Mutagenetix > Incidental Mutation

Incidental Mutation 'R5977:Or8b36'

481195

Institutional Source

Beutler Lab

Gene Symbol

Or8b36

Ensembl Gene

ENSMUSG00000094461

Gene Name

olfactory receptor family 8 subfamily B member 36

Synonyms

MOR162-6, Olfr883, GA_x6K02T2PVTD-31705144-31706073

MMRRC Submission

044159-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.106) question?

Stock #

R5977 (G1)

Quality Score

217.468

Status

Validated

Chromosome

Chromosomal Location

37937104-37938033 bp(+) (GRCm39)

Type of Mutation

frame shift

DNA Base Change (assembly)

ATTGCTGTTT to ATTGCTGTTTGCTGTTT at 37937836 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000072741 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072974]

AlphaFold

Q8VF64

Predicted Effect

probably null
Transcript: ENSMUST00000072974

SMART Domains

Protein: ENSMUSP00000072741
Gene: ENSMUSG00000094461

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	306	1.6e-48	PFAM
Pfam:7tm_1	41	288	3.7e-24	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.6%
20x: 96.3%

Validation Efficiency

97% (72/74)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017N19Rik	A	T	10: 100,451,106 (GRCm39)	R446S	probably damaging	Het
2900092C05Rik	A	T	7: 12,288,664 (GRCm39)	H159L	probably benign	Het
4933405O20Rik	G	A	7: 50,249,838 (GRCm39)	V291I	probably damaging	Het
A2ml1	A	G	6: 128,558,085 (GRCm39)	Y24H	probably damaging	Het
Adgrv1	C	T	13: 81,583,678 (GRCm39)		probably null	Het
Ankrd52	C	T	10: 128,218,566 (GRCm39)	H351Y	probably damaging	Het
Anks6	C	A	4: 47,035,748 (GRCm39)	A588S	probably benign	Het
Arl15	T	G	13: 114,070,645 (GRCm39)	V80G	probably damaging	Het
Atp8a1	A	G	5: 67,904,628 (GRCm39)	I532T	possibly damaging	Het
Birc6	T	C	17: 74,910,031 (GRCm39)	C1475R	probably damaging	Het
Carmil1	C	T	13: 24,253,719 (GRCm39)	R394Q	probably damaging	Het
Cbfa2t2	T	C	2: 154,359,697 (GRCm39)	I254T	probably damaging	Het
Cemip2	A	G	19: 21,803,447 (GRCm39)	T827A	probably benign	Het
Col6a3	A	G	1: 90,749,571 (GRCm39)	V421A	possibly damaging	Het
Cped1	T	C	6: 22,254,607 (GRCm39)	V1000A	probably damaging	Het
Cr1l	A	T	1: 194,797,076 (GRCm39)	Y282*	probably null	Het
Cryl1	G	T	14: 57,620,236 (GRCm39)	T43K	probably benign	Het
Csmd2	C	T	4: 127,952,827 (GRCm39)	P92L	probably damaging	Het
Ddx60	G	A	8: 62,474,444 (GRCm39)		probably null	Het
Dhrs7b	C	T	11: 60,743,328 (GRCm39)	R187*	probably null	Het
Dmtf1	T	C	5: 9,190,451 (GRCm39)	T88A	probably damaging	Het
Dnah2	T	C	11: 69,411,707 (GRCm39)	E305G	possibly damaging	Het
Dscaml1	A	C	9: 45,632,596 (GRCm39)	N1154T	probably benign	Het
Efhc1	A	G	1: 21,030,442 (GRCm39)	Y125C	probably damaging	Het
Egflam	T	A	15: 7,347,726 (GRCm39)	Y68F	possibly damaging	Het
Gcm2	A	G	13: 41,256,603 (GRCm39)	V382A	probably damaging	Het
Gm18358	A	G	7: 84,739,756 (GRCm39)		noncoding transcript	Het
Gm3443	T	G	19: 21,534,960 (GRCm39)	I75S	probably benign	Het
Gpr182	C	A	10: 127,586,748 (GRCm39)	V68F	possibly damaging	Het
Herc1	T	A	9: 66,340,604 (GRCm39)	M1651K	possibly damaging	Het
Hey1	A	T	3: 8,731,418 (GRCm39)		probably null	Het
Ighv1-43	A	C	12: 114,909,829 (GRCm39)	V31G	probably benign	Het
Il17rc	T	C	6: 113,459,692 (GRCm39)	V450A	probably damaging	Het
Kbtbd4	T	G	2: 90,736,487 (GRCm39)	V166G	probably benign	Het
Marveld2	T	C	13: 100,748,197 (GRCm39)	N294S	possibly damaging	Het
Mtdh	A	G	15: 34,099,720 (GRCm39)	K61E	probably damaging	Het
Muc5ac	T	C	7: 141,350,104 (GRCm39)	S616P	possibly damaging	Het
Myh15	T	C	16: 48,973,866 (GRCm39)	L1292P	probably damaging	Het
Nek8	C	T	11: 78,058,651 (GRCm39)	V550M	probably benign	Het
Nup155	T	A	15: 8,159,721 (GRCm39)		probably null	Het
Or2y17	G	A	11: 49,231,592 (GRCm39)	V78M	probably damaging	Het
Or7c70	A	T	10: 78,683,572 (GRCm39)	M59K	possibly damaging	Het
Papln	G	A	12: 83,831,143 (GRCm39)	W1099*	probably null	Het
Pcdhb17	A	G	18: 37,618,720 (GRCm39)	Y170C	probably damaging	Het
Pramel12	T	C	4: 143,144,229 (GRCm39)	Y192H	probably benign	Het
Prss39	T	G	1: 34,541,783 (GRCm39)	C287G	probably damaging	Het
Pyroxd2	A	G	19: 42,723,911 (GRCm39)	V338A	probably damaging	Het
Rab19	T	A	6: 39,360,860 (GRCm39)	F3I	probably benign	Het
Relt	A	G	7: 100,512,355 (GRCm39)		probably benign	Het
Sbf2	T	A	7: 109,977,193 (GRCm39)	H647L	probably benign	Het
Scube1	C	T	15: 83,513,689 (GRCm39)	C327Y	probably damaging	Het
Sec14l4	A	C	11: 3,990,055 (GRCm39)	Q118P	possibly damaging	Het
Shisa9	C	G	16: 12,085,292 (GRCm39)	D300E	probably benign	Het
Smg1	A	G	7: 117,740,580 (GRCm39)		probably benign	Het
Sncaip	A	G	18: 53,002,393 (GRCm39)	T305A	probably benign	Het
Sorcs3	T	C	19: 48,784,889 (GRCm39)	V1104A	probably damaging	Het
Ugt1a6b	C	T	1: 88,143,982 (GRCm39)	R201C	probably damaging	Het
Unc119b	A	G	5: 115,268,612 (GRCm39)	V91A	probably benign	Het
Uvssa	A	G	5: 33,547,204 (GRCm39)	K257E	probably damaging	Het
Vmn1r199	A	C	13: 22,567,416 (GRCm39)	M237L	probably benign	Het
Vmn1r69	G	A	7: 10,314,417 (GRCm39)	R26W	probably damaging	Het
Vmn2r54	A	G	7: 12,366,143 (GRCm39)	F264L	probably damaging	Het
Vmn2r7	C	T	3: 64,623,464 (GRCm39)	W285*	probably null	Het
Vmn2r78	T	A	7: 86,569,541 (GRCm39)	S145T	possibly damaging	Het
Vmn2r78	T	A	7: 86,604,115 (GRCm39)	N764K	probably benign	Het
Wdr5b	T	G	16: 35,862,374 (GRCm39)	H164Q	probably damaging	Het
Zcchc7	G	A	4: 44,894,982 (GRCm39)	V236I	possibly damaging	Het
Zfp729b	G	A	13: 67,739,740 (GRCm39)	R842C	probably benign	Het

