Mutagenetix > Incidental Mutation

Incidental Mutation 'R5987:Abca12'

481691

Institutional Source

Beutler Lab

Gene Symbol

Abca12

Ensembl Gene

ENSMUSG00000050296

Gene Name

ATP-binding cassette, sub-family A (ABC1), member 12

Synonyms

4833417A11Rik, 4832428G11Rik

MMRRC Submission

044167-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R5987 (G1)

Quality Score

199.009

Status

Not validated

Chromosome

Chromosomal Location

71242276-71414910 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 71258098 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Arginine at position 2411 (L2411R)

Ref Sequence

ENSEMBL: ENSMUSP00000084523 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087268]

AlphaFold

E9Q876

Predicted Effect

probably damaging
Transcript: ENSMUST00000087268
AA Change: L2411R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000084523
Gene: ENSMUSG00000050296
AA Change: L2411R

Domain	Start	End	E-Value	Type
transmembrane domain	24	43	N/A	INTRINSIC
low complexity region	246	259	N/A	INTRINSIC
Pfam:ABC2_membrane_3	885	1267	2.9e-24	PFAM
AAA	1370	1554	4.2e-10	SMART
low complexity region	1717	1735	N/A	INTRINSIC
Pfam:ABC2_membrane_3	1744	2206	9.6e-35	PFAM
AAA	2282	2467	4.61e-7	SMART

