Incidental Mutation 'R6084:Wdr24'
ID 482427
Institutional Source Beutler Lab
Gene Symbol Wdr24
Ensembl Gene ENSMUSG00000025737
Gene Name WD repeat domain 24
Synonyms
MMRRC Submission 044243-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6084 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 25823627-25828730 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to A at 25824530 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 109 (R109S)
Ref Sequence ENSEMBL: ENSMUSP00000026833 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026832] [ENSMUST00000026833] [ENSMUST00000045692] [ENSMUST00000123582] [ENSMUST00000133595]
AlphaFold Q8CFJ9
Predicted Effect probably benign
Transcript: ENSMUST00000026832
SMART Domains Protein: ENSMUSP00000026832
Gene: ENSMUSG00000025736

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
JmjC 140 271 5.27e-2 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000026833
AA Change: R109S

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000026833
Gene: ENSMUSG00000025737
AA Change: R109S

DomainStartEndE-ValueType
Blast:WD40 19 53 6e-8 BLAST
WD40 68 103 2.13e1 SMART
WD40 109 149 5.77e-5 SMART
WD40 152 192 4.48e-2 SMART
WD40 196 236 1.48e-11 SMART
WD40 244 282 1.66e0 SMART
WD40 286 327 2.48e0 SMART
low complexity region 605 623 N/A INTRINSIC
Blast:RING 743 780 2e-7 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000045692
SMART Domains Protein: ENSMUSP00000048562
Gene: ENSMUSG00000025738

DomainStartEndE-ValueType
low complexity region 49 65 N/A INTRINSIC
low complexity region 70 89 N/A INTRINSIC
Blast:FBOX 98 137 2e-14 BLAST
LRR 241 266 1.32e1 SMART
LRR 267 291 1.61e2 SMART
LRR 293 318 1.76e2 SMART
LRR 319 344 3.21e-4 SMART
LRR 345 370 7.67e-2 SMART
LRR 371 396 6.13e-1 SMART
LRR 421 446 3.52e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000123582
SMART Domains Protein: ENSMUSP00000119840
Gene: ENSMUSG00000025736

DomainStartEndE-ValueType
low complexity region 158 172 N/A INTRINSIC
low complexity region 194 208 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123692
Predicted Effect probably benign
Transcript: ENSMUST00000133595
SMART Domains Protein: ENSMUSP00000122744
Gene: ENSMUSG00000025736

DomainStartEndE-ValueType
transmembrane domain 55 74 N/A INTRINSIC
JmjC 185 316 5.27e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143296
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144589
Predicted Effect probably benign
Transcript: ENSMUST00000152434
SMART Domains Protein: ENSMUSP00000119378
Gene: ENSMUSG00000025736

