Incidental Mutation 'R6084:Map4'
| ID |
482401 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Map4
|
| Ensembl Gene |
ENSMUSG00000032479 |
| Gene Name |
microtubule-associated protein 4 |
| Synonyms |
MAP 4, Mtap4 |
| MMRRC Submission |
044243-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R6084 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
109760528-109913023 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 109893360 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 542
(L542P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000142439
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000035055]
[ENSMUST00000163979]
[ENSMUST00000164930]
[ENSMUST00000165876]
[ENSMUST00000198511]
[ENSMUST00000199498]
[ENSMUST00000199461]
[ENSMUST00000199161]
[ENSMUST00000199548]
|
| AlphaFold |
P27546 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000035055
AA Change: L695P
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000035055
Gene: ENSMUSG00000032479
AA Change: L695P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
254 |
265 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
266 |
379 |
4.96e-7 |
PROSPERO |
|
low complexity region
|
401 |
420 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
439 |
550 |
4.96e-7 |
PROSPERO |
|
low complexity region
|
659 |
674 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
742 |
N/A |
INTRINSIC |
|
low complexity region
|
760 |
775 |
N/A |
INTRINSIC |
|
low complexity region
|
879 |
889 |
N/A |
INTRINSIC |
|
Pfam:Tubulin-binding
|
903 |
926 |
2e-12 |
PFAM |
|
Pfam:Tubulin-binding
|
965 |
995 |
4.9e-18 |
PFAM |
|
Pfam:Tubulin-binding
|
996 |
1026 |
7.4e-18 |
PFAM |
|
Pfam:Tubulin-binding
|
1027 |
1058 |
4.4e-15 |
PFAM |
|
low complexity region
|
1093 |
1108 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000163190
AA Change: L1155P
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163979
|
| SMART Domains |
Protein: ENSMUSP00000129362
Gene: ENSMUSG00000032479
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
17 |
N/A |
INTRINSIC |
|
low complexity region
|
324 |
341 |
N/A |
INTRINSIC |
|
low complexity region
|
365 |
376 |
N/A |
INTRINSIC |
|
low complexity region
|
506 |
521 |
N/A |
INTRINSIC |
|
low complexity region
|
567 |
589 |
N/A |
INTRINSIC |
|
low complexity region
|
607 |
622 |
N/A |
INTRINSIC |
|
low complexity region
|
726 |
736 |
N/A |
INTRINSIC |
|
Pfam:Tubulin-binding
|
743 |
773 |
5.8e-16 |
PFAM |
|
Pfam:Tubulin-binding
|
774 |
804 |
2.2e-18 |
PFAM |
|
Pfam:Tubulin-binding
|
805 |
836 |
1.6e-11 |
PFAM |
|
low complexity region
|
871 |
886 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000164930
AA Change: L542P
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000131285
Gene: ENSMUSG00000032479
AA Change: L542P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
17 |
N/A |
INTRINSIC |
|
low complexity region
|
324 |
341 |
N/A |
INTRINSIC |
|
low complexity region
|
365 |
376 |
N/A |
INTRINSIC |
|
low complexity region
|
506 |
521 |
N/A |
INTRINSIC |
|
low complexity region
|
567 |
589 |
N/A |
INTRINSIC |
|
low complexity region
|
607 |
622 |
N/A |
INTRINSIC |
|
low complexity region
|
726 |
736 |
N/A |
INTRINSIC |
|
Pfam:Tubulin-binding
|
743 |
773 |
6e-16 |
PFAM |
|
Pfam:Tubulin-binding
|
774 |
804 |
4.5e-19 |
PFAM |
|
Pfam:Tubulin-binding
|
805 |
835 |
2.3e-18 |
PFAM |
|
Pfam:Tubulin-binding
|
836 |
867 |
1.6e-11 |
PFAM |
|
low complexity region
|
902 |
