Mutagenetix > Incidental Mutation

Incidental Mutation 'R5997:Dock4'

480641

Institutional Source

Beutler Lab

Gene Symbol

Dock4

Ensembl Gene

ENSMUSG00000035954

Gene Name

dedicator of cytokinesis 4

Synonyms

EST N28122, 6330411N01Rik

MMRRC Submission

044176-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.176) question?

Stock #

R5997 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

40445952-40846874 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 40755834 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 935 (L935Q)

Ref Sequence

ENSEMBL: ENSMUSP00000047387 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000037488] [ENSMUST00000220912]

AlphaFold

P59764

Predicted Effect

probably damaging
Transcript: ENSMUST00000037488
AA Change: L935Q

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000047387
Gene: ENSMUSG00000035954
AA Change: L935Q

Domain	Start	End	E-Value	Type
SH3	9	66	7.29e-10	SMART
Pfam:DOCK_N	69	392	8.2e-110	PFAM
Pfam:DOCK-C2	397	583	1.9e-55	PFAM
low complexity region	829	842	N/A	INTRINSIC
Pfam:DHR-2	1092	1596	5e-108	PFAM
low complexity region	1651	1664	N/A	INTRINSIC
low complexity region	1681	1696	N/A	INTRINSIC
low complexity region	1700	1713	N/A	INTRINSIC
low complexity region	1842	1872	N/A	INTRINSIC
low complexity region	1883	1896	N/A	INTRINSIC
low complexity region	1940	1950	N/A	INTRINSIC
low complexity region	1958	1973	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000220912
AA Change: L935Q

PolyPhen 2 Score 0.920 (Sensitivity: 0.81; Specificity: 0.94)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000222287

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.8%
3x: 99.4%
10x: 97.1%
20x: 90.5%

