Incidental Mutation 'R5980:Mup11'
ID 481366
Institutional Source Beutler Lab
Gene Symbol Mup11
Ensembl Gene ENSMUSG00000073834
Gene Name major urinary protein 11
Synonyms Gm12549
MMRRC Submission 044162-MU
Accession Numbers
Essential gene? Not available question?
Stock # R5980 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 60614465-60618410 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 60616887 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 16 (Y16H)
Ref Sequence ENSEMBL: ENSMUSP00000081592 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084544] [ENSMUST00000098046]
AlphaFold A2BIM8
P04938
Predicted Effect possibly damaging
Transcript: ENSMUST00000084544
AA Change: Y16H

PolyPhen 2 Score 0.672 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000081592
Gene: ENSMUSG00000073834
AA Change: Y16H

DomainStartEndE-ValueType
Pfam:Lipocalin 1 87 2.9e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000098046
AA Change: Y103H

PolyPhen 2 Score 0.359 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000095654
Gene: ENSMUSG00000073834
AA Change: Y103H

DomainStartEndE-ValueType
low complexity region 4 14 N/A INTRINSIC
Pfam:Lipocalin 35 174 3.4e-34 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148206
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154733
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.2%
Validation Efficiency 96% (50/52)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 T C 6: 128,544,018 (GRCm39) N508D possibly damaging Het
Ago1 C T 4: 126,354,362 (GRCm39) probably benign Het
Apol6 A T 15: 76,935,219 (GRCm39) T163S possibly damaging Het
Arhgap27 T C 11: 103,247,095 (GRCm39) T33A probably benign Het
Atg7 C A 6: 114,657,197 (GRCm39) F132L possibly damaging Het
Cep104 C A 4: 154,072,930 (GRCm39) A396E probably benign Het
Cers4 T A 8: 4,568,269 (GRCm39) C107* probably null Het
Cntn6 T C 6: 104,825,093 (GRCm39) S878P probably damaging Het
Dnah6 T C 6: 73,158,705 (GRCm39) K633E probably benign Het
Dst T A 1: 34,221,972 (GRCm39) I2592K probably benign Het
Ep400 G A 5: 110,881,595 (GRCm39) probably benign Het
Fbn1 A G 2: 125,157,324 (GRCm39) C2320R probably damaging Het
Gpi1 A G 7: 33,928,351 (GRCm39) probably null Het
Gse1 T G 8: 120,956,376 (GRCm39) probably benign Het
Hid1 G A 11: 115,241,774 (GRCm39) T612I possibly damaging Het
Ighmbp2 G T 19: 3,315,295 (GRCm39) H708Q probably benign Het
Igkv10-95 T C 6: 68,657,573 (GRCm39) S10P probably damaging Het
Igkv14-100 T C 6: 68,496,009 (GRCm39) V5A probably benign Het
Irgq G A 7: 24,232,770 (GRCm39) G204S probably damaging Het
Kansl1 T C 11: 104,234,463 (GRCm39) K681R possibly damaging Het
Kcnv1 C A 15: 44,972,810 (GRCm39) V358L probably damaging Het
Lrp2 A T 2: 69,365,349 (GRCm39) S275T probably damaging Het
Lysmd1 A T 3: 95,045,219 (GRCm39) D155V probably damaging Het
Magel2 A T 7: 62,030,344 (GRCm39) I1083F unknown Het
Mta3 T A 17: 84,015,834 (GRCm39) V12D probably damaging Het
Mtmr4 T C 11: 87,494,977 (GRCm39) I423T probably damaging Het
Mycbp G A 4: 123,804,889 (GRCm39) V91I probably benign Het
Ngly1 A C 14: 16,270,509 (GRCm38) Q72P possibly damaging Het
Nol4 T A 18: 23,085,258 (GRCm39) Q52L probably damaging Het
Nrcam T C 12: 44,618,416 (GRCm39) V808A probably damaging Het
Or10p22 A G 10: 128,826,309 (GRCm39) H176R probably damaging Het
Or5ak23 A T 2: 85,244,509 (GRCm39) F238Y probably damaging Het
Or8k24 A T 2: 86,216,141 (GRCm39) L207* probably null Het
Pate10 A C 9: 35,652,911 (GRCm39) D51A probably damaging Het
Pik3c2b C A 1: 133,016,046 (GRCm39) D869E probably benign Het
Pom121l2 T C 13: 22,167,546 (GRCm39) S606P probably damaging Het
Prdm15 G A 16: 97,613,770 (GRCm39) R517* probably null Het
Ralgapa1 T A 12: 55,817,401 (GRCm39) probably null Het
Saraf T A 8: 34,632,541 (GRCm39) F207I probably benign Het
Sema6d A G 2: 124,506,628 (GRCm39) D874G probably damaging Het
Sfrp5 A T 19: 42,190,411 (GRCm39) L14M unknown Het
Sidt1 A T 16: 44,083,675 (GRCm39) C485* probably null Het
Sptbn4 A G 7: 27,071,596 (GRCm39) Y1618H probably damaging Het
Syt14 T C 1: 192,662,716 (GRCm39) Q127R possibly damaging Het
Tbc1d2 C T 4: 46,629,912 (GRCm39) G252R probably benign Het
Ticrr G A 7: 79,310,703 (GRCm39) A206T probably damaging Het
Tmem132d T A 5: 127,861,662 (GRCm39) I820F probably benign Het
Trafd1 A G 5: 121,511,520 (GRCm39) Y433H probably damaging Het
Trim68 A G 7: 102,328,038 (GRCm39) V305A probably damaging Het
Vmn2r58 T A 7: 41,514,480 (GRCm39) Y163F possibly damaging Het
Vmn2r83 T A 10: 79,314,626 (GRCm39) H291Q probably benign Het
Vmn2r95 A G 17: 18,661,624 (GRCm39) I457V probably benign Het
Other mutations in Mup11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00955:Mup11 APN 4 60,615,549 (GRCm39) missense probably benign 0.16
IGL01118:Mup11 APN 4 60,615,779 (GRCm39) missense probably damaging 1.00
IGL01914:Mup11 APN 4 60,615,821 (GRCm39) splice site probably benign
IGL02991:Mup11 UTSW 4 60,618,275 (GRCm39) small deletion probably benign
R6164:Mup11 UTSW 4 60,618,239 (GRCm39) missense possibly damaging 0.49
R6589:Mup11 UTSW 4 60,615,540 (GRCm39) missense possibly damaging 0.68
R7208:Mup11 UTSW 4 60,615,725 (GRCm39) missense possibly damaging 0.80
R8072:Mup11 UTSW 4 60,615,777 (GRCm39) missense probably damaging 1.00
Z1176:Mup11 UTSW 4 60,616,214 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TTACTAGTAGGTGCAAGTTCCTG -3'
(R):5'- GCAAATTTGTGATTGCTAACGC -3'

Sequencing Primer
(F):5'- GGTGCAAGTTCCTGAGTTCAAAC -3'
(R):5'- CGCCTTTTGCTAATTTTACAAAAAC -3'
Posted On 2017-06-26