Mutagenetix > Incidental Mutation

Incidental Mutation 'R5986:Vmn1r115'

481649

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r115

Ensembl Gene

ENSMUSG00000091435

Gene Name

vomeronasal 1 receptor 115

Synonyms

Gm8549

MMRRC Submission

044166-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R5986 (G1)

Quality Score

177.009

Status

Not validated

Chromosome

Chromosomal Location

20844098-20844985 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 20844522 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Proline to Leucine at position 155 (P155L)

Ref Sequence

ENSEMBL: ENSMUSP00000128692 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169374]

AlphaFold

K7N6Y3

Predicted Effect

probably benign
Transcript: ENSMUST00000169374
AA Change: P155L

PolyPhen 2 Score 0.445 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000128692
Gene: ENSMUSG00000091435
AA Change: P155L

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	294	1.4e-15	PFAM
Pfam:7tm_1	31	292	3.5e-7	PFAM
Pfam:V1R	41	289	8e-15	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.7%
20x: 92.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700011H14Rik	A	T	14: 49,232,946	L172H	probably damaging	Het
Agl	A	T	3: 116,772,496	F992I	probably damaging	Het
Ampd1	T	C	3: 103,085,397	F152L	probably damaging	Het
Ank2	T	C	3: 127,012,686	H602R	possibly damaging	Het
Ankib1	T	C	5: 3,747,071	D247G	probably damaging	Het
Bccip	T	A	7: 133,720,865	H313Q	probably benign	Het
Ccdc94	G	A	17: 55,962,030	C46Y	probably damaging	Het
Cep250	A	G	2: 155,979,277	E929G	probably damaging	Het
Chl1	C	A	6: 103,709,191	L954I	probably benign	Het
Cog5	A	T	12: 31,660,717	D32V	probably benign	Het
Cyp4f16	C	A	17: 32,544,142	A187E	probably benign	Het
Dffb	A	T	4: 153,965,593	V271E	probably damaging	Het
Dnah8	A	G	17: 30,851,630	Y4430C	possibly damaging	Het
Dpp3	T	C	19: 4,918,357	E229G	probably benign	Het
Fat3	T	A	9: 15,998,317	N2130Y	probably benign	Het
Gm13128	G	T	4: 144,332,753	V345F	probably damaging	Het
Kcnk3	T	C	5: 30,588,378	V21A	possibly damaging	Het
Kif9	G	A	9: 110,490,026	S186N	probably benign	Het
Lhfpl3	C	A	5: 22,746,426	N78K	probably benign	Het
Ly6c1	A	G	15: 75,045,608	S64P	probably damaging	Het
Mapk10	T	C	5: 103,038,580	T59A	probably benign	Het
Mars	A	T	10: 127,304,302	C394*	probably null	Het
Mettl16	T	A	11: 74,792,237	D168E	possibly damaging	Het
Mgat2	A	T	12: 69,185,384	Q244L	probably benign	Het
Mrps30	A	G	13: 118,384,565		probably null	Het
Myrip	C	A	9: 120,461,421	A702E	probably damaging	Het
Nepn	T	C	10: 52,404,072	L420P	probably damaging	Het
Nrn1	A	T	13: 36,734,264	Y9*	probably null	Het
Nup107	T	C	10: 117,759,176	Y752C	probably damaging	Het
Nutm2	A	T	13: 50,474,460	D520V	probably damaging	Het
Olfm2	C	T	9: 20,675,650	C48Y	probably damaging	Het
Olfr27	A	G	9: 39,144,982	N294S	probably null	Het
Olfr592	T	C	7: 103,187,528	F309S	possibly damaging	Het
Osbpl1a	T	A	18: 12,905,081	D271V	probably damaging	Het
Osmr	G	T	15: 6,844,453	D154E	probably benign	Het
Pcdh9	A	G	14: 93,887,048	V562A	probably damaging	Het
Peak1	A	C	9: 56,259,442	S401A	probably benign	Het
Pigk	A	T	3: 152,740,849	H195L	probably benign	Het
Plekha6	G	C	1: 133,272,307	R208P	possibly damaging	Het
Ppp2r1a	C	T	17: 20,951,346	R28C	probably damaging	Het
Ptbp3	T	C	4: 59,493,311	D123G	probably benign	Het
Ptgr2	G	A	12: 84,308,346	E285K	possibly damaging	Het
Rassf1	G	T	9: 107,551,822	V76L	possibly damaging	Het
Sec22a	A	G	16: 35,314,091	V307A	probably damaging	Het
Skint5	C	T	4: 113,995,648	V18I	probably benign	Het
Slc1a5	T	C	7: 16,782,226	V109A	probably benign	Het
St8sia5	T	A	18: 77,254,782	M396K	possibly damaging	Het
Tiam1	T	C	16: 89,789,186	E602G	probably benign	Het
Tll1	T	C	8: 64,074,263	E408G	probably damaging	Het
Tpsb2	G	A	17: 25,367,134	V109M	probably benign	Het
Trib1	T	A	15: 59,654,602		probably null	Het
Trio	G	T	15: 27,851,933	A765E	possibly damaging	Het
Uggt2	A	T	14: 119,049,426	V193E	probably damaging	Het
Wdr31	A	G	4: 62,455,876	L292S	probably benign	Het
Xrra1	T	C	7: 99,876,255	I127T	probably benign	Het
Zfp442	G	A	2: 150,408,024	Q596*	probably null	Het

Other mutations in Vmn1r115

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02340:Vmn1r115	APN	7	20844528	missense	possibly damaging	0.70
R0243:Vmn1r115	UTSW	7	20844402	missense	probably benign	0.02
R1901:Vmn1r115	UTSW	7	20844273	missense	probably benign
R2020:Vmn1r115	UTSW	7	20844169	missense	probably null	0.38
R4411:Vmn1r115	UTSW	7	20844282	missense	probably benign	0.01
R4412:Vmn1r115	UTSW	7	20844282	missense	probably benign	0.01
R4413:Vmn1r115	UTSW	7	20844282	missense	probably benign	0.01
R5226:Vmn1r115	UTSW	7	20844244	missense	probably damaging	1.00
R5570:Vmn1r115	UTSW	7	20844630	missense	possibly damaging	0.87
R6180:Vmn1r115	UTSW	7	20844715	missense	probably damaging	0.98
R8169:Vmn1r115	UTSW	7	20844219	missense	probably damaging	1.00
R8310:Vmn1r115	UTSW	7	20844894	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACGGGTTGCTCTTGTCTCAG -3'
(R):5'- TCAGTCACATGGTGGCAAGAAG -3'

Sequencing Primer
(F):5'- GTCTCAGCTTGGCCTCTGG -3'
(R):5'- ACCTGTGTCCTGAGTATC -3'

Posted On

2017-06-26