Validation Efficiency

100% (78/78)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous disruption of this gene leads to complete embryonic lethality. Heterozygotes display altered blood vessel lumen formation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 78 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700061G19Rik	A	T	17: 56,876,373 (GRCm38)	D38V	probably benign	Het
Abcb9	A	T	5: 124,089,815 (GRCm38)	V121E	possibly damaging	Het
Adamts20	T	A	15: 94,379,747 (GRCm38)	Y278F	probably damaging	Het
Adcy7	A	T	8: 88,326,392 (GRCm38)	D972V	probably benign	Het
Adgrf3	C	A	5: 30,198,362 (GRCm38)		probably null	Het
Ahdc1	G	T	4: 133,063,895 (GRCm38)	G816C	probably benign	Het
Aifm3	A	G	16: 17,502,130 (GRCm38)	K283E	probably benign	Het
Akap6	T	C	12: 52,937,233 (GRCm38)		probably null	Het
Ank1	T	C	8: 23,099,662 (GRCm38)	L593P	probably damaging	Het
Apol11b	T	A	15: 77,635,497 (GRCm38)	T128S	probably benign	Het
C1qtnf7	C	A	5: 43,616,085 (GRCm38)	T235K	probably damaging	Het
Camk2a	A	T	18: 60,977,957 (GRCm38)	I73F	probably damaging	Het
Cd109	G	T	9: 78,705,062 (GRCm38)	V1244F	possibly damaging	Het
Cep164	A	G	9: 45,769,463 (GRCm38)	L1240S	possibly damaging	Het
Cnga1	T	A	5: 72,604,575 (GRCm38)	D532V	probably damaging	Het
Cyp4a14	A	T	4: 115,496,100 (GRCm38)	L5*	probably null	Het
Cyp4a30b	A	T	4: 115,459,391 (GRCm38)	K405*	probably null	Het
Dchs1	T	C	7: 105,754,095 (GRCm38)	D3080G	probably benign	Het
Ddx1	T	C	12: 13,237,799 (GRCm38)	D168G	probably damaging	Het
Dhx57	T	G	17: 80,245,806 (GRCm38)	K1231Q	probably damaging	Het
Dnah14	A	G	1: 181,770,105 (GRCm38)	N3640D	probably benign	Het
Dus2	A	T	8: 106,046,066 (GRCm38)	R269S	probably benign	Het
E230025N22Rik	G	A	18: 36,689,108 (GRCm38)	R201C	possibly damaging	Het
Erbb3	G	A	10: 128,583,185 (GRCm38)	T269M	probably damaging	Het
Fam71f2	T	A	6: 29,290,424 (GRCm38)	L267*	probably null	Het
Fbxo43	T	C	15: 36,162,093 (GRCm38)	R323G	probably damaging	Het
Fktn	A	G	4: 53,735,061 (GRCm38)	H233R	probably benign	Het
Ftsj3	A	T	11: 106,252,251 (GRCm38)	D412E	probably damaging	Het
Fzd7	A	T	1: 59,484,544 (GRCm38)	M529L	probably benign	Het
Fzr1	T	A	10: 81,370,826 (GRCm38)		probably null	Het
Ganc	T	G	2: 120,430,605 (GRCm38)	V257G	possibly damaging	Het
Gm4131	T	C	14: 62,464,758 (GRCm38)	K254E	probably damaging	Het
Gm6583	C	T	5: 112,355,008 (GRCm38)	V277M	possibly damaging	Het
Gm7347	G	T	5: 26,057,249 (GRCm38)	Y91*	probably null	Het
Gm9857	G	A	3: 108,940,165 (GRCm38)		probably benign	Het
Grpel1	T	C	5: 36,465,248 (GRCm38)	S19P	probably benign	Het
Gtf3c4	T	C	2: 28,833,711 (GRCm38)	K670E	possibly damaging	Het
