Incidental Mutation 'R5992:Corin'
| ID |
480877 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Corin
|
| Ensembl Gene |
ENSMUSG00000005220 |
| Gene Name |
corin |
| Synonyms |
Lrp4 |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.253)
|
| Stock # |
R5992 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
72300025-72504473 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 72316389 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Leucine
at position 699
(H699L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135889
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005352]
[ENSMUST00000167460]
[ENSMUST00000175766]
[ENSMUST00000176974]
[ENSMUST00000177290]
|
| AlphaFold |
Q9Z319 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000005352
AA Change: H840L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000005352
Gene: ENSMUSG00000005220
AA Change: H840L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
15 |
N/A |
INTRINSIC |
|
transmembrane domain
|
113 |
135 |
N/A |
INTRINSIC |
|
FRI
|
205 |
318 |
6.15e-11 |
SMART |
|
LDLa
|
336 |
372 |
1.31e-8 |
SMART |
|
LDLa
|
373 |
408 |
1.5e-8 |
SMART |
|
LDLa
|
409 |
447 |
5.47e-11 |
SMART |
|
LDLa
|
448 |
484 |
1.22e-8 |
SMART |
|
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
|
FRI
|
522 |
643 |
2.75e-31 |
SMART |
|
LDLa
|
647 |
684 |
2.19e-10 |
SMART |
|
LDLa
|
685 |
722 |
1.76e-5 |
SMART |
|
LDLa
|
723 |
759 |
4.18e-7 |
SMART |
|
SR
|
758 |
853 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
868 |
1097 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167460
AA Change: H774L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000127389
Gene: ENSMUSG00000005220
AA Change: H774L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
342 |
1.5e-8 |
SMART |
|
LDLa
|
343 |
381 |
5.47e-11 |
SMART |
|
LDLa
|
382 |
418 |
1.22e-8 |
SMART |
|
low complexity region
|
442 |
455 |
N/A |
INTRINSIC |
|
FRI
|
456 |
577 |
2.75e-31 |
SMART |
|
LDLa
|
581 |
618 |
2.19e-10 |
SMART |
|
LDLa
|
619 |
656 |
1.76e-5 |
SMART |
|
LDLa
|
657 |
693 |
4.18e-7 |
SMART |
|
SR
|
692 |
787 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
802 |
1031 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175766
AA Change: H699L
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000135889
Gene: ENSMUSG00000005220
AA Change: H699L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
45 |
67 |
N/A |
INTRINSIC |
|
FRI
|
137 |
250 |
6.15e-11 |
SMART |
|
LDLa
|
268 |
304 |
1.31e-8 |
SMART |
|
LDLa
|
305 |
343 |
2.07e-11 |
SMART |
|
low complexity region
|
367 |
380 |
N/A |
INTRINSIC |
|
FRI
|
381 |
502 |
2.75e-31 |
SMART |
|
LDLa
|
506 |
543 |
2.19e-10 |
SMART |
|
LDLa
|
544 |
581 |
1.76e-5 |
SMART |
|
LDLa
|
582 |
618 |
4.18e-7 |
SMART |
|
SR
|
617 |
712 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
727 |
956 |
5.45e-76 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176396
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176974
AA Change: H737L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000135722
Gene: ENSMUSG00000005220
AA Change: H737L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
344 |
3.86e-11 |
SMART |
|
LDLa
|
345 |
381 |
1.22e-8 |
SMART |
|
low complexity region
|
405 |
418 |
N/A |
INTRINSIC |
|
FRI
|
419 |
540 |
2.75e-31 |
SMART |
|
LDLa
|
544 |
581 |
2.19e-10 |
SMART |
|
LDLa
|
582 |
619 |
1.76e-5 |
SMART |
|
LDLa
|
620 |
656 |
4.18e-7 |
SMART |
|
SR
|
655 |
750 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
