Incidental Mutation 'R5998:Bcl6b'
ID |
480683 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Bcl6b
|
Ensembl Gene |
ENSMUSG00000000317 |
Gene Name |
B cell CLL/lymphoma 6, member B |
Synonyms |
Bazf |
MMRRC Submission |
044177-MU
|
Accession Numbers |
|
Essential gene? |
Possibly non essential
(E-score: 0.294)
|
Stock # |
R5998 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
11 |
Chromosomal Location |
70114954-70120624 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to C
at 70119009 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Methionine
at position 200
(I200M)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000000326
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000000326]
[ENSMUST00000153449]
|
AlphaFold |
O88282 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000000326
AA Change: I200M
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000000326 Gene: ENSMUSG00000000317 AA Change: I200M
Domain | Start | End | E-Value | Type |
BTB
|
38 |
135 |
2.17e-25 |
SMART |
low complexity region
|
143 |
163 |
N/A |
INTRINSIC |
ZnF_C2H2
|
323 |
345 |
4.11e-2 |
SMART |
ZnF_C2H2
|
351 |
373 |
2.12e-4 |
SMART |
ZnF_C2H2
|
379 |
401 |
8.34e-3 |
SMART |
ZnF_C2H2
|
407 |
429 |
1.12e-3 |
SMART |
ZnF_C2H2
|
435 |
458 |
1.33e-1 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000140542
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000153449
|
SMART Domains |
Protein: ENSMUSP00000121365 Gene: ENSMUSG00000000317
Domain | Start | End | E-Value | Type |
BTB
|
38 |
116 |
2.14e-6 |
SMART |
|
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.4%
- 10x: 97.3%
- 20x: 91.1%
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Homozygous null mice display decreased CD4+ and CD8+ cell numbers in the thymus. Homozygous mice for one null allele display decreased secondary responses of memory CD8+ T cells. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 32 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca13 |
G |
A |
11: 9,517,708 (GRCm39) |
V4437I |
probably damaging |
Het |
Acot12 |
T |
C |
13: 91,905,653 (GRCm39) |
I71T |
possibly damaging |
Het |
Adcy10 |
A |
G |
1: 165,369,218 (GRCm39) |
I630V |
probably benign |
Het |
Adcy3 |
T |
A |
12: 4,248,348 (GRCm39) |
V470E |
probably damaging |
Het |
Adcy6 |
C |
A |
15: 98,492,235 (GRCm39) |
E1008* |
probably null |
Het |
Adgrb3 |
A |
T |
1: 25,470,582 (GRCm39) |
|
probably null |
Het |
Ahrr |
T |
A |
13: 74,361,955 (GRCm39) |
S515C |
probably damaging |
Het |
Ankrd52 |
T |
C |
10: 128,218,992 (GRCm39) |
I416T |
probably damaging |
Het |
Arhgap45 |
T |
C |
10: 79,866,784 (GRCm39) |
S1096P |
probably damaging |
Het |
Atp8b4 |
A |
G |
2: 126,275,787 (GRCm39) |
|
probably null |
Het |
Btbd19 |
T |
A |
4: 116,978,196 (GRCm39) |
E234V |
probably benign |
Het |
Csmd1 |
G |
A |
8: 15,960,443 (GRCm39) |
T3324I |
probably damaging |
Het |
Cyp2a5 |
G |
A |
7: 26,536,578 (GRCm39) |
V186I |
probably benign |
Het |
Eif4a3l1 |
T |
C |
