Incidental Mutation 'R0517:Tas2r139'
ID 48224
Institutional Source Beutler Lab
Gene Symbol Tas2r139
Ensembl Gene ENSMUSG00000047102
Gene Name taste receptor, type 2, member 139
Synonyms mt2r34, Tas2r39
MMRRC Submission 038710-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0517 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 42117870-42118829 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 42118425 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Proline at position 186 (T186P)
Ref Sequence ENSEMBL: ENSMUSP00000062919 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057686]
AlphaFold Q7TQA5
Predicted Effect probably damaging
Transcript: ENSMUST00000057686
AA Change: T186P

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000062919
Gene: ENSMUSG00000047102
AA Change: T186P

DomainStartEndE-ValueType
Pfam:TAS2R 13 311 2.5e-64 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 92.1%
Validation Efficiency 100% (62/62)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a bitter taste receptor that detects green tea catechins, soy isoflavones, and theaflavins. The encoded protein is gustducin-linked and may activate alpha gustducin. This gene is intronless. [provided by RefSeq, Dec 2015]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410137M14Rik T A 17: 37,292,024 (GRCm39) probably benign Het
Acer1 T C 17: 57,262,569 (GRCm39) T194A probably benign Het
Adamts1 C A 16: 85,597,241 (GRCm39) D10Y possibly damaging Het
Adamts7 T C 9: 90,081,911 (GRCm39) V1612A probably benign Het
Adcyap1r1 T A 6: 55,468,282 (GRCm39) S373T probably damaging Het
Asic5 A T 3: 81,916,833 (GRCm39) I266F probably benign Het
Cacna1d A T 14: 29,901,232 (GRCm39) I274K probably damaging Het
Camsap2 G T 1: 136,221,126 (GRCm39) Q238K possibly damaging Het
Ceacam15 A C 7: 16,407,445 (GRCm39) L24* probably null Het
Cerk G A 15: 86,040,849 (GRCm39) T170I probably damaging Het
Cyp27b1 T C 10: 126,885,985 (GRCm39) probably null Het
Cyp2c65 T C 19: 39,070,792 (GRCm39) probably benign Het
Dennd5a A G 7: 109,533,968 (GRCm39) S75P probably damaging Het
Dhx9 C T 1: 153,354,662 (GRCm39) A146T possibly damaging Het
Dpysl5 A G 5: 30,935,410 (GRCm39) D171G probably damaging Het
Dsg3 A G 18: 20,662,082 (GRCm39) N449S probably benign Het
Eps8l3 T C 3: 107,790,776 (GRCm39) S189P probably benign Het
Exph5 A G 9: 53,284,062 (GRCm39) E381G probably benign Het
Fbxo46 A G 7: 18,870,799 (GRCm39) M473V possibly damaging Het
Fgf14 G A 14: 124,221,196 (GRCm39) P203S probably damaging Het
Foxf2 C T 13: 31,810,226 (GRCm39) A55V unknown Het
Galnt5 T G 2: 57,925,385 (GRCm39) probably benign Het
Glis2 T C 16: 4,429,416 (GRCm39) L181P probably damaging Het
Gm10000 T G 12: 104,442,667 (GRCm39) probably benign Het
Helz2 A G 2: 180,869,563 (GRCm39) S2959P probably benign Het
Hyal6 A G 6: 24,734,852 (GRCm39) N262D probably benign Het
Lgr4 T C 2: 109,841,665 (GRCm39) L526P probably damaging Het
Mapk1 A T 16: 16,833,910 (GRCm39) I88F probably benign Het
Mpg A T 11: 32,181,853 (GRCm39) H287L probably benign Het
Mpp4 A T 1: 59,163,886 (GRCm39) Y489* probably null Het
Mpzl1 T C 1: 165,429,359 (GRCm39) E224G probably damaging Het
Myh10 A G 11: 68,702,425 (GRCm39) probably null Het
