Mutagenetix > Incidental Mutation

Incidental Mutation 'R0513:Vmn2r118'

48060

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r118

Ensembl Gene

ENSMUSG00000091504

Gene Name

vomeronasal 2, receptor 118

Synonyms

EG383258, Vmn2r119, EG668547

MMRRC Submission

038707-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.125) question?

Stock #

R0513 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

55592341-55624672 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 55610970 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 181 (K181*)

Ref Sequence

ENSEMBL: ENSMUSP00000131128 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168440]

AlphaFold

E9Q1C1

Predicted Effect

probably null
Transcript: ENSMUST00000168440
AA Change: K181*

SMART Domains

Protein: ENSMUSP00000131128
Gene: ENSMUSG00000091504
AA Change: K181*

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	142	470	4.6e-27	PFAM
Pfam:NCD3G	513	566	2.6e-20	PFAM
Pfam:7tm_3	599	834	5.9e-55	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.5%
3x: 98.7%
10x: 96.6%
20x: 92.9%

Validation Efficiency

99% (122/123)

Allele List at MGI

Other mutations in this stock

Total: 118 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4833420G17Rik	A	G	13: 119,469,659 (GRCm38)	T146A	probably benign	Het
Abcg4	A	G	9: 44,281,687 (GRCm38)	S121P	possibly damaging	Het
Actr2	T	C	11: 20,080,124 (GRCm38)	T212A	probably damaging	Het
Adcy10	T	A	1: 165,519,519 (GRCm38)	D368E	probably benign	Het
Albfm1	A	T	5: 90,577,927 (GRCm38)	T333S	probably benign	Het
Anapc15	T	C	7: 101,898,540 (GRCm38)		probably benign	Het
Aox4	A	G	1: 58,217,519 (GRCm38)	R67G	probably benign	Het
Aox4	A	G	1: 58,247,300 (GRCm38)	D697G	probably damaging	Het
Arhgap42	A	T	9: 9,005,765 (GRCm38)	S755T	probably benign	Het
Atm	A	G	9: 53,503,948 (GRCm38)	V881A	probably benign	Het
Cdkal1	C	T	13: 29,625,965 (GRCm38)		probably benign	Het
Cfap20dc	A	C	14: 8,536,609 (GRCm38)	D199E	probably damaging	Het
Cfap61	C	A	2: 146,035,295 (GRCm38)	N491K	possibly damaging	Het
Chgb	T	C	2: 132,785,977 (GRCm38)		probably benign	Het
Chrna1	C	A	2: 73,568,082 (GRCm38)		probably benign	Het
Chst10	A	G	1: 38,865,763 (GRCm38)	L283P	probably damaging	Het
Clca3a1	A	G	3: 144,760,562 (GRCm38)		probably null	Het
Crppa	A	T	12: 36,390,468 (GRCm38)	H125L	probably damaging	Het
Cryzl1	G	T	16: 91,699,287 (GRCm38)	A1E	possibly damaging	Het
Csnk1a1	T	C	18: 61,576,547 (GRCm38)	Y213H	probably damaging	Het
Cspg4	A	G	9: 56,898,091 (GRCm38)	Q2062R	probably benign	Het
Ctnnal1	A	G	4: 56,835,348 (GRCm38)	C310R	probably benign	Het
D630003M21Rik	T	C	2: 158,200,308 (GRCm38)	E906G	probably benign	Het
D930048N14Rik	T	C	11: 51,654,928 (GRCm38)		probably benign	Het
Dag1	G	A	9: 108,208,485 (GRCm38)	P486S	possibly damaging	Het
