Incidental Mutation 'R6029:Fasn'
| ID |
480284 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Fasn
|
| Ensembl Gene |
ENSMUSG00000025153 |
| Gene Name |
fatty acid synthase |
| Synonyms |
A630082H08Rik, FAS |
| MMRRC Submission |
044201-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R6029 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
120696672-120715373 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 120711735 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 148
(F148L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000052872
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055655]
[ENSMUST00000205905]
[ENSMUST00000206589]
|
| AlphaFold |
P19096 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000055655
AA Change: F148L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000052872
Gene: ENSMUSG00000025153
AA Change: F148L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ketoacyl-synt
|
1 |
239 |
6.8e-73 |
PFAM |
|
Pfam:Ketoacyl-synt_C
|
243 |
360 |
3.7e-38 |
PFAM |
|
Pfam:KAsynt_C_assoc
|
362 |
474 |
8.2e-46 |
PFAM |
|
Pfam:Acyl_transf_1
|
493 |
810 |
9.5e-115 |
PFAM |
|
Pfam:PS-DH
|
853 |
1169 |
9.9e-24 |
PFAM |
|
low complexity region
|
1175 |
1204 |
N/A |
INTRINSIC |
|
Pfam:Methyltransf_12
|
1238 |
1337 |
2e-9 |
PFAM |
|
PKS_ER
|
1532 |
1847 |
1.44e-147 |
SMART |
|
PKS_KR
|
1878 |
2059 |
2.33e-42 |
SMART |
|
Pfam:PP-binding
|
2119 |
2185 |
1.1e-10 |
PFAM |
|
Pfam:Thioesterase
|
2235 |
2494 |
1.6e-62 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205905
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000206589
AA Change: F148L
PolyPhen 2
Score 0.769 (Sensitivity: 0.85; Specificity: 0.92)
|
| Meta Mutation Damage Score |
0.2919 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.7%
- 20x: 92.7%
|
| Validation Efficiency |
97% (87/90) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted mutation of this locus has implicated its product in embryogenesis as all homozygotes and most heterozygotes die prior to birth. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4932414N04Rik |
G |
A |
2: 68,524,370 (GRCm39) |
|
probably null |
Het |
| Adi1 |
G |
A |
12: 28,729,318 (GRCm39) |
|
probably benign |
Het |
| Afg3l2 |
G |
T |
18: 67,554,329 (GRCm39) |
L458M |
probably damaging |
Het |
| Apob |
A |
G |
12: 8,066,243 (GRCm39) |
E4371G |
probably damaging |
Het |
| Ash1l |
T |
C |
3: 88,892,326 (GRCm39) |
Y1402H |
probably damaging |
Het |
| Aspm |
T |
G |
1: 139,408,728 (GRCm39) |
C2538W |
possibly damaging |
Het |
| Brd10 |
A |
G |
19: 29,732,367 (GRCm39) |
|
probably benign |
Het |
| Btbd16 |
T |
C |
7: 130,420,802 (GRCm39) |
V353A |
probably benign |
Het |
| Cad |
C |
T |
5: 31,212,327 (GRCm39) |
S10L |
possibly damaging |
Het |
| Cdc42bpa |
T |
C |
1: 179,939,352 (GRCm39) |
S877P |
probably damaging |
Het |
| Cep152 |
A |
T |
2: 125,405,552 (GRCm39) |
V1660D |
probably benign |
Het |
| Clrn2 |
G |
T |
5: 45,617,528 (GRCm39) |
G133V |
probably damaging |
Het |
| Clstn2 |
T |
C |
9: 97,338,634 (GRCm39) |
I842V |
probably benign |
Het |
| Cpt1c |
C |
T |
7: 44,614,548 (GRCm39) |
A434T |
probably benign |
Het |
| D130052B06Rik |
G |
T |
11: 33,573,477 (GRCm39) |
V70L |
possibly damaging |
Het |
| Dlg1 |
T |
A |
16: 31,612,388 (GRCm39) |
V317E |
probably damaging |
Het |
| Dock10 |
T |
C |
1: 80,514,663 (GRCm39) |
E1084G |
possibly damaging |
Het |
| Dync2h1 |
A |
G |
9: 7,157,646 (GRCm39) |
V827A |
probably benign |
Het |
| E030030I06Rik |
A |
G |
