Incidental Mutation 'R0515:Mroh7'
ID 48178
Institutional Source Beutler Lab
Gene Symbol Mroh7
Ensembl Gene ENSMUSG00000047502
Gene Name maestro heat-like repeat family member 7
Synonyms Heatr8, Gm1027, LOC381538
MMRRC Submission 038709-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0515 (G1)
Quality Score 173
Status Validated
Chromosome 4
Chromosomal Location 106537614-106588122 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 106548861 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 1001 (M1001L)
Ref Sequence ENSEMBL: ENSMUSP00000102382 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106770]
AlphaFold A2AVR2
Predicted Effect probably benign
Transcript: ENSMUST00000106770
AA Change: M1001L

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000102382
Gene: ENSMUSG00000047502
AA Change: M1001L

DomainStartEndE-ValueType
low complexity region 39 61 N/A INTRINSIC
low complexity region 318 332 N/A INTRINSIC
low complexity region 563 573 N/A INTRINSIC
SCOP:d1b3ua_ 634 1218 6e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134160
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135000
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142954
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145374
Meta Mutation Damage Score 0.0655 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 92.6%
Validation Efficiency 98% (40/41)
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
App C T 16: 84,900,232 (GRCm39) probably benign Het
Arhgap11a G A 2: 113,667,816 (GRCm39) T395I possibly damaging Het
Arhgef38 T G 3: 132,855,301 (GRCm39) H262P probably damaging Het
Cd96 A G 16: 45,884,268 (GRCm39) probably benign Het
Cfap57 A G 4: 118,477,599 (GRCm39) S2P probably damaging Het
Cltc A G 11: 86,599,865 (GRCm39) S948P probably benign Het
Cyp3a41a A T 5: 145,654,810 (GRCm39) H30Q probably damaging Het
Dcp2 C T 18: 44,532,798 (GRCm39) L105F probably benign Het
Dennd4c T C 4: 86,731,703 (GRCm39) V887A possibly damaging Het
Dnaaf9 A G 2: 130,582,408 (GRCm39) V515A probably damaging Het
Gm11360 T A 13: 28,140,143 (GRCm39) D2E probably damaging Het
Gpank1 G T 17: 35,342,475 (GRCm39) A149S probably damaging Het
Gtf2i C A 5: 134,271,773 (GRCm39) S792I probably damaging Het
Hvcn1 A G 5: 122,371,582 (GRCm39) N41D probably damaging Het
Klk1b5 A G 7: 43,867,957 (GRCm39) Y43C probably damaging Het
Lmtk2 A G 5: 144,111,809 (GRCm39) D843G possibly damaging Het
Lrriq1 A T 10: 102,904,829 (GRCm39) probably null Het
Mapk8ip1 A T 2: 92,217,701 (GRCm39) I198N possibly damaging Het
Mill1 T C 7: 17,998,798 (GRCm39) V336A probably benign Het
Nfe2 T A 15: 103,157,854 (GRCm39) T46S probably null Het
Or8b40 T C 9: 38,027,313 (GRCm39) S74P probably damaging Het
Or9q1 T C 19: 13,805,185 (GRCm39) S192G probably damaging Het
Parp4 T C 14: 56,851,124 (GRCm39) V709A probably damaging Het
Pkd1l3 C G 8: 110,350,281 (GRCm39) D375E possibly damaging Het
