Incidental Mutation 'R6084:Olfr544'
ID 482386
Institutional Source Beutler Lab
Gene Symbol Olfr544
Ensembl Gene ENSMUSG00000043925
Gene Name olfactory receptor 544
Synonyms GA_x6K02T2PBJ9-5206624-5205620, MOR42-3
MMRRC Submission 044243-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.126) question?
Stock # R6084 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 102482031-102488313 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 102484389 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 244 (T244A)
Ref Sequence ENSEMBL: ENSMUSP00000051280 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051201] [ENSMUST00000219647]
AlphaFold E9PX47
Predicted Effect probably damaging
Transcript: ENSMUST00000051201
AA Change: T244A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000051280
Gene: ENSMUSG00000043925
AA Change: T244A

Pfam:7tm_4 35 314 1.2e-73 PFAM
Pfam:7TM_GPCR_Srsx 39 311 6.3e-8 PFAM
Pfam:7tm_1 45 296 2.4e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000219647
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 84 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arap2 T C 5: 62,670,954 (GRCm38) D958G possibly damaging Het
Bag4 T C 8: 25,771,231 (GRCm38) T161A probably benign Het
Bora A T 14: 99,062,294 (GRCm38) Q234L possibly damaging Het
Cacna2d2 T C 9: 107,497,521 (GRCm38) probably null Het
Cass4 G T 2: 172,426,912 (GRCm38) A307S probably benign Het
Cbln4 A T 2: 172,042,096 (GRCm38) V68E probably damaging Het
Cc2d2a T A 5: 43,668,673 (GRCm38) N2K probably benign Het
Ccnf T A 17: 24,231,837 (GRCm38) D389V probably damaging Het
Cdipt T C 7: 126,979,601 (GRCm38) S161P probably benign Het
Ceacam19 T C 7: 19,882,887 (GRCm38) I161V probably benign Het
Cfap65 A G 1: 74,920,405 (GRCm38) I862T probably damaging Het
Cfi T A 3: 129,858,370 (GRCm38) L230Q probably benign Het
Chac2 G A 11: 30,986,159 (GRCm38) R30W probably damaging Het
Cmc2 G A 8: 116,889,827 (GRCm38) probably benign Het
Col1a2 A T 6: 4,505,840 (GRCm38) M1L probably benign Het
Cox8a C A 19: 7,217,418 (GRCm38) R32L possibly damaging Het
Cubn T A 2: 13,430,897 (GRCm38) N1083Y probably damaging Het
D430042O09Rik G A 7: 125,814,865 (GRCm38) G394R probably benign Het
D630003M21Rik T C 2: 158,217,584 (GRCm38) D132G probably damaging Het
Dedd2 G A 7: 25,211,290 (GRCm38) P154S probably benign Het
Dnaaf3 T C 7: 4,524,213 (GRCm38) D358G probably benign Het
Dysf T A 6: 84,019,604 (GRCm38) F29L probably damaging Het
Dysf T C 6: 84,112,119 (GRCm38) L888P probably damaging Het
Ebf4 A G 2: 130,309,723 (GRCm38) D277G probably damaging Het
Ecm2 T A 13: 49,515,094 (GRCm38) L91* probably null Het
Foxs1 T C 2: 152,932,842 (GRCm38) D97G possibly damaging Het
Frs2 A C 10: 117,076,809 (GRCm38) probably null Het
Gm6768 A G 12: 119,261,651 (GRCm38) noncoding transcript Het
Grp A T 18: 65,879,937 (GRCm38) D58V probably damaging Het
Hif1a T G 12: 73,941,842 (GRCm38) F537C probably damaging Het
Icam4 G A 9: 21,029,539 (GRCm38) S29N probably benign Het
Itfg1 T C 8: 85,726,170 (GRCm38) E523G probably benign Het
Jph2 T C 2: 163,375,680 (GRCm38) K359E probably damaging Het
Kcnq2 A T 2: 181,087,656 (GRCm38) V490E possibly damaging Het
Klhl18 C T 9: 110,428,727 (GRCm38) M548I possibly damaging Het
Lpin3 A G 2: 160,895,801 (GRCm38) Y197C probably benign Het
Lrp1 T C 10: 127,560,553 (GRCm38) N2381D probably benign Het
Man1a A T 10: 53,919,211 (GRCm38) W649R probably damaging Het
Map4 T C 9: 110,064,292 (GRCm38) L542P probably damaging Het
Mboat2 A T 12: 24,878,285 (GRCm38) H52L probably damaging Het
Mok C G 12: 110,814,946 (GRCm38) S91T probably benign Het
Mtmr11 G T 3: 96,168,084 (GRCm38) R360L probably damaging Het
Myt1l G A 12: 29,832,332 (GRCm38) G509R unknown Het
Olfr1288 A T 2: 111,479,389 (GRCm38) N202Y probably damaging Het