Coding Region Coverage

1x: 99.9%
3x: 99.4%
10x: 97.2%
20x: 91.2%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality associated with defective skin development and abnormal lung morphology. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 93 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Als2	A	G	1: 59,206,587 (GRCm38)	W577R	probably damaging	Het
Aox2	C	A	1: 58,307,359 (GRCm38)	R551S	probably benign	Het
Areg	A	T	5: 91,146,718 (GRCm38)	H245L	possibly damaging	Het
Arhgap35	T	C	7: 16,563,467 (GRCm38)	T558A	possibly damaging	Het
Arhgef28	A	T	13: 97,936,860 (GRCm38)	C1322*	probably null	Het
Arhgef38	T	C	3: 133,206,958 (GRCm38)	R107G	possibly damaging	Het
Atf7ip	T	A	6: 136,571,502 (GRCm38)	F695L	probably damaging	Het
AW209491	C	T	13: 14,637,780 (GRCm38)	A406V	probably benign	Het
Bche	T	G	3: 73,648,678 (GRCm38)	Q549P	possibly damaging	Het
Blnk	A	G	19: 40,929,289 (GRCm38)	F417L	possibly damaging	Het
Bloc1s1	T	G	10: 128,923,386 (GRCm38)	K17T	probably damaging	Het
C330018D20Rik	G	T	18: 56,957,896 (GRCm38)	T65K	probably damaging	Het
Ccdc168	A	T	1: 44,057,257 (GRCm38)	N1560K	probably benign	Het
Cers1	T	A	8: 70,321,578 (GRCm38)	S162T	possibly damaging	Het
Cgn	T	C	3: 94,779,522 (GRCm38)	K157E	probably benign	Het
Cldn7	G	A	11: 69,967,668 (GRCm38)	R196Q	probably benign	Het
Clrn2	C	A	5: 45,454,027 (GRCm38)	Q73K	probably benign	Het
Cmss1	A	G	16: 57,302,245 (GRCm38)	V262A	probably benign	Het
Cpb2	T	A	14: 75,260,688 (GRCm38)	V97E	probably damaging	Het
Ctnnd2	G	A	15: 30,683,241 (GRCm38)	V463I	probably benign	Het
Cyp7a1	A	T	4: 6,268,476 (GRCm38)	S416R	probably benign	Het
Dip2b	C	T	15: 100,190,079 (GRCm38)	R965C	probably damaging	Het
Dkk3	T	C	7: 112,150,658 (GRCm38)	T102A	probably benign	Het
Dmap1	C	A	4: 117,680,842 (GRCm38)		probably null	Het
Dnah12	C	A	14: 26,886,871 (GRCm38)	D3872E	possibly damaging	Het
Dnah7b	A	G	1: 46,119,398 (GRCm38)		probably null	Het
Dnai1	C	T	4: 41,632,391 (GRCm38)	T575I	probably benign	Het
Dsg1a	T	A	18: 20,331,542 (GRCm38)	Y365N	probably damaging	Het
Dusp11	T	A	6: 85,959,233 (GRCm38)	K18*	probably null	Het
E2f2	A	T	4: 136,172,934 (GRCm38)	T52S	probably benign	Het
Elavl4	A	G	4: 110,290,644 (GRCm38)	L13S	probably benign	Het
Epor	T	C	9: 21,962,276 (GRCm38)	D59G	possibly damaging	Het
Eral1	A	G	11: 78,080,233 (GRCm38)	C43R	possibly damaging	Het
Fam135b	A	G	15: 71,490,848 (GRCm38)	V228A	probably benign	Het
Gba1	T	C	3: 89,205,822 (GRCm38)	S187P	probably damaging	Het
Gcc2	G	T	10: 58,255,847 (GRCm38)		probably benign	Het
Gdap2	C	A	3: 100,202,256 (GRCm38)		probably benign	Het
Gm10271	A	T	10: 116,972,592 (GRCm38)	F6L	probably damaging	Het
Gm10801	C	CGTG	2: 98,663,807 (GRCm38)		probably null	Het
Gpr160	T	C	3: 30,896,463 (GRCm38)	L228P	probably benign	Het
Gsdmc2	A	C	15: 63,830,866 (GRCm38)	V184G	probably benign	Het
Gtf2e2	A	T	8: 33,776,052 (GRCm38)	K252M	probably damaging	Het
Gtf2e2	G	T	8: 33,776,053 (GRCm38)	K252N	probably benign	Het
Gys1	T	C	7: 45,438,105 (GRCm38)	Y102H	probably benign	Het
