Incidental Mutation 'R5987:Rgs12'
| ID |
481721 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rgs12
|
| Ensembl Gene |
ENSMUSG00000029101 |
| Gene Name |
regulator of G-protein signaling 12 |
| Synonyms |
4632412M04Rik, 1200016K18Rik |
| MMRRC Submission |
044167-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.243)
|
| Stock # |
R5987 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
35106789-35196988 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 35177689 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 93
(N93S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000109923
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030984]
[ENSMUST00000087684]
[ENSMUST00000114280]
[ENSMUST00000114281]
[ENSMUST00000114283]
[ENSMUST00000114284]
[ENSMUST00000114285]
[ENSMUST00000156339]
[ENSMUST00000225237]
|
| AlphaFold |
Q8CGE9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000030984
AA Change: N741S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000030984
Gene: ENSMUSG00000029101
AA Change: N741S
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
29 |
98 |
5.25e-18 |
SMART |
|
PTB
|
224 |
373 |
5.05e-28 |
SMART |
|
low complexity region
|
443 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
643 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
685 |
697 |
N/A |
INTRINSIC |
|
RGS
|
715 |
832 |
2.84e-41 |
SMART |
|
low complexity region
|
849 |
865 |
N/A |
INTRINSIC |
|
low complexity region
|
868 |
880 |
N/A |
INTRINSIC |
|
low complexity region
|
911 |
928 |
N/A |
INTRINSIC |
|
RBD
|
962 |
1032 |
3.12e-28 |
SMART |
|
RBD
|
1034 |
1104 |
2.44e-21 |
SMART |
|
GoLoco
|
1187 |
1209 |
9.74e-9 |
SMART |
|
low complexity region
|
1259 |
1280 |
N/A |
INTRINSIC |
|
low complexity region
|
1292 |
1308 |
N/A |
INTRINSIC |
|
low complexity region
|
1359 |
1378 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000087684
AA Change: N741S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000084970
Gene: ENSMUSG00000029101
AA Change: N741S
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
29 |
98 |
5.25e-18 |
SMART |
|
PTB
|
224 |
373 |
5.05e-28 |
SMART |
|
low complexity region
|
443 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
643 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
685 |
697 |
N/A |
INTRINSIC |
|
RGS
|
715 |
832 |
2.84e-41 |
SMART |
|
Pfam:RGS12_us1
|
836 |
953 |
4.3e-61 |
PFAM |
|
RBD
|
962 |
1032 |
3.12e-28 |
SMART |
|
RBD
|
1034 |
1104 |
2.44e-21 |
SMART |
|
Pfam:RGS12_us2
|
1106 |
1180 |
2.4e-37 |
PFAM |
|
GoLoco
|
1187 |
1209 |
9.74e-9 |
SMART |
|
Pfam:RGS12_usC
|
1238 |
1379 |
9.2e-49 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000114280
AA Change: N83S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000109919
Gene: ENSMUSG00000029101
AA Change: N83S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
27 |
39 |
N/A |
INTRINSIC |
|
RGS
|
57 |
174 |
2.84e-41 |
SMART |
|
low complexity region
|
191 |
207 |
N/A |
INTRINSIC |
|
low complexity region
|
210 |
222 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
270 |
N/A |
INTRINSIC |
|
RBD
|
304 |
374 |
3.12e-28 |
SMART |
|
RBD
|
376 |
446 |
2.44e-21 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000114281
AA Change: N83S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000109920
Gene: ENSMUSG00000029101
AA Change: N83S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
27 |
39 |
