Incidental Mutation 'R5995:Or1e26'
ID 481080
Institutional Source Beutler Lab
Gene Symbol Or1e26
Ensembl Gene ENSMUSG00000095095
Gene Name olfactory receptor family 1 subfamily E member 26
Synonyms Olfr385, GA_x6K02T2P1NL-3760313-3759375, MOR135-3
MMRRC Submission 044174-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.166) question?
Stock # R5995 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 73479624-73480562 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 73480076 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 163 (I163V)
Ref Sequence ENSEMBL: ENSMUSP00000149293 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071553] [ENSMUST00000215689]
AlphaFold Q8VGT1
Predicted Effect probably benign
Transcript: ENSMUST00000071553
AA Change: I163V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000071484
Gene: ENSMUSG00000095095
AA Change: I163V

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.1e-55 PFAM
Pfam:7TM_GPCR_Srsx 35 305 1.7e-6 PFAM
Pfam:7tm_1 41 290 2.2e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215689
AA Change: I163V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.4%
  • 20x: 91.7%
Validation Efficiency 100% (56/56)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb8 C T 5: 24,605,137 (GRCm39) R108C possibly damaging Het
Adgrb2 C A 4: 129,910,896 (GRCm39) A1104E probably damaging Het
Adgrv1 A G 13: 81,614,378 (GRCm39) V4005A probably benign Het
Bend6 T C 1: 33,917,520 (GRCm39) probably null Het
Brwd1 A T 16: 95,865,987 (GRCm39) V265E probably damaging Het
Ccdc96 A G 5: 36,643,718 (GRCm39) I575V probably damaging Het
Cd109 A T 9: 78,607,561 (GRCm39) I1094L probably benign Het
Cd44 A G 2: 102,692,015 (GRCm39) V91A probably damaging Het
Cdv3 C G 9: 103,241,202 (GRCm39) G122R probably damaging Het
Ces2c T A 8: 105,577,533 (GRCm39) V272D possibly damaging Het
Colgalt1 T A 8: 72,075,754 (GRCm39) M467K probably damaging Het
Crtam G A 9: 40,905,836 (GRCm39) T31M possibly damaging Het
Cyp7a1 C T 4: 6,272,371 (GRCm39) V281M possibly damaging Het
Dnah7a A T 1: 53,659,829 (GRCm39) N726K probably benign Het
Dok6 T C 18: 89,439,142 (GRCm39) E232G possibly damaging Het
Gm12185 T C 11: 48,806,540 (GRCm39) E217G probably benign Het
Gm7247 C T 14: 51,601,805 (GRCm39) S26F probably benign Het
Gria1 A T 11: 57,180,111 (GRCm39) Y618F probably damaging Het
H2-T22 A G 17: 36,352,377 (GRCm39) Y183H probably benign Het
Hace1 A T 10: 45,546,487 (GRCm39) I374L probably benign Het
Hif3a T A 7: 16,787,694 (GRCm39) T132S probably benign Het
Hoxa3 T A 6: 52,147,263 (GRCm39) probably benign Het
Il27 A C 7: 126,188,535 (GRCm39) probably benign Het
Klhdc1 T C 12: 69,297,548 (GRCm39) Y40H probably damaging Het
Klhl33 T G 14: 51,130,108 (GRCm39) E462A possibly damaging Het
Myh10 T C 11: 68,705,809 (GRCm39) I1979T probably benign Het
Nfkbil1 G T 17: 35,439,774 (GRCm39) F246L probably benign Het
Nlrp1b A T 11: 71,072,572 (GRCm39) F424I probably damaging Het
Nod1 A G 6: 54,921,539 (GRCm39) Y260H probably damaging Het
Ofcc1 A G 13: 40,433,898 (GRCm39) L69P probably damaging Het
Onecut2 G T 18: 64,474,619 (GRCm39) R390L probably damaging Het
Oprm1 A C 10: 6,782,520 (GRCm39) M388L probably benign Het
Or10q3 A T 19: 11,848,226 (GRCm39) I118N possibly damaging Het
Or1o3 C A 17: 37,574,539 (GRCm39) Q5H probably benign Het
Or5aq1 T C 2: 86,966,200 (GRCm39) N155S probably damaging Het
Or5b96 A C 19: 12,867,961 (GRCm39) probably null Het
Or8g53 A G 9: 39,683,988 (GRCm39) V36A probably benign Het
Pcdhgc5 T A 18: 37,954,113 (GRCm39) Y462* probably null Het
Pex1 T A 5: 3,657,704 (GRCm39) M425K possibly damaging Het
Plec A T 15: 76,070,105 (GRCm39) Y1001N probably damaging Het
Poglut3 T C 9: 53,307,195 (GRCm39) Y380H probably damaging Het