H4c2	A	G	13: 23,757,226 (GRCm38)	D69G	probably damaging	Het
Ifit3b	A	C	19: 34,612,198 (GRCm38)	D258A	probably damaging	Het
Itpr3	T	A	17: 27,104,601 (GRCm38)	M1200K	probably damaging	Het
Kcng4	A	T	8: 119,626,359 (GRCm38)	F271I	probably damaging	Het
Klhdc2	C	T	12: 69,303,613 (GRCm38)	S144L	possibly damaging	Het
Lhcgr	A	G	17: 88,755,578 (GRCm38)	F222S	probably damaging	Het
Lrp5	C	G	19: 3,628,299 (GRCm38)	G519R	probably damaging	Het
Magel2	T	C	7: 62,378,767 (GRCm38)	V473A	probably benign	Het
Map1a	T	C	2: 121,304,295 (GRCm38)	V1864A	possibly damaging	Het
Mast4	T	A	13: 102,758,734 (GRCm38)	Q760H	probably damaging	Het
Mertk	A	G	2: 128,771,374 (GRCm38)	N437D	probably benign	Het
Mettl18	G	A	1: 163,996,775 (GRCm38)	V222I	probably benign	Het
Mical2	C	T	7: 112,334,948 (GRCm38)	T782M	probably benign	Het
Mocos	T	A	18: 24,686,693 (GRCm38)	V664E	probably damaging	Het
Neb	G	T	2: 52,295,294 (GRCm38)	N975K	probably benign	Het
Nectin3	A	T	16: 46,464,145 (GRCm38)	S59T	probably benign	Het
Nelfb	A	T	2: 25,203,888 (GRCm38)	M11K	probably damaging	Het
Nrp1	A	G	8: 128,476,169 (GRCm38)	N545S	probably damaging	Het
Or10ak11	T	C	4: 118,830,281 (GRCm38)	D53G	probably damaging	Het
Or2g1	T	A	17: 37,796,357 (GRCm38)	N304K	probably benign	Het
Or51b4	T	A	7: 103,881,700 (GRCm38)	D181V	probably damaging	Het
Or5b117	A	T	19: 13,453,960 (GRCm38)	S186T	possibly damaging	Het
Or5p67	T	A	7: 108,323,047 (GRCm38)	T210S	probably benign	Het
Or6c70	A	T	10: 129,874,521 (GRCm38)	F79I	probably damaging	Het
Or8g53	T	C	9: 39,772,540 (GRCm38)	T87A	probably benign	Het
P3h1	A	G	4: 119,246,665 (GRCm38)	H587R	probably damaging	Het
Paqr4	A	G	17: 23,739,858 (GRCm38)		probably null	Het
Pde12	A	G	14: 26,669,098 (GRCm38)	V152A	probably benign	Het
Ppip5k1	C	A	2: 121,350,491 (GRCm38)	E45*	probably null	Het
Ptch2	C	T	4: 117,110,057 (GRCm38)	A677V	probably benign	Het
Rgs12	A	G	5: 35,020,345 (GRCm38)	N93S	probably damaging	Het
Rif1	C	G	2: 52,095,844 (GRCm38)	L614V	probably damaging	Het
Rnf32	T	C	5: 29,203,147 (GRCm38)	S125P	probably damaging	Het
Robo4	A	G	9: 37,411,400 (GRCm38)	I850V	probably damaging	Het
Scap	T	A	9: 110,381,151 (GRCm38)	I876N	probably damaging	Het
Sin3a	A	G	9: 57,127,200 (GRCm38)	D1219G	possibly damaging	Het
Skint5	T	C	4: 113,885,808 (GRCm38)	E354G	unknown	Het
Spart	A	G	3: 55,126,541 (GRCm38)	D396G	probably benign	Het
Spindoc	G	A	19: 7,373,659 (GRCm38)	S311L	probably benign	Het
Spta1	G	T	1: 174,223,328 (GRCm38)	R1791L	probably damaging	Het
Tbck	T	C	3: 132,801,517 (GRCm38)	I750T	possibly damaging	Het
Tmem191	T	C	16: 17,276,470 (GRCm38)		probably null	Het
Trgv1	A	T	13: 19,340,304 (GRCm38)	Y66F	probably benign	Het
Vmn2r125	A	G	4: 156,349,997 (GRCm38)	Y26C	probably damaging	Het
Zbtb17	T	C	4: 141,464,817 (GRCm38)	C358R	possibly damaging	Het
Zfp180	G	A	7: 24,105,434 (GRCm38)	G426E	probably damaging	Het
Zfp445	A	G	9: 122,853,886 (GRCm38)	V330A	probably benign	Het
Zfp595	A	G	13: 67,317,624 (GRCm38)	C192R	probably damaging	Het
Zkscan4	A	G	13: 21,484,453 (GRCm38)	H387R	probably damaging	Het