Olfr341 A G 2: 36,479,512 (GRCm38) V206A probably benign Het
Olfr67 C T 7: 103,787,955 (GRCm38) M107I probably benign Het
Olfr836 A G 9: 19,121,327 (GRCm38) D121G probably damaging Het
Olfr867 A T 9: 20,054,883 (GRCm38) H75Q possibly damaging Het
Padi3 G T 4: 140,795,843 (GRCm38) T292N probably damaging Het
Pard6g A C 18: 80,117,205 (GRCm38) T178P possibly damaging Het
Pkd1l2 A T 8: 117,013,987 (GRCm38) Y2124N probably damaging Het
Plxdc1 G A 11: 97,928,463 (GRCm38) T398I probably damaging Het
Prickle2 A T 6: 92,416,848 (GRCm38) C225* probably null Het
Prmt2 G A 10: 76,210,444 (GRCm38) T317I probably benign Het
Psg22 T G 7: 18,719,780 (GRCm38) N172K probably benign Het
Ptpn9 C T 9: 57,033,163 (GRCm38) R196* probably null Het
Rap1b C T 10: 117,824,611 (GRCm38) V14I probably damaging Het
Rapgef4 T A 2: 72,196,278 (GRCm38) probably null Het
Rlf A T 4: 121,149,215 (GRCm38) M856K possibly damaging Het
Rnf149 A G 1: 39,577,174 (GRCm38) L34P probably benign Het
Rock1 T C 18: 10,101,007 (GRCm38) E636G probably benign Het
Rsad2 A T 12: 26,454,123 (GRCm38) Y136N probably damaging Het
Ryr3 T C 2: 112,908,493 (GRCm38) H563R probably damaging Het
Slc18b1 A G 10: 23,804,212 (GRCm38) M102V probably benign Het
Slc34a2 T A 5: 53,067,647 (GRCm38) C377S possibly damaging Het
Slco1c1 T C 6: 141,546,770 (GRCm38) V293A probably benign Het
Spidr A T 16: 16,140,024 (GRCm38) S80T possibly damaging Het
Syne1 C T 10: 5,348,994 (GRCm38) E1031K probably damaging Het
Synj2 G A 17: 6,017,614 (GRCm38) V121I probably damaging Het
Synj2 A T 17: 6,038,098 (GRCm38) T1430S probably damaging Het
Tecpr2 G T 12: 110,929,109 (GRCm38) K343N probably damaging Het
Tmem132d T A 5: 127,784,100 (GRCm38) I986F probably benign Het
Trib1 G A 15: 59,654,475 (GRCm38) R298H probably damaging Het
Ttll10 T A 4: 156,045,357 (GRCm38) D283V probably benign Het
Ttn T A 2: 76,814,779 (GRCm38) K673* probably null Het
Ubqlnl T A 7: 104,148,698 (GRCm38) M531L probably benign Het
Vmn2r120 A T 17: 57,525,721 (GRCm38) W153R probably benign Het
Vmn2r2 A C 3: 64,117,046 (GRCm38) S705A probably benign Het
Vmn2r32 T A 7: 7,464,210 (GRCm38) D773V probably benign Het
Vmn2r54 T A 7: 12,632,278 (GRCm38) Q243L probably damaging Het
Wdr24 C A 17: 25,824,530 (GRCm38) R109S probably damaging Het
Zfp113 T C 5: 138,145,668 (GRCm38) M107V probably benign Het
Zfp426 G T 9: 20,470,627 (GRCm38) Q341K possibly damaging Het
Zfp616 A T 11: 74,083,846 (GRCm38) K314* probably null Het
Other mutations in Olfr544
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01099:Olfr544 APN 7 102,484,478 (GRCm38) missense probably damaging 1.00
IGL01380:Olfr544 APN 7 102,484,385 (GRCm38) missense probably damaging 1.00
IGL01594:Olfr544 APN 7 102,485,047 (GRCm38) missense probably benign
R0732:Olfr544 UTSW 7 102,484,443 (GRCm38) missense probably benign 0.15
R1061:Olfr544 UTSW 7 102,484,114 (GRCm38) makesense probably null
R1387:Olfr544 UTSW 7 102,484,704 (GRCm38) missense probably benign 0.01
R2760:Olfr544 UTSW 7 102,484,376 (GRCm38) missense probably damaging 1.00
R5151:Olfr544 UTSW 7 102,484,985 (GRCm38) missense probably benign 0.00
R5916:Olfr544 UTSW 7 102,484,379 (GRCm38) missense probably damaging 1.00
R7069:Olfr544 UTSW 7 102,484,772 (GRCm38) missense possibly damaging 0.85
R7195:Olfr544 UTSW 7 102,484,367 (GRCm38) missense probably damaging 1.00
R7738:Olfr544 UTSW 7 102,484,611 (GRCm38) missense probably damaging 0.99
R8299:Olfr544 UTSW 7 102,484,202 (GRCm38) missense probably benign 0.01
R8433:Olfr544 UTSW 7 102,484,784 (GRCm38) missense probably benign 0.00
R9063:Olfr544 UTSW 7 102,484,724 (GRCm38) missense probably damaging 0.98
R9396:Olfr544 UTSW 7 102,484,973 (GRCm38) missense possibly damaging 0.95
R9698:Olfr544 UTSW 7 102,484,170 (GRCm38) nonsense probably null
Predicted Primers PCR Primer

Posted On 2017-07-14