Incidental Mutation 'R6083:Sipa1l2'
| ID |
482311 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Sipa1l2
|
| Ensembl Gene |
ENSMUSG00000001995 |
| Gene Name |
signal-induced proliferation-associated 1 like 2 |
| Synonyms |
|
| MMRRC Submission |
044242-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.324)
|
| Stock # |
R6083 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
125418063-125569808 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 125468473 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 842
(V842E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000148557
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000108775]
[ENSMUST00000212168]
[ENSMUST00000212987]
|
| AlphaFold |
Q80TE4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000108775
AA Change: V842E
PolyPhen 2
Score 0.795 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000104405
Gene: ENSMUSG00000001995
AA Change: V842E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
53 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
163 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
261 |
272 |
N/A |
INTRINSIC |
|
low complexity region
|
427 |
449 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
625 |
807 |
2.6e-67 |
PFAM |
|
PDZ
|
960 |
1026 |
6.47e-9 |
SMART |
|
low complexity region
|
1091 |
1103 |
N/A |
INTRINSIC |
|
low complexity region
|
1120 |
1138 |
N/A |
INTRINSIC |
|
low complexity region
|
1220 |
1238 |
N/A |
INTRINSIC |
|
low complexity region
|
1299 |
1312 |
N/A |
INTRINSIC |
|
low complexity region
|
1321 |
1329 |
N/A |
INTRINSIC |
|
low complexity region
|
1334 |
1355 |
N/A |
INTRINSIC |
|
low complexity region
|
1404 |
1418 |
N/A |
INTRINSIC |
|
Pfam:SPAR_C
|
1421 |
1666 |
2.5e-76 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000212168
AA Change: V842E
PolyPhen 2
Score 0.870 (Sensitivity: 0.83; Specificity: 0.93)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000212987
AA Change: V842E
PolyPhen 2
Score 0.795 (Sensitivity: 0.85; Specificity: 0.93)
|
| Meta Mutation Damage Score |
0.1777 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.4%
- 20x: 95.6%
|
| Validation Efficiency |
96% (76/79) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper. A similar protein in rat acts as a GTPases for the small GTPase Rap. [provided by RefSeq, Sep 2015]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2810021J22Rik |
C |
A |
11: 58,878,851 (GRCm38) |
P73Q |
possibly damaging |
Het |
| Aak1 |
A |
T |
6: 86,963,996 (GRCm38) |
I591F |
unknown |
Het |
| Ace |
C |
A |
11: 105,985,267 (GRCm38) |
Y816* |
probably null |
Het |
| Ahnak2 |
A |
G |
12: 112,782,612 (GRCm38) |
V1205A |
probably benign |
Het |
| Ahnak2 |
T |
G |
12: 112,782,999 (GRCm38) |
Q1076P |
probably benign |
Het |
| Ap2a1 |
G |
A |
7: 44,907,751 (GRCm38) |
R263W |
probably damaging |
Het |
| Arhgap29 |
A |
G |
3: 121,992,748 (GRCm38) |
T257A |
probably benign |
Het |
| Bora |
A |
T |
14: 99,062,294 (GRCm38) |
Q234L |
possibly damaging |
Het |
| Ccdc17 |
A |
T |
4: 116,596,926 (GRCm38) |
Q47L |
possibly damaging |
Het |
| Cep170 |
C |
T |
1: 176,774,625 (GRCm38) |
R305H |
probably damaging |
Het |
| Cyb5r4 |
C |
T |
9: 87,057,168 (GRCm38) |
P335S |
probably damaging |
Het |
| Cyp2c54 |
A |
G |
19: 40,073,762 (GRCm38) |
L17P |
probably benign |
Het |
| Cyp2c69 |
A |
T |
19: 39,849,456 (GRCm38) |
V394E |
probably damaging |
Het |
| Dedd2 |
G |
A |
7: 25,211,290 (GRCm38) |
P154S |
probably benign |
Het |
| Defb36 |
A |
T |
2: 152,604,488 (GRCm38) |
M1L |
unknown |
Het |
| Dnaja1 |
A |
G |
4: 40,731,713 (GRCm38) |
D263G |
probably benign |
Het |
| Dock10 |
T |
C |
1: 80,532,431 (GRCm38) |
N1560S |
probably damaging |
