|Institutional Source||Beutler Lab|
|Gene Name||fos-like antigen 2|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R5982 (G1)|
|Chromosomal Location||32135801-32157842 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 32146873 bp|
|Amino Acid Change||Isoleucine to Valine at position 51 (I51V)|
|Ref Sequence||ENSEMBL: ENSMUSP00000031017 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000031017]|
|Predicted Effect||probably benign
AA Change: I51V
PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
AA Change: I51V
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.0594|
|Coding Region Coverage||
|Validation Efficiency||98% (81/83)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]
PHENOTYPE: Mice homozygous for disruptions in this gene die within one week after birth and show postnatal growth retardation. Further analysis of one allele showed abnormal cartilage development, with delayed bone ossification and impaired chondrocyte differentiation. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Fosl2||
(F):5'- TGACACATAGCCCAGAGATGG -3'
(R):5'- CGATGGTCTTGATCACTCCAG -3'
(F):5'- CCCAGAGATGGATAAGATCTTCTTGG -3'
(R):5'- ATGGTCTTGATCACTCCAGGTCTG -3'