Other mutations in Abca12

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00089:Abca12	APN	1	71,303,541 (GRCm38)	missense	possibly damaging	0.64
IGL00556:Abca12	APN	1	71,353,757 (GRCm38)	missense	probably benign	0.00
IGL00813:Abca12	APN	1	71,353,762 (GRCm38)	critical splice acceptor site	probably null
IGL00835:Abca12	APN	1	71,302,733 (GRCm38)	missense	probably damaging	1.00
IGL00921:Abca12	APN	1	71,285,729 (GRCm38)	missense	probably damaging	1.00
IGL01011:Abca12	APN	1	71,263,632 (GRCm38)	missense	probably benign	0.02
IGL01066:Abca12	APN	1	71,353,730 (GRCm38)	missense	possibly damaging	0.95
IGL01082:Abca12	APN	1	71,314,114 (GRCm38)	missense	probably damaging	1.00
IGL01310:Abca12	APN	1	71,284,156 (GRCm38)	missense	probably benign	0.00
IGL01360:Abca12	APN	1	71,286,489 (GRCm38)	missense	possibly damaging	0.95
IGL01585:Abca12	APN	1	71,319,886 (GRCm38)	missense	probably benign	0.00
IGL01608:Abca12	APN	1	71,259,442 (GRCm38)	missense	probably damaging	1.00
IGL01687:Abca12	APN	1	71,267,610 (GRCm38)	splice site	probably benign
IGL01700:Abca12	APN	1	71,280,390 (GRCm38)	missense	probably benign
IGL01723:Abca12	APN	1	71,314,168 (GRCm38)	missense	probably benign	0.01
IGL01804:Abca12	APN	1	71,276,183 (GRCm38)	missense	probably benign	0.01
IGL01982:Abca12	APN	1	71,346,698 (GRCm38)	missense	probably benign	0.34
IGL02136:Abca12	APN	1	71,247,142 (GRCm38)	missense	probably damaging	1.00
IGL02172:Abca12	APN	1	71,302,658 (GRCm38)	missense	probably benign	0.09
IGL02222:Abca12	APN	1	71,282,886 (GRCm38)	missense	probably benign	0.40
IGL02266:Abca12	APN	1	71,268,201 (GRCm38)	nonsense	probably null
IGL02449:Abca12	APN	1	71,401,749 (GRCm38)	splice site	probably null
IGL02471:Abca12	APN	1	71,258,198 (GRCm38)	missense	probably benign	0.00
IGL02496:Abca12	APN	1	71,288,553 (GRCm38)	missense	possibly damaging	0.55
IGL02552:Abca12	APN	1	71,294,747 (GRCm38)	missense	probably damaging	0.96
IGL02795:Abca12	APN	1	71,288,748 (GRCm38)	missense	probably damaging	1.00
IGL03000:Abca12	APN	1	71,321,800 (GRCm38)	missense	probably benign	0.01
IGL03031:Abca12	APN	1	71,314,024 (GRCm38)	missense	probably benign	0.00
IGL03131:Abca12	APN	1	71,346,702 (GRCm38)	missense	probably benign
IGL03260:Abca12	APN	1	71,284,099 (GRCm38)	missense	probably damaging	1.00
IGL03324:Abca12	APN	1	71,314,008 (GRCm38)	missense	probably benign
IGL03408:Abca12	APN	1	71,264,795 (GRCm38)	missense	probably damaging	1.00
R0016:Abca12	UTSW	1	71,294,800 (GRCm38)	missense	probably benign	0.35
R0016:Abca12	UTSW	1	71,294,800 (GRCm38)	missense	probably benign	0.35
R0121:Abca12	UTSW	1	71,259,786 (GRCm38)	splice site	probably null
R0172:Abca12	UTSW	1	71,279,402 (GRCm38)	missense	probably damaging	0.99
R0196:Abca12	UTSW	1	71,259,813 (GRCm38)	missense	possibly damaging	0.81
R0400:Abca12	UTSW	1	71,259,776 (GRCm38)	splice site	probably benign
R0466:Abca12	UTSW	1	71,302,663 (GRCm38)	missense	probably damaging	1.00
R0616:Abca12	UTSW	1	71,302,671 (GRCm38)	missense	probably damaging	1.00
R0668:Abca12	UTSW	1	71,263,614 (GRCm38)	missense	probably damaging	1.00