10: 22,024,832 (GRCm39) |
L27P |
unknown |
Het |
| Ero1b |
T |
A |
13: 12,589,714 (GRCm39) |
L39Q |
probably damaging |
Het |
| Erp27 |
T |
C |
6: 136,888,609 (GRCm39) |
D123G |
probably damaging |
Het |
| Fbxl5 |
T |
C |
5: 43,922,746 (GRCm39) |
E218G |
probably damaging |
Het |
| Fbxw28 |
A |
T |
9: 109,158,493 (GRCm39) |
D210E |
probably damaging |
Het |
| Gm10653 |
T |
A |
9: 62,748,796 (GRCm39) |
|
probably benign |
Het |
| Gm17067 |
A |
G |
7: 42,357,554 (GRCm39) |
L316S |
probably benign |
Het |
| Gm29106 |
T |
C |
1: 118,127,990 (GRCm39) |
S561P |
probably damaging |
Het |
| Hmcn1 |
C |
A |
1: 150,508,188 (GRCm39) |
K3699N |
probably benign |
Het |
| Itch |
T |
A |
2: 155,021,009 (GRCm39) |
|
probably null |
Het |
| Itpr3 |
C |
T |
17: 27,317,145 (GRCm39) |
A800V |
probably damaging |
Het |
| Kdm2b |
A |
T |
5: 123,017,650 (GRCm39) |
M1052K |
probably damaging |
Het |
| Kdm4b |
T |
C |
17: 56,703,576 (GRCm39) |
M712T |
probably damaging |
Het |
| Kmt5b |
A |
G |
19: 3,852,104 (GRCm39) |
E137G |
probably damaging |
Het |
| Krt33a |
G |
A |
11: 99,903,289 (GRCm39) |
T251I |
probably benign |
Het |
| Lrrc4b |
G |
T |
7: 44,111,754 (GRCm39) |
R542L |
probably benign |
Het |
| Macf1 |
C |
A |
4: 123,401,126 (GRCm39) |
S653I |
probably damaging |
Het |
| Macrod2 |
G |
A |
2: 142,160,367 (GRCm39) |
V408M |
probably damaging |
Het |
| Macroh2a2 |
T |
C |
10: 61,583,541 (GRCm39) |
T200A |
possibly damaging |
Het |
| Mapkapk3 |
G |
T |
9: 107,166,425 (GRCm39) |
A40E |
possibly damaging |
Het |
| Mmp20 |
G |
A |
9: 7,639,302 (GRCm39) |
V157I |
probably benign |
Het |
| Mrps28 |
T |
C |
3: 8,988,805 (GRCm39) |
R18G |
possibly damaging |
Het |
| Msrb2 |
T |
A |
2: 19,399,122 (GRCm39) |
C162S |
probably damaging |
Het |
| Naa80 |
A |
G |
9: 107,460,753 (GRCm39) |
Y216C |
probably damaging |
Het |
| Nckap5 |
T |
G |
1: 125,953,523 (GRCm39) |
T1078P |
possibly damaging |
Het |
| Nectin3 |
T |
C |
16: 46,256,763 (GRCm39) |
Y91C |
probably benign |
Het |
| Nf2 |
G |
T |
11: 4,734,566 (GRCm39) |
|
probably null |
Het |
| Or10d1b |
G |
A |
9: 39,613,696 (GRCm39) |
A123V |
probably damaging |
Het |
| Or13a23-ps1 |
A |
T |
7: 140,118,789 (GRCm39) |
M120L |
unknown |
Het |
| Or1e16 |
AGCGGTCGTAGGC |
AGC |
11: 73,286,480 (GRCm39) |
|
probably null |
Het |
| Or2y10 |
A |
T |
11: 49,455,428 (GRCm39) |
I227F |
possibly damaging |
Het |
| Or4c29 |
T |
C |
2: 88,740,380 (GRCm39) |
D119G |
probably damaging |
Het |
| Or4g7 |
T |
A |
2: 111,309,310 (GRCm39) |
Y60* |
probably null |
Het |
| Or8b36 |
ATTGCTGTTT |
ATTGCTGTTTGCTGTTT |
9: 37,937,836 (GRCm39) |
|
probably null |
Het |
| Oxr1 |
T |
G |
15: 41,689,297 (GRCm39) |
L507W |
probably damaging |
Het |
| Plxna2 |
A |
T |
1: 194,481,883 (GRCm39) |
K1451M |
probably damaging |
Het |
| Plxna2 |
A |
G |
1: 194,476,735 (GRCm39) |
M1184V |
probably benign |
Het |
| Pofut1 |
G |
A |
2: 153,101,713 (GRCm39) |
|
probably null |
Het |
| Ppp1r16b |
T |
C |
2: 158,597,137 (GRCm39) |
V257A |
possibly damaging |
Het |
| Prss56 |
G |
A |
1: 87,115,279 (GRCm39) |
W498* |
probably null |
Het |
| Ptpru |
A |
G |
4: 131,498,604 (GRCm39) |
F1329S |
probably damaging |
Het |
| Pusl1 |
A |
G |
4: 155,973,920 (GRCm39) |
F278S |
probably damaging |
Het |
| Qars1 |
A |
T |
9: 108,390,889 (GRCm39) |
L470F |
probably damaging |
Het |
| Rbm8a2 |
T |
C |
1: 175,806,312 (GRCm39) |
D55G |
probably benign |
Het |
| Rora |
T |
A |
9: 69,271,734 (GRCm39) |
N181K |
probably benign |
Het |
| Rufy3 |
A |
G |
5: 88,775,114 (GRCm39) |