765 |
994 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177290
AA Change: H707L
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000135511
Gene: ENSMUSG00000005220
AA Change: H707L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
72 |
185 |
6.15e-11 |
SMART |
|
LDLa
|
203 |
239 |
1.31e-8 |
SMART |
|
LDLa
|
240 |
275 |
1.5e-8 |
SMART |
|
LDLa
|
276 |
314 |
5.47e-11 |
SMART |
|
LDLa
|
315 |
351 |
1.22e-8 |
SMART |
|
low complexity region
|
375 |
388 |
N/A |
INTRINSIC |
|
FRI
|
389 |
510 |
2.75e-31 |
SMART |
|
LDLa
|
514 |
551 |
2.19e-10 |
SMART |
|
LDLa
|
552 |
589 |
1.76e-5 |
SMART |
|
LDLa
|
590 |
626 |
4.18e-7 |
SMART |
|
SR
|
625 |
720 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
735 |
964 |
5.45e-76 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.4%
- 20x: 91.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
PHENOTYPE: Homozygous null mice display hypertension that is enhanced by high-salt diet and pregnancy, increased body weight, and cardiac hypertrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 73 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aars2 |
T |
A |
17: 45,508,623 (GRCm38) |
L188* |
probably null |
Het |
| Acod1 |
C |
T |
14: 103,055,035 (GRCm38) |
R332C |
probably damaging |
Het |
| Adamts3 |
T |
A |
5: 89,691,335 (GRCm38) |
K852M |
probably damaging |
Het |
| Adm |
A |
T |
7: 110,627,696 (GRCm38) |
|
probably benign |
Het |
| Aff4 |
A |
G |
11: 53,373,010 (GRCm38) |
S286G |
probably damaging |
Het |
| Ank2 |
A |
G |
3: 126,959,651 (GRCm38) |
|
probably null |
Het |
| Aqr |
A |
T |
2: 114,143,049 (GRCm38) |
Y427* |
probably null |
Het |
| Arid1b |
C |
A |
17: 4,994,956 (GRCm38) |
|
probably benign |
Het |
| Arpp21 |
T |
A |
9: 112,143,485 (GRCm38) |
R259* |
probably null |
Het |
| Cep290 |
C |
T |
10: 100,543,321 (GRCm38) |
A55V |
possibly damaging |
Het |
| Chsy3 |
GT |
G |
18: 59,176,166 (GRCm38) |
163 |
probably null |
Het |
| Clcn2 |
T |
C |
16: 20,713,654 (GRCm38) |
E68G |
possibly damaging |
Het |
| Cyld |
T |
C |
8: 88,733,053 (GRCm38) |
Y446H |
probably damaging |
Het |
| Dcst1 |
T |
A |
3: 89,352,576 (GRCm38) |
E613V |
probably damaging |
Het |
| Dlk1 |
T |
C |
12: 109,455,581 (GRCm38) |
C74R |
probably damaging |
Het |
| Dnah12 |
A |
C |
14: 26,697,341 (GRCm38) |
K128T |
probably benign |
Het |
| Dspp |
T |
A |
5: 104,178,451 (GRCm38) |
S893R |
unknown |
Het |
| Dtl |
A |
T |
1: 191,568,572 (GRCm38) |
|
probably null |
Het |
| F2rl1 |
T |
A |
13: 95,514,270 (GRCm38) |
S35C |
probably benign |
Het |
| Fcgbp |
A |
T |
7: 28,120,534 (GRCm38) |
Y2562F |
probably benign |
Het |
| Fgf10 |
A |
T |
13: 118,715,508 (GRCm38) |
D42V |
probably benign |
Het |
| Gm10271 |
A |
T |
10: 116,972,592 (GRCm38) |
F6L |
probably damaging |
Het |
| Gm21190 |
T |
A |
5: 15,524,851 (GRCm38) |
E256D |
probably damaging |
Het |
| Gm5157 |
A |
G |
7: 21,185,421 (GRCm38) |
S66P |
probably damaging |
Het |
| Hal |
T |
G |
10: 93,490,916 (GRCm38) |
L138R |
probably damaging |
Het |
| Hsd17b3 |
T |
C |
13: 64,059,470 (GRCm38) |
|
probably null |
Het |
| Lrrc37 |
A |
T |
11: 103,613,792 (GRCm38) |
M2450K |
possibly damaging |
Het |
| Lrsam1 |
T |
C |
2: 32,955,222 (GRCm38) |
T94A |
probably benign |
Het |
| Macc1 |
T |
C |
12: 119,447,585 (GRCm38) |
V696A |
probably damaging |
Het |
| Magi2 |
G |
A |
5: 19,227,291 (GRCm38) |
M1I |
probably null |
Het |
| Marchf7 |
C |
A |
2: 60,245,220 (GRCm38) |
N674K |
probably benign |
Het |
| Mfap1b |
A |