Hist1h2bf	G	A	13: 23,574,103 (GRCm38)		probably benign	Het
Hmcn1	G	T	1: 150,704,173 (GRCm38)	Q1938K	possibly damaging	Het
Hnrnpk	T	C	13: 58,399,157 (GRCm38)	D71G	probably damaging	Het
Hspa4l	G	A	3: 40,767,979 (GRCm38)	R311H	probably damaging	Het
Igkv3-5	T	A	6: 70,663,704 (GRCm38)	F56L	probably benign	Het
Igkv6-20	T	A	6: 70,335,914 (GRCm38)	T92S	possibly damaging	Het
Krt8	C	T	15: 102,000,594 (GRCm38)	V200I	possibly damaging	Het
Lamb2	A	T	9: 108,480,388 (GRCm38)	T66S	possibly damaging	Het
Lamp3	A	G	16: 19,701,028 (GRCm38)	L135S	probably benign	Het
Lrguk	A	G	6: 34,129,143 (GRCm38)	Y701C	probably damaging	Het
Mcc	G	T	18: 44,449,321 (GRCm38)	L588M	probably damaging	Het
Mcidas	T	A	13: 112,998,586 (GRCm38)	L234Q	probably damaging	Het
Mtmr14	T	A	6: 113,280,614 (GRCm38)	L208Q	probably damaging	Het
Myof	A	G	19: 37,905,299 (GRCm38)	F1139L	possibly damaging	Het
Nlrp14	C	A	7: 107,182,496 (GRCm38)	T300K	probably benign	Het
Olfr1474	A	G	19: 13,471,506 (GRCm38)	I179V	probably benign	Het
Olfr165	T	A	16: 19,407,944 (GRCm38)	H24L	probably benign	Het
Olfr716	A	T	7: 107,147,328 (GRCm38)	E4V	possibly damaging	Het
Olfr890	A	T	9: 38,143,801 (GRCm38)	Y217F	probably damaging	Het
Orc2	A	G	1: 58,472,388 (GRCm38)	I354T	probably damaging	Het
Pard3b	G	T	1: 62,076,409 (GRCm38)	S140I	probably damaging	Het
Pcgf5	A	G	19: 36,434,603 (GRCm38)	D49G	probably benign	Het
Pcsk6	T	C	7: 65,959,293 (GRCm38)	F388S	probably damaging	Het
Prokr2	A	C	2: 132,381,442 (GRCm38)	I60S	probably damaging	Het
Rab33b	A	G	3: 51,484,479 (GRCm38)	T50A	possibly damaging	Het
Rbms3	T	C	9: 116,719,389 (GRCm38)	D61G	probably damaging	Het
Rhcg	T	A	7: 79,600,514 (GRCm38)	K274*	probably null	Het
Rnf112	C	T	11: 61,451,022 (GRCm38)	V319M	possibly damaging	Het
Rnf44	A	T	13: 54,682,800 (GRCm38)	S265T	possibly damaging	Het
Sf3a3	A	G	4: 124,722,058 (GRCm38)	D168G	probably damaging	Het
Sik2	A	G	9: 50,895,342 (GRCm38)		probably null	Het
Slco1a5	T	A	6: 142,253,113 (GRCm38)	L275F	probably benign	Het
Smtnl1	T	C	2: 84,815,378 (GRCm38)	H383R	probably damaging	Het
Spns3	T	G	11: 72,539,078 (GRCm38)	T175P	probably damaging	Het
Togaram1	A	G	12: 64,995,538 (GRCm38)	T1174A	probably benign	Het
Tradd	C	T	8: 105,260,645 (GRCm38)	E10K	possibly damaging	Het
Ttc7b	A	T	12: 100,373,560 (GRCm38)	Y579N	probably damaging	Het
Uncx	G	A	5: 139,547,589 (GRCm38)	G470R	probably damaging	Het
Vav3	T	A	3: 109,501,461 (GRCm38)	M177K	probably damaging	Het
Wfs1	A	T	5: 36,967,750 (GRCm38)	I599N	probably damaging	Het
Zfp454	G	A	11: 50,873,622 (GRCm38)	H217Y	probably damaging	Het