917 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000165876
AA Change: L695P
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000132662
Gene: ENSMUSG00000032479
AA Change: L695P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
254 |
265 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
266 |
379 |
4.95e-7 |
PROSPERO |
|
low complexity region
|
401 |
420 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
439 |
550 |
4.95e-7 |
PROSPERO |
|
low complexity region
|
659 |
674 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
742 |
N/A |
INTRINSIC |
|
low complexity region
|
760 |
775 |
N/A |
INTRINSIC |
|
low complexity region
|
879 |
889 |
N/A |
INTRINSIC |
|
Pfam:Tubulin-binding
|
896 |
926 |
8.5e-16 |
PFAM |
|
Pfam:Tubulin-binding
|
965 |
995 |
6.4e-19 |
PFAM |
|
Pfam:Tubulin-binding
|
996 |
1026 |
3.3e-18 |
PFAM |
|
Pfam:Tubulin-binding
|
1027 |
1058 |
2.3e-11 |
PFAM |
|
low complexity region
|
1093 |
1108 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000198185
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000198511
|
| SMART Domains |
Protein: ENSMUSP00000142558
Gene: ENSMUSG00000032479
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
17 |
N/A |
INTRINSIC |
|
Pfam:Tubulin-binding
|
24 |
54 |
7.3e-14 |
PFAM |
|
Pfam:Tubulin-binding
|
55 |
85 |
5.3e-17 |
PFAM |
|
Pfam:Tubulin-binding
|
86 |
116 |
2.8e-16 |
PFAM |
|
Pfam:Tubulin-binding
|
117 |
148 |
1.9e-9 |
PFAM |
|
low complexity region
|
183 |
198 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000199498
AA Change: L542P
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000142439
Gene: ENSMUSG00000032479
AA Change: L542P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
17 |
N/A |
INTRINSIC |
|
low complexity region
|
324 |
341 |
N/A |
INTRINSIC |
|
low complexity region
|
365 |
376 |
N/A |
INTRINSIC |
|
low complexity region
|
506 |
521 |
N/A |
INTRINSIC |
|
low complexity region
|
567 |
589 |
N/A |
INTRINSIC |
|
low complexity region
|
607 |
622 |
N/A |
INTRINSIC |
|
low complexity region
|
726 |
736 |
N/A |
INTRINSIC |
|
Pfam:Tubulin-binding
|
743 |
773 |
5.8e-16 |
PFAM |
|
Pfam:Tubulin-binding
|
774 |
804 |
2.2e-18 |
PFAM |
|
Pfam:Tubulin-binding
|
805 |
836 |
1.6e-11 |
PFAM |
|
low complexity region
|
871 |
886 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199461
|
| SMART Domains |
Protein: ENSMUSP00000143296
Gene: ENSMUSG00000032479
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
99 |
109 |
N/A |
INTRINSIC |
|
Pfam:Tubulin-binding
|
116 |
146 |
1e-13 |
PFAM |
|
Pfam:Tubulin-binding
|
147 |
177 |
3.8e-16 |
PFAM |
|
Pfam:Tubulin-binding
|
178 |
209 |
2.6e-9 |
PFAM |
|
low complexity region
|
244 |
259 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199161
|
| SMART Domains |
Protein: ENSMUSP00000143205
Gene: ENSMUSG00000032479
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Tubulin-binding
|
16 |
46 |
6.7e-14 |
PFAM |
|
Pfam:Tubulin-binding
|
47 |
77 |
4.9e-17 |
PFAM |
|
Pfam:Tubulin-binding
|
78 |
108 |
2.5e-16 |
PFAM |
|
Pfam:Tubulin-binding
|
109 |
140 |
1.7e-9 |
PFAM |
|
low complexity region
|
176 |
191 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199548
|
| SMART Domains |
Protein: ENSMUSP00000143408
Gene: ENSMUSG00000032479
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
99 |
109 |
N/A |
INTRINSIC |
|
Pfam:Tubulin-binding
|
116 |
146 |
1.1e-13 |
PFAM |
|
Pfam:Tubulin-binding
|
147 |
177 |
7.9e-17 |
PFAM |
|
Pfam:Tubulin-binding
|
178 |
208 |
4.1e-16 |
PFAM |
|
Pfam:Tubulin-binding