N/A |
INTRINSIC |
|
RGS
|
57 |
174 |
2.84e-41 |
SMART |
|
low complexity region
|
191 |
207 |
N/A |
INTRINSIC |
|
low complexity region
|
210 |
222 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
270 |
N/A |
INTRINSIC |
|
RBD
|
304 |
374 |
3.12e-28 |
SMART |
|
RBD
|
376 |
446 |
2.44e-21 |
SMART |
|
GoLoco
|
529 |
551 |
9.74e-9 |
SMART |
|
low complexity region
|
601 |
622 |
N/A |
INTRINSIC |
|
low complexity region
|
634 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
701 |
720 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000114283
AA Change: N83S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000109922
Gene: ENSMUSG00000029101
AA Change: N83S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
27 |
39 |
N/A |
INTRINSIC |
|
RGS
|
57 |
174 |
2.84e-41 |
SMART |
|
low complexity region
|
191 |
207 |
N/A |
INTRINSIC |
|
low complexity region
|
210 |
222 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
270 |
N/A |
INTRINSIC |
|
RBD
|
304 |
374 |
3.12e-28 |
SMART |
|
RBD
|
376 |
446 |
2.44e-21 |
SMART |
|
GoLoco
|
529 |
551 |
9.74e-9 |
SMART |
|
low complexity region
|
601 |
622 |
N/A |
INTRINSIC |
|
low complexity region
|
634 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
729 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000114284
AA Change: N93S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000109923
Gene: ENSMUSG00000029101
AA Change: N93S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
37 |
49 |
N/A |
INTRINSIC |
|
RGS
|
67 |
184 |
2.84e-41 |
SMART |
|
low complexity region
|
201 |
217 |
N/A |
INTRINSIC |
|
low complexity region
|
220 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
263 |
280 |
N/A |
INTRINSIC |
|
RBD
|
314 |
384 |
3.12e-28 |
SMART |
|
RBD
|
386 |
456 |
2.44e-21 |
SMART |
|
GoLoco
|
539 |
561 |
9.74e-9 |
SMART |
|
low complexity region
|
611 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
644 |
660 |
N/A |
INTRINSIC |
|
low complexity region
|
711 |
730 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000114285
AA Change: N93S
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000109924
Gene: ENSMUSG00000029101
AA Change: N93S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
37 |
49 |
N/A |
INTRINSIC |
|
RGS
|
67 |
184 |
2.84e-41 |
SMART |
|
low complexity region
|
201 |
217 |
N/A |
INTRINSIC |
|
low complexity region
|
220 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
263 |
280 |
N/A |
INTRINSIC |
|
RBD
|
314 |
384 |
3.12e-28 |
SMART |
|
RBD
|
386 |
456 |
2.44e-21 |
SMART |
|
GoLoco
|
539 |
561 |
9.74e-9 |
SMART |
|
low complexity region
|
611 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
644 |
660 |
N/A |
INTRINSIC |
|
low complexity region
|
707 |
739 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000128161
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000135403
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141562
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153972
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000175356
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000201936
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156339
|
| SMART Domains |
Protein: ENSMUSP00000115064
Gene: ENSMUSG00000029101
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RGS
|
1 |
30 |
1.3e-7 |
PFAM |
|
low complexity region
|
48 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