Other mutations in Dock4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Dock4	APN	12	40,832,306 (GRCm38)	missense	possibly damaging	0.48
IGL00726:Dock4	APN	12	40,790,068 (GRCm38)	splice site	probably benign
IGL00790:Dock4	APN	12	40,834,391 (GRCm38)	missense	probably damaging	1.00
IGL01061:Dock4	APN	12	40,702,969 (GRCm38)	missense	probably benign	0.01
IGL01083:Dock4	APN	12	40,788,381 (GRCm38)	splice site	probably benign
IGL01412:Dock4	APN	12	40,730,041 (GRCm38)	splice site	probably benign
IGL01583:Dock4	APN	12	40,810,467 (GRCm38)	nonsense	probably null
IGL01603:Dock4	APN	12	40,693,031 (GRCm38)	missense	probably damaging	1.00
IGL01766:Dock4	APN	12	40,446,379 (GRCm38)	nonsense	probably null
IGL02067:Dock4	APN	12	40,834,385 (GRCm38)	missense	probably damaging	1.00
IGL02302:Dock4	APN	12	40,725,777 (GRCm38)	missense	probably damaging	1.00
IGL02406:Dock4	APN	12	40,777,207 (GRCm38)	missense	probably benign	0.01
IGL02547:Dock4	APN	12	40,737,479 (GRCm38)	missense	probably benign
IGL02613:Dock4	APN	12	40,810,466 (GRCm38)	missense	probably damaging	1.00
IGL02643:Dock4	APN	12	40,668,430 (GRCm38)	missense	probably damaging	1.00
IGL02952:Dock4	APN	12	40,710,903 (GRCm38)	critical splice donor site	probably null
IGL02994:Dock4	APN	12	40,779,160 (GRCm38)	missense	probably damaging	0.99
IGL03096:Dock4	APN	12	40,748,001 (GRCm38)	missense	probably benign	0.00
IGL03144:Dock4	APN	12	40,692,907 (GRCm38)	splice site	probably benign
IGL03223:Dock4	APN	12	40,817,594 (GRCm38)	missense	probably damaging	1.00
IGL03296:Dock4	APN	12	40,733,257 (GRCm38)	missense	possibly damaging	0.84
IGL03349:Dock4	APN	12	40,733,310 (GRCm38)	missense	probably benign	0.42
IGL03353:Dock4	APN	12	40,817,758 (GRCm38)	splice site	probably null
BB005:Dock4	UTSW	12	40,788,303 (GRCm38)	missense	probably damaging	0.98
BB015:Dock4	UTSW	12	40,788,303 (GRCm38)	missense	probably damaging	0.98
R0046:Dock4	UTSW	12	40,737,360 (GRCm38)	splice site	probably benign
R0046:Dock4	UTSW	12	40,737,360 (GRCm38)	splice site	probably benign
R0110:Dock4	UTSW	12	40,621,312 (GRCm38)	splice site	probably benign
R0238:Dock4	UTSW	12	40,737,540 (GRCm38)	missense	probably damaging	0.98
R0238:Dock4	UTSW	12	40,737,540 (GRCm38)	missense	probably damaging	0.98
R0239:Dock4	UTSW	12	40,737,540 (GRCm38)	missense	probably damaging	0.98
R0239:Dock4	UTSW	12	40,737,540 (GRCm38)	missense	probably damaging	0.98
R0472:Dock4	UTSW	12	40,838,438 (GRCm38)	intron	probably benign
R0616:Dock4	UTSW	12	40,704,415 (GRCm38)	missense	probably benign	0.31
R0647:Dock4	UTSW	12	40,710,884 (GRCm38)	missense	probably damaging	1.00
R0706:Dock4	UTSW	12	40,702,923 (GRCm38)	missense	probably damaging	0.98
R0791:Dock4	UTSW	12	40,704,481 (GRCm38)	missense	probably damaging	1.00
R0940:Dock4	UTSW	12	40,631,627 (GRCm38)	splice site	probably benign
R1087:Dock4	UTSW	12	40,729,938 (GRCm38)	missense	probably benign	0.40
R1180:Dock4	UTSW	12	40,640,414 (GRCm38)	missense	possibly damaging	0.52
R1194:Dock4	UTSW	12	40,829,616 (GRCm38)	missense	probably damaging	1.00
R1463:Dock4	UTSW	12	40,816,325 (GRCm38)	frame shift	probably null
R1468:Dock4	UTSW	12	40,755,810 (GRCm38)	missense	probably benign	0.00
R1468:Dock4	UTSW	12	40,755,810 (GRCm38)	missense	probably benign	0.00
R1523:Dock4	UTSW	12	40,693,025 (GRCm38)	missense	possibly damaging	0.88
R1616:Dock4	UTSW	12	40,669,045 (GRCm38)	missense	probably damaging	0.99
R1682:Dock4	UTSW	12	40,725,780 (GRCm38)	missense	probably damaging	1.00
R1691:Dock4	UTSW	12	40,725,755 (GRCm38)	missense	probably benign	0.26
