|Institutional Source||Beutler Lab|
|Gene Name||dipeptidylpeptidase 10|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R5979 (G1)|
|Chromosomal Location||123321471-124045559 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||A to G at 123384283 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000108225 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000112603] [ENSMUST00000112606]|
|AlphaFold||no structure available at present|
|Meta Mutation Damage Score||0.9495|
|Coding Region Coverage||
|Validation Efficiency||100% (87/87)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Dpp10||
(F):5'- GGACCTTTGGGATAGCATTGAAAATG -3'
(R):5'- CTATGTCTGTAACTAAGCAGCCAC -3'
(F):5'- GGATAGCATTGAAAATGTAAATGAGG -3'
(R):5'- GTAACTAAGCAGCCACTTTCTG -3'