6: 136,305,622 (GRCm39) |
F28L |
probably benign |
Het |
Glb1l2 |
G |
A |
9: 26,677,299 (GRCm39) |
T533I |
possibly damaging |
Het |
Helz |
G |
T |
11: 107,576,360 (GRCm39) |
E1851* |
probably null |
Het |
Igkv15-103 |
T |
A |
6: 68,414,489 (GRCm39) |
F13Y |
unknown |
Het |
Kcnq2 |
T |
C |
2: 180,728,801 (GRCm39) |
H548R |
probably damaging |
Het |
Mcm3ap |
T |
C |
10: 76,316,976 (GRCm39) |
|
probably null |
Het |
Micall2 |
T |
C |
5: 139,692,666 (GRCm39) |
|
probably null |
Het |
Mill2 |
A |
G |
7: 18,573,989 (GRCm39) |
R25G |
probably benign |
Het |
Mtcl1 |
G |
A |
17: 66,675,275 (GRCm39) |
H1041Y |
probably damaging |
Het |
Or5k16 |
T |
C |
16: 58,736,993 (GRCm39) |
T4A |
probably benign |
Het |
Or8d2b |
G |
A |
9: 38,789,165 (GRCm39) |
R231H |
probably damaging |
Het |
Pigt |
A |
G |
2: 164,349,374 (GRCm39) |
E559G |
possibly damaging |
Het |
Pkdrej |
A |
G |
15: 85,699,654 (GRCm39) |
V2094A |
probably benign |
Het |
Prkdc |
T |
A |
16: 15,601,021 (GRCm39) |
L2894Q |
probably damaging |
Het |
Saxo4 |
A |
T |
19: 10,458,716 (GRCm39) |
W105R |
possibly damaging |
Het |
Speer4a2 |
T |
C |
5: 26,289,704 (GRCm39) |
D241G |
probably damaging |
Het |
Tmem63b |
A |
G |
17: 45,980,926 (GRCm39) |
V256A |
possibly damaging |
Het |
Zfp516 |
T |
C |
18: 82,974,639 (GRCm39) |
L279P |
probably damaging |
Het |
Zfp780b |
T |
A |
7: 27,664,047 (GRCm39) |
K169N |
probably benign |
Het |
|
Other mutations in Bcl6b |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00561:Bcl6b
|
APN |
11 |
70,119,310 (GRCm39) |
unclassified |
probably benign |
|
IGL01942:Bcl6b
|
APN |
11 |
70,117,569 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02338:Bcl6b
|
APN |
11 |
70,119,918 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02725:Bcl6b
|
APN |
11 |
70,119,344 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02741:Bcl6b
|
APN |
11 |
70,119,942 (GRCm39) |
missense |
probably damaging |
0.99 |
R4407:Bcl6b
|
UTSW |
11 |
70,116,929 (GRCm39) |
missense |
probably damaging |
1.00 |
R5508:Bcl6b
|
UTSW |
11 |
70,116,919 (GRCm39) |
missense |
probably damaging |
1.00 |
R6257:Bcl6b
|
UTSW |
11 |
70,116,878 (GRCm39) |
missense |
probably benign |
|
R6600:Bcl6b
|
UTSW |
11 |
70,119,954 (GRCm39) |
missense |
probably damaging |
1.00 |
R7107:Bcl6b
|
UTSW |
11 |
70,117,396 (GRCm39) |
missense |
probably damaging |
1.00 |
R7896:Bcl6b
|
UTSW |
11 |
70,117,848 (GRCm39) |
nonsense |
probably null |
|
R8690:Bcl6b
|
UTSW |
11 |
70,117,447 (GRCm39) |
missense |
probably damaging |
0.99 |
R9223:Bcl6b
|
UTSW |
11 |
70,117,400 (GRCm39) |
nonsense |
probably null |
|
R9594:Bcl6b
|
UTSW |
11 |
70,118,858 (GRCm39) |
critical splice donor site |
probably null |
|
R9733:Bcl6b
|
UTSW |
11 |
70,119,323 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Predicted Primers |
PCR Primer
(F):5'- CAATGGCCTACTCAATGGCTC -3'
(R):5'- TCTAGGCATCTCCTTGCGAC -3'
Sequencing Primer
(F):5'- GTGGACCAGACTCTAAAACTCTTGG -3'
(R):5'- ATCTCCTTGCGACCTGTGGAG -3'
|
Posted On |
2017-06-26 |