79 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156819
|
| SMART Domains |
Protein: ENSMUSP00000116913
Gene: ENSMUSG00000029101
| Domain | Start | End | E-Value | Type |
|---|
|
RBD
|
21 |
91 |
3.12e-28 |
SMART |
|
RBD
|
93 |
163 |
2.44e-21 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000225237
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.4%
- 10x: 97.2%
- 20x: 91.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca12 |
A |
C |
1: 71,297,257 (GRCm39) |
L2411R |
probably damaging |
Het |
| Als2 |
A |
G |
1: 59,245,746 (GRCm39) |
W577R |
probably damaging |
Het |
| Aox1 |
C |
A |
1: 58,346,518 (GRCm39) |
R551S |
probably benign |
Het |
| Areg |
A |
T |
5: 91,294,577 (GRCm39) |
H245L |
possibly damaging |
Het |
| Arhgap35 |
T |
C |
7: 16,297,392 (GRCm39) |
T558A |
possibly damaging |
Het |
| Arhgef28 |
A |
T |
13: 98,073,368 (GRCm39) |
C1322* |
probably null |
Het |
| Arhgef38 |
T |
C |
3: 132,912,719 (GRCm39) |
R107G |
possibly damaging |
Het |
| Atf7ip |
T |
A |
6: 136,548,500 (GRCm39) |
F695L |
probably damaging |
Het |
| AW209491 |
C |
T |
13: 14,812,365 (GRCm39) |
A406V |
probably benign |
Het |
| Bche |
T |
G |
3: 73,556,011 (GRCm39) |
Q549P |
possibly damaging |
Het |
| Blnk |
A |
G |
19: 40,917,733 (GRCm39) |
F417L |
possibly damaging |
Het |
| Bloc1s1 |
T |
G |
10: 128,759,255 (GRCm39) |
K17T |
probably damaging |
Het |
| C330018D20Rik |
G |
T |
18: 57,090,968 (GRCm39) |
T65K |
probably damaging |
Het |
| Ccdc168 |
A |
T |
1: 44,096,417 (GRCm39) |
N1560K |
probably benign |
Het |
| Cers1 |
T |
A |
8: 70,774,228 (GRCm39) |
S162T |
possibly damaging |
Het |
| Cgn |
T |
C |
3: 94,686,832 (GRCm39) |
K157E |
probably benign |
Het |
| Cldn7 |
G |
A |
11: 69,858,494 (GRCm39) |
R196Q |
probably benign |
Het |
| Clrn2 |
C |
A |
5: 45,611,369 (GRCm39) |
Q73K |
probably benign |
Het |
| Cmss1 |
A |
G |
16: 57,122,608 (GRCm39) |
V262A |
probably benign |
Het |
| Cpb2 |
T |
A |
14: 75,498,128 (GRCm39) |
V97E |
probably damaging |
Het |
| Ctnnd2 |
G |
A |
15: 30,683,387 (GRCm39) |
V463I |
probably benign |
Het |
| Cyp7a1 |
A |
T |
4: 6,268,476 (GRCm39) |
S416R |
probably benign |
Het |
| Dip2b |
C |
T |
15: 100,087,960 (GRCm39) |
R965C |
probably damaging |
Het |
| Dkk3 |
T |
C |
7: 111,749,865 (GRCm39) |
T102A |
probably benign |
Het |
| Dmap1 |
C |
A |
4: 117,538,039 (GRCm39) |
|
probably null |
Het |
| Dnah12 |
C |
A |
14: 26,608,828 (GRCm39) |
D3872E |
possibly damaging |
Het |
| Dnah7b |
A |
G |
1: 46,158,558 (GRCm39) |
|
probably null |
Het |
| Dnai1 |
C |
T |
4: 41,632,391 (GRCm39) |
T575I |
probably benign |
Het |
| Dsg1a |
T |
A |
18: 20,464,599 (GRCm39) |
Y365N |
probably damaging |
Het |
| Dusp11 |
T |
A |
6: 85,936,215 (GRCm39) |
K18* |
probably null |
Het |
| E2f2 |
A |
T |
4: 135,900,245 (GRCm39) |
T52S |
probably benign |
Het |
| Elavl4 |
A |
G |
4: 110,147,841 (GRCm39) |
L13S |
probably benign |
Het |
| Epor |
T |
C |
9: 21,873,572 (GRCm39) |
D59G |
possibly damaging |
Het |
| Eral1 |
A |
G |
11: 77,971,059 (GRCm39) |
C43R |
possibly damaging |
Het |
| Fam135b |
A |
G |
15: 71,362,697 (GRCm39) |
V228A |
probably benign |
Het |
| Gba1 |
T |
C |
3: 89,113,129 (GRCm39) |
S187P |
probably damaging |
Het |
| Gcc2 |
G |
T |
10: 58,091,669 (GRCm39) |
|
probably benign |
Het |
| Gdap2 |
C |
A |
3: 100,109,572 (GRCm39) |
|
probably benign |
Het |
| Gm10271 |
A |
T |
10: 116,808,497 (GRCm39) |
F6L |
probably damaging |
