Incidental Mutation 'R5978:Rnf115'
ID 481243
Institutional Source Beutler Lab
Gene Symbol Rnf115
Ensembl Gene ENSMUSG00000028098
Gene Name ring finger protein 115
Synonyms Rabring7, Zfp364, 2610028E05Rik
MMRRC Submission 044160-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5978 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 96634869-96698471 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 96695982 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 256 (I256N)
Ref Sequence ENSEMBL: ENSMUSP00000029740 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029740] [ENSMUST00000199051]
AlphaFold Q9D0C1
Predicted Effect probably damaging
Transcript: ENSMUST00000029740
AA Change: I256N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000029740
Gene: ENSMUSG00000028098
AA Change: I256N

DomainStartEndE-ValueType
low complexity region 2 17 N/A INTRINSIC
RING 229 269 1.14e-8 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197286
Predicted Effect probably benign
Transcript: ENSMUST00000199051
SMART Domains Protein: ENSMUSP00000143321
Gene: ENSMUSG00000028098

DomainStartEndE-ValueType
low complexity region 2 17 N/A INTRINSIC
Pfam:zf-RING_3 18 49 4.5e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199974
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anks6 T A 4: 47,049,252 (GRCm39) S218C probably damaging Het
Atp2c2 G A 8: 120,476,614 (GRCm39) probably null Het
Ccdc146 T G 5: 21,521,966 (GRCm39) I353L probably benign Het
Cst3 A T 2: 148,714,741 (GRCm39) M112K probably benign Het
Cst3 T G 2: 148,714,742 (GRCm39) M112L probably benign Het
Cyp2j11 A C 4: 96,207,589 (GRCm39) L242R probably damaging Het
Eif5b T C 1: 38,037,361 (GRCm39) probably null Het
Espl1 A G 15: 102,224,209 (GRCm39) I1253M possibly damaging Het
Fstl5 C T 3: 76,052,392 (GRCm39) H41Y probably damaging Het
Gm11011 T C 2: 169,426,361 (GRCm39) K84R unknown Het
Hax1 GTCATCATCATCATCATC GTCATCATCATCATCATCATC 3: 89,905,247 (GRCm39) probably benign Het
Heatr5b C A 17: 79,113,465 (GRCm39) V923F probably damaging Het
Hnrnpll G A 17: 80,341,620 (GRCm39) T473M probably damaging Het
Iars1 T A 13: 49,876,469 (GRCm39) Y845N probably damaging Het
Il34 T A 8: 111,469,317 (GRCm39) D166V probably damaging Het
Kel T A 6: 41,664,979 (GRCm39) H595L probably benign Het
Krt77 T C 15: 101,771,363 (GRCm39) I313M probably benign Het
Krt84 T C 15: 101,438,665 (GRCm39) E274G probably damaging Het
Mctp2 T C 7: 71,739,936 (GRCm39) Y818C probably damaging Het
Mrc1 A T 2: 14,320,204 (GRCm39) Y1046F probably damaging Het
Myom1 A T 17: 71,424,438 (GRCm39) D1429V probably damaging Het
Ncapg2 T C 12: 116,388,291 (GRCm39) M325T possibly damaging Het
Nf1 T A 11: 79,431,245 (GRCm39) I1902N probably damaging Het
Nkain3 A T 4: 20,485,026 (GRCm39) probably null Het
Nlrc5 A T 8: 95,215,221 (GRCm39) N940Y probably damaging Het
Nlrp9a T A 7: 26,256,703 (GRCm39) I107K probably damaging Het
Ntn5 T C 7: 45,343,437 (GRCm39) S328P possibly damaging Het
Or1j17 A C 2: 36,578,694 (GRCm39) K227Q probably benign Het
Parp8 A C 13: 117,032,268 (GRCm39) S302A probably benign Het
Ptgr2 G T 12: 84,342,032 (GRCm39) E27* probably null Het
Ryr3 T A 2: 112,502,614 (GRCm39) H3515L probably benign Het
Scel A G 14: 103,766,690 (GRCm39) probably null Het
Slc4a5 T A 6: 83,254,518 (GRCm39) S572T probably benign Het
Slc4a9 T G 18: 36,668,456 (GRCm39) I705S probably damaging Het
Spint4 C T 2: 164,542,252 (GRCm39) P101L probably damaging Het
Syt9 T A 7: 107,035,620 (GRCm39) D212E probably benign Het
Tmem39a T A 16: 38,411,392 (GRCm39) M449K probably benign Het
Ttn T C 2: 76,639,143 (GRCm39) T13877A possibly damaging Het
Ube2v2 T C 16: 15,394,991 (GRCm39) N20S probably benign Het
Vmn1r14 C T 6: 57,210,929 (GRCm39) S169F probably benign Het
Vps13d T C 4: 144,849,181 (GRCm39) H2410R probably benign Het
Wdr81 G A 11: 75,335,224 (GRCm39) L1781F probably damaging Het
Zfp91 A G 19: 12,747,515 (GRCm39) I536T probably benign Het
Other mutations in Rnf115
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03388:Rnf115 APN 3 96,695,984 (GRCm39) missense probably damaging 0.98
R0051:Rnf115 UTSW 3 96,692,338 (GRCm39) missense probably damaging 1.00
R0051:Rnf115 UTSW 3 96,692,338 (GRCm39) missense probably damaging 1.00
R1864:Rnf115 UTSW 3 96,635,153 (GRCm39) unclassified probably benign
R3015:Rnf115 UTSW 3 96,661,675 (GRCm39) missense probably damaging 1.00
R4030:Rnf115 UTSW 3 96,693,299 (GRCm39) missense probably damaging 1.00
R4590:Rnf115 UTSW 3 96,695,889 (GRCm39) missense probably benign 0.00
R5370:Rnf115 UTSW 3 96,665,336 (GRCm39) missense probably benign 0.05
R5820:Rnf115 UTSW 3 96,635,164 (GRCm39) unclassified probably benign
R8767:Rnf115 UTSW 3 96,695,907 (GRCm39) missense probably damaging 1.00
R9351:Rnf115 UTSW 3 96,695,994 (GRCm39) missense probably damaging 1.00
R9649:Rnf115 UTSW 3 96,665,337 (GRCm39) missense probably damaging 0.98
R9650:Rnf115 UTSW 3 96,665,337 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- ACACCTACGTTTCTTGGGTTG -3'
(R):5'- AATGCCAGCAGTACTAGGGTC -3'

Sequencing Primer
(F):5'- AGGTTAGCCTTGACCATCCGTG -3'
(R):5'- CAGCAGTACTAGGGTCCGCAAG -3'
Posted On 2017-06-26