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160275
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160349
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160829
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180868
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 84 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arap2 T C 5: 62,670,954 (GRCm38) D958G possibly damaging Het
Bag4 T C 8: 25,771,231 (GRCm38) T161A probably benign Het
Bora A T 14: 99,062,294 (GRCm38) Q234L possibly damaging Het
Cacna2d2 T C 9: 107,497,521 (GRCm38) probably null Het
Cass4 G T 2: 172,426,912 (GRCm38) A307S probably benign Het
Cbln4 A T 2: 172,042,096 (GRCm38) V68E probably damaging Het
Cc2d2a T A 5: 43,668,673 (GRCm38) N2K probably benign Het
Ccnf T A 17: 24,231,837 (GRCm38) D389V probably damaging Het
Cdipt T C 7: 126,979,601 (GRCm38) S161P probably benign Het
Ceacam19 T C 7: 19,882,887 (GRCm38) I161V probably benign Het
Cfap65 A G 1: 74,920,405 (GRCm38) I862T probably damaging Het
Cfi T A 3: 129,858,370 (GRCm38) L230Q probably benign Het
Chac2 G A 11: 30,986,159 (GRCm38) R30W probably damaging Het
Cmc2 G A 8: 116,889,827 (GRCm38) probably benign Het
Col1a2 A T 6: 4,505,840 (GRCm38) M1L probably benign Het
Cox8a C A 19: 7,217,418 (GRCm38) R32L possibly damaging Het
Cubn T A 2: 13,430,897 (GRCm38) N1083Y probably damaging Het
D430042O09Rik G A 7: 125,814,865 (GRCm38) G394R probably benign Het
D630003M21Rik T C 2: 158,217,584 (GRCm38) D132G probably damaging Het
Dedd2 G A 7: 25,211,290 (GRCm38) P154S probably benign Het
Dnaaf3 T C 7: 4,524,213 (GRCm38) D358G probably benign Het
Dysf T A 6: 84,019,604 (GRCm38) F29L probably damaging Het
Dysf T C 6: 84,112,119 (GRCm38) L888P probably damaging Het
Ebf4 A G 2: 130,309,723 (GRCm38) D277G probably damaging Het
Ecm2 T A 13: 49,515,094 (GRCm38) L91* probably null Het
Foxs1 T C 2: 152,932,842 (GRCm38) D97G possibly damaging Het
Frs2 A C 10: 117,076,809 (GRCm38) probably null Het
Gm6768 A G 12: 119,261,651 (GRCm38) noncoding transcript Het
Grp A T 18: 65,879,937 (GRCm38) D58V probably damaging Het
Hif1a T G 12: 73,941,842 (GRCm38) F537C probably damaging Het
Icam4 G A 9: 21,029,539 (GRCm38) S29N probably benign Het
Itfg1 T C 8: 85,726,170 (GRCm38) E523G probably benign Het
Jph2 T C 2: 163,375,680 (GRCm38) K359E probably damaging Het
Kcnq2 A T 2: 181,087,656 (GRCm38) V490E possibly damaging Het
Klhl18 C T 9: 110,428,727 (GRCm38) M548I possibly damaging Het
Lpin3 A G 2: 160,895,801 (GRCm38) Y197C probably benign Het
Lrp1 T C 10: 127,560,553 (GRCm38) N2381D probably benign Het
Man1a A T 10: 53,919,211 (GRCm38) W649R probably damaging Het
Map4 T C 9: 110,064,292 (GRCm38) L542P probably damaging Het
Mboat2 A T 12: 24,878,285 (GRCm38) H52L probably damaging Het
Mok C G 12: 110,814,946 (GRCm38) S91T probably benign Het
Mtmr11 G T 3: 96,168,084 (GRCm38) R360L probably damaging Het
Myt1l G A 12: 29,832,332 (GRCm38) G509R unknown Het
Olfr1288 A T 2: 111,479,389 (GRCm38) N202Y probably damaging Het
Olfr341 A G 2: 36,479,512 (GRCm38) V206A probably benign Het
Olfr544 T C 7: 102,484,389 (GRCm38) T244A probably damaging Het
Olfr67 C T 7: 103,787,955 (GRCm38) M107I probably benign Het
Olfr836 A G 9: 19,121,327 (GRCm38) D121G probably damaging Het
Olfr867 A T 9: 20,054,883 (GRCm38) H75Q possibly damaging Het
Padi3 G T 4: 140,795,843 (GRCm38) T292N probably damaging Het
