Incidental Mutation 'R5989:Sfta2'
ID481905
Institutional Source Beutler Lab
Gene Symbol Sfta2
Ensembl Gene ENSMUSG00000090509
Gene Namesurfactant associated 2
SynonymsEG433102
MMRRC Submission 044169-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.068) question?
Stock #R5989 (G1)
Quality Score103.008
Status Not validated
Chromosome17
Chromosomal Location35601549-35650571 bp(+) (GRCm38)
Type of Mutationintron
DNA Base Change (assembly) G to T at 35649780 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000134221 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171166] [ENSMUST00000174521]
Predicted Effect probably benign
Transcript: ENSMUST00000171166
SMART Domains Protein: ENSMUSP00000132839
Gene: ENSMUSG00000090509

DomainStartEndE-ValueType
low complexity region 3 17 N/A INTRINSIC
Pfam:SFTA2 19 77 1.5e-37 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173162
Predicted Effect probably benign
Transcript: ENSMUST00000174521
SMART Domains Protein: ENSMUSP00000134221
Gene: ENSMUSG00000090509

DomainStartEndE-ValueType
Pfam:SFTA2 80 117 9.2e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174534
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.4%
  • 10x: 97.0%
  • 20x: 90.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cartpt T A 13: 99,898,984 I109F probably damaging Het
Csmd3 G A 15: 47,590,764 P3562L possibly damaging Het
Cyp2c40 T C 19: 39,807,580 D118G probably benign Het
Dmrt1 T A 19: 25,545,881 S199T possibly damaging Het
Ebf1 G T 11: 44,996,171 C565F probably damaging Het
Ggnbp1 A G 17: 27,029,747 R97G probably benign Het
Gm10271 A T 10: 116,972,592 F6L probably damaging Het
Gm10767 G A 13: 66,907,986 M14I probably damaging Het
Gm42417 A G 1: 36,532,192 F183L probably damaging Het
Ipcef1 A T 10: 6,979,532 Y69* probably null Het
Lcp1 A T 14: 75,199,387 M58L probably benign Het
Mtif2 A G 11: 29,530,098 T55A probably damaging Het
Nefm A G 14: 68,124,329 V162A probably benign Het
Nmral1 G A 16: 4,719,038 probably benign Het
Olfr191 A T 16: 59,086,334 W50R probably benign Het
Panx2 T C 15: 89,060,252 L60P probably damaging Het
Prkag3 T C 1: 74,741,274 N411D probably benign Het
Prrxl1 A G 14: 32,608,188 N116S probably benign Het
Rnd2 C T 11: 101,468,999 L57F probably damaging Het
Rttn G A 18: 88,973,626 D110N probably damaging Het
Slc17a3 A G 13: 23,842,428 probably benign Het
Spem1 G A 11: 69,821,125 P238S possibly damaging Het
Tmem200c G T 17: 68,837,436 probably benign Het
Trpm2 A G 10: 77,959,900 F131S probably damaging Het
Vps51 A G 19: 6,076,372 S117P probably damaging Het
Zbtb21 G A 16: 97,951,499 P556L probably damaging Het
Other mutations in Sfta2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01022:Sfta2 APN 17 35650444 missense possibly damaging 0.93
R1077:Sfta2 UTSW 17 35650127 intron probably benign
R4194:Sfta2 UTSW 17 35628165 critical splice donor site probably null
R4578:Sfta2 UTSW 17 35649883 intron probably benign
R4841:Sfta2 UTSW 17 35649881 intron probably benign
R4842:Sfta2 UTSW 17 35649881 intron probably benign
R7409:Sfta2 UTSW 17 35614518 missense unknown
Predicted Primers
Posted On2017-06-26