Het |
| Efnb2 |
T |
C |
8: 8,622,328 (GRCm38) |
|
probably null |
Het |
| Eif3e |
A |
G |
15: 43,266,144 (GRCm38) |
I196T |
probably damaging |
Het |
| Ercc4 |
T |
A |
16: 13,110,039 (GRCm38) |
C24* |
probably null |
Het |
| Fmn1 |
A |
G |
2: 113,364,303 (GRCm38) |
E116G |
unknown |
Het |
| Gnas |
A |
G |
2: 174,297,862 (GRCm38) |
M1V |
probably null |
Het |
| Grin2a |
C |
A |
16: 9,579,540 (GRCm38) |
M894I |
probably benign |
Het |
| Herc2 |
G |
T |
7: 56,228,505 (GRCm38) |
S4566I |
probably benign |
Het |
| Hmcn1 |
G |
T |
1: 150,755,294 (GRCm38) |
P918T |
probably damaging |
Het |
| Hmcn1 |
G |
A |
1: 150,755,293 (GRCm38) |
P918L |
probably damaging |
Het |
| Hsd3b2 |
T |
A |
3: 98,712,056 (GRCm38) |
Y191F |
possibly damaging |
Het |
| Ifit1bl2 |
A |
C |
19: 34,619,817 (GRCm38) |
F133C |
possibly damaging |
Het |
| Itih2 |
T |
C |
2: 10,108,894 (GRCm38) |
|
probably benign |
Het |
| Itsn1 |
T |
C |
16: 91,853,011 (GRCm38) |
L191P |
probably benign |
Het |
| Kdr |
T |
C |
5: 75,944,366 (GRCm38) |
K1068R |
probably damaging |
Het |
| Lmtk2 |
T |
C |
5: 144,182,756 (GRCm38) |
L1345P |
probably damaging |
Het |
| Man2b2 |
T |
A |
5: 36,809,041 (GRCm38) |
D936V |
probably damaging |
Het |
| Mapk1ip1 |
G |
A |
7: 138,836,588 (GRCm38) |
R38* |
probably null |
Het |
| Med13l |
T |
C |
5: 118,721,486 (GRCm38) |
V246A |
possibly damaging |
Het |
| Mlec |
T |
A |
5: 115,148,049 (GRCm38) |
T248S |
probably benign |
Het |
| Mslnl |
T |
A |
17: 25,737,902 (GRCm38) |
V54D |
possibly damaging |
Het |
| Muc16 |
G |
A |
9: 18,657,212 (GRCm38) |
T1337I |
unknown |
Het |
| Nek7 |
C |
T |
1: 138,515,654 (GRCm38) |
S187N |
probably damaging |
Het |
| Neto2 |
A |
G |
8: 85,640,585 (GRCm38) |
V538A |
probably benign |
Het |
| Nktr |
T |
C |
9: 121,750,136 (GRCm38) |
|
probably benign |
Het |
| Npy6r |
A |
G |
18: 44,276,492 (GRCm38) |
K327E |
probably damaging |
Het |
| Olfr1230 |
T |
A |
2: 89,297,024 (GRCm38) |
D82V |
probably damaging |
Het |
| Olfr1245 |
T |
C |
2: 89,575,672 (GRCm38) |
D18G |
probably benign |
Het |
| Olfr1463 |
A |
T |
19: 13,234,525 (GRCm38) |
I92F |
probably benign |
Het |
| Olfr402 |
A |
G |
11: 74,155,570 (GRCm38) |
M139V |
possibly damaging |
Het |
| Olfr705 |
A |
G |
7: 106,873,582 (GRCm38) |
I221T |
probably damaging |
Het |
| Pcdhga4 |
A |
T |
18: 37,687,425 (GRCm38) |
N676Y |
probably damaging |
Het |
| Pde2a |
T |
C |
7: 101,502,879 (GRCm38) |
I331T |
possibly damaging |
Het |
| Pip5k1b |
A |
T |
19: 24,304,035 (GRCm38) |
Y486* |
probably null |
Het |
| Plch2 |
A |
G |
4: 155,000,818 (GRCm38) |
M272T |
probably benign |
Het |
| Rbm12 |
G |
A |
2: 156,097,726 (GRCm38) |
|
probably benign |
Het |
| Rgs19 |
T |
C |
2: 181,689,507 (GRCm38) |
E111G |
probably damaging |
Het |
| Rhbdf1 |
T |
C |
11: 32,210,066 (GRCm38) |
N145S |
probably damaging |
Het |
| Rnf4 |
T |
A |
5: 34,351,221 (GRCm38) |
|
probably null |
Het |
| Rpa1 |
T |
C |
11: 75,314,911 (GRCm38) |
T207A |
probably damaging |
Het |
| Rufy4 |
A |
C |
1: 74,129,397 (GRCm38) |
Q113P |
probably damaging |
Het |
| Sh3pxd2b |
T |
G |
11: 32,422,985 (GRCm38) |
S717R |
probably benign |
Het |
| Sin3a |
A |
T |
9: 57,107,540 (GRCm38) |
I682F |
probably damaging |
Het |
| Slc5a4a |
A |
G |
10: 76,147,597 (GRCm38) |
I23V |
unknown |
Het |
| Slitrk5 |
A |
G |
14: 111,681,725 (GRCm38) |
N927S |
probably benign |
Het |
| Smc6 |
A |
G |
12: 11,276,353 (GRCm38) |
K117R |
possibly damaging |
Het |
| Sod2 |
G |
A |
17: 13,008,031 (GRCm38) |
|
probably benign |
Het |
| Stxbp1 |
A |
G |
2: 32,796,018 (GRCm38) |
I567T |
possibly damaging |
Het |
| Tbkbp1 |
C |
A |
11: 97,147,380 (GRCm38) |
L209F |
probably damaging |
Het |
| Tll1 |
G |
T |
8: 64,038,586 (GRCm38) |
