adgre4 UTSW 17 56,159,340 (GRCm39) missense probably benign 0.04
R7467:Adgre4 UTSW 17 56,098,952 (GRCm39) missense probably benign 0.00
R7875:Adgre4 UTSW 17 56,099,016 (GRCm39) missense probably benign 0.00
R8007:Adgre4 UTSW 17 56,121,233 (GRCm39) missense probably damaging 0.99
R8096:Adgre4 UTSW 17 56,127,700 (GRCm39) missense probably damaging 1.00
R8172:Adgre4 UTSW 17 56,104,769 (GRCm39) missense probably benign 0.00
R8512:Adgre4 UTSW 17 56,125,760 (GRCm39) critical splice donor site probably null
R8972:Adgre4 UTSW 17 56,109,189 (GRCm39) missense probably damaging 1.00
R9018:Adgre4 UTSW 17 56,098,993 (GRCm39) missense probably benign 0.00
R9049:Adgre4 UTSW 17 56,092,094 (GRCm39) missense probably benign 0.05
S24628:Adgre4 UTSW 17 56,159,288 (GRCm39) missense probably benign 0.03
X0010:Adgre4 UTSW 17 56,121,308 (GRCm39) missense probably damaging 1.00
Z1177:Adgre4 UTSW 17 56,121,152 (GRCm39) critical splice acceptor site probably null
Predicted Primers PCR Primer
(F):5'- AGCATAGTGACTAACATTGTTGGC -3'
(R):5'- CCAATGCTCTACCAGGCTAAG -3'

Sequencing Primer
(F):5'- GACTAACATTGTTGGCTTTTGGAAC -3'
(R):5'- GCTCACCTATTCTGACATAGAGATG -3'
Posted On 2017-06-26