Incidental Mutation 'R5998:Saxo4'
ID |
480695 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Saxo4
|
Ensembl Gene |
ENSMUSG00000035179 |
Gene Name |
stabilizer of axonemal microtubules 4 |
Synonyms |
IIIG9, IIIG9L, 4930579J09Rik, Ppp1r32, IIIG9S |
MMRRC Submission |
044177-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R5998 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
19 |
Chromosomal Location |
10451599-10460292 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 10458716 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tryptophan to Arginine
at position 105
(W105R)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000035684
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000038842]
|
AlphaFold |
no structure available at present |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000038842
AA Change: W105R
PolyPhen 2
Score 0.496 (Sensitivity: 0.88; Specificity: 0.90)
|
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.4%
- 10x: 97.3%
- 20x: 91.1%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 32 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca13 |
G |
A |
11: 9,517,708 (GRCm39) |
V4437I |
probably damaging |
Het |
Acot12 |
T |
C |
13: 91,905,653 (GRCm39) |
I71T |
possibly damaging |
Het |
Adcy10 |
A |
G |
1: 165,369,218 (GRCm39) |
I630V |
probably benign |
Het |
Adcy3 |
T |
A |
12: 4,248,348 (GRCm39) |
V470E |
probably damaging |
Het |
Adcy6 |
C |
A |
15: 98,492,235 (GRCm39) |
E1008* |
probably null |
Het |
Adgrb3 |
A |
T |
1: 25,470,582 (GRCm39) |
|
probably null |
Het |
Ahrr |
T |
A |
13: 74,361,955 (GRCm39) |
S515C |
probably damaging |
Het |
Ankrd52 |
T |
C |
10: 128,218,992 (GRCm39) |
I416T |
probably damaging |
Het |
Arhgap45 |
T |
C |
10: 79,866,784 (GRCm39) |
S1096P |
probably damaging |
Het |
Atp8b4 |
A |
G |
2: 126,275,787 (GRCm39) |
|
probably null |
Het |
Bcl6b |
A |
C |
11: 70,119,009 (GRCm39) |
I200M |
probably damaging |
Het |
Btbd19 |
T |
A |
4: 116,978,196 (GRCm39) |
E234V |
probably benign |
Het |
Csmd1 |
G |
A |
8: 15,960,443 (GRCm39) |
T3324I |
probably damaging |
Het |
Cyp2a5 |
G |
A |
7: 26,536,578 (GRCm39) |
V186I |
probably benign |
Het |
Eif4a3l1 |
T |
C |
6: 136,305,622 (GRCm39) |
F28L |
probably benign |
Het |
Glb1l2 |
G |
A |
9: 26,677,299 (GRCm39) |
T533I |
possibly damaging |
Het |
Helz |
G |
T |
11: 107,576,360 (GRCm39) |
E1851* |
probably null |
Het |
Igkv15-103 |
T |
A |
6: 68,414,489 (GRCm39) |
F13Y |
unknown |
Het |
Kcnq2 |
T |
C |
2: 180,728,801 (GRCm39) |
H548R |
probably damaging |
Het |
Mcm3ap |
T |
C |
10: 76,316,976 (GRCm39) |
|
probably null |
Het |
Micall2 |
T |
C |
5: 139,692,666 (GRCm39) |
|
probably null |
Het |
Mill2 |
A |
G |
7: 18,573,989 (GRCm39) |
R25G |
probably benign |
Het |
Mtcl1 |
G |
A |
17: 66,675,275 (GRCm39) |
H1041Y |
probably damaging |
Het |
Or5k16 |
T |
C |
16: 58,736,993 (GRCm39) |
T4A |
probably benign |
Het |
Or8d2b |
G |
A |