|
209 |
240 |
2.8e-9 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.2%
- 20x: 94.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
PHENOTYPE: Mice homozygous for a gene trapped allele are viable and do not display any overt phenotypic abnormalities. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arap2 |
T |
C |
5: 62,828,297 (GRCm39) |
D958G |
possibly damaging |
Het |
| Bag4 |
T |
C |
8: 26,261,259 (GRCm39) |
T161A |
probably benign |
Het |
| Bora |
A |
T |
14: 99,299,730 (GRCm39) |
Q234L |
possibly damaging |
Het |
| Cacna2d2 |
T |
C |
9: 107,374,720 (GRCm39) |
|
probably null |
Het |
| Cass4 |
G |
T |
2: 172,268,832 (GRCm39) |
A307S |
probably benign |
Het |
| Cbln4 |
A |
T |
2: 171,884,016 (GRCm39) |
V68E |
probably damaging |
Het |
| Cc2d2a |
T |
A |
5: 43,826,015 (GRCm39) |
N2K |
probably benign |
Het |
| Ccnf |
T |
A |
17: 24,450,811 (GRCm39) |
D389V |
probably damaging |
Het |
| Cdipt |
T |
C |
7: 126,578,773 (GRCm39) |
S161P |
probably benign |
Het |
| Ceacam19 |
T |
C |
7: 19,616,812 (GRCm39) |
I161V |
probably benign |
Het |
| Cfap65 |
A |
G |
1: 74,959,564 (GRCm39) |
I862T |
probably damaging |
Het |
| Cfi |
T |
A |
3: 129,652,019 (GRCm39) |
L230Q |
probably benign |
Het |
| Chac2 |
G |
A |
11: 30,936,159 (GRCm39) |
R30W |
probably damaging |
Het |
| Cmc2 |
G |
A |
8: 117,616,566 (GRCm39) |
|
probably benign |
Het |
| Col1a2 |
A |
T |
6: 4,505,840 (GRCm39) |
M1L |
probably benign |
Het |
| Cox8a |
C |
A |
19: 7,194,783 (GRCm39) |
R32L |
possibly damaging |
Het |
| Cubn |
T |
A |
2: 13,435,708 (GRCm39) |
N1083Y |
probably damaging |
Het |
| D630003M21Rik |
T |
C |
2: 158,059,504 (GRCm39) |
D132G |
probably damaging |
Het |
| Dedd2 |
G |
A |
7: 24,910,715 (GRCm39) |
P154S |
probably benign |
Het |
| Dnaaf3 |
T |
C |
7: 4,527,212 (GRCm39) |
D358G |
probably benign |
Het |
| Dysf |
T |
A |
6: 83,996,586 (GRCm39) |
F29L |
probably damaging |
Het |
| Dysf |
T |
C |
6: 84,089,101 (GRCm39) |
L888P |
probably damaging |
Het |
| Ebf4 |
A |
G |
2: 130,151,643 (GRCm39) |
D277G |
probably damaging |
Het |
| Ecm2 |
T |
A |
13: 49,668,570 (GRCm39) |
L91* |
probably null |
Het |
| Foxs1 |
T |
C |
2: 152,774,762 (GRCm39) |
D97G |
possibly damaging |
Het |
| Frs2 |
A |
C |
10: 116,912,714 (GRCm39) |
|
probably null |
Het |
| Grp |
A |
T |
18: 66,013,008 (GRCm39) |
D58V |
probably damaging |
Het |
| Hif1a |
T |
G |
12: 73,988,616 (GRCm39) |
F537C |
probably damaging |
Het |
| Icam4 |
G |
A |
9: 20,940,835 (GRCm39) |
S29N |
probably benign |
Het |
| Itfg1 |
T |
C |
8: 86,452,799 (GRCm39) |
E523G |
probably benign |
Het |
| Jph2 |
T |
C |
2: 163,217,600 (GRCm39) |
K359E |
probably damaging |
Het |
| Katnip |
G |
A |
7: 125,414,037 (GRCm39) |
G394R |
probably benign |
Het |
| Kcnq2 |
A |
T |
2: 180,729,449 (GRCm39) |
V490E |
possibly damaging |
Het |
| Klhl18 |
C |
T |
9: 110,257,795 (GRCm39) |
M548I |
possibly damaging |
Het |
| Lpin3 |
A |
G |
2: 160,737,721 (GRCm39) |
Y197C |
probably benign |
Het |
| Lrp1 |
T |
C |
10: 127,396,422 (GRCm39) |
N2381D |
probably benign |
Het |
| Man1a |
A |
T |
10: 53,795,307 (GRCm39) |
W649R |
probably damaging |
Het |
| Mboat2 |
A |
T |
12: 24,928,284 (GRCm39) |
H52L |
probably damaging |
Het |
| Mok |
C |
G |
12: 110,781,380 (GRCm39) |
S91T |
probably benign |
Het |
| Mtmr11 |
G |
T |
3: 96,075,400 (GRCm39) |
R360L |
probably damaging |
Het |
| Myt1l |
G |
A |
12: 29,882,331 (GRCm39) |
G509R |
unknown |
Het |
| Ncoa4-ps |
A |
G |
12: 119,225,386 (GRCm39) |