Pou2f2 T G 7: 24,796,869 (GRCm39) K236Q probably damaging Het
Rbm20 G A 19: 53,839,698 (GRCm39) E896K possibly damaging Het
Sh3tc2 T A 18: 62,123,081 (GRCm39) L614Q probably damaging Het
Skint5 T A 4: 113,751,029 (GRCm39) I339F unknown Het
Slc2a7 T C 4: 150,252,797 (GRCm39) I479T probably damaging Het
Snrk A G 9: 121,986,288 (GRCm39) N219S probably damaging Het
Supt20 T C 3: 54,616,474 (GRCm39) S245P probably damaging Het
Ttn A G 2: 76,591,636 (GRCm39) I21011T probably damaging Het
Vmn2r11 T A 5: 109,194,921 (GRCm39) I802F probably damaging Het
Vmn2r92 T C 17: 18,389,213 (GRCm39) probably null Het
Ythdc2 T A 18: 45,019,320 (GRCm39) M1363K probably damaging Het
Zan T C 5: 137,377,071 (GRCm39) probably benign Het
Zfp521 C A 18: 13,850,681 (GRCm39) C1261F probably damaging Het
Zfp980 A T 4: 145,428,479 (GRCm39) K403* probably null Het
Other mutations in Or1e26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01570:Or1e26 APN 11 73,480,209 (GRCm39) missense probably benign 0.34
IGL02045:Or1e26 APN 11 73,480,058 (GRCm39) missense probably damaging 1.00
IGL02324:Or1e26 APN 11 73,480,081 (GRCm39) missense probably benign 0.02
IGL02328:Or1e26 APN 11 73,480,081 (GRCm39) missense probably benign 0.02
IGL02562:Or1e26 APN 11 73,480,237 (GRCm39) missense probably benign
IGL02715:Or1e26 APN 11 73,479,947 (GRCm39) missense probably benign 0.00
IGL03182:Or1e26 APN 11 73,480,268 (GRCm39) missense probably benign 0.04
IGL03048:Or1e26 UTSW 11 73,479,831 (GRCm39) missense possibly damaging 0.56
R0346:Or1e26 UTSW 11 73,480,283 (GRCm39) missense probably damaging 1.00
R0675:Or1e26 UTSW 11 73,480,078 (GRCm39) missense probably damaging 1.00
R0751:Or1e26 UTSW 11 73,479,970 (GRCm39) missense probably benign 0.02
R1220:Or1e26 UTSW 11 73,480,203 (GRCm39) nonsense probably null
R1389:Or1e26 UTSW 11 73,480,369 (GRCm39) missense possibly damaging 0.88
R1484:Or1e26 UTSW 11 73,480,187 (GRCm39) missense possibly damaging 0.91
R1619:Or1e26 UTSW 11 73,480,118 (GRCm39) missense probably damaging 1.00
R2290:Or1e26 UTSW 11 73,479,745 (GRCm39) missense probably benign 0.37
R3713:Or1e26 UTSW 11 73,479,731 (GRCm39) missense probably damaging 1.00
R3781:Or1e26 UTSW 11 73,480,194 (GRCm39) nonsense probably null
R3781:Or1e26 UTSW 11 73,479,839 (GRCm39) missense probably damaging 1.00
R3782:Or1e26 UTSW 11 73,480,194 (GRCm39) nonsense probably null
R3782:Or1e26 UTSW 11 73,479,839 (GRCm39) missense probably damaging 1.00
R4402:Or1e26 UTSW 11 73,480,081 (GRCm39) missense probably benign 0.02
R4721:Or1e26 UTSW 11 73,480,273 (GRCm39) missense probably damaging 1.00
R5157:Or1e26 UTSW 11 73,480,549 (GRCm39) missense probably damaging 1.00
R6373:Or1e26 UTSW 11 73,479,724 (GRCm39) missense probably benign 0.42
R6658:Or1e26 UTSW 11 73,479,874 (GRCm39) missense probably damaging 0.99
R7046:Or1e26 UTSW 11 73,480,558 (GRCm39) missense probably benign
R7096:Or1e26 UTSW 11 73,480,463 (GRCm39) missense probably benign 0.03
R7238:Or1e26 UTSW 11 73,480,561 (GRCm39) start codon destroyed probably null 0.99
R7537:Or1e26 UTSW 11 73,480,094 (GRCm39) missense probably benign 0.04
R7548:Or1e26 UTSW 11 73,479,802 (GRCm39) missense possibly damaging 0.56
R7888:Or1e26 UTSW 11 73,480,354 (GRCm39) missense probably damaging 0.99
R7968:Or1e26 UTSW 11 73,480,154 (GRCm39) missense probably benign 0.05
R8923:Or1e26 UTSW 11 73,480,076 (GRCm39) missense probably benign
R9006:Or1e26 UTSW 11 73,480,036 (GRCm39) missense probably benign 0.40
R9281:Or1e26 UTSW 11 73,480,133 (GRCm39) missense probably benign
R9689:Or1e26 UTSW 11 73,479,686 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCTATTCCCCGTGTAGATG -3'
(R):5'- CCAAGTTGCTGCAGAACATG -3'

Sequencing Primer
(F):5'- GGCTATTCCCCGTGTAGATGAAAAC -3'
(R):5'- GACACAACCATCTCCTATGTAGGTTG -3'
Posted On 2017-06-26