9: 38,789,165 (GRCm39) |
R231H |
probably damaging |
Het |
Pigt |
A |
G |
2: 164,349,374 (GRCm39) |
E559G |
possibly damaging |
Het |
Pkdrej |
A |
G |
15: 85,699,654 (GRCm39) |
V2094A |
probably benign |
Het |
Prkdc |
T |
A |
16: 15,601,021 (GRCm39) |
L2894Q |
probably damaging |
Het |
Speer4a2 |
T |
C |
5: 26,289,704 (GRCm39) |
D241G |
probably damaging |
Het |
Tmem63b |
A |
G |
17: 45,980,926 (GRCm39) |
V256A |
possibly damaging |
Het |
Zfp516 |
T |
C |
18: 82,974,639 (GRCm39) |
L279P |
probably damaging |
Het |
Zfp780b |
T |
A |
7: 27,664,047 (GRCm39) |
K169N |
probably benign |
Het |
|
Other mutations in Saxo4 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00959:Saxo4
|
APN |
19 |
10,454,887 (GRCm39) |
critical splice donor site |
probably null |
|
IGL00979:Saxo4
|
APN |
19 |
10,451,863 (GRCm39) |
makesense |
probably null |
|
IGL02405:Saxo4
|
APN |
19 |
10,451,930 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02664:Saxo4
|
APN |
19 |
10,459,655 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03105:Saxo4
|
APN |
19 |
10,454,384 (GRCm39) |
splice site |
probably benign |
|
R0255:Saxo4
|
UTSW |
19 |
10,452,418 (GRCm39) |
missense |
probably damaging |
1.00 |
R0268:Saxo4
|
UTSW |
19 |
10,454,449 (GRCm39) |
missense |
possibly damaging |
0.88 |
R1018:Saxo4
|
UTSW |
19 |
10,456,824 (GRCm39) |
splice site |
probably benign |
|
R1559:Saxo4
|
UTSW |
19 |
10,458,770 (GRCm39) |
missense |
probably benign |
0.01 |
R2384:Saxo4
|
UTSW |
19 |
10,458,646 (GRCm39) |
critical splice donor site |
probably null |
|
R4362:Saxo4
|
UTSW |
19 |
10,452,385 (GRCm39) |
missense |
probably damaging |
1.00 |
R4884:Saxo4
|
UTSW |
19 |
10,451,865 (GRCm39) |
makesense |
probably null |
|
R6130:Saxo4
|
UTSW |
19 |
10,455,128 (GRCm39) |
missense |
probably benign |
0.16 |
R6360:Saxo4
|
UTSW |
19 |
10,456,845 (GRCm39) |
missense |
probably damaging |
1.00 |
R6388:Saxo4
|
UTSW |
19 |
10,459,665 (GRCm39) |
missense |
probably damaging |
1.00 |
R6625:Saxo4
|
UTSW |
19 |
10,459,100 (GRCm39) |
missense |
probably damaging |
0.97 |
R6754:Saxo4
|
UTSW |
19 |
10,454,453 (GRCm39) |
missense |
probably damaging |
1.00 |
R7188:Saxo4
|
UTSW |
19 |
10,459,702 (GRCm39) |
missense |
probably benign |
0.15 |
R7361:Saxo4
|
UTSW |
19 |
10,456,943 (GRCm39) |
missense |
probably damaging |
1.00 |
R7679:Saxo4
|
UTSW |
19 |
10,459,618 (GRCm39) |
missense |
probably damaging |
1.00 |
R8157:Saxo4
|
UTSW |
19 |
10,455,629 (GRCm39) |
missense |
probably damaging |
1.00 |
R8797:Saxo4
|
UTSW |
19 |
10,455,602 (GRCm39) |
missense |
probably benign |
0.43 |
R8859:Saxo4
|
UTSW |
19 |
10,459,599 (GRCm39) |
missense |
probably damaging |
1.00 |
R9315:Saxo4
|
UTSW |
19 |
10,458,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TATGCAATGGGTAGAGGTGC -3'
(R):5'- TCCAAAGCAAGGCCTGAATG -3'
Sequencing Primer
(F):5'- CTACTTCAGCTTGCTAGAGGAAC -3'
(R):5'- AGATGATGCTCCTGGGAATAAGTAC -3'
|
Posted On |
2017-06-26 |