G |
2: 121,470,295 (GRCm38) |
V34A |
probably benign |
Het |
| Mob3b |
G |
A |
4: 35,084,069 (GRCm38) |
S40L |
probably benign |
Het |
| Ndufs2 |
A |
T |
1: 171,236,418 (GRCm38) |
V386E |
probably damaging |
Het |
| Nfic |
C |
T |
10: 81,420,747 (GRCm38) |
A19T |
probably damaging |
Het |
| Nfs1 |
G |
A |
2: 156,134,453 (GRCm38) |
R174W |
probably damaging |
Het |
| Nin |
G |
T |
12: 70,045,524 (GRCm38) |
S670R |
possibly damaging |
Het |
| Nrxn1 |
T |
C |
17: 90,623,507 (GRCm38) |
I754V |
probably benign |
Het |
| Nwd1 |
T |
C |
8: 72,653,573 (GRCm38) |
|
probably null |
Het |
| Or4a39 |
T |
A |
2: 89,406,879 (GRCm38) |
M67L |
probably benign |
Het |
| Or4c1 |
T |
A |
2: 89,303,359 (GRCm38) |
T78S |
possibly damaging |
Het |
| Or51a6 |
G |
T |
7: 102,955,009 (GRCm38) |
N197K |
probably benign |
Het |
| Pcdhgb8 |
A |
G |
18: 37,763,449 (GRCm38) |
E524G |
probably damaging |
Het |
| Phlpp1 |
A |
T |
1: 106,318,993 (GRCm38) |
R638* |
probably null |
Het |
| Pkmyt1 |
G |
C |
17: 23,735,326 (GRCm38) |
W360S |
probably benign |
Het |
| Plxnd1 |
C |
A |
6: 115,967,787 (GRCm38) |
|
probably null |
Het |
| Poldip3 |
A |
T |
15: 83,129,229 (GRCm38) |
N322K |
probably damaging |
Het |
| Prmt3 |
A |
T |
7: 49,828,947 (GRCm38) |
I419L |
probably benign |
Het |
| Prss36 |
A |
T |
7: 127,944,830 (GRCm38) |
V123E |
probably damaging |
Het |
| Prss58 |
A |
G |
6: 40,897,769 (GRCm38) |
I46T |
probably damaging |
Het |
| Rac1 |
T |
C |
5: 143,506,998 (GRCm38) |
|
probably benign |
Het |
| Rb1cc1 |
A |
G |
1: 6,233,996 (GRCm38) |
Y36C |
probably damaging |
Het |
| Rif1 |
C |
G |
2: 52,095,844 (GRCm38) |
L614V |
probably damaging |
Het |
| Rnd2 |
C |
T |
11: 101,468,999 (GRCm38) |
L57F |
probably damaging |
Het |
| Rp1 |
A |
T |
1: 4,148,703 (GRCm38) |
F951L |
unknown |
Het |
| Rps6ka5 |
G |
T |
12: 100,575,250 (GRCm38) |
P417T |
possibly damaging |
Het |
| Ryr1 |
A |
G |
7: 29,067,637 (GRCm38) |
W2967R |
probably damaging |
Het |
| Sacs |
T |
A |
14: 61,205,543 (GRCm38) |
S1679R |
probably damaging |
Het |
| Scn1a |
A |
C |
2: 66,335,456 (GRCm38) |
W153G |
probably damaging |
Het |
| Serpinb7 |
A |
G |
1: 107,445,996 (GRCm38) |
Y114C |
probably damaging |
Het |
| Son |
T |
C |
16: 91,658,904 (GRCm38) |
M1513T |
probably benign |
Het |
| Spag8 |
C |
T |
4: 43,651,534 (GRCm38) |
V447M |
probably benign |
Het |
| St3gal2 |
T |
A |
8: 110,969,553 (GRCm38) |
Y257N |
probably damaging |
Het |
| Tars1 |
A |
T |
15: 11,397,196 (GRCm38) |
D40E |
probably damaging |
Het |
| Tlr3 |
T |
C |
8: 45,397,814 (GRCm38) |
H158R |
probably benign |
Het |
| Tppp2 |
G |
T |
14: 51,918,935 (GRCm38) |
V50L |
probably benign |
Het |
| Trrap |
T |
C |
5: 144,810,184 (GRCm38) |
S1503P |
probably benign |
Het |
| Ttll4 |
T |
G |
1: 74,685,391 (GRCm38) |
S573R |
probably damaging |
Het |
| Vmn2r104 |
A |
T |
17: 20,029,485 (GRCm38) |
N841K |
probably damaging |
Het |
| Vmn2r3 |
A |
T |
3: 64,259,647 (GRCm38) |
C688S |
probably damaging |
Het |
| Vps16 |
T |
C |
2: 130,424,449 (GRCm38) |
|
probably null |
Het |
| Zfp608 |
G |
A |
18: 54,899,248 (GRCm38) |
T540I |
probably benign |
Het |
| Zfp775 |
G |
A |
6: 48,619,816 (GRCm38) |
R208Q |
probably damaging |
Het |
|
| Other mutations in Corin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00557:Corin
|
APN |
5 |
72,304,888 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01114:Corin
|
APN |
5 |
72,305,011 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01351:Corin
|
APN |
5 |