R0928:Abca12	UTSW	1	71,349,174 (GRCm38)	missense	probably benign	0.06
R1036:Abca12	UTSW	1	71,263,410 (GRCm38)	critical splice donor site	probably null
R1086:Abca12	UTSW	1	71,295,061 (GRCm38)	splice site	probably benign
R1300:Abca12	UTSW	1	71,244,808 (GRCm38)	missense	probably damaging	1.00
R1337:Abca12	UTSW	1	71,294,819 (GRCm38)	missense	probably benign	0.03
R1356:Abca12	UTSW	1	71,302,953 (GRCm38)	splice site	probably benign
R1372:Abca12	UTSW	1	71,294,857 (GRCm38)	missense	probably damaging	1.00
R1434:Abca12	UTSW	1	71,309,800 (GRCm38)	missense	probably benign	0.00
R1580:Abca12	UTSW	1	71,265,965 (GRCm38)	missense	possibly damaging	0.65
R1675:Abca12	UTSW	1	71,263,411 (GRCm38)	critical splice donor site	probably null
R1773:Abca12	UTSW	1	71,288,596 (GRCm38)	missense	probably damaging	1.00
R1829:Abca12	UTSW	1	71,295,029 (GRCm38)	missense	probably benign	0.26
R1922:Abca12	UTSW	1	71,319,924 (GRCm38)	missense	probably benign	0.10
R1927:Abca12	UTSW	1	71,244,840 (GRCm38)	missense	probably damaging	1.00
R2115:Abca12	UTSW	1	71,244,771 (GRCm38)	missense	probably benign	0.01
R2146:Abca12	UTSW	1	71,263,488 (GRCm38)	missense	probably benign	0.02
R2148:Abca12	UTSW	1	71,263,488 (GRCm38)	missense	probably benign	0.02
R2149:Abca12	UTSW	1	71,263,488 (GRCm38)	missense	probably benign	0.02
R2150:Abca12	UTSW	1	71,263,488 (GRCm38)	missense	probably benign	0.02
R2299:Abca12	UTSW	1	71,258,222 (GRCm38)	missense	probably damaging	1.00
R2392:Abca12	UTSW	1	71,258,105 (GRCm38)	missense	probably damaging	1.00
R2571:Abca12	UTSW	1	71,249,885 (GRCm38)	missense	probably benign	0.00
R3077:Abca12	UTSW	1	71,267,605 (GRCm38)	missense	probably benign	0.02
R3078:Abca12	UTSW	1	71,267,605 (GRCm38)	missense	probably benign	0.02
R3705:Abca12	UTSW	1	71,285,705 (GRCm38)	missense	probably damaging	1.00
R3800:Abca12	UTSW	1	71,265,887 (GRCm38)	missense	probably damaging	1.00
R3905:Abca12	UTSW	1	71,279,457 (GRCm38)	missense	probably benign	0.02
R3905:Abca12	UTSW	1	71,268,230 (GRCm38)	missense	possibly damaging	0.79
R3962:Abca12	UTSW	1	71,274,515 (GRCm38)	splice site	probably null
R4082:Abca12	UTSW	1	71,267,463 (GRCm38)	missense	possibly damaging	0.64
R4131:Abca12	UTSW	1	71,319,871 (GRCm38)	critical splice donor site	probably null
R4214:Abca12	UTSW	1	71,288,697 (GRCm38)	missense	probably damaging	0.99
R4403:Abca12	UTSW	1	71,267,436 (GRCm38)	missense	probably damaging	1.00
R4524:Abca12	UTSW	1	71,302,917 (GRCm38)	missense	probably benign	0.19
R4615:Abca12	UTSW	1	71,330,334 (GRCm38)	missense	probably benign
R4617:Abca12	UTSW	1	71,330,334 (GRCm38)	missense	probably benign
R4714:Abca12	UTSW	1	71,321,450 (GRCm38)	missense	probably benign	0.00
R4809:Abca12	UTSW	1	71,278,856 (GRCm38)	missense	probably benign	0.10
R4810:Abca12	UTSW	1	71,303,612 (GRCm38)	missense	probably benign	0.00
R4825:Abca12	UTSW	1	71,302,685 (GRCm38)	missense	possibly damaging	0.70
R4990:Abca12	UTSW	1	71,294,939 (GRCm38)	missense	possibly damaging	0.61
R5013:Abca12	UTSW	1	71,264,767 (GRCm38)	missense	probably damaging	0.99