Dgkq	A	G	5: 108,656,495 (GRCm38)	L33P	probably benign	Het
Dlc1	C	T	8: 36,584,010 (GRCm38)	G856R	probably damaging	Het
Dst	T	A	1: 34,219,531 (GRCm38)		probably benign	Het
Dtl	A	T	1: 191,569,707 (GRCm38)	Y79*	probably null	Het
Egfr	T	G	11: 16,872,855 (GRCm38)	L406R	probably damaging	Het
Elp3	A	T	14: 65,563,246 (GRCm38)		probably null	Het
Fbxw19	C	A	9: 109,481,553 (GRCm38)		probably null	Het
Frs2	T	C	10: 117,074,665 (GRCm38)	E264G	possibly damaging	Het
Fscn2	G	T	11: 120,361,880 (GRCm38)	V58L	probably damaging	Het
Gm17324	G	A	9: 78,448,725 (GRCm38)		probably benign	Het
Gm4787	A	T	12: 81,378,312 (GRCm38)	N357K	probably benign	Het
Gm9956	G	T	10: 56,745,195 (GRCm38)			Het
Gsg1l	C	T	7: 126,020,623 (GRCm38)		probably null	Het
Herc1	G	A	9: 66,445,645 (GRCm38)	V2138M	possibly damaging	Het
Htr2a	T	C	14: 74,706,324 (GRCm38)	L448P	probably benign	Het
Ing3	C	T	6: 21,970,035 (GRCm38)	S255L	probably damaging	Het
Krt78	T	C	15: 101,950,949 (GRCm38)	D271G	probably damaging	Het
Lmbrd2	T	A	15: 9,194,729 (GRCm38)	L606H	probably damaging	Het
Lmod1	T	A	1: 135,325,168 (GRCm38)	N53K	probably damaging	Het
Lsr	G	C	7: 30,958,338 (GRCm38)	A467G	probably benign	Het
Mbtd1	T	A	11: 93,932,212 (GRCm38)		probably null	Het
Mill1	T	A	7: 18,264,877 (GRCm38)	Y337*	probably null	Het
Mlxipl	A	T	5: 135,137,263 (GRCm38)	Q833L	probably benign	Het
Mon2	C	T	10: 123,038,610 (GRCm38)	V278M	probably damaging	Het
Mxra8	A	C	4: 155,841,733 (GRCm38)	M180L	probably benign	Het
Myo18a	A	T	11: 77,811,594 (GRCm38)		probably benign	Het
Myo1c	T	G	11: 75,665,831 (GRCm38)		probably null	Het
Myo1g	T	C	11: 6,510,203 (GRCm38)	T782A	probably benign	Het
Ncapd3	A	G	9: 27,064,105 (GRCm38)		probably benign	Het
Neb	T	C	2: 52,308,687 (GRCm38)	D414G	probably damaging	Het
Nedd4l	T	A	18: 65,195,185 (GRCm38)		probably benign	Het
Nf2	T	C	11: 4,791,185 (GRCm38)	K343R	possibly damaging	Het
Nfasc	A	T	1: 132,603,846 (GRCm38)	D733E	possibly damaging	Het
Nolc1	G	A	19: 46,084,159 (GRCm38)	D699N	probably damaging	Het
Nrbp2	C	T	15: 76,088,976 (GRCm38)	A45T	probably benign	Het
Obscn	A	G	11: 59,061,522 (GRCm38)	V3907A	possibly damaging	Het
Or2b6	A	T	13: 21,638,949 (GRCm38)	D191E	probably benign	Het
Or2y6	T	C	11: 52,213,749 (GRCm38)	Q80R	possibly damaging	Het
Or8b8	A	T	9: 37,898,055 (GRCm38)	Y217F	probably damaging	Het
Pank2	C	T	2: 131,282,606 (GRCm38)	T290I	probably damaging	Het
Pbx4	T	C	8: 69,864,879 (GRCm38)	V171A	probably benign	Het
Pcgf1	G	T	6: 83,080,574 (GRCm38)	V75F	probably damaging	Het
Pik3ca	T	C	3: 32,461,511 (GRCm38)	S778P	probably damaging	Het
Pld6	T	C	11: 59,785,221 (GRCm38)	I141M	probably damaging	Het
Polq	T	A	16: 37,094,502 (GRCm38)	V2508E	probably damaging	Het
Prkca	C	G	11: 108,014,376 (GRCm38)	D179H	possibly damaging	Het
Pspn	T	C	17: 56,999,720 (GRCm38)	S70G	probably damaging	Het
