Mutagenetix > Incidental Mutation

Incidental Mutation 'R6030:Ifi44'

480316

Institutional Source

Beutler Lab

Gene Symbol

Ifi44

Ensembl Gene

ENSMUSG00000028037

Gene Name

interferon-induced protein 44

Synonyms

A430056A10Rik, p44, MTAP44

MMRRC Submission

044202-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6030 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

151730922-151749960 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 151749558 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Arginine at position 10 (Q10R)

Ref Sequence

ENSEMBL: ENSMUSP00000029671 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000029671]

AlphaFold

Q8BV66

Predicted Effect

probably benign
Transcript: ENSMUST00000029671
AA Change: Q10R

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000029671
Gene: ENSMUSG00000028037
AA Change: Q10R

Domain	Start	End	E-Value	Type
Pfam:TLD	26	147	2.8e-7	PFAM
low complexity region	193	208	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127733

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133888

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149919

Coding Region Coverage

1x: 99.9%
3x: 99.4%
10x: 96.1%
20x: 86.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 77 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410131K14Rik	T	C	5: 118,255,733	W59R	probably damaging	Het
Abca16	A	G	7: 120,533,798	N1317D	probably benign	Het
Abhd8	T	A	8: 71,458,150	Y338F	possibly damaging	Het
Actg2	G	T	6: 83,516,364	N297K	probably damaging	Het
Agap1	A	G	1: 89,630,434	D148G	probably damaging	Het
Alox12	T	C	11: 70,254,591	D52G	possibly damaging	Het
Ano5	T	A	7: 51,574,825	S496T	probably damaging	Het
Arl6ip4	T	C	5: 124,117,905		probably null	Het
Atp4a	G	C	7: 30,722,516	E826Q	probably damaging	Het
Bbs7	T	C	3: 36,602,911	D256G	probably damaging	Het
Bckdha	T	A	7: 25,631,441	D50V	probably damaging	Het
Cast	A	G	13: 74,695,937	S693P	possibly damaging	Het
Col6a1	T	C	10: 76,709,866	Y924C	unknown	Het
Crkl	A	G	16: 17,452,740	Y88C	probably damaging	Het
Cse1l	T	C	2: 166,919,621	F32L	probably benign	Het
Dmxl2	C	T	9: 54,393,673	V2385I	probably benign	Het
Dnah1	T	A	14: 31,268,027	I3219F	probably damaging	Het
Dnah17	C	T	11: 118,025,549	R4266H	probably benign	Het
Efcab5	A	G	11: 77,121,262	L722P	probably damaging	Het
Emilin3	C	A	2: 160,909,185	V215L	probably benign	Het
Esr1	A	T	10: 4,746,622	N157I	possibly damaging	Het
Esrrg	A	G	1: 188,198,707	M309V	probably benign	Het
Fam120b	G	A	17: 15,401,910	R50Q	probably damaging	Het
Fat2	G	T	11: 55,310,303	Y648*	probably null	Het
Gbp2b	T	A	3: 142,603,653	I175N	probably benign	Het
Gm1043	T	A	5: 37,154,608		probably benign	Het
Gm21060	A	G	19: 61,296,973	C33R	possibly damaging	Het
Gm9803	C	T	10: 43,524,256	A30V	probably benign	Het
Gpx6	C	T	13: 21,312,340	S28L	probably benign	Het
Hyls1	G	A	9: 35,561,184	S312F	probably benign	Het
Impa2	T	C	18: 67,318,428	V264A	probably benign	Het
Khdc1a	A	T	1: 21,350,884	M98L	probably benign	Het
Lrrc45	T	A	11: 120,720,648	L616*	probably null	Het
Mios	A	T	6: 8,215,704	H300L	probably benign	Het
Mllt6	A	T	11: 97,677,225	T827S	probably damaging	Het
Mrc1	C	A	2: 14,316,901	D1068E	probably benign	Het
Ndst3	T	C	3: 123,552,519	Y702C	probably damaging	Het
Nek11	T	A	9: 105,204,888		probably null	Het
Nek4	T	C	14: 30,956,933	F138S	probably damaging	Het
Nfatc4	T	A	14: 55,832,440	Y688*	probably null	Het
Nlrx1	C	T	9: 44,263,760	V240M	probably damaging	Het
Npy6r	A	T	18: 44,276,082	Y190F	probably benign	Het
Olfr338	T	G	2: 36,377,544	L256R	probably damaging	Het
Olfr472	A	G	7: 107,903,413	E232G	probably benign	Het
Olfr509	A	C	7: 108,646,226	S117A	possibly damaging	Het
Olfr548-ps1	C	A	7: 102,542,610	R225S	probably benign	Het
Olfr780	A	T	10: 129,322,369	T249S	probably benign	Het
Olfr960	T	C	9: 39,623,341	F71L	probably damaging	Het
Osbpl7	A	C	11: 97,052,261	H113P	probably benign	Het
Pck1	A	G	2: 173,154,857	E188G	probably benign	Het
Pimreg	A	G	11: 72,045,750	D213G	probably benign	Het
Pkd1l2	A	G	8: 117,043,237	I1160T	probably damaging	Het
Ppargc1b	G	A	18: 61,307,934	Q622*	probably null	Het
Ppfia2	T	A	10: 106,906,477	C1044S	probably damaging	Het
Ppp4r3a	A	G	12: 101,058,400	V280A	probably damaging	Het
Ptprf	T	C	4: 118,211,048	N1764D	probably benign	Het
Pygm	C	T	19: 6,388,812	R311C	possibly damaging	Het
Rab7b	A	G	1: 131,698,561	K109R	probably damaging	Het
Rsf1	GGCG	GGCGACGGCTGCG	7: 97,579,906		probably benign	Het
Sdccag3	T	C	2: 26,386,971	D249G	possibly damaging	Het
Setbp1	T	G	18: 78,857,711	I914L	probably benign	Het
Shprh	A	C	10: 11,151,991	Q114P	probably benign	Het
Slc5a9	T	C	4: 111,885,528	I456V	possibly damaging	Het
Slc8b1	T	C	5: 120,519,920		probably null	Het
Spin1	T	A	13: 51,139,516	Y87*	probably null	Het
Srebf2	T	C	15: 82,177,276		probably null	Het
Sufu	T	C	19: 46,475,539	Y397H	probably damaging	Het
Tgfb3	A	C	12: 86,063,850	V242G	probably benign	Het
Tgm3	A	T	2: 130,042,000	Y526F	probably damaging	Het
Tmem209	A	G	6: 30,482,968	L508P	probably damaging	Het
Tmem67	T	C	4: 12,063,799	D454G	probably benign	Het
Ttn	T	C	2: 76,816,599	E3280G	possibly damaging	Het
Tusc3	G	C	8: 39,071,406	G200R	probably damaging	Het
Umps	A	G	16: 33,962,138	V138A	probably benign	Het
Wdr66	C	T	5: 123,274,204	T532M	probably damaging	Het
Ypel1	A	G	16: 17,084,513		probably null	Het
Zdhhc19	T	A	16: 32,499,042	L63Q	probably null	Het

