Mutagenetix > Incidental Mutation

Incidental Mutation 'R5983:Vmn2r104'

481534

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r104

Ensembl Gene

ENSMUSG00000090315

Gene Name

vomeronasal 2, receptor 104

Synonyms

V2r7

MMRRC Submission

044164-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.109) question?

Stock #

R5983 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

20249687-20268467 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 20261970 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Proline to Serine at position 387 (P387S)

Ref Sequence

ENSEMBL: ENSMUSP00000129895 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168050]

AlphaFold

E9Q2J5

Predicted Effect

probably damaging
Transcript: ENSMUST00000168050
AA Change: P387S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000129895
Gene: ENSMUSG00000090315
AA Change: P387S

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	85	457	4e-38	PFAM
Pfam:NCD3G	512	565	2.1e-20	PFAM
Pfam:7tm_3	598	833	1.7e-52	PFAM

Meta Mutation Damage Score

0.6329

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.6%
20x: 92.6%

Validation Efficiency

100% (29/29)

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc2	T	A	19: 43,807,942 (GRCm39)	M861K	probably benign	Het
Abhd18	T	A	3: 40,864,979 (GRCm39)	F73L	probably damaging	Het
Abraxas1	A	G	5: 100,955,777 (GRCm39)	V237A	probably benign	Het
Adam26b	T	C	8: 43,974,378 (GRCm39)	Y208C	probably damaging	Het
Aire	A	G	10: 77,878,903 (GRCm39)	L48P	probably damaging	Het
Bach2	A	T	4: 32,563,324 (GRCm39)	E597V	probably damaging	Het
Ccdc170	A	T	10: 4,470,851 (GRCm39)	R232*	probably null	Het
Cfap100	A	C	6: 90,396,373 (GRCm39)		probably benign	Het
Dppa2	G	A	16: 48,136,204 (GRCm39)	M185I	probably benign	Het
Ecsit	C	T	9: 21,989,443 (GRCm39)		probably null	Het
Fbxw26	A	G	9: 109,547,033 (GRCm39)	I464T	possibly damaging	Het
Grm8	T	C	6: 27,760,220 (GRCm39)	K370R	probably benign	Het
Ide	C	T	19: 37,249,549 (GRCm39)		probably null	Het
Katnip	T	A	7: 125,449,545 (GRCm39)	W870R	probably damaging	Het
Morn3	T	C	5: 123,175,851 (GRCm39)	D179G	possibly damaging	Het
Nkapd1	A	G	9: 50,519,142 (GRCm39)	S157P	probably damaging	Het
Nvl	A	T	1: 180,964,471 (GRCm39)	D102E	probably benign	Het
Or5an10	T	A	19: 12,276,467 (GRCm39)	I10F	probably benign	Het
Rbm5	G	A	9: 107,622,141 (GRCm39)	P611L	probably damaging	Het
Rsph9	A	G	17: 46,440,406 (GRCm39)	M230T	probably benign	Het
Sacs	G	A	14: 61,442,648 (GRCm39)	V1565M	probably damaging	Het
Serpina3n	T	C	12: 104,375,288 (GRCm39)	L120P	probably damaging	Het
Spsb2	A	C	6: 124,786,711 (GRCm39)	E148A	probably benign	Het
Tmc2	T	A	2: 130,089,896 (GRCm39)	M627K	probably damaging	Het
Tmem147	T	C	7: 30,427,484 (GRCm39)	D111G	probably damaging	Het
Ttn	A	G	2: 76,572,725 (GRCm39)	V17729A	possibly damaging	Het
Zfp940	C	T	7: 29,544,477 (GRCm39)	V477M	possibly damaging	Het
Zw10	A	G	9: 48,988,745 (GRCm39)		probably null	Het

