Incidental Mutation 'R5986:Nutm2'
ID 481669
Institutional Source Beutler Lab
Gene Symbol Nutm2
Ensembl Gene ENSMUSG00000071909
Gene Name NUT family member 2
Synonyms LOC328250, Gm806
MMRRC Submission 044166-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5986 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 50621343-50629391 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 50628496 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 520 (D520V)
Ref Sequence ENSEMBL: ENSMUSP00000094390 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096633]
AlphaFold Q3V0C3
Predicted Effect probably damaging
Transcript: ENSMUST00000096633
AA Change: D520V

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000094390
Gene: ENSMUSG00000071909
AA Change: D520V

DomainStartEndE-ValueType
Pfam:NUT 27 733 9e-277 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000185962
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 92.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agl A T 3: 116,566,145 (GRCm39) F992I probably damaging Het
Ampd1 T C 3: 102,992,713 (GRCm39) F152L probably damaging Het
Ank2 T C 3: 126,806,335 (GRCm39) H602R possibly damaging Het
Ankib1 T C 5: 3,797,071 (GRCm39) D247G probably damaging Het
Bccip T A 7: 133,322,594 (GRCm39) H313Q probably benign Het
Ccdc198 A T 14: 49,470,403 (GRCm39) L172H probably damaging Het
Cep250 A G 2: 155,821,197 (GRCm39) E929G probably damaging Het
Chl1 C A 6: 103,686,152 (GRCm39) L954I probably benign Het
Cog5 A T 12: 31,710,716 (GRCm39) D32V probably benign Het
Cyp4f16 C A 17: 32,763,116 (GRCm39) A187E probably benign Het
Dffb A T 4: 154,050,050 (GRCm39) V271E probably damaging Het
Dnah8 A G 17: 31,070,604 (GRCm39) Y4430C possibly damaging Het
Dpp3 T C 19: 4,968,385 (GRCm39) E229G probably benign Het
Fat3 T A 9: 15,909,613 (GRCm39) N2130Y probably benign Het
Kcnk3 T C 5: 30,745,722 (GRCm39) V21A possibly damaging Het
Kif9 G A 9: 110,319,094 (GRCm39) S186N probably benign Het
Lhfpl3 C A 5: 22,951,424 (GRCm39) N78K probably benign Het
Ly6c1 A G 15: 74,917,457 (GRCm39) S64P probably damaging Het
Mapk10 T C 5: 103,186,446 (GRCm39) T59A probably benign Het
Mars1 A T 10: 127,140,171 (GRCm39) C394* probably null Het
Mettl16 T A 11: 74,683,063 (GRCm39) D168E possibly damaging Het
Mgat2 A T 12: 69,232,158 (GRCm39) Q244L probably benign Het
Mrps30 A G 13: 118,521,101 (GRCm39) probably null Het
Myrip C A 9: 120,290,487 (GRCm39) A702E probably damaging Het
Nepn T C 10: 52,280,168 (GRCm39) L420P probably damaging Het
Nrn1 A T 13: 36,918,238 (GRCm39) Y9* probably null Het
Nup107 T C 10: 117,595,081 (GRCm39) Y752C probably damaging Het
Olfm2 C T 9: 20,586,946 (GRCm39) C48Y probably damaging Het
Or52j3 T C 7: 102,836,735 (GRCm39) F309S possibly damaging Het
Or8g19 A G 9: 39,056,278 (GRCm39) N294S probably null Het
Osbpl1a T A 18: 13,038,138 (GRCm39) D271V probably damaging Het
Osmr G T 15: 6,873,934 (GRCm39) D154E probably benign Het
Pcdh9 A G 14: 94,124,484 (GRCm39) V562A probably damaging Het
Peak1 A C 9: 56,166,726 (GRCm39) S401A probably benign Het
Pigk A T 3: 152,446,486 (GRCm39) H195L probably benign Het
Plekha6 G C 1: 133,200,045 (GRCm39) R208P possibly damaging Het
Ppp2r1a C T 17: 21,171,608 (GRCm39) R28C probably damaging Het
Pramel30 G T 4: 144,059,323 (GRCm39) V345F probably damaging Het
Ptbp3 T C 4: 59,493,311 (GRCm39) D123G probably benign Het
Ptgr2 G A 12: 84,355,120 (GRCm39) E285K possibly damaging Het
Rassf1 G T 9: 107,429,021 (GRCm39) V76L possibly damaging Het
Sec22a A G 16: 35,134,461 (GRCm39) V307A probably damaging Het
Skint5 C T 4: 113,852,845 (GRCm39) V18I probably benign Het
Slc1a5 T C 7: 16,516,151 (GRCm39) V109A probably benign Het
St8sia5 T A 18: 77,342,478 (GRCm39) M396K possibly damaging Het
Tiam1 T C 16: 89,586,074 (GRCm39) E602G probably benign Het
Tll1 T C 8: 64,527,297 (GRCm39) E408G probably damaging Het
