Incidental Mutation 'R5524:Agbl5'
| ID |
482216 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Agbl5
|
| Ensembl Gene |
ENSMUSG00000029165 |
| Gene Name |
ATP/GTP binding protein-like 5 |
| Synonyms |
Ccp5, 9430057O19Rik |
| MMRRC Submission |
043082-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5524 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
31046038-31064309 bp(+) (GRCm39) |
| Type of Mutation |
splice site (2034 bp from exon) |
| DNA Base Change (assembly) |
G to A
at 31051247 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000144274
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000069705]
[ENSMUST00000114700]
[ENSMUST00000200695]
[ENSMUST00000200850]
[ENSMUST00000202060]
[ENSMUST00000201917]
[ENSMUST00000201168]
[ENSMUST00000201225]
[ENSMUST00000201817]
[ENSMUST00000202109]
|
| AlphaFold |
Q09M02 |
| Predicted Effect |
silent
Transcript: ENSMUST00000069705
|
| SMART Domains |
Protein: ENSMUSP00000063228
Gene: ENSMUSG00000029165
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
50 |
N/A |
INTRINSIC |
|
Pfam:Peptidase_M14
|
191 |
361 |
8.4e-19 |
PFAM |
|
low complexity region
|
384 |
399 |
N/A |
INTRINSIC |
|
Blast:Zn_pept
|
424 |
489 |
4e-14 |
BLAST |
|
low complexity region
|
538 |
548 |
N/A |
INTRINSIC |
|
low complexity region
|
643 |
654 |
N/A |
INTRINSIC |
|
| Predicted Effect |
silent
Transcript: ENSMUST00000114700
|
| SMART Domains |
Protein: ENSMUSP00000110348
Gene: ENSMUSG00000029165
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
50 |
N/A |
INTRINSIC |
|
Pfam:Peptidase_M14
|
220 |
390 |
1.1e-18 |
PFAM |
|
low complexity region
|
413 |
428 |
N/A |
INTRINSIC |
|
Blast:Zn_pept
|
453 |
518 |
5e-14 |
BLAST |
|
low complexity region
|
567 |
577 |
N/A |
INTRINSIC |
|
low complexity region
|
672 |
683 |
N/A |
INTRINSIC |
|
low complexity region
|
743 |
762 |
N/A |
INTRINSIC |
|
low complexity region
|
766 |
787 |
N/A |
INTRINSIC |
|
low complexity region
|
824 |
835 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000134956
AA Change: W481*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000200695
|
| SMART Domains |
Protein: ENSMUSP00000144109
Gene: ENSMUSG00000029165
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
50 |
N/A |
INTRINSIC |
|
SCOP:d2ctc__
|
148 |
177 |
5e-4 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000200850
|
| SMART Domains |
Protein: ENSMUSP00000144274
Gene: ENSMUSG00000029165
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
50 |
N/A |
INTRINSIC |
|
SCOP:d1jqga1
|
178 |
229 |
1e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000200990
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000201014
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000202757
|
| Predicted Effect |
silent
Transcript: ENSMUST00000202060
|
| SMART Domains |
Protein: ENSMUSP00000144018
Gene: ENSMUSG00000029165
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
50 |
N/A |
INTRINSIC |
|
Pfam:Peptidase_M14
|
196 |
373 |
5.9e-13 |
PFAM |
|
low complexity region
|
384 |
399 |
N/A |
INTRINSIC |
|
Blast:Zn_pept
|
424 |
489 |
5e-14 |
BLAST |
|
low complexity region
|
538 |
548 |
N/A |
INTRINSIC |
|
low complexity region
|
643 |
654 |
N/A |
