Incidental Mutation 'R0515:Dcp2'
ID 48202
Institutional Source Beutler Lab
Gene Symbol Dcp2
Ensembl Gene ENSMUSG00000024472
Gene Name decapping mRNA 2
Synonyms 2410015D23Rik, 5730537H01Rik
MMRRC Submission 038709-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.957) question?
Stock # R0515 (G1)
Quality Score 225
Status Validated
Chromosome 18
Chromosomal Location 44513569-44558036 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 44532798 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 105 (L105F)
Ref Sequence ENSEMBL: ENSMUSP00000025350 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025350] [ENSMUST00000202306]
AlphaFold Q9CYC6
Predicted Effect probably benign
Transcript: ENSMUST00000025350
AA Change: L105F

PolyPhen 2 Score 0.415 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000025350
Gene: ENSMUSG00000024472
AA Change: L105F

DomainStartEndE-ValueType
DCP2 10 94 4.23e-50 SMART
Pfam:NUDIX 97 219 6.5e-17 PFAM
low complexity region 240 258 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000202306
SMART Domains Protein: ENSMUSP00000144010
Gene: ENSMUSG00000024472

DomainStartEndE-ValueType
DCP2 10 82 5.7e-28 SMART
Meta Mutation Damage Score 0.4526 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 92.6%
Validation Efficiency 98% (40/41)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele are viable and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
App C T 16: 84,900,232 (GRCm39) probably benign Het
Arhgap11a G A 2: 113,667,816 (GRCm39) T395I possibly damaging Het
Arhgef38 T G 3: 132,855,301 (GRCm39) H262P probably damaging Het
Cd96 A G 16: 45,884,268 (GRCm39) probably benign Het
Cfap57 A G 4: 118,477,599 (GRCm39) S2P probably damaging Het
Cltc A G 11: 86,599,865 (GRCm39) S948P probably benign Het
Cyp3a41a A T 5: 145,654,810 (GRCm39) H30Q probably damaging Het
Dennd4c T C 4: 86,731,703 (GRCm39) V887A possibly damaging Het
Dnaaf9 A G 2: 130,582,408 (GRCm39) V515A probably damaging Het
Gm11360 T A 13: 28,140,143 (GRCm39) D2E probably damaging Het
Gpank1 G T 17: 35,342,475 (GRCm39) A149S probably damaging Het
Gtf2i C A 5: 134,271,773 (GRCm39) S792I probably damaging Het
Hvcn1 A G 5: 122,371,582 (GRCm39) N41D probably damaging Het
Klk1b5 A G 7: 43,867,957 (GRCm39) Y43C probably damaging Het
Lmtk2 A G 5: 144,111,809 (GRCm39) D843G possibly damaging Het
Lrriq1 A T 10: 102,904,829 (GRCm39) probably null Het
Mapk8ip1 A T 2: 92,217,701 (GRCm39) I198N possibly damaging Het
Mill1 T C 7: 17,998,798 (GRCm39) V336A probably benign Het
Mroh7 T A 4: 106,548,861 (GRCm39) M1001L probably benign Het
Nfe2 T A 15: 103,157,854 (GRCm39) T46S probably null Het
Or8b40 T C 9: 38,027,313 (GRCm39) S74P probably damaging Het
Or9q1 T C 19: 13,805,185 (GRCm39) S192G probably damaging Het
Parp4 T C 14: 56,851,124 (GRCm39) V709A probably damaging Het
Pkd1l3 C G 8: 110,350,281 (GRCm39) D375E possibly damaging Het
Prex2 A T 1: 11,270,098 (GRCm39) Q1261L probably damaging Het
Prl8a8 T A 13: 27,692,350 (GRCm39) I214L probably damaging Het
Rictor C T 15: 6,798,782 (GRCm39) T343M probably damaging Het
Sema6a G A 18: 47,423,112 (GRCm39) probably null Het
Siglecf T C 7: 43,005,055 (GRCm39) probably null Het
Slco1b2 T C 6: 141,615,136 (GRCm39) F347S possibly damaging Het
Sox13 A T 1: 133,311,457 (GRCm39) Y592N probably damaging Het
Synj1 C T 16: 90,790,910 (GRCm39) A84T possibly damaging Het
Tent5b A T 4: 133,213,450 (GRCm39) H107L possibly damaging Het
Trpv5 T A 6: 41,651,145 (GRCm39) probably benign Het
Tshz1 A G 18: 84,034,090 (GRCm39) V106A probably benign Het
Other mutations in Dcp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02801:Dcp2 APN 18 44,550,778 (GRCm39) missense probably damaging 1.00
belay UTSW 18 44,529,019 (GRCm39) missense probably damaging 0.99
PIT4431001:Dcp2 UTSW 18 44,545,638 (GRCm39) missense probably benign 0.15
R0051:Dcp2 UTSW 18 44,538,441 (GRCm39) splice site probably benign
R0761:Dcp2 UTSW 18 44,543,300 (GRCm39) missense probably benign 0.01
R1696:Dcp2 UTSW 18 44,533,391 (GRCm39) missense probably damaging 1.00
R1803:Dcp2 UTSW 18 44,528,984 (GRCm39) missense probably damaging 1.00
R1928:Dcp2 UTSW 18 44,538,638 (GRCm39) critical splice donor site probably null
R1964:Dcp2 UTSW 18 44,529,038 (GRCm39) missense possibly damaging 0.50
R2014:Dcp2 UTSW 18 44,543,363 (GRCm39) missense probably benign 0.00
R2209:Dcp2 UTSW 18 44,538,581 (GRCm39) nonsense probably null
R4167:Dcp2 UTSW 18 44,529,034 (GRCm39) missense probably damaging 1.00
R4668:Dcp2 UTSW 18 44,548,429 (GRCm39) splice site probably null
R4877:Dcp2 UTSW 18 44,550,659 (GRCm39) missense probably benign 0.11
R5147:Dcp2 UTSW 18 44,550,662 (GRCm39) nonsense probably null
R5559:Dcp2 UTSW 18 44,538,554 (GRCm39) missense probably damaging 1.00
R6533:Dcp2 UTSW 18 44,532,731 (GRCm39) missense probably benign 0.25
R7406:Dcp2 UTSW 18 44,543,254 (GRCm39) missense probably benign 0.00
R7469:Dcp2 UTSW 18 44,529,019 (GRCm39) missense probably damaging 0.99
R7850:Dcp2 UTSW 18 44,533,415 (GRCm39) nonsense probably null
R8054:Dcp2 UTSW 18 44,538,774 (GRCm39) missense probably benign 0.02
R8315:Dcp2 UTSW 18 44,529,071 (GRCm39) missense probably benign 0.01
R9422:Dcp2 UTSW 18 44,538,361 (GRCm39) missense probably damaging 1.00
R9423:Dcp2 UTSW 18 44,538,361 (GRCm39) missense probably damaging 1.00
R9424:Dcp2 UTSW 18 44,538,361 (GRCm39) missense probably damaging 1.00
R9425:Dcp2 UTSW 18 44,538,361 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CGGGAGTCTAGCACTGATGATCCTTA -3'
(R):5'- ATGCAGGCAAAGCATCCAAAATTTAGTT -3'

Sequencing Primer
(F):5'- cacagtgtcactccagcc -3'
(R):5'- TCGGCCATCACATCACTAGA -3'
Posted On 2013-06-12