D262G |
probably damaging |
Het |
| Sh3gl2 |
G |
A |
4: 85,299,651 (GRCm39) |
V212M |
probably damaging |
Het |
| Sis |
G |
A |
3: 72,835,641 (GRCm39) |
T907I |
probably benign |
Het |
| Slc38a3 |
A |
T |
9: 107,529,374 (GRCm39) |
I456N |
probably damaging |
Het |
| Slc4a8 |
T |
A |
15: 100,705,220 (GRCm39) |
C809S |
probably benign |
Het |
| Snap91 |
A |
T |
9: 86,707,133 (GRCm39) |
|
probably null |
Het |
| Spaca6 |
A |
G |
17: 18,051,458 (GRCm39) |
T45A |
probably benign |
Het |
| Speer1m |
A |
T |
5: 11,970,680 (GRCm39) |
L84F |
probably damaging |
Het |
| Spry1 |
T |
C |
3: 37,696,997 (GRCm39) |
I80T |
possibly damaging |
Het |
| St8sia2 |
A |
G |
7: 73,610,458 (GRCm39) |
L275P |
possibly damaging |
Het |
| Supt7l |
C |
A |
5: 31,684,331 (GRCm39) |
|
probably null |
Het |
| Tdo2 |
T |
A |
3: 81,868,747 (GRCm39) |
K304N |
probably damaging |
Het |
| Tdrd12 |
A |
T |
7: 35,184,655 (GRCm39) |
Y753N |
probably damaging |
Het |
| Topbp1 |
A |
T |
9: 103,222,152 (GRCm39) |
Q1341L |
probably benign |
Het |
| Trim14 |
G |
T |
4: 46,506,998 (GRCm39) |
A406E |
probably benign |
Het |
| Trp63 |
C |
T |
16: 25,686,964 (GRCm39) |
R393W |
probably damaging |
Het |
| Trrap |
T |
C |
5: 144,754,489 (GRCm39) |
V1932A |
possibly damaging |
Het |
| Trrap |
T |
C |
5: 144,762,724 (GRCm39) |
M2399T |
possibly damaging |
Het |
| Unc45b |
A |
G |
11: 82,804,153 (GRCm39) |
N110S |
probably damaging |
Het |
| Usp32 |
G |
T |
11: 84,916,408 (GRCm39) |
H845Q |
probably damaging |
Het |
| Usp44 |
G |
A |
10: 93,682,494 (GRCm39) |
D268N |
probably damaging |
Het |
| Vmn1r18 |
T |
G |
6: 57,367,451 (GRCm39) |
R34S |
possibly damaging |
Het |
| Vmn2r103 |
T |
A |
17: 20,014,478 (GRCm39) |
Y423* |
probably null |
Het |
| Wapl |
A |
T |
14: 34,461,204 (GRCm39) |
E1054V |
possibly damaging |
Het |
| Zbtb8b |
A |
G |
4: 129,322,286 (GRCm39) |
Y392H |
probably damaging |
Het |
| Zdhhc2 |
A |
T |
8: 40,925,968 (GRCm39) |
Q321L |
probably null |
Het |
| Zfp983 |
A |
G |
17: 21,881,401 (GRCm39) |
D443G |
probably benign |
Het |
|
| Other mutations in Fasn |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00468:Fasn
|
APN |
11 |
120,711,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01014:Fasn
|
APN |
11 |
120,708,055 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01131:Fasn
|
APN |
11 |
120,705,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01603:Fasn
|
APN |
11 |
120,706,891 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01606:Fasn
|
APN |
11 |
120,699,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01897:Fasn
|
APN |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01899:Fasn
|
APN |
11 |
120,710,975 (GRCm39) |
splice site |
probably benign |
|
|
IGL01987:Fasn
|
APN |
11 |
120,708,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02103:Fasn
|
APN |
11 |
120,702,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02212:Fasn
|
APN |
11 |
120,698,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02294:Fasn
|
APN |
11 |
120,701,102 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02336:Fasn
|
APN |
11 |
120,704,562 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02417:Fasn
|
APN |
11 |
120,711,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02452:Fasn
|
APN |
11 |
120,699,006 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02559:Fasn
|
APN |
11 |
120,699,892 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02724:Fasn
|
APN |
11 |
120,700,659 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02862:Fasn