INTRINSIC |
|
low complexity region
|
714 |
733 |
N/A |
INTRINSIC |
|
low complexity region
|
752 |
768 |
N/A |
INTRINSIC |
|
| Predicted Effect |
silent
Transcript: ENSMUST00000201917
|
| SMART Domains |
Protein: ENSMUSP00000144188
Gene: ENSMUSG00000029165
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
50 |
N/A |
INTRINSIC |
|
Pfam:Peptidase_M14
|
196 |
372 |
6.5e-13 |
PFAM |
|
low complexity region
|
384 |
399 |
N/A |
INTRINSIC |
|
Blast:Zn_pept
|
424 |
489 |
5e-14 |
BLAST |
|
low complexity region
|
538 |
548 |
N/A |
INTRINSIC |
|
low complexity region
|
643 |
654 |
N/A |
INTRINSIC |
|
low complexity region
|
714 |
733 |
N/A |
INTRINSIC |
|
low complexity region
|
737 |
758 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
806 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000201167
|
| Predicted Effect |
silent
Transcript: ENSMUST00000201168
|
| SMART Domains |
Protein: ENSMUSP00000143808
Gene: ENSMUSG00000029165
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
50 |
N/A |
INTRINSIC |
|
Pfam:Peptidase_M14
|
196 |
370 |
7.3e-13 |
PFAM |
|
low complexity region
|
384 |
399 |
N/A |
INTRINSIC |
|
Blast:Zn_pept
|
424 |
489 |
5e-14 |
BLAST |
|
low complexity region
|
538 |
548 |
N/A |
INTRINSIC |
|
low complexity region
|
643 |
654 |
N/A |
INTRINSIC |
|
low complexity region
|
714 |
733 |
N/A |
INTRINSIC |
|
low complexity region
|
737 |
758 |
N/A |
INTRINSIC |
|
low complexity region
|
836 |
847 |
N/A |
INTRINSIC |
|
| Predicted Effect |
silent
Transcript: ENSMUST00000201225
|
| SMART Domains |
Protein: ENSMUSP00000143934
Gene: ENSMUSG00000029165
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
50 |
N/A |
INTRINSIC |
|
Pfam:Peptidase_M14
|
196 |
373 |
5.9e-13 |
PFAM |
|
low complexity region
|
384 |
399 |
N/A |
INTRINSIC |
|
Blast:Zn_pept
|
424 |
489 |
5e-14 |
BLAST |
|
low complexity region
|
538 |
548 |
N/A |
INTRINSIC |
|
low complexity region
|
643 |
654 |
N/A |
INTRINSIC |
|
low complexity region
|
714 |
733 |
N/A |
INTRINSIC |
|
low complexity region
|
752 |
768 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000201918
|
| Predicted Effect |
silent
Transcript: ENSMUST00000201817
|
| SMART Domains |
Protein: ENSMUSP00000144304
Gene: ENSMUSG00000029165
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
50 |
N/A |
INTRINSIC |
|
Pfam:Peptidase_M14
|
196 |
372 |
6.4e-13 |
PFAM |
|
low complexity region
|
384 |
399 |
N/A |
INTRINSIC |
|
Blast:Zn_pept
|
424 |
489 |
5e-14 |
BLAST |
|
low complexity region
|
538 |
548 |
N/A |
INTRINSIC |
|
low complexity region
|
643 |
654 |
N/A |
INTRINSIC |
|
low complexity region
|
714 |
733 |
N/A |
INTRINSIC |
|
low complexity region
|
737 |
758 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000202893
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000202565
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000201901
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000201523
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000202109
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 98.3%
- 3x: 97.3%
- 10x: 95.4%
- 20x: 91.4%
|
| Validation Efficiency |