Other mutations in Vmn2r104

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn2r104	APN	17	20,258,501 (GRCm39)	missense	probably damaging	0.98
IGL01098:Vmn2r104	APN	17	20,268,358 (GRCm39)	missense	probably benign	0.27
IGL01333:Vmn2r104	APN	17	20,263,055 (GRCm39)	missense	probably benign	0.17
IGL01527:Vmn2r104	APN	17	20,263,158 (GRCm39)	missense	possibly damaging	0.82
IGL01773:Vmn2r104	APN	17	20,260,930 (GRCm39)	missense	probably benign	0.10
IGL01939:Vmn2r104	APN	17	20,250,187 (GRCm39)	missense	probably damaging	0.99
IGL02121:Vmn2r104	APN	17	20,262,056 (GRCm39)	nonsense	probably null
IGL02305:Vmn2r104	APN	17	20,263,118 (GRCm39)	missense	probably benign	0.09
IGL02374:Vmn2r104	APN	17	20,263,048 (GRCm39)	missense	probably benign	0.34
IGL03260:Vmn2r104	APN	17	20,263,083 (GRCm39)	missense	probably benign	0.05
IGL03366:Vmn2r104	APN	17	20,249,866 (GRCm39)	missense	probably damaging	1.00
R0091:Vmn2r104	UTSW	17	20,262,075 (GRCm39)	missense	possibly damaging	0.79
R0125:Vmn2r104	UTSW	17	20,250,069 (GRCm39)	missense	probably damaging	0.98
R0257:Vmn2r104	UTSW	17	20,249,889 (GRCm39)	missense	probably damaging	1.00
R0381:Vmn2r104	UTSW	17	20,268,264 (GRCm39)	nonsense	probably null
R0709:Vmn2r104	UTSW	17	20,263,166 (GRCm39)	missense	probably damaging	1.00
R0786:Vmn2r104	UTSW	17	20,262,987 (GRCm39)	missense	probably benign
R1575:Vmn2r104	UTSW	17	20,262,477 (GRCm39)	missense	probably damaging	1.00
R1827:Vmn2r104	UTSW	17	20,262,497 (GRCm39)	missense	probably damaging	0.97
R1932:Vmn2r104	UTSW	17	20,261,031 (GRCm39)	missense	probably damaging	1.00
R1956:Vmn2r104	UTSW	17	20,262,313 (GRCm39)	missense	probably damaging	0.98
R2203:Vmn2r104	UTSW	17	20,250,083 (GRCm39)	missense	probably benign	0.05
R2205:Vmn2r104	UTSW	17	20,250,083 (GRCm39)	missense	probably benign	0.05
R2859:Vmn2r104	UTSW	17	20,268,455 (GRCm39)	missense	possibly damaging	0.82
R3701:Vmn2r104	UTSW	17	20,249,818 (GRCm39)	missense	probably damaging	1.00
R3834:Vmn2r104	UTSW	17	20,250,183 (GRCm39)	missense	probably benign	0.02
R4151:Vmn2r104	UTSW	17	20,250,147 (GRCm39)	missense	probably damaging	1.00
R4470:Vmn2r104	UTSW	17	20,262,503 (GRCm39)	missense	probably damaging	1.00
R4625:Vmn2r104	UTSW	17	20,268,443 (GRCm39)	missense	probably benign	0.00
R4754:Vmn2r104	UTSW	17	20,261,030 (GRCm39)	nonsense	probably null
R4911:Vmn2r104	UTSW	17	20,250,288 (GRCm39)	missense	probably benign	0.00
R5270:Vmn2r104	UTSW	17	20,258,528 (GRCm39)	missense	probably damaging	1.00
R5279:Vmn2r104	UTSW	17	20,262,146 (GRCm39)	missense	probably benign	0.07
R5311:Vmn2r104	UTSW	17	20,250,163 (GRCm39)	missense	probably damaging	1.00
R5370:Vmn2r104	UTSW	17	20,250,450 (GRCm39)	missense	probably damaging	0.97
R5461:Vmn2r104	UTSW	17	20,250,343 (GRCm39)	missense	probably damaging	1.00
R5683:Vmn2r104	UTSW	17	20,260,981 (GRCm39)	nonsense	probably null