R5026:Abca12	UTSW	1	71,317,224 (GRCm38)	missense	probably benign	0.04
R5064:Abca12	UTSW	1	71,300,960 (GRCm38)	missense	probably damaging	1.00
R5188:Abca12	UTSW	1	71,291,492 (GRCm38)	missense	probably benign	0.23
R5234:Abca12	UTSW	1	71,263,664 (GRCm38)	missense	probably damaging	0.99
R5267:Abca12	UTSW	1	71,335,774 (GRCm38)	splice site	probably benign
R5302:Abca12	UTSW	1	71,283,952 (GRCm38)	missense	possibly damaging	0.91
R5441:Abca12	UTSW	1	71,295,056 (GRCm38)	missense	probably damaging	1.00
R5451:Abca12	UTSW	1	71,294,917 (GRCm38)	missense	possibly damaging	0.94
R5526:Abca12	UTSW	1	71,292,446 (GRCm38)	missense	probably benign	0.29
R5529:Abca12	UTSW	1	71,264,881 (GRCm38)	missense	probably damaging	1.00
R5615:Abca12	UTSW	1	71,307,059 (GRCm38)	missense	probably damaging	1.00
R5649:Abca12	UTSW	1	71,291,342 (GRCm38)	missense	probably damaging	1.00
R5800:Abca12	UTSW	1	71,321,432 (GRCm38)	missense	possibly damaging	0.78
R5807:Abca12	UTSW	1	71,303,492 (GRCm38)	missense	probably damaging	1.00
R5878:Abca12	UTSW	1	71,346,633 (GRCm38)	missense	possibly damaging	0.79
R6280:Abca12	UTSW	1	71,272,460 (GRCm38)	missense	probably benign	0.04
R6316:Abca12	UTSW	1	71,313,959 (GRCm38)	missense	probably benign	0.01
R6337:Abca12	UTSW	1	71,295,013 (GRCm38)	missense	probably damaging	1.00
R6383:Abca12	UTSW	1	71,247,184 (GRCm38)	missense	probably benign	0.03
R6564:Abca12	UTSW	1	71,309,850 (GRCm38)	missense	possibly damaging	0.57
R6582:Abca12	UTSW	1	71,258,225 (GRCm38)	missense	probably benign	0.00
R6756:Abca12	UTSW	1	71,259,353 (GRCm38)	splice site	probably null
R6876:Abca12	UTSW	1	71,263,508 (GRCm38)	missense	probably damaging	0.98
R6999:Abca12	UTSW	1	71,317,162 (GRCm38)	nonsense	probably null
R7145:Abca12	UTSW	1	71,307,053 (GRCm38)	missense	possibly damaging	0.92
R7272:Abca12	UTSW	1	71,248,432 (GRCm38)	missense	probably damaging	0.99
R7285:Abca12	UTSW	1	71,349,155 (GRCm38)	nonsense	probably null
R7421:Abca12	UTSW	1	71,247,136 (GRCm38)	nonsense	probably null
R7531:Abca12	UTSW	1	71,247,173 (GRCm38)	missense	probably damaging	0.99
R7592:Abca12	UTSW	1	71,288,677 (GRCm38)	missense	probably benign	0.01
R7687:Abca12	UTSW	1	71,258,182 (GRCm38)	missense	probably benign	0.00
R7690:Abca12	UTSW	1	71,314,154 (GRCm38)	missense	probably benign	0.00
R7709:Abca12	UTSW	1	71,335,728 (GRCm38)	missense	probably benign	0.00
R7736:Abca12	UTSW	1	71,319,964 (GRCm38)	missense	probably benign	0.01
R7754:Abca12	UTSW	1	71,302,887 (GRCm38)	missense	probably benign
R7761:Abca12	UTSW	1	71,330,288 (GRCm38)	missense	probably damaging	1.00
R7808:Abca12	UTSW	1	71,274,634 (GRCm38)	splice site	probably null
R7816:Abca12	UTSW	1	71,292,429 (GRCm38)	missense	probably benign	0.01
R7821:Abca12	UTSW	1	71,259,791 (GRCm38)	missense	probably benign	0.12
R7827:Abca12	UTSW	1	71,414,678 (GRCm38)	start gained	probably benign
R7829:Abca12	UTSW	1	71,292,421 (GRCm38)	missense	probably benign	0.37
R7863:Abca12	UTSW	1	71,293,497 (GRCm38)	missense	probably damaging	0.96
R8053:Abca12	UTSW	1	71,349,169 (GRCm38)	nonsense	probably null