72,338,991 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01516:Corin
|
APN |
5 |
72,454,487 (GRCm38) |
nonsense |
probably null |
|
|
IGL01785:Corin
|
APN |
5 |
72,339,876 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01786:Corin
|
APN |
5 |
72,339,876 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01845:Corin
|
APN |
5 |
72,353,939 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02097:Corin
|
APN |
5 |
72,372,146 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02629:Corin
|
APN |
5 |
72,332,673 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03085:Corin
|
APN |
5 |
72,353,930 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03120:Corin
|
APN |
5 |
72,360,689 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03150:Corin
|
APN |
5 |
72,302,858 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03183:Corin
|
APN |
5 |
72,301,586 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03185:Corin
|
APN |
5 |
72,332,781 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03408:Corin
|
APN |
5 |
72,342,961 (GRCm38) |
missense |
probably benign |
0.40 |
|
alpaca
|
UTSW |
5 |
72,503,952 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R0078:Corin
|
UTSW |
5 |
72,454,473 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R0724:Corin
|
UTSW |
5 |
72,332,795 (GRCm38) |
splice site |
probably benign |
|
|
R1065:Corin
|
UTSW |
5 |
72,301,650 (GRCm38) |
nonsense |
probably null |
|
|
R1301:Corin
|
UTSW |
5 |
72,304,933 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R1466:Corin
|
UTSW |
5 |
72,302,790 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1466:Corin
|
UTSW |
5 |
72,302,790 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1520:Corin
|
UTSW |
5 |
72,330,895 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1584:Corin
|
UTSW |
5 |
72,302,790 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1617:Corin
|
UTSW |
5 |
72,503,952 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R1912:Corin
|
UTSW |
5 |
72,358,403 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2059:Corin
|
UTSW |
5 |
72,316,051 (GRCm38) |
missense |
possibly damaging |
0.76 |
|
R2173:Corin
|
UTSW |
5 |
72,504,079 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2242:Corin
|
UTSW |
5 |
72,332,711 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2373:Corin
|
UTSW |
5 |
72,339,038 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2850:Corin
|
UTSW |
5 |
72,304,955 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3683:Corin
|
UTSW |
5 |
72,330,855 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3684:Corin
|
UTSW |
5 |
72,330,855 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3790:Corin
|
UTSW |
5 |
72,435,298 (GRCm38) |
missense |
probably benign |
0.38 |
|
R3847:Corin
|
UTSW |
5 |
72,422,165 (GRCm38) |
missense |
probably benign |
0.13 |
|
R3926:Corin
|
UTSW |
5 |
72,372,130 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3939:Corin
|
UTSW |
5 |
72,339,879 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R3945:Corin
|
UTSW |
5 |
72,358,424 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4079:Corin
|
UTSW |
5 |
72,503,883 (GRCm38) |
missense |
probably benign |
0.03 |
|
R4224:Corin
|
UTSW |
5 |
72,343,108 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4473:Corin
|
UTSW |
5 |
72,339,057 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4585:Corin
|
UTSW |
5 |
72,329,699 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4586:Corin