|
noncoding transcript |
Het |
| Or1j13 |
A |
G |
2: 36,369,524 (GRCm39) |
V206A |
probably benign |
Het |
| Or4g7 |
A |
T |
2: 111,309,734 (GRCm39) |
N202Y |
probably damaging |
Het |
| Or52z1 |
C |
T |
7: 103,437,162 (GRCm39) |
M107I |
probably benign |
Het |
| Or55b4 |
T |
C |
7: 102,133,596 (GRCm39) |
T244A |
probably damaging |
Het |
| Or7d11 |
A |
T |
9: 19,966,179 (GRCm39) |
H75Q |
possibly damaging |
Het |
| Or7g21 |
A |
G |
9: 19,032,623 (GRCm39) |
D121G |
probably damaging |
Het |
| Padi3 |
G |
T |
4: 140,523,154 (GRCm39) |
T292N |
probably damaging |
Het |
| Pard6g |
A |
C |
18: 80,160,420 (GRCm39) |
T178P |
possibly damaging |
Het |
| Pkd1l2 |
A |
T |
8: 117,740,726 (GRCm39) |
Y2124N |
probably damaging |
Het |
| Plxdc1 |
G |
A |
11: 97,819,289 (GRCm39) |
T398I |
probably damaging |
Het |
| Prickle2 |
A |
T |
6: 92,393,829 (GRCm39) |
C225* |
probably null |
Het |
| Prmt2 |
G |
A |
10: 76,046,278 (GRCm39) |
T317I |
probably benign |
Het |
| Psg22 |
T |
G |
7: 18,453,705 (GRCm39) |
N172K |
probably benign |
Het |
| Ptpn9 |
C |
T |
9: 56,940,447 (GRCm39) |
R196* |
probably null |
Het |
| Rap1b |
C |
T |
10: 117,660,516 (GRCm39) |
V14I |
probably damaging |
Het |
| Rapgef4 |
T |
A |
2: 72,026,622 (GRCm39) |
|
probably null |
Het |
| Rlf |
A |
T |
4: 121,006,412 (GRCm39) |
M856K |
possibly damaging |
Het |
| Rnf149 |
A |
G |
1: 39,616,255 (GRCm39) |
L34P |
probably benign |
Het |
| Rock1 |
T |
C |
18: 10,101,007 (GRCm39) |
E636G |
probably benign |
Het |
| Rsad2 |
A |
T |
12: 26,504,122 (GRCm39) |
Y136N |
probably damaging |
Het |
| Ryr3 |
T |
C |
2: 112,738,838 (GRCm39) |
H563R |
probably damaging |
Het |
| Slc18b1 |
A |
G |
10: 23,680,110 (GRCm39) |
M102V |
probably benign |
Het |
| Slc34a2 |
T |
A |
5: 53,224,989 (GRCm39) |
C377S |
possibly damaging |
Het |
| Slco1c1 |
T |
C |
6: 141,492,496 (GRCm39) |
V293A |
probably benign |
Het |
| Spidr |
A |
T |
16: 15,957,888 (GRCm39) |
S80T |
possibly damaging |
Het |
| Syne1 |
C |
T |
10: 5,298,994 (GRCm39) |
E1031K |
probably damaging |
Het |
| Synj2 |
G |
A |
17: 6,067,889 (GRCm39) |
V121I |
probably damaging |
Het |
| Synj2 |
A |
T |
17: 6,088,373 (GRCm39) |
T1430S |
probably damaging |
Het |
| Tecpr2 |
G |
T |
12: 110,895,543 (GRCm39) |
K343N |
probably damaging |
Het |
| Tmem132d |
T |
A |
5: 127,861,164 (GRCm39) |
I986F |
probably benign |
Het |
| Trib1 |
G |
A |
15: 59,526,324 (GRCm39) |
R298H |
probably damaging |
Het |
| Ttll10 |
T |
A |
4: 156,129,814 (GRCm39) |
D283V |
probably benign |
Het |
| Ttn |
T |
A |
2: 76,645,123 (GRCm39) |
K673* |
probably null |
Het |
| Ubqlnl |
T |
A |
7: 103,797,905 (GRCm39) |
M531L |
probably benign |
Het |
| Vmn2r120 |
A |
T |
17: 57,832,721 (GRCm39) |
W153R |
probably benign |
Het |
| Vmn2r2 |
A |
C |
3: 64,024,467 (GRCm39) |
S705A |
probably benign |
Het |
| Vmn2r32 |
T |
A |
7: 7,467,209 (GRCm39) |
D773V |
probably benign |
Het |
| Vmn2r54 |
T |
A |
7: 12,366,205 (GRCm39) |
Q243L |
probably damaging |
Het |
| Wdr24 |
C |
A |
17: 26,043,504 (GRCm39) |
R109S |
probably damaging |
Het |
| Zfp113 |
T |
C |
5: 138,143,930 (GRCm39) |
M107V |
probably benign |
Het |
| Zfp426 |
G |
T |
9: 20,381,923 (GRCm39) |
Q341K |
possibly damaging |
Het |
| Zfp616 |
A |
T |
11: 73,974,672 (GRCm39) |
K314* |
probably null |
Het |
|
| Other mutations in Map4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00565:Map4
|
APN |
9 |
109,901,672 (GRCm39) |
splice site |
probably benign |
|
|
IGL01331:Map4
|
APN |
9 |