100% (76/76) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a metallocarboxypeptidase involved in protein deglutamylation and a member of the peptidase M14 family of proteins. The encoded protein has been described as a "dual-functional" deglutamylase that can remove glutamate residues from both carboxyl termini and side chains of protein substrates. This deglutamylase activity may be important in antiviral immunity. Mutations in this gene are associated with retinitis pigmentosa. [provided by RefSeq, Jul 2016]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to HSV or VACV infection. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700010L04Rik |
T |
A |
7: 82,503,150 (GRCm39) |
|
noncoding transcript |
Het |
| 6030469F06Rik |
A |
G |
12: 31,234,862 (GRCm39) |
|
noncoding transcript |
Het |
| A830031A19Rik |
T |
A |
11: 24,008,776 (GRCm39) |
I13F |
unknown |
Het |
| Acsbg2 |
A |
C |
17: 57,157,197 (GRCm39) |
L309R |
probably damaging |
Het |
| Adam32 |
A |
T |
8: 25,412,328 (GRCm39) |
M76K |
probably damaging |
Het |
| Adamts14 |
C |
A |
10: 61,066,222 (GRCm39) |
R297L |
probably damaging |
Het |
| Asb14 |
A |
G |
14: 26,622,408 (GRCm39) |
K80E |
possibly damaging |
Het |
| Baiap2l1 |
T |
C |
5: 144,217,759 (GRCm39) |
T276A |
probably benign |
Het |
| Cacna1d |
G |
A |
14: 29,764,086 (GRCm39) |
P2127S |
probably benign |
Het |
| Ces2g |
A |
G |
8: 105,693,527 (GRCm39) |
T403A |
probably benign |
Het |
| Cgn |
A |
C |
3: 94,687,299 (GRCm39) |
M1R |
probably null |
Het |
| Chd5 |
T |
G |
4: 152,461,087 (GRCm39) |
S1226A |
probably benign |
Het |
| Col18a1 |
A |
G |
10: 76,894,558 (GRCm39) |
V1497A |
probably damaging |
Het |
| Cpd |
A |
T |
11: 76,688,727 (GRCm39) |
Y848* |
probably null |
Het |
| Cyp2a12 |
T |
C |
7: 26,730,656 (GRCm39) |
V207A |
probably benign |
Het |
| Cyth1 |
G |
A |
11: 118,073,593 (GRCm39) |
R247W |
probably benign |
Het |
| Derl3 |
T |
C |
10: 75,730,324 (GRCm39) |
V129A |
possibly damaging |
Het |
| Ehmt2 |
C |
T |
17: 35,118,067 (GRCm39) |
R40* |
probably null |
Het |
| Eml1 |
A |
T |
12: 108,487,635 (GRCm39) |
I518L |
probably damaging |
Het |
| Eri1 |
A |
G |
8: 35,945,763 (GRCm39) |
V174A |
probably benign |
Het |
| Fgd3 |
T |
A |
13: 49,431,053 (GRCm39) |
I435F |
probably damaging |
Het |
| Foxd1 |
T |
G |
13: 98,492,412 (GRCm39) |
S429A |
unknown |
Het |
| Ftcd |
T |
A |
10: 76,425,165 (GRCm39) |
|
probably benign |
Het |
| Gm5478 |
G |
T |
15: 101,553,102 (GRCm39) |
N323K |
probably benign |
Het |
| Gnpda1 |
G |
T |
18: 38,468,161 (GRCm39) |
P45Q |
probably damaging |
Het |
| Kif20a |
G |
T |
18: 34,763,678 (GRCm39) |
|
probably null |
Het |
| Klrb1 |
T |
C |
6: 128,689,296 (GRCm39) |
|
probably null |
Het |
| Lcorl |
C |
A |
5: 45,932,864 (GRCm39) |
|
probably null |
Het |
| Lcorl |
T |
A |
5: 45,932,865 (GRCm39) |
|
probably null |
Het |
| Lrp1b |
T |
A |
2: 41,000,900 (GRCm39) |
K2108M |
probably damaging |
Het |
| Lyst |
C |
T |
13: 13,921,364 (GRCm39) |
P3437S |
probably benign |
Het |
| Macrod2 |
A |
T |
2: 142,159,863 (GRCm39) |
M349L |
possibly damaging |
Het |
| Marchf7 |
T |
C |
2: 60,075,647 (GRCm39) |
|
probably benign |
Het |
| Mcm9 |
A |
T |
10: 53,424,786 (GRCm39) |
C601* |
probably null |
Het |
| Muc19 |
G |
T |
15: 91,778,587 (GRCm39) |
|