|
UTSW |
5 |
72,329,699 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4849:Corin
|
UTSW |
5 |
72,302,835 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4926:Corin
|
UTSW |
5 |
72,372,182 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5080:Corin
|
UTSW |
5 |
72,353,851 (GRCm38) |
intron |
probably benign |
|
|
R5138:Corin
|
UTSW |
5 |
72,339,059 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5262:Corin
|
UTSW |
5 |
72,304,955 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5268:Corin
|
UTSW |
5 |
72,343,019 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5302:Corin
|
UTSW |
5 |
72,316,098 (GRCm38) |
missense |
probably benign |
0.07 |
|
R5307:Corin
|
UTSW |
5 |
72,356,978 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5324:Corin
|
UTSW |
5 |
72,435,257 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5352:Corin
|
UTSW |
5 |
72,305,033 (GRCm38) |
missense |
probably benign |
0.04 |
|
R5373:Corin
|
UTSW |
5 |
72,304,953 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5374:Corin
|
UTSW |
5 |
72,304,953 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5484:Corin
|
UTSW |
5 |
72,358,484 (GRCm38) |
missense |
probably benign |
0.15 |
|
R5502:Corin
|
UTSW |
5 |
72,316,106 (GRCm38) |
nonsense |
probably null |
|
|
R5544:Corin
|
UTSW |
5 |
72,305,014 (GRCm38) |
nonsense |
probably null |
|
|
R5682:Corin
|
UTSW |
5 |
72,422,154 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R5818:Corin
|
UTSW |
5 |
72,435,395 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6115:Corin
|
UTSW |
5 |
72,360,729 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6181:Corin
|
UTSW |
5 |
72,372,096 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6317:Corin
|
UTSW |
5 |
72,339,045 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7053:Corin
|
UTSW |
5 |
72,301,527 (GRCm38) |
missense |
probably benign |
0.28 |
|
R7242:Corin
|
UTSW |
5 |
72,305,055 (GRCm38) |
missense |
probably benign |
0.14 |
|
R7452:Corin
|
UTSW |
5 |
72,435,247 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7783:Corin
|
UTSW |
5 |
72,301,624 (GRCm38) |
missense |
probably benign |
0.26 |
|
R7903:Corin
|
UTSW |
5 |
72,301,500 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7956:Corin
|
UTSW |
5 |
72,422,187 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8007:Corin
|
UTSW |
5 |
72,316,103 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R8125:Corin
|
UTSW |
5 |
72,358,463 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R8215:Corin
|
UTSW |
5 |
72,305,018 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8251:Corin
|
UTSW |
5 |
72,356,926 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8364:Corin
|
UTSW |
5 |
72,304,931 (GRCm38) |
missense |
probably benign |
|
|
R8505:Corin
|
UTSW |
5 |
72,435,407 (GRCm38) |
missense |
probably benign |
0.21 |
|
R8746:Corin
|
UTSW |
5 |
72,435,352 (GRCm38) |
missense |
probably benign |
0.31 |
|
R8887:Corin
|
UTSW |
5 |
72,329,610 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9484:Corin
|
UTSW |
5 |
72,339,937 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9640:Corin
|
UTSW |
5 |
72,435,254 (GRCm38) |
missense |
probably benign |
|
|
Z1177:Corin
|
UTSW |
5 |
72,454,493 (GRCm38) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGTTCATTCGGGCAGCAG -3'
(R):5'- TATATGCTTCCGCTGTGGTC -3'
Sequencing Primer
(F):5'- CGGCCACAGTCTAACAAGGATG -3'
(R):5'- CCGCTGTGGTCTCCAAC -3'
|
| Posted On |
2017-06-26 |
Incidental Mutation