Tpsb2 G A 17: 25,586,108 (GRCm39) V109M probably benign Het
Trib1 T A 15: 59,526,451 (GRCm39) probably null Het
Trio G T 15: 27,852,019 (GRCm39) A765E possibly damaging Het
Uggt2 A T 14: 119,286,838 (GRCm39) V193E probably damaging Het
Vmn1r115 G A 7: 20,578,447 (GRCm39) P155L probably benign Het
Wdr31 A G 4: 62,374,113 (GRCm39) L292S probably benign Het
Xrra1 T C 7: 99,525,462 (GRCm39) I127T probably benign Het
Yju2 G A 17: 56,269,030 (GRCm39) C46Y probably damaging Het
Zfp442 G A 2: 150,249,944 (GRCm39) Q596* probably null Het
Other mutations in Nutm2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00885:Nutm2 APN 13 50,628,896 (GRCm39) missense probably benign 0.18
IGL01087:Nutm2 APN 13 50,623,665 (GRCm39) missense probably damaging 1.00
IGL01707:Nutm2 APN 13 50,623,753 (GRCm39) missense probably damaging 0.96
IGL02085:Nutm2 APN 13 50,627,829 (GRCm39) splice site probably null
IGL02238:Nutm2 APN 13 50,625,075 (GRCm39) missense probably damaging 1.00
IGL02369:Nutm2 APN 13 50,623,944 (GRCm39) missense probably benign 0.16
IGL02429:Nutm2 APN 13 50,623,516 (GRCm39) missense probably benign 0.44
IGL03083:Nutm2 APN 13 50,621,480 (GRCm39) missense probably damaging 0.98
R0233:Nutm2 UTSW 13 50,621,441 (GRCm39) missense probably benign 0.41
R0233:Nutm2 UTSW 13 50,621,441 (GRCm39) missense probably benign 0.41
R0321:Nutm2 UTSW 13 50,626,991 (GRCm39) missense probably damaging 0.98
R1481:Nutm2 UTSW 13 50,623,517 (GRCm39) missense probably damaging 0.99
R1605:Nutm2 UTSW 13 50,623,955 (GRCm39) missense possibly damaging 0.68
R1679:Nutm2 UTSW 13 50,623,422 (GRCm39) missense probably benign 0.17
R1744:Nutm2 UTSW 13 50,623,390 (GRCm39) missense probably benign 0.03
R1768:Nutm2 UTSW 13 50,627,152 (GRCm39) missense probably damaging 1.00
R1969:Nutm2 UTSW 13 50,627,878 (GRCm39) missense probably damaging 1.00
R2026:Nutm2 UTSW 13 50,628,856 (GRCm39) missense probably benign 0.00
R2187:Nutm2 UTSW 13 50,621,453 (GRCm39) missense probably benign 0.00
R3912:Nutm2 UTSW 13 50,626,976 (GRCm39) missense possibly damaging 0.92
R4025:Nutm2 UTSW 13 50,623,389 (GRCm39) missense probably benign
R4367:Nutm2 UTSW 13 50,623,920 (GRCm39) missense probably benign 0.01
R4668:Nutm2 UTSW 13 50,627,033 (GRCm39) missense probably benign 0.18
R4940:Nutm2 UTSW 13 50,628,909 (GRCm39) missense possibly damaging 0.58
R4987:Nutm2 UTSW 13 50,626,379 (GRCm39) missense possibly damaging 0.93
R4988:Nutm2 UTSW 13 50,626,379 (GRCm39) missense possibly damaging 0.93
R5821:Nutm2 UTSW 13 50,623,891 (GRCm39) missense probably benign 0.01
R6189:Nutm2 UTSW 13 50,623,774 (GRCm39) missense possibly damaging 0.91
R7101:Nutm2 UTSW 13 50,626,934 (GRCm39) missense probably benign 0.00
R7192:Nutm2 UTSW 13 50,627,105 (GRCm39) missense probably damaging 1.00
R7394:Nutm2 UTSW 13 50,624,043 (GRCm39) missense probably damaging 1.00
R7591:Nutm2 UTSW 13 50,627,903 (GRCm39) missense probably damaging 0.98
R8217:Nutm2 UTSW 13 50,623,759 (GRCm39) missense probably benign 0.16
R8347:Nutm2 UTSW 13 50,626,373 (GRCm39) missense probably benign 0.05
R8811:Nutm2 UTSW 13 50,623,989 (GRCm39) missense probably benign 0.02
R9093:Nutm2 UTSW 13 50,628,964 (GRCm39) missense probably damaging 1.00
R9420:Nutm2 UTSW 13 50,626,964 (GRCm39) missense probably damaging 1.00
R9507:Nutm2 UTSW 13 50,621,455 (GRCm39) missense probably benign
R9532:Nutm2 UTSW 13 50,628,475 (GRCm39) missense probably benign 0.00
R9632:Nutm2 UTSW 13 50,628,901 (GRCm39) missense probably benign 0.10
R9650:Nutm2 UTSW 13 50,623,755 (GRCm39) missense probably benign 0.25
R9683:Nutm2 UTSW 13 50,629,017 (GRCm39) missense possibly damaging 0.92
X0028:Nutm2 UTSW 13 50,626,990 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- TGACTAGTCCCTTGGCTAACTC -3'
(R):5'- ACGGGGAATACCAGTGTATCTG -3'

Sequencing Primer
(F):5'- TTGGCTAACTCCACCCAAATG -3'
(R):5'- GGAATACCAGTGTATCTGACGTC -3'
Posted On 2017-06-26