Prex2 A T 1: 11,270,098 (GRCm39) Q1261L probably damaging Het
Prl8a8 T A 13: 27,692,350 (GRCm39) I214L probably damaging Het
Rictor C T 15: 6,798,782 (GRCm39) T343M probably damaging Het
Sema6a G A 18: 47,423,112 (GRCm39) probably null Het
Siglecf T C 7: 43,005,055 (GRCm39) probably null Het
Slco1b2 T C 6: 141,615,136 (GRCm39) F347S possibly damaging Het
Sox13 A T 1: 133,311,457 (GRCm39) Y592N probably damaging Het
Synj1 C T 16: 90,790,910 (GRCm39) A84T possibly damaging Het
Tent5b A T 4: 133,213,450 (GRCm39) H107L possibly damaging Het
Trpv5 T A 6: 41,651,145 (GRCm39) probably benign Het
Tshz1 A G 18: 84,034,090 (GRCm39) V106A probably benign Het
Other mutations in Mroh7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01722:Mroh7 APN 4 106,560,358 (GRCm39) missense probably benign 0.00
IGL01729:Mroh7 APN 4 106,561,402 (GRCm39) missense possibly damaging 0.66
IGL01834:Mroh7 APN 4 106,538,071 (GRCm39) missense probably benign 0.00
IGL02003:Mroh7 APN 4 106,559,726 (GRCm39) missense probably damaging 0.96
IGL02135:Mroh7 APN 4 106,559,707 (GRCm39) missense probably damaging 1.00
IGL02335:Mroh7 APN 4 106,564,979 (GRCm39) missense probably damaging 1.00
IGL02532:Mroh7 APN 4 106,577,788 (GRCm39) missense probably benign 0.04
IGL02896:Mroh7 APN 4 106,557,013 (GRCm39) missense possibly damaging 0.94
IGL03066:Mroh7 APN 4 106,549,595 (GRCm39) missense possibly damaging 0.85
IGL03298:Mroh7 APN 4 106,571,288 (GRCm39) nonsense probably null
holy UTSW 4 106,567,152 (GRCm39) splice site probably null
moley UTSW 4 106,551,509 (GRCm39) splice site probably null
P0016:Mroh7 UTSW 4 106,565,054 (GRCm39) critical splice acceptor site probably null
R0019:Mroh7 UTSW 4 106,578,623 (GRCm39) missense probably benign 0.07
R0094:Mroh7 UTSW 4 106,560,381 (GRCm39) missense probably damaging 0.98
R0105:Mroh7 UTSW 4 106,568,467 (GRCm39) missense possibly damaging 0.49
R0105:Mroh7 UTSW 4 106,568,467 (GRCm39) missense possibly damaging 0.49
R0828:Mroh7 UTSW 4 106,557,073 (GRCm39) missense probably damaging 0.99
R0831:Mroh7 UTSW 4 106,537,990 (GRCm39) missense possibly damaging 0.92
R1107:Mroh7 UTSW 4 106,564,791 (GRCm39) splice site probably null
R1301:Mroh7 UTSW 4 106,577,692 (GRCm39) missense probably damaging 0.99
R1456:Mroh7 UTSW 4 106,552,338 (GRCm39) splice site probably benign
R1491:Mroh7 UTSW 4 106,560,255 (GRCm39) missense probably benign 0.11
R1540:Mroh7 UTSW 4 106,560,273 (GRCm39) missense probably benign 0.11
R1560:Mroh7 UTSW 4 106,568,451 (GRCm39) missense possibly damaging 0.78
R1645:Mroh7 UTSW 4 106,577,865 (GRCm39) missense probably benign 0.19
R1804:Mroh7 UTSW 4 106,551,589 (GRCm39) missense possibly damaging 0.76
R2162:Mroh7 UTSW 4 106,557,378 (GRCm39) missense probably damaging 0.96
R2265:Mroh7 UTSW 4 106,578,124 (GRCm39) missense probably benign 0.01
R2866:Mroh7 UTSW 4 106,548,287 (GRCm39) missense probably damaging 1.00
R3716:Mroh7 UTSW 4 106,561,407 (GRCm39) missense probably benign 0.25