109,863,869 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01599:Map4
|
APN |
9 |
109,863,836 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL01631:Map4
|
APN |
9 |
109,892,201 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02208:Map4
|
APN |
9 |
109,807,938 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
IGL02455:Map4
|
APN |
9 |
109,828,901 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02625:Map4
|
APN |
9 |
109,893,485 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4486001:Map4
|
UTSW |
9 |
109,901,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Map4
|
UTSW |
9 |
109,896,692 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0384:Map4
|
UTSW |
9 |
109,863,696 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0392:Map4
|
UTSW |
9 |
109,907,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0496:Map4
|
UTSW |
9 |
109,868,918 (GRCm39) |
intron |
probably benign |
|
|
R0526:Map4
|
UTSW |
9 |
109,866,346 (GRCm39) |
splice site |
probably null |
|
|
R0555:Map4
|
UTSW |
9 |
109,808,171 (GRCm39) |
splice site |
probably benign |
|
|
R0571:Map4
|
UTSW |
9 |
109,865,834 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0698:Map4
|
UTSW |
9 |
109,897,856 (GRCm39) |
nonsense |
probably null |
|
|
R0762:Map4
|
UTSW |
9 |
109,867,546 (GRCm39) |
intron |
probably benign |
|
|
R0862:Map4
|
UTSW |
9 |
109,808,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0864:Map4
|
UTSW |
9 |
109,808,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1168:Map4
|
UTSW |
9 |
109,864,032 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1238:Map4
|
UTSW |
9 |
109,897,648 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1735:Map4
|
UTSW |
9 |
109,864,023 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1869:Map4
|
UTSW |
9 |
109,897,996 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1869:Map4
|
UTSW |
9 |
109,864,032 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2196:Map4
|
UTSW |
9 |
109,900,116 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2264:Map4
|
UTSW |
9 |
109,910,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2507:Map4
|
UTSW |
9 |
109,866,551 (GRCm39) |
intron |
probably benign |
|
|
R2512:Map4
|
UTSW |
9 |
109,863,770 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R3087:Map4
|
UTSW |
9 |
109,882,257 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R3154:Map4
|
UTSW |
9 |
109,828,860 (GRCm39) |
missense |
probably benign |
0.19 |
|
R3498:Map4
|
UTSW |
9 |
109,864,280 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3547:Map4
|
UTSW |
9 |
109,881,266 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R3751:Map4
|
UTSW |
9 |
109,867,742 (GRCm39) |
intron |
probably benign |
|
|
R4036:Map4
|
UTSW |
9 |
109,861,283 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4423:Map4
|
UTSW |
9 |
109,896,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4505:Map4
|
UTSW |
9 |
109,861,253 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4561:Map4
|
UTSW |
9 |
109,881,439 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4577:Map4
|
UTSW |
9 |
109,910,489 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R4601:Map4
|
UTSW |
9 |
109,881,887 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4795:Map4
|
UTSW |
9 |
109,864,331 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4801:Map4
|
UTSW |
9 |
109,864,325 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4802:Map4
|
UTSW |
9 |