Het |
| Gm10801 |
C |
CGTG |
2: 98,494,152 (GRCm39) |
|
probably null |
Het |
| Gpr160 |
T |
C |
3: 30,950,612 (GRCm39) |
L228P |
probably benign |
Het |
| Gsdmc2 |
A |
C |
15: 63,702,715 (GRCm39) |
V184G |
probably benign |
Het |
| Gtf2e2 |
A |
T |
8: 34,266,080 (GRCm39) |
K252M |
probably damaging |
Het |
| Gtf2e2 |
G |
T |
8: 34,266,081 (GRCm39) |
K252N |
probably benign |
Het |
| Gys1 |
T |
C |
7: 45,087,529 (GRCm39) |
Y102H |
probably benign |
Het |
| H4c2 |
A |
G |
13: 23,941,209 (GRCm39) |
D69G |
probably damaging |
Het |
| Ifit3b |
A |
C |
19: 34,589,598 (GRCm39) |
D258A |
probably damaging |
Het |
| Itpr3 |
T |
A |
17: 27,323,575 (GRCm39) |
M1200K |
probably damaging |
Het |
| Kcng4 |
A |
T |
8: 120,353,098 (GRCm39) |
F271I |
probably damaging |
Het |
| Klhdc2 |
C |
T |
12: 69,350,387 (GRCm39) |
S144L |
possibly damaging |
Het |
| Lhcgr |
A |
G |
17: 89,063,006 (GRCm39) |
F222S |
probably damaging |
Het |
| Lrp5 |
C |
G |
19: 3,678,299 (GRCm39) |
G519R |
probably damaging |
Het |
| Magel2 |
T |
C |
7: 62,028,515 (GRCm39) |
V473A |
probably benign |
Het |
| Map1a |
T |
C |
2: 121,134,776 (GRCm39) |
V1864A |
possibly damaging |
Het |
| Mast4 |
T |
A |
13: 102,895,242 (GRCm39) |
Q760H |
probably damaging |
Het |
| Mertk |
A |
G |
2: 128,613,294 (GRCm39) |
N437D |
probably benign |
Het |
| Mettl18 |
G |
A |
1: 163,824,344 (GRCm39) |
V222I |
probably benign |
Het |
| Mical2 |
C |
T |
7: 111,934,155 (GRCm39) |
T782M |
probably benign |
Het |
| Mocos |
T |
A |
18: 24,819,750 (GRCm39) |
V664E |
probably damaging |
Het |
| Neb |
G |
T |
2: 52,185,306 (GRCm39) |
N975K |
probably benign |
Het |
| Nectin3 |
A |
T |
16: 46,284,508 (GRCm39) |
S59T |
probably benign |
Het |
| Nelfb |
A |
T |
2: 25,093,900 (GRCm39) |
M11K |
probably damaging |
Het |
| Nrp1 |
A |
G |
8: 129,202,650 (GRCm39) |
N545S |
probably damaging |
Het |
| Or10ak11 |
T |
C |
4: 118,687,478 (GRCm39) |
D53G |
probably damaging |
Het |
| Or2g1 |
T |
A |
17: 38,107,248 (GRCm39) |
N304K |
probably benign |
Het |
| Or51b4 |
T |
A |
7: 103,530,907 (GRCm39) |
D181V |
probably damaging |
Het |
| Or5b117 |
A |
T |
19: 13,431,324 (GRCm39) |
S186T |
possibly damaging |
Het |
| Or5p67 |
T |
A |
7: 107,922,254 (GRCm39) |
T210S |
probably benign |
Het |
| Or6c70 |
A |
T |
10: 129,710,390 (GRCm39) |
F79I |
probably damaging |
Het |
| Or8g53 |
T |
C |
9: 39,683,836 (GRCm39) |
T87A |
probably benign |
Het |
| P3h1 |
A |
G |
4: 119,103,862 (GRCm39) |
H587R |
probably damaging |
Het |
| Paqr4 |
A |
G |
17: 23,958,832 (GRCm39) |
|
probably null |
Het |
| Pde12 |
A |
G |
14: 26,390,253 (GRCm39) |
V152A |
probably benign |
Het |
| Ppip5k1 |
C |
A |
2: 121,180,972 (GRCm39) |
E45* |
probably null |
Het |
| Ptch2 |
C |
T |
4: 116,967,254 (GRCm39) |
A677V |
probably benign |
Het |
| Rif1 |
C |
G |
2: 51,985,856 (GRCm39) |
L614V |
probably damaging |
Het |
| Rnf32 |
T |
C |
5: 29,408,145 (GRCm39) |
S125P |
probably damaging |
Het |
| Robo4 |
A |
G |
9: 37,322,696 (GRCm39) |
I850V |
probably damaging |
Het |
| Scap |
T |
A |
9: 110,210,219 (GRCm39) |
I876N |
probably damaging |
Het |
| Sin3a |
A |
G |
9: 57,034,484 (GRCm39) |
D1219G |
possibly damaging |
Het |
| Skint5 |
T |
C |
4: 113,743,005 (GRCm39) |
E354G |
unknown |
Het |
| Spart |
A |
G |
3: 55,033,962 (GRCm39) |
D396G |
probably benign |
Het |
| Spindoc |
G |
A |
19: 7,351,024 (GRCm39) |
S311L |
probably benign |
Het |
| Spta1 |
