Incidental Mutation 'R6032:Or8g17'
ID 480454
Institutional Source Beutler Lab
Gene Symbol Or8g17
Ensembl Gene ENSMUSG00000058820
Gene Name olfactory receptor family 8 subfamily G member 17
Synonyms MOR171-10, M15, Olfr146, GA_x6K02T2PVTD-32715386-32714466
MMRRC Submission 044204-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R6032 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 38929915-38930835 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 38930261 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 192 (I192T)
Ref Sequence ENSEMBL: ENSMUSP00000149294 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073671] [ENSMUST00000214369] [ENSMUST00000214410] [ENSMUST00000215383]
AlphaFold Q60884
Predicted Effect probably benign
Transcript: ENSMUST00000073671
AA Change: I192T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000073352
Gene: ENSMUSG00000058820
AA Change: I192T

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 7.6e-54 PFAM
Pfam:7tm_1 41 290 8.1e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214369
Predicted Effect probably benign
Transcript: ENSMUST00000214410
AA Change: I192T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000215383
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.4%
  • 10x: 96.0%
  • 20x: 85.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930505A04Rik C T 11: 30,376,349 (GRCm39) V173M probably damaging Het
A2ml1 T A 6: 128,526,799 (GRCm39) K1071* probably null Het
Abca13 G T 11: 9,247,752 (GRCm39) V2500F possibly damaging Het
Adamdec1 T C 14: 68,816,633 (GRCm39) E85G probably damaging Het
Aldh8a1 T C 10: 21,264,970 (GRCm39) V199A probably benign Het
Aoc2 G A 11: 101,216,627 (GRCm39) V237M probably damaging Het
Aplp2 C T 9: 31,062,240 (GRCm39) R672H probably damaging Het
Apob A G 12: 8,045,513 (GRCm39) N886S probably benign Het
Ascc3 C T 10: 50,718,279 (GRCm39) R1991* probably null Het
Atp6v1a T C 16: 43,927,303 (GRCm39) Y328C probably damaging Het
Bag4 T C 8: 26,267,521 (GRCm39) Y103C probably damaging Het
Crem C T 18: 3,267,673 (GRCm39) R190Q probably damaging Het
Crybg1 A G 10: 43,832,756 (GRCm39) S2000P probably damaging Het
Cubn T A 2: 13,329,995 (GRCm39) T2629S probably benign Het
Cyp3a44 G T 5: 145,714,756 (GRCm39) S465Y probably damaging Het
Daam2 A C 17: 49,793,525 (GRCm39) F331V probably damaging Het
Dnajc3 T C 14: 119,205,443 (GRCm39) S146P possibly damaging Het
Dscam A G 16: 96,451,191 (GRCm39) probably null Het
Fam184b G A 5: 45,740,238 (GRCm39) S316L probably benign Het
Fat2 G C 11: 55,144,760 (GRCm39) T4038S probably damaging Het
Fbxl19 C T 7: 127,360,437 (GRCm39) R439C probably damaging Het
Gm3454 T A 15: 75,183,448 (GRCm39) noncoding transcript Het
Gpatch3 A G 4: 133,305,617 (GRCm39) E284G probably benign Het
Grm1 A T 10: 10,595,549 (GRCm39) I693N probably damaging Het
Gsdme T A 6: 50,222,934 (GRCm39) Q127L probably damaging Het
Ifnlr1 A G 4: 135,432,937 (GRCm39) K458E probably benign Het
Kcns2 T C 15: 34,839,080 (GRCm39) F148L probably benign Het
Lama1 A G 17: 68,057,638 (GRCm39) T571A probably benign Het
Loxhd1 G A 18: 77,469,254 (GRCm39) V108M probably damaging Het
Mef2c A T 13: 83,810,478 (GRCm39) T375S probably benign Het
Ncor1 A T 11: 62,264,147 (GRCm39) D144E possibly damaging Het
Nos3 A T 5: 24,584,809 (GRCm39) T738S probably benign Het
Nrxn2 A T 19: 6,567,162 (GRCm39) T1353S probably damaging Het