Other mutations in Or8b36

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00980:Or8b36	APN	9	37,937,107 (GRCm39)	missense	probably benign	0.02
IGL02092:Or8b36	APN	9	37,937,917 (GRCm39)	missense	possibly damaging	0.80
IGL02351:Or8b36	APN	9	37,937,332 (GRCm39)	missense	possibly damaging	0.78
IGL02358:Or8b36	APN	9	37,937,332 (GRCm39)	missense	possibly damaging	0.78
IGL02807:Or8b36	APN	9	37,937,485 (GRCm39)	missense	probably damaging	1.00
R0972:Or8b36	UTSW	9	37,937,856 (GRCm39)	missense	possibly damaging	0.88
R1016:Or8b36	UTSW	9	37,937,987 (GRCm39)	missense	probably damaging	0.98
R1818:Or8b36	UTSW	9	37,937,803 (GRCm39)	missense	probably damaging	1.00
R4466:Or8b36	UTSW	9	37,937,479 (GRCm39)	missense	probably damaging	0.99
R4871:Or8b36	UTSW	9	37,937,822 (GRCm39)	missense	probably damaging	1.00
R5979:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6026:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6027:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6029:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6035:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6035:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6053:Or8b36	UTSW	9	37,937,837 (GRCm39)	frame shift	probably null
R6092:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6106:Or8b36	UTSW	9	37,937,762 (GRCm39)	missense	probably damaging	1.00
R6131:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6132:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6133:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6134:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6153:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6251:Or8b36	UTSW	9	37,937,842 (GRCm39)	frame shift	probably null
R6251:Or8b36	UTSW	9	37,937,841 (GRCm39)	frame shift	probably null
R6251:Or8b36	UTSW	9	37,937,833 (GRCm39)	frame shift	probably null
R6251:Or8b36	UTSW	9	37,937,844 (GRCm39)	frame shift	probably null
R6300:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6301:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6305:Or8b36	UTSW	9	37,937,838 (GRCm39)	frame shift	probably null
R6305:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6307:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6312:Or8b36	UTSW	9	37,937,842 (GRCm39)	frame shift	probably null
R6312:Or8b36	UTSW	9	37,937,837 (GRCm39)	frame shift	probably null
R6312:Or8b36	UTSW	9	37,937,836 (GRCm39)	frame shift	probably null
R6312:Or8b36	UTSW	9	37,937,845 (GRCm39)	frame shift	probably null
R6312:Or8b36	UTSW	9	37,937,843 (GRCm39)	nonsense	probably null
R6813:Or8b36	UTSW	9	37,937,129 (GRCm39)	missense	probably damaging	1.00
R7134:Or8b36	UTSW	9	37,937,795 (GRCm39)	missense	probably benign	0.00
R7775:Or8b36	UTSW	9	37,937,963 (GRCm39)	missense	probably damaging	1.00
R7778:Or8b36	UTSW	9	37,937,963 (GRCm39)	missense	probably damaging	1.00
R7984:Or8b36	UTSW	9	37,937,155 (GRCm39)	missense	probably damaging	1.00
R8326:Or8b36	UTSW	9	37,938,014 (GRCm39)	missense	probably benign	0.00
R9154:Or8b36	UTSW	9	37,937,690 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TGACCTTCTGTGATGGCAAC -3'
(R):5'- CCTCAGAAGCCATAAGATTTTAGTTCC -3'

Sequencing Primer
(F):5'- ATCACTATGCATGTGACATACTTCC -3'
(R):5'- CCACTTAGGTAAAACTCCTTTTCATC -3'

Posted On

2017-06-26