G |
T |
1: 174,050,894 (GRCm39) |
R1791L |
probably damaging |
Het |
| Tbck |
T |
C |
3: 132,507,278 (GRCm39) |
I750T |
possibly damaging |
Het |
| Tmem191 |
T |
C |
16: 17,094,334 (GRCm39) |
|
probably null |
Het |
| Trgv1 |
A |
T |
13: 19,524,474 (GRCm39) |
Y66F |
probably benign |
Het |
| Vmn2r125 |
A |
G |
4: 156,702,292 (GRCm39) |
Y26C |
probably damaging |
Het |
| Zbtb17 |
T |
C |
4: 141,192,128 (GRCm39) |
C358R |
possibly damaging |
Het |
| Zfp180 |
G |
A |
7: 23,804,859 (GRCm39) |
G426E |
probably damaging |
Het |
| Zfp445 |
A |
G |
9: 122,682,951 (GRCm39) |
V330A |
probably benign |
Het |
| Zfp595 |
A |
G |
13: 67,465,688 (GRCm39) |
C192R |
probably damaging |
Het |
| Zkscan4 |
A |
G |
13: 21,668,623 (GRCm39) |
H387R |
probably damaging |
Het |
|
| Other mutations in Rgs12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01443:Rgs12
|
APN |
5 |
35,132,563 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02296:Rgs12
|
APN |
5 |
35,123,464 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02337:Rgs12
|
APN |
5 |
35,177,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02483:Rgs12
|
APN |
5 |
35,187,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02869:Rgs12
|
APN |
5 |
35,183,227 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02989:Rgs12
|
APN |
5 |
35,122,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0015:Rgs12
|
UTSW |
5 |
35,180,120 (GRCm39) |
unclassified |
probably benign |
|
|
R0015:Rgs12
|
UTSW |
5 |
35,180,120 (GRCm39) |
unclassified |
probably benign |
|
|
R0046:Rgs12
|
UTSW |
5 |
35,122,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0046:Rgs12
|
UTSW |
5 |
35,122,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0106:Rgs12
|
UTSW |
5 |
35,124,008 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0106:Rgs12
|
UTSW |
5 |
35,124,008 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0233:Rgs12
|
UTSW |
5 |
35,187,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0233:Rgs12
|
UTSW |
5 |
35,187,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0245:Rgs12
|
UTSW |
5 |
35,187,424 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0611:Rgs12
|
UTSW |
5 |
35,176,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0704:Rgs12
|
UTSW |
5 |
35,180,466 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0723:Rgs12
|
UTSW |
5 |
35,181,710 (GRCm39) |
unclassified |
probably benign |
|
|
R1174:Rgs12
|
UTSW |
5 |
35,123,809 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1538:Rgs12
|
UTSW |
5 |
35,178,511 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1556:Rgs12
|
UTSW |
5 |
35,196,626 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1774:Rgs12
|
UTSW |
5 |
35,123,747 (GRCm39) |
missense |
probably benign |
0.34 |
|
R1791:Rgs12
|
UTSW |
5 |
35,123,456 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1866:Rgs12
|
UTSW |
5 |
35,123,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1872:Rgs12
|
UTSW |
5 |
35,123,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1923:Rgs12
|
UTSW |
5 |
35,189,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2012:Rgs12
|
UTSW |
5 |
35,187,872 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2107:Rgs12
|
UTSW |
5 |
35,124,079 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R3730:Rgs12
|
UTSW |
5 |
35,189,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3731:Rgs12
|
UTSW |
5 |