|
probably null |
Het |
| Tmem38b |
T |
C |
4: 53,840,765 (GRCm38) |
L60S |
probably damaging |
Het |
| Trib1 |
G |
A |
15: 59,654,475 (GRCm38) |
R298H |
probably damaging |
Het |
| Trim30b |
A |
G |
7: 104,366,142 (GRCm38) |
V13A |
probably damaging |
Het |
| Trip11 |
G |
A |
12: 101,889,742 (GRCm38) |
T425I |
probably benign |
Het |
| Ttn |
C |
A |
2: 76,889,973 (GRCm38) |
|
probably benign |
Het |
| Tymp |
GC |
GCC |
15: 89,374,364 (GRCm38) |
|
probably null |
Het |
| Ush2a |
T |
A |
1: 188,267,023 (GRCm38) |
S177T |
probably damaging |
Het |
| Usp40 |
A |
T |
1: 87,978,559 (GRCm38) |
S651R |
probably benign |
Het |
| Vmn1r125 |
T |
C |
7: 21,272,719 (GRCm38) |
S181P |
probably damaging |
Het |
| Vmn1r198 |
T |
A |
13: 22,354,758 (GRCm38) |
V138D |
possibly damaging |
Het |
| Vmn1r56 |
A |
G |
7: 5,196,318 (GRCm38) |
L100P |
probably damaging |
Het |
| Vmn2r32 |
T |
A |
7: 7,464,210 (GRCm38) |
D773V |
probably benign |
Het |
| Vmn2r53 |
A |
C |
7: 12,581,881 (GRCm38) |
H670Q |
probably benign |
Het |
| Vmn2r69 |
A |
T |
7: 85,406,503 (GRCm38) |
I809N |
probably damaging |
Het |
| Wdr7 |
G |
A |
18: 63,728,469 (GRCm38) |
G184D |
probably damaging |
Het |
| Wnk1 |
C |
T |
6: 120,037,601 (GRCm38) |
G11D |
probably damaging |
Het |
| Zfp110 |
A |
C |
7: 12,844,675 (GRCm38) |
E171A |
possibly damaging |
Het |
| Zkscan6 |
T |
C |
11: 65,815,931 (GRCm38) |
V134A |
probably damaging |
Het |
|
| Other mutations in Sipa1l2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00534:Sipa1l2
|
APN |
8 |
125,491,806 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00939:Sipa1l2
|
APN |
8 |
125,464,435 (GRCm38) |
splice site |
probably benign |
|
|
IGL00965:Sipa1l2
|
APN |
8 |
125,447,874 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL01321:Sipa1l2
|
APN |
8 |
125,491,518 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01450:Sipa1l2
|
APN |
8 |
125,422,577 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL01753:Sipa1l2
|
APN |
8 |
125,453,292 (GRCm38) |
splice site |
probably benign |
|
|
IGL01930:Sipa1l2
|
APN |
8 |
125,419,239 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02041:Sipa1l2
|
APN |
8 |
125,491,819 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02215:Sipa1l2
|
APN |
8 |
125,447,837 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
IGL02272:Sipa1l2
|
APN |
8 |
125,492,011 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02370:Sipa1l2
|
APN |
8 |
125,480,269 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02538:Sipa1l2
|
APN |
8 |
125,451,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02633:Sipa1l2
|
APN |
8 |
125,447,768 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03394:Sipa1l2
|
APN |
8 |
125,491,659 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
Rebellious
|
UTSW |
8 |
125,468,339 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0144:Sipa1l2
|
UTSW |
8 |
125,449,876 (GRCm38) |
splice site |
probably null |
|
|
R0153:Sipa1l2
|
UTSW |
8 |
125,421,898 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0276:Sipa1l2
|
UTSW |
8 |
125,421,940 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0318:Sipa1l2
|
UTSW |
8 |
125,447,697 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R0373:Sipa1l2
|
UTSW |
8 |
125,464,410 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0427:Sipa1l2
|
UTSW |
8 |
125,480,332 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0634:Sipa1l2
|
UTSW |
8 |
125,422,624 (GRCm38) |
nonsense |
probably null |
|
|
R1377:Sipa1l2
|
UTSW |
8 |
125,491,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1404:Sipa1l2
|
UTSW |
8 |
125,449,973 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1404:Sipa1l2
|
UTSW |
8 |