Ptchd4	C	T	17: 42,503,746 (GRCm38)	T846I	probably benign	Het
Reg3g	A	C	6: 78,467,844 (GRCm38)	Y50*	probably null	Het
Rev3l	C	T	10: 39,828,143 (GRCm38)	H2062Y	probably benign	Het
Rsph4a	C	T	10: 33,912,991 (GRCm38)	Q611*	probably null	Het
Scart1	C	A	7: 140,224,960 (GRCm38)	C625*	probably null	Het
Scgb1b20	G	A	7: 33,373,314 (GRCm38)		probably null	Het
Sfxn5	T	C	6: 85,269,973 (GRCm38)		probably benign	Het
Sh3tc1	T	A	5: 35,700,307 (GRCm38)	Q1179L	possibly damaging	Het
Skint11	A	G	4: 114,194,565 (GRCm38)	I37V	probably benign	Het
Slc35f5	T	C	1: 125,576,169 (GRCm38)		probably benign	Het
Slc8a2	A	C	7: 16,157,339 (GRCm38)	D768A	probably damaging	Het
Slco6b1	A	G	1: 96,997,184 (GRCm38)		noncoding transcript	Het
Smurf2	T	A	11: 106,836,105 (GRCm38)	T453S	probably benign	Het
Spag16	A	G	1: 70,493,768 (GRCm38)		probably benign	Het
Spindoc	G	A	19: 7,374,144 (GRCm38)	T205I	probably benign	Het
Stab1	T	C	14: 31,148,945 (GRCm38)	I1316V	probably benign	Het
Stox2	T	C	8: 47,193,865 (GRCm38)	R187G	probably damaging	Het
Tcea2	A	C	2: 181,684,481 (GRCm38)	T93P	probably benign	Het
Tenm4	T	C	7: 96,895,623 (GRCm38)	M2311T	probably benign	Het
Tmem63a	A	G	1: 180,960,461 (GRCm38)	Q260R	probably benign	Het
Tnpo2	A	T	8: 85,053,529 (GRCm38)	H698L	probably benign	Het
Trim33	A	G	3: 103,310,384 (GRCm38)	D215G	probably damaging	Het
Ttc3	T	A	16: 94,426,212 (GRCm38)	I727N	probably damaging	Het
Ttn	T	A	2: 76,943,325 (GRCm38)	K2271N	probably damaging	Het
Ubr2	T	A	17: 46,986,779 (GRCm38)	K223*	probably null	Het
Ubr4	A	G	4: 139,416,875 (GRCm38)	M1410V	possibly damaging	Het
Ugt2b35	T	C	5: 87,003,412 (GRCm38)		probably benign	Het
Ulk4	T	A	9: 121,152,325 (GRCm38)	H880L	probably benign	Het
Unc80	G	A	1: 66,622,474 (GRCm38)	C1686Y	possibly damaging	Het
Upf2	T	A	2: 5,957,667 (GRCm38)	L60Q	unknown	Het
Usf2	A	T	7: 30,954,736 (GRCm38)		probably benign	Het
Usp21	T	A	1: 171,283,014 (GRCm38)		probably benign	Het
Usp21	T	A	1: 171,283,012 (GRCm38)		probably benign	Het
Vmn2r124	T	A	17: 18,073,729 (GRCm38)	S693T	possibly damaging	Het
Vmn2r76	C	A	7: 86,228,779 (GRCm38)	G470V	probably benign	Het
Vps13c	A	C	9: 67,930,735 (GRCm38)	I1856L	probably benign	Het
Vps50	C	T	6: 3,520,210 (GRCm38)	L119F	probably damaging	Het
Wdfy3	T	A	5: 101,890,789 (GRCm38)	S2012C	probably damaging	Het
Zfp1008	A	C	13: 62,605,215 (GRCm38)	V99G	possibly damaging	Het
Zfp142	A	G	1: 74,571,555 (GRCm38)	V924A	probably damaging	Het
Zfp217	C	T	2: 170,115,462 (GRCm38)	A539T	probably benign	Het
Zfp235	T	C	7: 24,142,219 (GRCm38)	S688P	probably damaging	Het
Zfp39	C	T	11: 58,889,987 (GRCm38)	V650I	probably benign	Het
Zfp82	A	T	7: 30,056,840 (GRCm38)	N272K	probably damaging	Het
Zfyve21	A	C	12: 111,823,264 (GRCm38)	D54A	possibly damaging	Het
Zfyve26	C	T	12: 79,244,484 (GRCm38)	D2116N	probably damaging	Het