R1693:Dock4	UTSW	12	40,834,722 (GRCm38)	missense	probably benign	0.07
R1737:Dock4	UTSW	12	40,807,001 (GRCm38)	splice site	probably null
R1802:Dock4	UTSW	12	40,794,598 (GRCm38)	missense	possibly damaging	0.90
R1813:Dock4	UTSW	12	40,636,228 (GRCm38)	missense	probably damaging	1.00
R1846:Dock4	UTSW	12	40,733,268 (GRCm38)	missense	probably benign	0.00
R1959:Dock4	UTSW	12	40,710,798 (GRCm38)	missense	probably damaging	1.00
R1975:Dock4	UTSW	12	40,779,642 (GRCm38)	splice site	probably benign
R1986:Dock4	UTSW	12	40,730,063 (GRCm38)	missense	probably damaging	1.00
R2105:Dock4	UTSW	12	40,692,989 (GRCm38)	missense	probably benign	0.00
R2134:Dock4	UTSW	12	40,745,668 (GRCm38)	missense	probably benign
R2135:Dock4	UTSW	12	40,745,668 (GRCm38)	missense	probably benign
R2154:Dock4	UTSW	12	40,844,548 (GRCm38)	small insertion	probably benign
R2154:Dock4	UTSW	12	40,820,662 (GRCm38)	missense	probably damaging	1.00
R2864:Dock4	UTSW	12	40,730,073 (GRCm38)	missense	probably damaging	1.00
R2890:Dock4	UTSW	12	40,623,801 (GRCm38)	critical splice acceptor site	probably null
R3086:Dock4	UTSW	12	40,731,863 (GRCm38)	missense	probably benign	0.02
R3808:Dock4	UTSW	12	40,672,810 (GRCm38)	missense	probably damaging	0.99
R3811:Dock4	UTSW	12	40,779,124 (GRCm38)	missense	possibly damaging	0.87
R3836:Dock4	UTSW	12	40,794,624 (GRCm38)	critical splice donor site	probably null
R3838:Dock4	UTSW	12	40,794,624 (GRCm38)	critical splice donor site	probably null
R4091:Dock4	UTSW	12	40,844,267 (GRCm38)	missense	probably damaging	0.99
R4735:Dock4	UTSW	12	40,631,526 (GRCm38)	missense	probably benign	0.31
R4752:Dock4	UTSW	12	40,446,365 (GRCm38)	missense	probably benign	0.04
R4828:Dock4	UTSW	12	40,668,437 (GRCm38)	missense	probably damaging	1.00
R5039:Dock4	UTSW	12	40,817,746 (GRCm38)	missense	probably damaging	1.00
R5092:Dock4	UTSW	12	40,844,441 (GRCm38)	missense	probably benign
R5146:Dock4	UTSW	12	40,649,492 (GRCm38)	splice site	probably null
R5213:Dock4	UTSW	12	40,676,742 (GRCm38)	missense	probably damaging	1.00
R5214:Dock4	UTSW	12	40,704,466 (GRCm38)	missense	probably benign	0.00
R5270:Dock4	UTSW	12	40,733,271 (GRCm38)	missense	probably benign	0.02
R5426:Dock4	UTSW	12	40,745,745 (GRCm38)	missense	probably damaging	1.00
R5474:Dock4	UTSW	12	40,745,731 (GRCm38)	missense	probably benign
R5544:Dock4	UTSW	12	40,834,702 (GRCm38)	missense	possibly damaging	0.87
R5615:Dock4	UTSW	12	40,649,480 (GRCm38)	missense	probably benign	0.22
R5649:Dock4	UTSW	12	40,844,540 (GRCm38)	missense	probably benign	0.03
R5702:Dock4	UTSW	12	40,737,491 (GRCm38)	missense	probably benign	0.02
R5846:Dock4	UTSW	12	40,817,736 (GRCm38)	missense	probably damaging	1.00
R5847:Dock4	UTSW	12	40,621,251 (GRCm38)	missense	probably damaging	0.97
R5895:Dock4	UTSW	12	40,755,813 (GRCm38)	missense	probably damaging	1.00
R6011:Dock4	UTSW	12	40,817,757 (GRCm38)	critical splice donor site	probably null
R6022:Dock4	UTSW	12	40,748,110 (GRCm38)	missense	probably benign	0.04
R6038:Dock4	UTSW	12	40,733,351 (GRCm38)	splice site	probably null
R6038:Dock4	UTSW	12	40,733,351 (GRCm38)	splice site	probably null
R6179:Dock4	UTSW	12	40,731,869 (GRCm38)	missense	probably benign	0.00
R6479:Dock4	UTSW	12	40,828,955 (GRCm38)	missense	probably damaging	1.00
R6516:Dock4	UTSW	12	40,731,899 (GRCm38)	missense	possibly damaging	0.94
R6748:Dock4	UTSW	12	40,704,466 (GRCm38)	missense	probably benign	0.44
R6752:Dock4	UTSW	12	40,820,617 (GRCm38)	missense	probably damaging	1.00
R6814:Dock4	UTSW	12	40,812,326 (GRCm38)	critical splice donor site	probably null