R8093:Abca12	UTSW	1	71,280,393 (GRCm38)	missense	probably benign	0.00
R8120:Abca12	UTSW	1	71,259,381 (GRCm38)	missense	possibly damaging	0.92
R8136:Abca12	UTSW	1	71,248,397 (GRCm38)	missense	probably benign	0.15
R8155:Abca12	UTSW	1	71,291,338 (GRCm38)	missense	probably damaging	1.00
R8189:Abca12	UTSW	1	71,285,726 (GRCm38)	missense	probably damaging	1.00
R8233:Abca12	UTSW	1	71,351,757 (GRCm38)	missense	probably benign	0.00
R8249:Abca12	UTSW	1	71,321,812 (GRCm38)	missense	probably benign	0.00
R8255:Abca12	UTSW	1	71,319,899 (GRCm38)	missense	probably benign	0.13
R8300:Abca12	UTSW	1	71,313,964 (GRCm38)	missense	possibly damaging	0.77
R8339:Abca12	UTSW	1	71,285,672 (GRCm38)	missense	probably damaging	1.00
R8490:Abca12	UTSW	1	71,284,097 (GRCm38)	missense	probably damaging	1.00
R8494:Abca12	UTSW	1	71,288,662 (GRCm38)	missense	probably benign	0.02
R8527:Abca12	UTSW	1	71,309,888 (GRCm38)	critical splice acceptor site	probably null
R8542:Abca12	UTSW	1	71,309,888 (GRCm38)	critical splice acceptor site	probably null
R8692:Abca12	UTSW	1	71,288,715 (GRCm38)	missense	probably damaging	0.96
R8723:Abca12	UTSW	1	71,321,738 (GRCm38)	missense	probably benign	0.04
R8796:Abca12	UTSW	1	71,258,089 (GRCm38)	critical splice donor site	probably benign
R8911:Abca12	UTSW	1	71,341,531 (GRCm38)	missense	probably benign	0.07
R8913:Abca12	UTSW	1	71,264,813 (GRCm38)	missense	probably damaging	1.00
R8957:Abca12	UTSW	1	71,321,625 (GRCm38)	missense	possibly damaging	0.90
R9000:Abca12	UTSW	1	71,314,036 (GRCm38)	missense	probably damaging	1.00
R9137:Abca12	UTSW	1	71,259,366 (GRCm38)	missense	possibly damaging	0.80
R9228:Abca12	UTSW	1	71,293,440 (GRCm38)	missense	probably damaging	1.00
R9237:Abca12	UTSW	1	71,279,398 (GRCm38)	missense	probably damaging	0.97
R9299:Abca12	UTSW	1	71,319,883 (GRCm38)	missense	possibly damaging	0.48
R9419:Abca12	UTSW	1	71,303,490 (GRCm38)	missense	possibly damaging	0.81
R9492:Abca12	UTSW	1	71,258,221 (GRCm38)	missense	possibly damaging	0.81
R9538:Abca12	UTSW	1	71,341,513 (GRCm38)	missense	probably benign	0.04
R9585:Abca12	UTSW	1	71,303,586 (GRCm38)	missense	probably damaging	1.00
R9658:Abca12	UTSW	1	71,286,475 (GRCm38)	missense	probably damaging	0.97
R9763:Abca12	UTSW	1	71,263,558 (GRCm38)	missense	possibly damaging	0.84
X0013:Abca12	UTSW	1	71,248,433 (GRCm38)	missense	probably damaging	0.99
X0018:Abca12	UTSW	1	71,314,510 (GRCm38)	missense	probably benign
X0063:Abca12	UTSW	1	71,349,064 (GRCm38)	missense	probably benign	0.15
X0065:Abca12	UTSW	1	71,341,461 (GRCm38)	critical splice donor site	probably null
Z1176:Abca12	UTSW	1	71,284,070 (GRCm38)	missense	probably damaging	1.00
Z1177:Abca12	UTSW	1	71,292,531 (GRCm38)	missense	probably damaging	0.98
Z1177:Abca12	UTSW	1	71,282,811 (GRCm38)	missense	probably damaging	0.98
Z1177:Abca12	UTSW	1	71,276,082 (GRCm38)	missense	possibly damaging	0.94

Predicted Primers

PCR Primer
(F):5'- AGACACAAAGTGCTTCCCGAG -3'
(R):5'- TAAGGGTTTGAACGAGGGTC -3'

Sequencing Primer
(F):5'- TCCCGAGGACACTGTCATGATC -3'
(R):5'- AGGGTCGGATGCCTAATTCCTC -3'

Posted On

2017-06-26