125,449,973 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1435:Sipa1l2
|
UTSW |
8 |
125,468,725 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1523:Sipa1l2
|
UTSW |
8 |
125,447,613 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R1577:Sipa1l2
|
UTSW |
8 |
125,492,262 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1581:Sipa1l2
|
UTSW |
8 |
125,491,617 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R1583:Sipa1l2
|
UTSW |
8 |
125,421,895 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1719:Sipa1l2
|
UTSW |
8 |
125,444,535 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1730:Sipa1l2
|
UTSW |
8 |
125,480,141 (GRCm38) |
splice site |
probably null |
|
|
R1940:Sipa1l2
|
UTSW |
8 |
125,480,148 (GRCm38) |
splice site |
probably benign |
|
|
R2007:Sipa1l2
|
UTSW |
8 |
125,439,437 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2141:Sipa1l2
|
UTSW |
8 |
125,491,491 (GRCm38) |
missense |
probably benign |
0.07 |
|
R2203:Sipa1l2
|
UTSW |
8 |
125,491,627 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2764:Sipa1l2
|
UTSW |
8 |
125,492,374 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3722:Sipa1l2
|
UTSW |
8 |
125,473,584 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3787:Sipa1l2
|
UTSW |
8 |
125,450,383 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R3787:Sipa1l2
|
UTSW |
8 |
125,423,205 (GRCm38) |
missense |
probably benign |
|
|
R4106:Sipa1l2
|
UTSW |
8 |
125,492,308 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4117:Sipa1l2
|
UTSW |
8 |
125,468,510 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4194:Sipa1l2
|
UTSW |
8 |
125,491,672 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4237:Sipa1l2
|
UTSW |
8 |
125,491,656 (GRCm38) |
missense |
probably benign |
0.44 |
|
R4240:Sipa1l2
|
UTSW |
8 |
125,491,656 (GRCm38) |
missense |
probably benign |
0.44 |
|
R4448:Sipa1l2
|
UTSW |
8 |
125,492,355 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4515:Sipa1l2
|
UTSW |
8 |
125,492,226 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4519:Sipa1l2
|
UTSW |
8 |
125,492,226 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4523:Sipa1l2
|
UTSW |
8 |
125,492,424 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4557:Sipa1l2
|
UTSW |
8 |
125,464,415 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4667:Sipa1l2
|
UTSW |
8 |
125,453,470 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R4687:Sipa1l2
|
UTSW |
8 |
125,491,245 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4854:Sipa1l2
|
UTSW |
8 |
125,473,601 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4890:Sipa1l2
|
UTSW |
8 |
125,491,867 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5065:Sipa1l2
|
UTSW |
8 |
125,491,585 (GRCm38) |
missense |
probably benign |
0.19 |
|
R5194:Sipa1l2
|
UTSW |
8 |
125,439,273 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R5266:Sipa1l2
|
UTSW |
8 |
125,492,126 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5475:Sipa1l2
|
UTSW |
8 |
125,491,595 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5718:Sipa1l2
|
UTSW |
8 |
125,491,248 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5910:Sipa1l2
|
UTSW |
8 |
125,491,684 (GRCm38) |
missense |
probably benign |
0.42 |
|
R5916:Sipa1l2
|
UTSW |
8 |
125,468,573 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5941:Sipa1l2
|
UTSW |
8 |
125,473,536 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6185:Sipa1l2
|
UTSW |
8 |
125,468,253 (GRCm38) |
nonsense |
probably null |
|
|
R6235:Sipa1l2
|
UTSW |
8 |
125,474,871 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6274:Sipa1l2
|
UTSW |
8 |
125,469,872 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6299:Sipa1l2