Other mutations in Ifi44

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00858:Ifi44	APN	3	151749580	missense	probably benign	0.03
IGL01477:Ifi44	APN	3	151745998	splice site	probably benign
IGL01571:Ifi44	APN	3	151745537	missense	probably damaging	0.97
IGL02165:Ifi44	APN	3	151749430	missense	probably damaging	1.00
IGL02238:Ifi44	APN	3	151732382	makesense	probably null
IGL02609:Ifi44	APN	3	151732497	missense	probably damaging	1.00
IGL02650:Ifi44	APN	3	151745855	missense	probably damaging	1.00
IGL02726:Ifi44	APN	3	151749596	start gained	probably benign
IGL02977:Ifi44	APN	3	151739379	missense	probably benign	0.00
R0201:Ifi44	UTSW	3	151745636	missense	probably damaging	1.00
R0454:Ifi44	UTSW	3	151745497	missense	possibly damaging	0.78
R0763:Ifi44	UTSW	3	151749498	missense	probably damaging	1.00
R1640:Ifi44	UTSW	3	151732534	missense	probably benign	0.00
R1747:Ifi44	UTSW	3	151749285	missense	probably benign	0.00
R2278:Ifi44	UTSW	3	151732388	missense	probably benign
R3816:Ifi44	UTSW	3	151749257	missense	possibly damaging	0.92
R4075:Ifi44	UTSW	3	151745976	missense	probably benign	0.00
R4084:Ifi44	UTSW	3	151745489	critical splice donor site	probably null
R4782:Ifi44	UTSW	3	151745592	missense	probably damaging	0.99
R5071:Ifi44	UTSW	3	151749632	start gained	probably benign
R5074:Ifi44	UTSW	3	151749632	start gained	probably benign
R6030:Ifi44	UTSW	3	151749558	missense	probably benign	0.00
R6128:Ifi44	UTSW	3	151749186	missense	probably benign	0.00
R6192:Ifi44	UTSW	3	151745639	critical splice acceptor site	probably null
R6434:Ifi44	UTSW	3	151749189	missense	probably benign	0.02
R6536:Ifi44	UTSW	3	151732489	missense	probably benign	0.03
R6902:Ifi44	UTSW	3	151745899	missense	possibly damaging	0.92
R6946:Ifi44	UTSW	3	151745899	missense	possibly damaging	0.92
R7346:Ifi44	UTSW	3	151732457	missense	probably benign
R7608:Ifi44	UTSW	3	151732408	missense	probably damaging	0.97
R7704:Ifi44	UTSW	3	151732424	missense	probably benign	0.44
R7971:Ifi44	UTSW	3	151749220	missense	possibly damaging	0.89
R8255:Ifi44	UTSW	3	151745982	missense	probably benign	0.00
R8428:Ifi44	UTSW	3	151739341	nonsense	probably null
R8940:Ifi44	UTSW	3	151749309	missense	probably benign	0.00
R9087:Ifi44	UTSW	3	151745880	missense	probably damaging	1.00
R9259:Ifi44	UTSW	3	151749238	missense	possibly damaging	0.75
R9436:Ifi44	UTSW	3	151749249	missense	probably benign	0.00
R9516:Ifi44	UTSW	3	151732471	missense	probably damaging	0.97
R9619:Ifi44	UTSW	3	151745872	missense	probably damaging	0.97
Z1176:Ifi44	UTSW	3	151732453	missense	probably damaging	1.00
Z1177:Ifi44	UTSW	3	151749438	missense	probably damaging	1.00

Predicted Primers

Posted On

2017-06-26