noncoding transcript |
Het |
| Mycbp2 |
T |
C |
14: 103,532,673 (GRCm39) |
D427G |
probably damaging |
Het |
| Nap1l5 |
C |
A |
6: 58,883,763 (GRCm39) |
V64L |
possibly damaging |
Het |
| Ncam2 |
C |
T |
16: 81,231,766 (GRCm39) |
R77* |
probably null |
Het |
| Npas3 |
T |
C |
12: 54,115,721 (GRCm39) |
V863A |
possibly damaging |
Het |
| Nr2c2 |
T |
A |
6: 92,116,746 (GRCm39) |
|
probably null |
Het |
| Oosp3 |
T |
C |
19: 11,682,794 (GRCm39) |
F56S |
possibly damaging |
Het |
| Or1a1b |
A |
T |
11: 74,097,409 (GRCm39) |
L211Q |
probably damaging |
Het |
| Or5k17 |
C |
T |
16: 58,746,172 (GRCm39) |
C254Y |
probably benign |
Het |
| Or8g20 |
C |
T |
9: 39,396,283 (GRCm39) |
V89M |
probably damaging |
Het |
| Plgrkt |
G |
A |
19: 29,327,850 (GRCm39) |
P78S |
probably damaging |
Het |
| Prss36 |
G |
A |
7: 127,533,637 (GRCm39) |
Q56* |
probably null |
Het |
| Ptprz1 |
A |
G |
6: 22,986,317 (GRCm39) |
|
probably null |
Het |
| Qsox2 |
A |
T |
2: 26,107,699 (GRCm39) |
F265I |
probably damaging |
Het |
| R3hcc1l |
G |
T |
19: 42,552,307 (GRCm39) |
E435* |
probably null |
Het |
| Shbg |
T |
C |
11: 69,507,588 (GRCm39) |
D163G |
probably benign |
Het |
| Skint7 |
T |
A |
4: 111,837,546 (GRCm39) |
L108H |
probably damaging |
Het |
| Smtnl1 |
T |
A |
2: 84,649,238 (GRCm39) |
E5D |
probably benign |
Het |
| Spock1 |
C |
T |
13: 57,704,608 (GRCm39) |
G120D |
probably damaging |
Het |
| Stk11ip |
G |
T |
1: 75,508,971 (GRCm39) |
C700F |
probably damaging |
Het |
| Sult4a1 |
C |
T |
15: 83,974,159 (GRCm39) |
|
probably null |
Het |
| Syngap1 |
A |
G |
17: 27,176,126 (GRCm39) |
H138R |
probably damaging |
Het |
| Tdrd7 |
A |
G |
4: 46,034,301 (GRCm39) |
K1016E |
probably benign |
Het |
| Tmem167b |
T |
C |
3: 108,467,569 (GRCm39) |
K26E |
possibly damaging |
Het |
| Tnfaip3 |
A |
G |
10: 18,883,943 (GRCm39) |
S146P |
probably damaging |
Het |
| Ttn |
C |
T |
2: 76,607,060 (GRCm39) |
V16242I |
possibly damaging |
Het |
| Vmn2r-ps3 |
T |
A |
3: 63,960,870 (GRCm39) |
|
noncoding transcript |
Het |
| Vps13c |
T |
C |
9: 67,864,838 (GRCm39) |
F3049S |
probably damaging |
Het |
| Vstm2l |
T |
C |
2: 157,777,355 (GRCm39) |
W78R |
probably damaging |
Het |
| Wbp1l |
C |
A |
19: 46,642,695 (GRCm39) |
A216D |
possibly damaging |
Het |
| Zer1 |
C |
G |
2: 29,994,866 (GRCm39) |
V510L |
probably damaging |
Het |
| Zfp28 |
A |
T |
7: 6,397,850 (GRCm39) |
|
probably null |
Het |
| Zfp352 |
C |
A |
4: 90,113,341 (GRCm39) |
P494T |
possibly damaging |
Het |
| Zfp353-ps |
A |
G |
8: 42,535,600 (GRCm39) |
|
noncoding transcript |
Het |
| Zfp563 |
A |
T |
17: 33,321,515 (GRCm39) |
|
probably null |
Het |
| Zim1 |
T |
C |
7: 6,680,320 (GRCm39) |
N448D |
probably benign |
Het |
|
| Other mutations in Agbl5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01315:Agbl5
|
APN |
5 |
31,050,578 (GRCm39) |
missense |
probably benign |
0.00 |
|
sausage
|
UTSW |
5 |
31,051,702 (GRCm39) |
nonsense |
probably null |
|
|
R0355:Agbl5
|
UTSW |
5 |
31,049,335 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0575:Agbl5
|
UTSW |
5 |
31,051,798 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1694:Agbl5
|
UTSW |
5 |
31,050,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1709:Agbl5