Or2b7 G T 13: 21,740,077 (GRCm39) S38R probably benign Het
Or4f4b T C 2: 111,314,195 (GRCm39) L140P probably damaging Het
Pfpl A G 19: 12,406,747 (GRCm39) T333A probably damaging Het
Postn A T 3: 54,284,137 (GRCm39) I565F possibly damaging Het
Ppef2 A G 5: 92,378,383 (GRCm39) V604A probably benign Het
Pramel13 A C 4: 144,119,598 (GRCm39) I323S possibly damaging Het
Rel A G 11: 23,692,684 (GRCm39) S450P probably benign Het
Rpap2 A C 5: 107,745,661 (GRCm39) D3A probably damaging Het
Shisa9 T C 16: 11,802,772 (GRCm39) F110L possibly damaging Het
Slc25a10 A T 11: 120,385,784 (GRCm39) probably null Het
Slx4 A T 16: 3,798,021 (GRCm39) F1454L probably damaging Het
Smc1b A T 15: 84,950,430 (GRCm39) V1198D possibly damaging Het
Supt5 T C 7: 28,015,600 (GRCm39) Y879C probably damaging Het
Tbx15 T C 3: 99,259,833 (GRCm39) M568T probably benign Het
Tle4 T C 19: 14,429,472 (GRCm39) H698R possibly damaging Het
Trappc9 T C 15: 72,797,379 (GRCm39) N803D probably benign Het
Trim10 A T 17: 37,182,606 (GRCm39) R157S possibly damaging Het
Wsb1 T C 11: 79,131,025 (GRCm39) probably benign Het
Zfp106 T C 2: 120,365,874 (GRCm39) S178G probably benign Het
Zftraf1 C T 15: 76,543,058 (GRCm39) R34Q probably damaging Het
Other mutations in Or8g17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01533:Or8g17 APN 9 38,930,097 (GRCm39) missense probably damaging 0.98
IGL01655:Or8g17 APN 9 38,930,214 (GRCm39) missense probably benign 0.00
IGL01804:Or8g17 APN 9 38,930,697 (GRCm39) missense probably benign 0.13
IGL02098:Or8g17 APN 9 38,930,187 (GRCm39) missense probably damaging 1.00
IGL02719:Or8g17 APN 9 38,930,312 (GRCm39) missense probably benign 0.11
R0531:Or8g17 UTSW 9 38,930,472 (GRCm39) missense probably damaging 0.97
R1270:Or8g17 UTSW 9 38,930,543 (GRCm39) missense possibly damaging 0.90
R1511:Or8g17 UTSW 9 38,930,321 (GRCm39) missense probably benign 0.03
R1590:Or8g17 UTSW 9 38,930,253 (GRCm39) missense probably benign 0.09
R1649:Or8g17 UTSW 9 38,930,776 (GRCm39) missense probably benign 0.03
R3419:Or8g17 UTSW 9 38,930,372 (GRCm39) missense probably benign 0.03
R4669:Or8g17 UTSW 9 38,930,675 (GRCm39) missense probably benign 0.10
R4788:Or8g17 UTSW 9 38,930,217 (GRCm39) missense probably benign 0.07
R5184:Or8g17 UTSW 9 38,929,998 (GRCm39) missense probably damaging 0.98
R5581:Or8g17 UTSW 9 38,929,998 (GRCm39) missense probably damaging 0.98
R6032:Or8g17 UTSW 9 38,930,261 (GRCm39) missense probably benign 0.00
R6319:Or8g17 UTSW 9 38,930,810 (GRCm39) missense probably damaging 1.00
R6626:Or8g17 UTSW 9 38,930,402 (GRCm39) missense possibly damaging 0.63
R6693:Or8g17 UTSW 9 38,930,097 (GRCm39) missense probably damaging 0.98
R7165:Or8g17 UTSW 9 38,934,566 (GRCm39) start gained probably benign
R7947:Or8g17 UTSW 9 38,930,747 (GRCm39) missense probably damaging 0.99
R7957:Or8g17 UTSW 9 38,930,349 (GRCm39) missense probably benign
R8052:Or8g17 UTSW 9 38,930,783 (GRCm39) missense probably damaging 0.99
R8162:Or8g17 UTSW 9 38,930,249 (GRCm39) missense probably benign 0.01
R9004:Or8g17 UTSW 9 38,930,580 (GRCm39) missense probably benign 0.01
R9083:Or8g17 UTSW 9 38,930,016 (GRCm39) missense probably damaging 1.00
R9584:Or8g17 UTSW 9 38,930,462 (GRCm39) missense probably damaging 1.00
Z1088:Or8g17 UTSW 9 38,930,085 (GRCm39) missense probably damaging 1.00
Z1191:Or8g17 UTSW 9 38,930,229 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2017-06-26