R5795:Vmn2r104	UTSW	17	20,250,544 (GRCm39)	missense	possibly damaging	0.89
R5795:Vmn2r104	UTSW	17	20,250,372 (GRCm39)	missense	probably benign	0.02
R5970:Vmn2r104	UTSW	17	20,249,733 (GRCm39)	missense	probably benign	0.01
R5992:Vmn2r104	UTSW	17	20,249,747 (GRCm39)	missense	probably damaging	1.00
R6066:Vmn2r104	UTSW	17	20,258,573 (GRCm39)	missense	possibly damaging	0.69
R6156:Vmn2r104	UTSW	17	20,261,909 (GRCm39)	missense	probably damaging	1.00
R6182:Vmn2r104	UTSW	17	20,250,507 (GRCm39)	missense	probably benign	0.16
R6245:Vmn2r104	UTSW	17	20,261,829 (GRCm39)	missense	possibly damaging	0.69
R6333:Vmn2r104	UTSW	17	20,249,848 (GRCm39)	missense	probably benign	0.30
R6573:Vmn2r104	UTSW	17	20,262,487 (GRCm39)	missense	probably damaging	1.00
R7101:Vmn2r104	UTSW	17	20,250,358 (GRCm39)	missense	possibly damaging	0.65
R7123:Vmn2r104	UTSW	17	20,261,088 (GRCm39)	missense	probably benign	0.12
R7485:Vmn2r104	UTSW	17	20,249,737 (GRCm39)	missense	probably benign	0.01
R7514:Vmn2r104	UTSW	17	20,249,791 (GRCm39)	missense	probably damaging	1.00
R7634:Vmn2r104	UTSW	17	20,261,971 (GRCm39)	missense	possibly damaging	0.48
R7958:Vmn2r104	UTSW	17	20,262,988 (GRCm39)	missense	probably benign
R8031:Vmn2r104	UTSW	17	20,263,048 (GRCm39)	missense	probably benign	0.34
R8094:Vmn2r104	UTSW	17	20,250,483 (GRCm39)	missense	possibly damaging	0.77
R8191:Vmn2r104	UTSW	17	20,250,465 (GRCm39)	missense	possibly damaging	0.89
R8308:Vmn2r104	UTSW	17	20,261,040 (GRCm39)	missense	possibly damaging	0.55
R8691:Vmn2r104	UTSW	17	20,262,110 (GRCm39)	missense	probably damaging	0.98
R8795:Vmn2r104	UTSW	17	20,262,988 (GRCm39)	missense	probably benign
R8900:Vmn2r104	UTSW	17	20,261,924 (GRCm39)	missense	probably damaging	0.99
R8913:Vmn2r104	UTSW	17	20,249,968 (GRCm39)	missense	probably damaging	1.00
R9180:Vmn2r104	UTSW	17	20,263,087 (GRCm39)	missense	probably benign	0.00
R9199:Vmn2r104	UTSW	17	20,262,097 (GRCm39)	missense	probably damaging	0.99
R9282:Vmn2r104	UTSW	17	20,261,098 (GRCm39)	missense	probably damaging	1.00
R9303:Vmn2r104	UTSW	17	20,268,439 (GRCm39)	missense	possibly damaging	0.90
R9305:Vmn2r104	UTSW	17	20,268,439 (GRCm39)	missense	possibly damaging	0.90
R9322:Vmn2r104	UTSW	17	20,263,087 (GRCm39)	missense	probably benign	0.00
R9325:Vmn2r104	UTSW	17	20,268,433 (GRCm39)	missense	possibly damaging	0.95
R9414:Vmn2r104	UTSW	17	20,250,250 (GRCm39)	missense	probably damaging	0.99
R9785:Vmn2r104	UTSW	17	20,268,409 (GRCm39)	missense	probably benign
RF007:Vmn2r104	UTSW	17	20,268,302 (GRCm39)	missense	probably benign	0.36
Z1177:Vmn2r104	UTSW	17	20,250,051 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GCAAAGTTCATATGTAAGAGTGCTGAC -3'
(R):5'- CATGTTAGACTCATTCCATGGAAG -3'

Sequencing Primer
(F):5'- AGAGTGCTGACAATAAAATACAGTAG -3'
(R):5'- CCATGGAAGTTTCATTTTTAGACAC -3'

Posted On

2017-06-26