Odad2 A C 18: 7,223,621 (GRCm39) L474R probably damaging Het
Or13p8 T A 4: 118,583,831 (GRCm39) I129K probably damaging Het
Or5m9 T C 2: 85,877,548 (GRCm39) S241P probably damaging Het
Paip1 T A 13: 119,584,326 (GRCm39) F196I probably damaging Het
Pde3a A T 6: 141,444,383 (GRCm39) K1064* probably null Het
Pira2 A T 7: 3,847,196 (GRCm39) probably benign Het
Pros1 A G 16: 62,723,881 (GRCm39) S210G probably benign Het
Rbm15 A T 3: 107,238,685 (GRCm39) L571Q probably damaging Het
Scn1a T A 2: 66,132,751 (GRCm39) T1194S possibly damaging Het
Sema6a G A 18: 47,423,112 (GRCm39) probably null Het
Serpina1e G A 12: 103,915,486 (GRCm39) T240I probably benign Het
Setx T G 2: 29,047,145 (GRCm39) S1874R probably benign Het
Sgsm2 G T 11: 74,758,477 (GRCm39) T256K possibly damaging Het
Slc44a1 T C 4: 53,542,366 (GRCm39) V300A probably damaging Het
Spata46 A G 1: 170,139,178 (GRCm39) Y59C probably damaging Het
Supt3 T C 17: 45,430,158 (GRCm39) F404L probably benign Het
Tars1 T A 15: 11,394,452 (GRCm39) K62* probably null Het
Tasor2 T A 13: 3,616,964 (GRCm39) T2367S possibly damaging Het
Tc2n C T 12: 101,615,454 (GRCm39) S457N probably damaging Het
Tox4 A T 14: 52,530,085 (GRCm39) S582C probably benign Het
Trappc12 T C 12: 28,747,133 (GRCm39) probably benign Het
Ubqlnl G T 7: 103,797,845 (GRCm39) Q551K probably damaging Het
Ubr4 A G 4: 139,119,435 (GRCm39) T205A probably benign Het
Urb1 G A 16: 90,574,310 (GRCm39) Q924* probably null Het
Vmn1r49 A G 6: 90,049,720 (GRCm39) L94P probably damaging Het
Vmn2r120 T C 17: 57,815,949 (GRCm39) Y802C probably damaging Het
Xrcc1 C T 7: 24,269,744 (GRCm39) probably benign Het
Other mutations in Tas2r139
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00863:Tas2r139 APN 6 42,118,055 (GRCm39) missense probably damaging 1.00
IGL01593:Tas2r139 APN 6 42,117,891 (GRCm39) missense probably benign 0.01
IGL01835:Tas2r139 APN 6 42,118,366 (GRCm39) missense probably benign 0.21
IGL02990:Tas2r139 APN 6 42,118,038 (GRCm39) missense probably damaging 1.00
R1106:Tas2r139 UTSW 6 42,118,479 (GRCm39) missense probably benign 0.36
R1352:Tas2r139 UTSW 6 42,117,874 (GRCm39) missense probably benign 0.28
R4352:Tas2r139 UTSW 6 42,118,689 (GRCm39) missense probably damaging 1.00
R4632:Tas2r139 UTSW 6 42,118,432 (GRCm39) missense probably damaging 1.00
R4785:Tas2r139 UTSW 6 42,118,218 (GRCm39) missense probably damaging 1.00
R4947:Tas2r139 UTSW 6 42,118,500 (GRCm39) missense possibly damaging 0.82
R5888:Tas2r139 UTSW 6 42,118,430 (GRCm39) missense probably damaging 1.00
R6796:Tas2r139 UTSW 6 42,118,526 (GRCm39) missense probably damaging 1.00
R8058:Tas2r139 UTSW 6 42,118,753 (GRCm39) missense probably benign 0.01
R8075:Tas2r139 UTSW 6 42,118,154 (GRCm39) missense probably benign 0.00
R8319:Tas2r139 UTSW 6 42,118,720 (GRCm39) missense probably benign 0.01
R9087:Tas2r139 UTSW 6 42,118,168 (GRCm39) missense probably damaging 1.00
R9185:Tas2r139 UTSW 6 42,118,099 (GRCm39) missense probably benign 0.25
R9803:Tas2r139 UTSW 6 42,118,066 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGGACACATTTTCCAGCAGACTCC -3'
(R):5'- TTTGATGGCCTGCATATGAGCCTC -3'

Sequencing Primer
(F):5'- GGCCTCCAAAGCATCATGTTG -3'
(R):5'- TGCATATGAGCCTCTATGCAG -3'
Posted On 2013-06-12