|
APN |
11 |
120,709,805 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02947:Fasn
|
APN |
11 |
120,706,502 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03025:Fasn
|
APN |
11 |
120,708,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03131:Fasn
|
APN |
11 |
120,701,550 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03157:Fasn
|
APN |
11 |
120,698,735 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL03182:Fasn
|
APN |
11 |
120,703,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03370:Fasn
|
APN |
11 |
120,703,621 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
BB007:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
BB017:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0243:Fasn
|
UTSW |
11 |
120,706,141 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0304:Fasn
|
UTSW |
11 |
120,710,762 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0389:Fasn
|
UTSW |
11 |
120,707,008 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0449:Fasn
|
UTSW |
11 |
120,701,894 (GRCm39) |
missense |
probably benign |
|
|
R0626:Fasn
|
UTSW |
11 |
120,702,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1037:Fasn
|
UTSW |
11 |
120,700,277 (GRCm39) |
missense |
probably benign |
|
|
R1061:Fasn
|
UTSW |
11 |
120,713,008 (GRCm39) |
splice site |
probably null |
|
|
R1109:Fasn
|
UTSW |
11 |
120,703,150 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1498:Fasn
|
UTSW |
11 |
120,706,245 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1552:Fasn
|
UTSW |
11 |
120,709,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1568:Fasn
|
UTSW |
11 |
120,704,075 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1624:Fasn
|
UTSW |
11 |
120,703,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Fasn
|
UTSW |
11 |
120,707,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1826:Fasn
|
UTSW |
11 |
120,699,325 (GRCm39) |
splice site |
probably benign |
|
|
R1846:Fasn
|
UTSW |
11 |
120,704,133 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2298:Fasn
|
UTSW |
11 |
120,704,642 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2513:Fasn
|
UTSW |
11 |
120,705,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3001:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3002:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3154:Fasn
|
UTSW |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3434:Fasn
|
UTSW |
11 |
120,713,599 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4794:Fasn
|
UTSW |
11 |
120,702,121 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4840:Fasn
|
UTSW |
11 |
120,703,885 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4863:Fasn
|
UTSW |
11 |
120,699,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4876:Fasn
|
UTSW |
11 |
120,703,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4914:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4915:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4916:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4918:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4936:Fasn
|
UTSW |
11 |
120,706,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5025:Fasn
|
UTSW |
11 |
120,702,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5092:Fasn
|
UTSW |
11 |
120,705,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5120:Fasn
|
UTSW |
11 |
120,702,217 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5175:Fasn
|
UTSW |
11 |
120,707,195 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5183:Fasn