Other mutations in Vmn2r118

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00091:Vmn2r118	APN	17	55,592,708 (GRCm38)	missense	probably damaging	1.00
IGL00976:Vmn2r118	APN	17	55,593,204 (GRCm38)	missense	probably damaging	1.00
IGL01419:Vmn2r118	APN	17	55,593,000 (GRCm38)	missense	probably benign	0.01
IGL01796:Vmn2r118	APN	17	55,608,585 (GRCm38)	missense	probably benign	0.30
IGL01799:Vmn2r118	APN	17	55,592,990 (GRCm38)	missense	probably damaging	1.00
IGL02002:Vmn2r118	APN	17	55,592,619 (GRCm38)	missense	probably damaging	1.00
IGL02075:Vmn2r118	APN	17	55,610,517 (GRCm38)	missense	probably benign	0.18
IGL02172:Vmn2r118	APN	17	55,624,598 (GRCm38)	missense	probably benign	0.00
IGL02529:Vmn2r118	APN	17	55,610,870 (GRCm38)	missense	possibly damaging	0.58
IGL02712:Vmn2r118	APN	17	55,592,655 (GRCm38)	missense	probably benign	0.21
IGL03096:Vmn2r118	APN	17	55,607,996 (GRCm38)	missense	probably damaging	1.00
R0306:Vmn2r118	UTSW	17	55,608,616 (GRCm38)	missense	possibly damaging	0.89
R0329:Vmn2r118	UTSW	17	55,610,717 (GRCm38)	missense	probably damaging	1.00
R0330:Vmn2r118	UTSW	17	55,610,717 (GRCm38)	missense	probably damaging	1.00
R0396:Vmn2r118	UTSW	17	55,608,643 (GRCm38)	missense	probably benign	0.00
R0411:Vmn2r118	UTSW	17	55,611,021 (GRCm38)	splice site	probably benign
R0627:Vmn2r118	UTSW	17	55,610,772 (GRCm38)	missense	probably benign	0.01
R0638:Vmn2r118	UTSW	17	55,608,466 (GRCm38)	missense	probably benign	0.03
R1328:Vmn2r118	UTSW	17	55,608,620 (GRCm38)	missense	probably benign	0.01
R1366:Vmn2r118	UTSW	17	55,593,237 (GRCm38)	nonsense	probably null
R1465:Vmn2r118	UTSW	17	55,610,935 (GRCm38)	missense	probably benign	0.33
R1465:Vmn2r118	UTSW	17	55,610,935 (GRCm38)	missense	probably benign	0.33
R1511:Vmn2r118	UTSW	17	55,608,496 (GRCm38)	nonsense	probably null
R1515:Vmn2r118	UTSW	17	55,610,643 (GRCm38)	missense	probably benign	0.25
R1550:Vmn2r118	UTSW	17	55,608,083 (GRCm38)	missense	probably damaging	1.00
R1779:Vmn2r118	UTSW	17	55,611,530 (GRCm38)	missense	probably benign	0.03
R1834:Vmn2r118	UTSW	17	55,592,456 (GRCm38)	missense	probably damaging	1.00
R1840:Vmn2r118	UTSW	17	55,610,406 (GRCm38)	nonsense	probably null
R1854:Vmn2r118	UTSW	17	55,611,556 (GRCm38)	missense	possibly damaging	0.57
R1967:Vmn2r118	UTSW	17	55,592,882 (GRCm38)	missense	probably damaging	1.00
R1976:Vmn2r118	UTSW	17	55,592,925 (GRCm38)	missense	probably damaging	1.00
R2308:Vmn2r118	UTSW	17	55,624,650 (GRCm38)	missense	probably benign	0.33
R3700:Vmn2r118	UTSW	17	55,608,421 (GRCm38)	missense	possibly damaging	0.68
R4334:Vmn2r118	UTSW	17	55,610,347 (GRCm38)	missense	possibly damaging	0.58
R4647:Vmn2r118	UTSW	17	55,610,665 (GRCm38)	missense	probably damaging	1.00