R3718:Mroh7 UTSW 4 106,561,407 (GRCm39) missense probably benign 0.25
R4530:Mroh7 UTSW 4 106,577,634 (GRCm39) missense possibly damaging 0.71
R4661:Mroh7 UTSW 4 106,548,710 (GRCm39) critical splice donor site probably null
R4706:Mroh7 UTSW 4 106,548,821 (GRCm39) missense possibly damaging 0.86
R4910:Mroh7 UTSW 4 106,567,152 (GRCm39) splice site probably null
R4965:Mroh7 UTSW 4 106,548,184 (GRCm39) missense possibly damaging 0.77
R4969:Mroh7 UTSW 4 106,538,070 (GRCm39) missense probably benign
R4971:Mroh7 UTSW 4 106,548,749 (GRCm39) missense probably benign 0.04
R5083:Mroh7 UTSW 4 106,547,515 (GRCm39) missense probably benign 0.03
R5207:Mroh7 UTSW 4 106,578,583 (GRCm39) missense probably damaging 0.97
R5364:Mroh7 UTSW 4 106,548,840 (GRCm39) missense probably benign 0.10
R5392:Mroh7 UTSW 4 106,568,448 (GRCm39) critical splice donor site probably null
R5630:Mroh7 UTSW 4 106,577,764 (GRCm39) missense possibly damaging 0.71
R5691:Mroh7 UTSW 4 106,559,815 (GRCm39) missense probably damaging 0.96
R5703:Mroh7 UTSW 4 106,565,757 (GRCm39) missense possibly damaging 0.77
R5707:Mroh7 UTSW 4 106,539,082 (GRCm39) missense possibly damaging 0.73
R5919:Mroh7 UTSW 4 106,551,509 (GRCm39) splice site probably null
R5979:Mroh7 UTSW 4 106,578,123 (GRCm39) missense probably benign 0.00
R6479:Mroh7 UTSW 4 106,560,385 (GRCm39) missense possibly damaging 0.75
R6520:Mroh7 UTSW 4 106,578,460 (GRCm39) missense probably benign 0.00
R6657:Mroh7 UTSW 4 106,559,697 (GRCm39) nonsense probably null
R6732:Mroh7 UTSW 4 106,537,910 (GRCm39) frame shift probably null
R6817:Mroh7 UTSW 4 106,571,312 (GRCm39) missense probably benign 0.00
R6980:Mroh7 UTSW 4 106,557,434 (GRCm39) missense probably benign 0.05
R7062:Mroh7 UTSW 4 106,541,177 (GRCm39) missense probably damaging 1.00
R7116:Mroh7 UTSW 4 106,568,517 (GRCm39) missense probably benign 0.07
R7134:Mroh7 UTSW 4 106,577,791 (GRCm39) missense probably damaging 0.99
R7169:Mroh7 UTSW 4 106,548,836 (GRCm39) missense probably damaging 0.99
R7419:Mroh7 UTSW 4 106,541,115 (GRCm39) missense probably benign
R7516:Mroh7 UTSW 4 106,548,316 (GRCm39) missense probably benign 0.00
R7525:Mroh7 UTSW 4 106,566,899 (GRCm39) missense probably benign 0.22
R7540:Mroh7 UTSW 4 106,577,595 (GRCm39) missense possibly damaging 0.85
R7849:Mroh7 UTSW 4 106,578,287 (GRCm39) missense probably benign
R7920:Mroh7 UTSW 4 106,564,773 (GRCm39) missense probably benign
R7998:Mroh7 UTSW 4 106,568,478 (GRCm39) missense probably benign 0.02
R8026:Mroh7 UTSW 4 106,578,634 (GRCm39) missense probably benign 0.01
R8122:Mroh7 UTSW 4 106,559,726 (GRCm39) missense probably damaging 0.96
R8249:Mroh7 UTSW 4 106,578,409 (GRCm39) missense probably benign 0.00
R9188:Mroh7 UTSW 4 106,566,789 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CCGATGCCTTACGTCAGTGAAGTG -3'
(R):5'- AGCTTAGCCTTGTAGAAGCTGCCC -3'

Sequencing Primer
(F):5'- TCAGTGAAGTGGGGCAGC -3'
(R):5'- GACTCAGATGGCTAACTTGTGAC -3'
Posted On 2013-06-12