|
UTSW |
11 |
120,699,708 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5506:Fasn
|
UTSW |
11 |
120,700,336 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5557:Fasn
|
UTSW |
11 |
120,703,252 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5614:Fasn
|
UTSW |
11 |
120,704,154 (GRCm39) |
missense |
probably benign |
|
|
R5728:Fasn
|
UTSW |
11 |
120,704,339 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5838:Fasn
|
UTSW |
11 |
120,706,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5959:Fasn
|
UTSW |
11 |
120,699,390 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6134:Fasn
|
UTSW |
11 |
120,713,012 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6335:Fasn
|
UTSW |
11 |
120,706,185 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6452:Fasn
|
UTSW |
11 |
120,706,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6627:Fasn
|
UTSW |
11 |
120,709,753 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6742:Fasn
|
UTSW |
11 |
120,701,279 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6767:Fasn
|
UTSW |
11 |
120,708,313 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6927:Fasn
|
UTSW |
11 |
120,699,115 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6976:Fasn
|
UTSW |
11 |
120,710,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7092:Fasn
|
UTSW |
11 |
120,710,946 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7157:Fasn
|
UTSW |
11 |
120,701,291 (GRCm39) |
nonsense |
probably null |
|
|
R7373:Fasn
|
UTSW |
11 |
120,704,802 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7575:Fasn
|
UTSW |
11 |
120,703,513 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7652:Fasn
|
UTSW |
11 |
120,707,154 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7670:Fasn
|
UTSW |
11 |
120,704,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7806:Fasn
|
UTSW |
11 |
120,700,821 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7930:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R8007:Fasn
|
UTSW |
11 |
120,700,353 (GRCm39) |
missense |
probably benign |
|
|
R8012:Fasn
|
UTSW |
11 |
120,702,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8185:Fasn
|
UTSW |
11 |
120,702,969 (GRCm39) |
missense |
probably benign |
0.42 |
|
R8557:Fasn
|
UTSW |
11 |
120,706,610 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8711:Fasn
|
UTSW |
11 |
120,709,944 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8772:Fasn
|
UTSW |
11 |
120,711,362 (GRCm39) |
missense |
probably benign |
|
|
R8856:Fasn
|
UTSW |
11 |
120,708,979 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8875:Fasn
|
UTSW |
11 |
120,703,224 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9071:Fasn
|
UTSW |
11 |
120,708,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9153:Fasn
|
UTSW |
11 |
120,706,496 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9238:Fasn
|
UTSW |
11 |
120,705,871 (GRCm39) |
missense |
probably benign |
|
|
R9249:Fasn
|
UTSW |
11 |
120,703,915 (GRCm39) |
missense |
probably benign |
|
|
R9345:Fasn
|
UTSW |
11 |
120,706,735 (GRCm39) |
missense |
probably benign |
0.22 |
|
X0067:Fasn
|
UTSW |
11 |
120,707,129 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Fasn
|
UTSW |
11 |
120,706,297 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGTAGTGCCAGCAAGCTG -3'
(R):5'- TTAGAGGTTCACTGTGGCCC -3'
Sequencing Primer
(F):5'- TCCAGGGCAATGCTTGGTC -3'
(R):5'- GATGGCATCTCTCTCACCCAAG -3'
|
| Posted On |
2017-06-26 |
Incidental Mutation