35,189,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3808:Rgs12
|
UTSW |
5 |
35,189,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3826:Rgs12
|
UTSW |
5 |
35,123,359 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3827:Rgs12
|
UTSW |
5 |
35,123,359 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3829:Rgs12
|
UTSW |
5 |
35,123,359 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3830:Rgs12
|
UTSW |
5 |
35,123,359 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4392:Rgs12
|
UTSW |
5 |
35,189,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4617:Rgs12
|
UTSW |
5 |
35,177,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5132:Rgs12
|
UTSW |
5 |
35,147,156 (GRCm39) |
intron |
probably benign |
|
|
R5213:Rgs12
|
UTSW |
5 |
35,122,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5296:Rgs12
|
UTSW |
5 |
35,178,448 (GRCm39) |
unclassified |
probably benign |
|
|
R5480:Rgs12
|
UTSW |
5 |
35,123,455 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5510:Rgs12
|
UTSW |
5 |
35,123,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5708:Rgs12
|
UTSW |
5 |
35,123,696 (GRCm39) |
missense |
probably benign |
0.41 |
|
R6053:Rgs12
|
UTSW |
5 |
35,123,296 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6113:Rgs12
|
UTSW |
5 |
35,177,667 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6401:Rgs12
|
UTSW |
5 |
35,177,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6736:Rgs12
|
UTSW |
5 |
35,180,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6807:Rgs12
|
UTSW |
5 |
35,180,515 (GRCm39) |
missense |
probably null |
0.27 |
|
R6857:Rgs12
|
UTSW |
5 |
35,187,366 (GRCm39) |
nonsense |
probably null |
|
|
R7082:Rgs12
|
UTSW |
5 |
35,124,050 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7250:Rgs12
|
UTSW |
5 |
35,122,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7276:Rgs12
|
UTSW |
5 |
35,183,715 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7444:Rgs12
|
UTSW |
5 |
35,183,287 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7632:Rgs12
|
UTSW |
5 |
35,122,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8049:Rgs12
|
UTSW |
5 |
35,183,374 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8089:Rgs12
|
UTSW |
5 |
35,177,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8241:Rgs12
|
UTSW |
5 |
35,123,117 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8797:Rgs12
|
UTSW |
5 |
35,186,915 (GRCm39) |
missense |
|
|
|
R8927:Rgs12
|
UTSW |
5 |
35,123,633 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8928:Rgs12
|
UTSW |
5 |
35,123,633 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9073:Rgs12
|
UTSW |
5 |
35,177,753 (GRCm39) |
unclassified |
probably benign |
|
|
R9211:Rgs12
|
UTSW |
5 |
35,123,165 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9485:Rgs12
|
UTSW |
5 |
35,189,614 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9550:Rgs12
|
UTSW |
5 |
35,196,665 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Rgs12
|
UTSW |
5 |
35,123,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Rgs12
|
UTSW |
5 |
35,183,696 (GRCm39) |
missense |
probably benign |
0.44 |
|
Z1177:Rgs12
|
UTSW |
5 |
35,122,198 (GRCm39) |
start gained |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCCCTTGAGAAAAGAGCTGTG -3'
(R):5'- GAAGCAGAAATGTCACCGTTC -3'
Sequencing Primer
(F):5'- CCACTCACGTGTGCTGC -3'
(R):5'- CTTTAAAGTCAGTAAGAAGCATCCC -3'
|
| Posted On |
2017-06-26 |
Incidental Mutation