Incidental Mutation 'R5994:Olfr978'
ID481012
Institutional Source Beutler Lab
Gene Symbol Olfr978
Ensembl Gene ENSMUSG00000044292
Gene Nameolfactory receptor 978
SynonymsMOR223-3, GA_x6K02T2PVTD-33692287-33693222
MMRRC Submission 044173-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.139) question?
Stock #R5994 (G1)
Quality Score225.009
Status Not validated
Chromosome9
Chromosomal Location39992113-39995095 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 39994223 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Stop codon at position 138 (R138*)
Ref Sequence ENSEMBL: ENSMUSP00000151115 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057161] [ENSMUST00000215523] [ENSMUST00000217600]
Predicted Effect probably null
Transcript: ENSMUST00000057161
AA Change: R138*
SMART Domains Protein: ENSMUSP00000060106
Gene: ENSMUSG00000044292
AA Change: R138*

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 3.2e-56 PFAM
Pfam:7tm_1 39 287 1.4e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215523
Predicted Effect probably null
Transcript: ENSMUST00000217600
AA Change: R138*
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.4%
  • 20x: 91.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m A T 6: 121,670,903 H1118L probably benign Het
Abca8b A G 11: 109,949,766 probably null Het
Abcb5 A T 12: 118,965,260 probably null Het
Adcy6 A T 15: 98,593,664 I1016N probably damaging Het
Afg3l2 A T 18: 67,429,070 C312S probably damaging Het
Ano8 C T 8: 71,484,834 V89M probably damaging Het
Arhgap21 C T 2: 20,881,376 G330D possibly damaging Het
Caskin1 T C 17: 24,496,961 L195P probably damaging Het
Cfap54 A G 10: 93,039,081 I514T probably damaging Het
Ctdsp2 G A 10: 126,995,820 probably benign Het
Cyp4x1 T C 4: 115,121,945 I152V probably benign Het
Dglucy G A 12: 100,842,700 R219Q probably benign Het
Disp3 G T 4: 148,254,284 A810E possibly damaging Het
Dtx4 T C 19: 12,501,153 Y22C probably damaging Het
Edaradd A T 13: 12,478,496 I105N probably damaging Het
Eepd1 C T 9: 25,603,453 P519S probably damaging Het
Fscn3 A T 6: 28,430,295 S155C probably benign Het
Gm10134 A T 2: 28,506,246 E51V probably damaging Het
Gm7247 C T 14: 51,364,348 S26F probably benign Het
Golga7 T C 8: 23,250,265 E83G probably benign Het
Gpr12 T C 5: 146,583,431 H227R probably damaging Het
Hoxa2 T G 6: 52,164,392 S85R possibly damaging Het
Hrnr T C 3: 93,332,300 S3282P unknown Het
Ift74 C A 4: 94,691,724 T543K possibly damaging Het
Klf10 C A 15: 38,296,041 R420L probably damaging Het
Krt77 T A 15: 101,862,855 I338F probably damaging Het
Limch1 A T 5: 66,974,622 S152C probably damaging Het
Mgat4e T A 1: 134,541,496 H270L probably benign Het
Myrf A T 19: 10,219,117 L504Q probably null Het
Nckipsd A G 9: 108,813,977 Q366R probably benign Het
Npy5r A T 8: 66,682,099 V14D probably benign Het
Nrap T A 19: 56,351,599 R830* probably null Het
Ogfrl1 A T 1: 23,378,989 Y103N probably damaging Het
P2rx4 T A 5: 122,725,079 L232H probably damaging Het
Pabpc2 A T 18: 39,773,894 T71S probably benign Het
Paip2b C A 6: 83,808,885 S121I probably damaging Het
Pofut1 C T 2: 153,261,229 T261I possibly damaging Het