109,864,325 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4999:Map4
|
UTSW |
9 |
109,867,445 (GRCm39) |
intron |
probably benign |
|
|
R5020:Map4
|
UTSW |
9 |
109,897,868 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5021:Map4
|
UTSW |
9 |
109,867,157 (GRCm39) |
nonsense |
probably null |
|
|
R5049:Map4
|
UTSW |
9 |
109,908,882 (GRCm39) |
nonsense |
probably null |
|
|
R5451:Map4
|
UTSW |
9 |
109,866,851 (GRCm39) |
intron |
probably benign |
|
|
R5452:Map4
|
UTSW |
9 |
109,866,851 (GRCm39) |
intron |
probably benign |
|
|
R5453:Map4
|
UTSW |
9 |
109,866,851 (GRCm39) |
intron |
probably benign |
|
|
R5492:Map4
|
UTSW |
9 |
109,881,450 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R5532:Map4
|
UTSW |
9 |
109,863,746 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5602:Map4
|
UTSW |
9 |
109,881,768 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5628:Map4
|
UTSW |
9 |
109,910,915 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5896:Map4
|
UTSW |
9 |
109,901,702 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6017:Map4
|
UTSW |
9 |
109,863,687 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6294:Map4
|
UTSW |
9 |
109,831,814 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6397:Map4
|
UTSW |
9 |
109,856,784 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6773:Map4
|
UTSW |
9 |
109,863,993 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6997:Map4
|
UTSW |
9 |
109,881,982 (GRCm39) |
missense |
probably benign |
0.35 |
|
R7141:Map4
|
UTSW |
9 |
109,807,938 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R7187:Map4
|
UTSW |
9 |
109,882,201 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7320:Map4
|
UTSW |
9 |
109,910,585 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7469:Map4
|
UTSW |
9 |
109,856,865 (GRCm39) |
splice site |
probably null |
|
|
R7479:Map4
|
UTSW |
9 |
109,897,892 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7487:Map4
|
UTSW |
9 |
109,856,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7690:Map4
|
UTSW |
9 |
109,828,861 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7780:Map4
|
UTSW |
9 |
109,863,720 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7998:Map4
|
UTSW |
9 |
109,908,929 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8028:Map4
|
UTSW |
9 |
109,897,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8557:Map4
|
UTSW |
9 |
109,893,370 (GRCm39) |
splice site |
probably null |
|
|
R8950:Map4
|
UTSW |
9 |
109,901,702 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8972:Map4
|
UTSW |
9 |
109,864,185 (GRCm39) |
missense |
probably benign |
|
|
R9145:Map4
|
UTSW |
9 |
109,855,268 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9297:Map4
|
UTSW |
9 |
109,882,480 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9332:Map4
|
UTSW |
9 |
109,864,223 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9354:Map4
|
UTSW |
9 |
109,897,847 (GRCm39) |
missense |
probably benign |
|
|
R9419:Map4
|
UTSW |
9 |
109,882,029 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9430:Map4
|
UTSW |
9 |
109,863,760 (GRCm39) |
missense |
probably benign |
0.41 |
|
R9437:Map4
|
UTSW |
9 |
109,864,155 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9718:Map4
|
UTSW |
9 |
109,901,774 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Map4
|
UTSW |
9 |
109,897,591 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CAGTTGCATCAATCCTCATTGC -3'
(R):5'- AAATCTTCTCCGGGCACAG -3'
|
| Posted On |
2017-07-14 |
Incidental Mutation