R6864:Dock4	UTSW	12	40,745,746 (GRCm38)	missense	probably damaging	1.00
R6872:Dock4	UTSW	12	40,812,326 (GRCm38)	critical splice donor site	probably null
R6891:Dock4	UTSW	12	40,779,136 (GRCm38)	missense	probably damaging	1.00
R6937:Dock4	UTSW	12	40,834,635 (GRCm38)	missense	probably benign	0.01
R6950:Dock4	UTSW	12	40,733,314 (GRCm38)	missense	possibly damaging	0.80
R7081:Dock4	UTSW	12	40,621,286 (GRCm38)	missense	probably damaging	1.00
R7129:Dock4	UTSW	12	40,828,879 (GRCm38)	missense	probably damaging	1.00
R7140:Dock4	UTSW	12	40,636,159 (GRCm38)	missense	probably benign	0.06
R7241:Dock4	UTSW	12	40,794,860 (GRCm38)	missense	probably damaging	1.00
R7378:Dock4	UTSW	12	40,788,244 (GRCm38)	missense	possibly damaging	0.94
R7714:Dock4	UTSW	12	40,725,649 (GRCm38)	nonsense	probably null
R7720:Dock4	UTSW	12	40,806,975 (GRCm38)	missense	probably damaging	0.99
R7756:Dock4	UTSW	12	40,710,879 (GRCm38)	missense	probably benign	0.02
R7758:Dock4	UTSW	12	40,710,879 (GRCm38)	missense	probably benign	0.02
R7759:Dock4	UTSW	12	40,817,736 (GRCm38)	missense	probably damaging	1.00
R7787:Dock4	UTSW	12	40,725,677 (GRCm38)	missense	probably benign
R7879:Dock4	UTSW	12	40,730,084 (GRCm38)	missense	possibly damaging	0.76
R7928:Dock4	UTSW	12	40,788,303 (GRCm38)	missense	probably damaging	0.98
R8000:Dock4	UTSW	12	40,833,119 (GRCm38)	missense	probably benign	0.05
R8042:Dock4	UTSW	12	40,745,760 (GRCm38)	missense	probably benign	0.01
R8231:Dock4	UTSW	12	40,702,951 (GRCm38)	missense	possibly damaging	0.88
R8234:Dock4	UTSW	12	40,834,838 (GRCm38)	splice site	probably null
R8758:Dock4	UTSW	12	40,788,232 (GRCm38)	missense	probably benign	0.12
R8871:Dock4	UTSW	12	40,745,731 (GRCm38)	missense	probably benign
R8873:Dock4	UTSW	12	40,676,768 (GRCm38)	nonsense	probably null
R8884:Dock4	UTSW	12	40,806,885 (GRCm38)	missense	probably damaging	1.00
R9164:Dock4	UTSW	12	40,704,338 (GRCm38)	missense	probably damaging	1.00
R9225:Dock4	UTSW	12	40,829,670 (GRCm38)	missense	probably benign	0.02
R9276:Dock4	UTSW	12	40,649,405 (GRCm38)	missense	possibly damaging	0.48
R9307:Dock4	UTSW	12	40,636,156 (GRCm38)	missense	probably damaging	1.00
R9675:Dock4	UTSW	12	40,844,394 (GRCm38)	small insertion	probably benign
R9675:Dock4	UTSW	12	40,844,380 (GRCm38)	small insertion	probably benign
R9676:Dock4	UTSW	12	40,844,398 (GRCm38)	small insertion	probably benign
R9676:Dock4	UTSW	12	40,844,388 (GRCm38)	small insertion	probably benign
R9676:Dock4	UTSW	12	40,844,380 (GRCm38)	small insertion	probably benign
R9676:Dock4	UTSW	12	40,844,402 (GRCm38)	small insertion	probably benign
R9678:Dock4	UTSW	12	40,844,397 (GRCm38)	small insertion	probably benign
R9678:Dock4	UTSW	12	40,844,388 (GRCm38)	small insertion	probably benign
R9678:Dock4	UTSW	12	40,844,380 (GRCm38)	small insertion	probably benign
R9691:Dock4	UTSW	12	40,636,098 (GRCm38)	missense	probably damaging	1.00
RF018:Dock4	UTSW	12	40,844,399 (GRCm38)	frame shift	probably null
RF025:Dock4	UTSW	12	40,844,393 (GRCm38)	frame shift	probably null
RF063:Dock4	UTSW	12	40,844,399 (GRCm38)	frame shift	probably null
X0028:Dock4	UTSW	12	40,669,047 (GRCm38)	missense	probably benign	0.25
Z1176:Dock4	UTSW	12	40,631,616 (GRCm38)	missense	probably benign	0.16
Z1176:Dock4	UTSW	12	40,631,614 (GRCm38)	missense	probably benign	0.01
Z1177:Dock4	UTSW	12	40,817,641 (GRCm38)	missense	possibly damaging	0.88

Predicted Primers

PCR Primer
(F):5'- GGGTAAACCTGGGATCATAGC -3'
(R):5'- AGACCTCCCCTGGAAACTTTTC -3'

Sequencing Primer
(F):5'- GGTAAACCTGGGATCATAGCAACTTC -3'
(R):5'- TGATGCCTTTCTCCAAAATAACAGC -3'

Posted On

2017-06-26