Ppp6c G T 2: 39,210,992 T46K possibly damaging Het
Prkd2 C A 7: 16,850,336 H371Q probably benign Het
Prrc2c A T 1: 162,674,156 probably null Het
Psd3 C T 8: 67,719,968 A894T probably damaging Het
Pygm A T 19: 6,398,043 probably null Het
Pzp A T 6: 128,491,597 M989K probably damaging Het
Ralgapa2 A T 2: 146,361,453 S1159T probably benign Het
Rapgefl1 T C 11: 98,850,160 F575L probably benign Het
Rassf6 A G 5: 90,617,768 L28S probably damaging Het
Rbp3 G T 14: 33,954,900 K268N probably damaging Het
Rela C T 19: 5,647,064 T433M possibly damaging Het
Rnf103 T A 6: 71,496,910 S102R probably damaging Het
Scarf2 A G 16: 17,806,379 N516S probably damaging Het
Sdcbp2 T C 2: 151,587,483 I241T probably damaging Het
Sept7 T C 9: 25,288,198 I131T possibly damaging Het
Sh3pxd2b T C 11: 32,407,570 F191L probably damaging Het
Siglec15 C A 18: 78,047,375 C236F probably damaging Het
Slc11a2 T C 15: 100,397,681 T520A probably benign Het
Slc26a11 C A 11: 119,379,912 F553L probably benign Het
Smchd1 G A 17: 71,365,409 P1596S possibly damaging Het
Taar7b A G 10: 24,000,348 H137R probably damaging Het
Thap12 T A 7: 98,716,030 C468* probably null Het
Timp4 C T 6: 115,247,354 G118D probably damaging Het
Tnnt3 A G 7: 142,511,266 K48E probably damaging Het
Trmt10a T A 3: 138,156,714 I255N probably damaging Het
Ttll10 T C 4: 156,048,732 probably null Het
Ube4b A G 4: 149,372,932 Y283H probably damaging Het
Ucp1 G T 8: 83,293,938 V126L possibly damaging Het
Unc13b T A 4: 43,172,596 probably benign Het
Vps13b T C 15: 35,875,772 S2768P probably damaging Het
Zcchc6 T G 13: 59,789,209 Y806S probably damaging Het
Zfp101 T A 17: 33,380,962 M607L probably benign Het
Zfp292 C T 4: 34,805,464 V2527M possibly damaging Het
Zfp503 T A 14: 21,985,562 T429S possibly damaging Het
Other mutations in Olfr978
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01570:Olfr978 APN 9 39994329 missense probably damaging 0.99
IGL02429:Olfr978 APN 9 39993842 missense probably benign
IGL02887:Olfr978 APN 9 39993813 start codon destroyed probably null 0.99
R0190:Olfr978 UTSW 9 39994544 missense probably benign 0.01
R0355:Olfr978 UTSW 9 39994163 missense possibly damaging 0.72
R1348:Olfr978 UTSW 9 39993828 missense probably benign
R1856:Olfr978 UTSW 9 39994359 missense probably benign 0.29
R3853:Olfr978 UTSW 9 39994154 missense probably damaging 0.99
R3886:Olfr978 UTSW 9 39994539 missense probably damaging 1.00
R5678:Olfr978 UTSW 9 39993903 missense probably benign 0.00
R6185:Olfr978 UTSW 9 39994124 missense probably benign 0.19
R6721:Olfr978 UTSW 9 39994307 missense possibly damaging 0.55
R7414:Olfr978 UTSW 9 39994053 missense possibly damaging 0.53
R7556:Olfr978 UTSW 9 39994682 missense probably damaging 1.00
R8192:Olfr978 UTSW 9 39994171 missense probably damaging 1.00
R8422:Olfr978 UTSW 9 39994554 missense probably damaging 0.99
X0025:Olfr978 UTSW 9 39993944 missense possibly damaging 0.62
Predicted Primers PCR Primer
(F):5'- ATGACTTTGGTGTCCACAGG -3'
(R):5'- ATCCTCAGGATGGAGCAGAC -3'

Sequencing Primer
(F):5'- AGGGGGCGGGGCTATCTC -3'
(R):5'- AGATGACCATCTCATTGGCTG -3'
Posted On2017-06-26