R4709:Vmn2r118	UTSW	17	55,610,860 (GRCm38)	missense	probably damaging	1.00
R4805:Vmn2r118	UTSW	17	55,592,581 (GRCm38)	missense	probably damaging	1.00
R4858:Vmn2r118	UTSW	17	55,592,894 (GRCm38)	missense	probably damaging	0.98
R5384:Vmn2r118	UTSW	17	55,611,565 (GRCm38)	missense	probably benign	0.00
R5385:Vmn2r118	UTSW	17	55,611,565 (GRCm38)	missense	probably benign	0.00
R5664:Vmn2r118	UTSW	17	55,592,765 (GRCm38)	missense	possibly damaging	0.46
R5740:Vmn2r118	UTSW	17	55,593,103 (GRCm38)	missense	probably benign	0.00
R5927:Vmn2r118	UTSW	17	55,624,494 (GRCm38)	missense	probably benign	0.04
R6143:Vmn2r118	UTSW	17	55,592,871 (GRCm38)	missense	possibly damaging	0.92
R6513:Vmn2r118	UTSW	17	55,608,093 (GRCm38)	missense	probably damaging	1.00
R6573:Vmn2r118	UTSW	17	55,592,996 (GRCm38)	missense	probably damaging	1.00
R6760:Vmn2r118	UTSW	17	55,592,714 (GRCm38)	missense	possibly damaging	0.92
R6794:Vmn2r118	UTSW	17	55,592,348 (GRCm38)	missense	possibly damaging	0.48
R6929:Vmn2r118	UTSW	17	55,610,440 (GRCm38)	missense	probably benign	0.01
R7201:Vmn2r118	UTSW	17	55,608,496 (GRCm38)	nonsense	probably null
R7539:Vmn2r118	UTSW	17	55,592,853 (GRCm38)	missense	probably damaging	0.98
R7836:Vmn2r118	UTSW	17	55,593,242 (GRCm38)	missense	probably damaging	0.99
R8179:Vmn2r118	UTSW	17	55,608,484 (GRCm38)	missense	probably benign	0.36
R8248:Vmn2r118	UTSW	17	55,610,936 (GRCm38)	missense	probably benign	0.18
R8347:Vmn2r118	UTSW	17	55,610,423 (GRCm38)	missense	possibly damaging	0.94
R8415:Vmn2r118	UTSW	17	55,608,057 (GRCm38)	missense	probably benign	0.08
R8428:Vmn2r118	UTSW	17	55,608,642 (GRCm38)	missense	probably benign	0.33
R8917:Vmn2r118	UTSW	17	55,610,216 (GRCm38)	missense	possibly damaging	0.82
R8993:Vmn2r118	UTSW	17	55,610,835 (GRCm38)	missense	possibly damaging	0.72
R9038:Vmn2r118	UTSW	17	55,611,649 (GRCm38)	missense	probably damaging	1.00
R9155:Vmn2r118	UTSW	17	55,610,207 (GRCm38)	missense	probably null	0.83
R9603:Vmn2r118	UTSW	17	55,592,837 (GRCm38)	missense	probably damaging	1.00
R9742:Vmn2r118	UTSW	17	55,611,009 (GRCm38)	missense	probably damaging	0.98
R9749:Vmn2r118	UTSW	17	55,608,415 (GRCm38)	critical splice donor site	probably null
R9792:Vmn2r118	UTSW	17	55,592,496 (GRCm38)	missense	probably damaging	0.99
R9793:Vmn2r118	UTSW	17	55,592,496 (GRCm38)	missense	probably damaging	0.99
R9795:Vmn2r118	UTSW	17	55,592,496 (GRCm38)	missense	probably damaging	0.99
X0022:Vmn2r118	UTSW	17	55,593,218 (GRCm38)	missense	probably damaging	1.00
Z1176:Vmn2r118	UTSW	17	55,610,655 (GRCm38)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TGGTGAACCAGATTTTCTGTGTGCC -3'
(R):5'- GTGGAAGCATTTGGAAACTGCCTG -3'

Sequencing Primer
(F):5'- CTGTGGAATCACATTCACAAAGG -3'
(R):5'- GTTGAACTCTACATTTCCAGAGG -3'

Posted On

2013-06-12