|
UTSW |
8 |
125,453,464 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R6374:Sipa1l2
|
UTSW |
8 |
125,444,630 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6459:Sipa1l2
|
UTSW |
8 |
125,444,484 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6462:Sipa1l2
|
UTSW |
8 |
125,491,230 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6496:Sipa1l2
|
UTSW |
8 |
125,449,894 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6543:Sipa1l2
|
UTSW |
8 |
125,450,362 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
R7154:Sipa1l2
|
UTSW |
8 |
125,468,339 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7192:Sipa1l2
|
UTSW |
8 |
125,422,609 (GRCm38) |
missense |
probably benign |
0.09 |
|
R7240:Sipa1l2
|
UTSW |
8 |
125,469,860 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7361:Sipa1l2
|
UTSW |
8 |
125,453,332 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7383:Sipa1l2
|
UTSW |
8 |
125,447,646 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7417:Sipa1l2
|
UTSW |
8 |
125,482,106 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R7604:Sipa1l2
|
UTSW |
8 |
125,419,272 (GRCm38) |
missense |
probably benign |
0.45 |
|
R7658:Sipa1l2
|
UTSW |
8 |
125,492,290 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7743:Sipa1l2
|
UTSW |
8 |
125,464,233 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7781:Sipa1l2
|
UTSW |
8 |
125,491,827 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R7812:Sipa1l2
|
UTSW |
8 |
125,491,595 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7829:Sipa1l2
|
UTSW |
8 |
125,451,988 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7880:Sipa1l2
|
UTSW |
8 |
125,464,393 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7884:Sipa1l2
|
UTSW |
8 |
125,447,598 (GRCm38) |
missense |
probably benign |
|
|
R8057:Sipa1l2
|
UTSW |
8 |
125,468,530 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8082:Sipa1l2
|
UTSW |
8 |
125,491,809 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R8092:Sipa1l2
|
UTSW |
8 |
125,419,168 (GRCm38) |
missense |
probably benign |
0.03 |
|
R8247:Sipa1l2
|
UTSW |
8 |
125,422,633 (GRCm38) |
missense |
probably benign |
0.29 |
|
R8252:Sipa1l2
|
UTSW |
8 |
125,468,671 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8386:Sipa1l2
|
UTSW |
8 |
125,492,093 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8466:Sipa1l2
|
UTSW |
8 |
125,492,246 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8697:Sipa1l2
|
UTSW |
8 |
125,482,116 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8725:Sipa1l2
|
UTSW |
8 |
125,450,386 (GRCm38) |
missense |
probably benign |
0.28 |
|
R8727:Sipa1l2
|
UTSW |
8 |
125,450,386 (GRCm38) |
missense |
probably benign |
0.28 |
|
R9048:Sipa1l2
|
UTSW |
8 |
125,447,726 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
R9224:Sipa1l2
|
UTSW |
8 |
125,491,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9279:Sipa1l2
|
UTSW |
8 |
125,482,157 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9392:Sipa1l2
|
UTSW |
8 |
125,468,221 (GRCm38) |
missense |
probably benign |
|
|
R9574:Sipa1l2
|
UTSW |
8 |
125,442,714 (GRCm38) |
missense |
probably benign |
|
|
R9591:Sipa1l2
|
UTSW |
8 |
125,492,373 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9614:Sipa1l2
|
UTSW |
8 |
125,469,826 (GRCm38) |
missense |
probably null |
0.01 |
|
R9690:Sipa1l2
|
UTSW |
8 |
125,492,257 (GRCm38) |
missense |
probably benign |
|
|
X0027:Sipa1l2
|
UTSW |
8 |
125,492,136 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Sipa1l2
|
UTSW |
8 |
125,447,556 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAAGTCCAGCCAATCACGTC -3'
(R):5'- AAAGTCAGCTGTCTTCCGG -3'
|
| Posted On |
2017-07-14 |
Incidental Mutation