|
UTSW |
5 |
31,063,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1829:Agbl5
|
UTSW |
5 |
31,060,408 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2434:Agbl5
|
UTSW |
5 |
31,051,357 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3418:Agbl5
|
UTSW |
5 |
31,062,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4827:Agbl5
|
UTSW |
5 |
31,053,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4828:Agbl5
|
UTSW |
5 |
31,048,059 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4830:Agbl5
|
UTSW |
5 |
31,048,059 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5017:Agbl5
|
UTSW |
5 |
31,060,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5018:Agbl5
|
UTSW |
5 |
31,060,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5036:Agbl5
|
UTSW |
5 |
31,060,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5038:Agbl5
|
UTSW |
5 |
31,060,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5052:Agbl5
|
UTSW |
5 |
31,048,558 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5071:Agbl5
|
UTSW |
5 |
31,060,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5073:Agbl5
|
UTSW |
5 |
31,060,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5074:Agbl5
|
UTSW |
5 |
31,060,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5081:Agbl5
|
UTSW |
5 |
31,060,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5083:Agbl5
|
UTSW |
5 |
31,060,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5103:Agbl5
|
UTSW |
5 |
31,051,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5107:Agbl5
|
UTSW |
5 |
31,049,822 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5130:Agbl5
|
UTSW |
5 |
31,060,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5395:Agbl5
|
UTSW |
5 |
31,047,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5522:Agbl5
|
UTSW |
5 |
31,051,247 (GRCm39) |
splice site |
probably null |
|
|
R5526:Agbl5
|
UTSW |
5 |
31,051,247 (GRCm39) |
splice site |
probably null |
|
|
R5657:Agbl5
|
UTSW |
5 |
31,051,390 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5790:Agbl5
|
UTSW |
5 |
31,051,702 (GRCm39) |
nonsense |
probably null |
|
|
R6301:Agbl5
|
UTSW |
5 |
31,049,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6891:Agbl5
|
UTSW |
5 |
31,052,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6919:Agbl5
|
UTSW |
5 |
31,062,061 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7388:Agbl5
|
UTSW |
5 |
31,060,583 (GRCm39) |
nonsense |
probably null |
|
|
R7392:Agbl5
|
UTSW |
5 |
31,048,115 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7410:Agbl5
|
UTSW |
5 |
31,048,032 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7452:Agbl5
|
UTSW |
5 |
31,050,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8312:Agbl5
|
UTSW |
5 |
31,051,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8901:Agbl5
|
UTSW |
5 |
31,048,435 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
RF007:Agbl5
|
UTSW |
5 |
31,060,589 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CGTCTTCCATAGAGCTGAGAACC -3'
(R):5'- ACCTGTGGATTATCCCTGAGG -3'
Sequencing Primer
(F):5'- TCTGAGCTTAAAAGAAACAGTGC -3'
(R):5'- AGGCTTTGTAGATTGCGACAC -3'
|
| Posted On |
2017-07-11 |
Incidental Mutation