Pard6g A C 18: 80,117,205 (GRCm38) T178P possibly damaging Het
Pkd1l2 A T 8: 117,013,987 (GRCm38) Y2124N probably damaging Het
Plxdc1 G A 11: 97,928,463 (GRCm38) T398I probably damaging Het
Prickle2 A T 6: 92,416,848 (GRCm38) C225* probably null Het
Prmt2 G A 10: 76,210,444 (GRCm38) T317I probably benign Het
Psg22 T G 7: 18,719,780 (GRCm38) N172K probably benign Het
Ptpn9 C T 9: 57,033,163 (GRCm38) R196* probably null Het
Rap1b C T 10: 117,824,611 (GRCm38) V14I probably damaging Het
Rapgef4 T A 2: 72,196,278 (GRCm38) probably null Het
Rlf A T 4: 121,149,215 (GRCm38) M856K possibly damaging Het
Rnf149 A G 1: 39,577,174 (GRCm38) L34P probably benign Het
Rock1 T C 18: 10,101,007 (GRCm38) E636G probably benign Het
Rsad2 A T 12: 26,454,123 (GRCm38) Y136N probably damaging Het
Ryr3 T C 2: 112,908,493 (GRCm38) H563R probably damaging Het
Slc18b1 A G 10: 23,804,212 (GRCm38) M102V probably benign Het
Slc34a2 T A 5: 53,067,647 (GRCm38) C377S possibly damaging Het
Slco1c1 T C 6: 141,546,770 (GRCm38) V293A probably benign Het
Spidr A T 16: 16,140,024 (GRCm38) S80T possibly damaging Het
Syne1 C T 10: 5,348,994 (GRCm38) E1031K probably damaging Het
Synj2 G A 17: 6,017,614 (GRCm38) V121I probably damaging Het
Synj2 A T 17: 6,038,098 (GRCm38) T1430S probably damaging Het
Tecpr2 G T 12: 110,929,109 (GRCm38) K343N probably damaging Het
Tmem132d T A 5: 127,784,100 (GRCm38) I986F probably benign Het
Trib1 G A 15: 59,654,475 (GRCm38) R298H probably damaging Het
Ttll10 T A 4: 156,045,357 (GRCm38) D283V probably benign Het
Ttn T A 2: 76,814,779 (GRCm38) K673* probably null Het
Ubqlnl T A 7: 104,148,698 (GRCm38) M531L probably benign Het
Vmn2r120 A T 17: 57,525,721 (GRCm38) W153R probably benign Het
Vmn2r2 A C 3: 64,117,046 (GRCm38) S705A probably benign Het
Vmn2r32 T A 7: 7,464,210 (GRCm38) D773V probably benign Het
Vmn2r54 T A 7: 12,632,278 (GRCm38) Q243L probably damaging Het
Zfp113 T C 5: 138,145,668 (GRCm38) M107V probably benign Het
Zfp426 G T 9: 20,470,627 (GRCm38) Q341K possibly damaging Het
Zfp616 A T 11: 74,083,846 (GRCm38) K314* probably null Het
Other mutations in Wdr24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00942:Wdr24 APN 17 25,826,621 (GRCm38) missense probably benign 0.20
IGL01700:Wdr24 APN 17 25,825,828 (GRCm38) missense probably damaging 1.00
IGL01763:Wdr24 APN 17 25,826,190 (GRCm38) missense probably benign 0.20
IGL02567:Wdr24 APN 17 25,824,348 (GRCm38) missense probably damaging 0.99
IGL03100:Wdr24 APN 17 25,825,707 (GRCm38) missense possibly damaging 0.47
R0012:Wdr24 UTSW 17 25,827,113 (GRCm38) missense probably benign
R0799:Wdr24 UTSW 17 25,826,128 (GRCm38) missense probably damaging 1.00
R1015:Wdr24 UTSW 17 25,828,238 (GRCm38) missense probably benign 0.12
R1276:Wdr24 UTSW 17 25,827,467 (GRCm38) missense probably benign 0.02
R1297:Wdr24 UTSW 17 25,827,348 (GRCm38) missense possibly damaging 0.90
R1934:Wdr24 UTSW 17 25,824,266 (GRCm38) missense possibly damaging 0.89
R2030:Wdr24 UTSW 17 25,826,043 (GRCm38) missense probably benign 0.38
R2069:Wdr24 UTSW 17 25,826,282 (GRCm38) missense probably damaging 1.00
R2508:Wdr24 UTSW 17 25,824,299 (GRCm38) missense possibly damaging 0.52
R4601:Wdr24 UTSW 17 25,828,207 (GRCm38) splice site probably null
R4604:Wdr24 UTSW 17 25,828,505 (GRCm38) missense probably damaging 1.00
R4894:Wdr24 UTSW 17 25,826,127 (GRCm38) missense probably damaging 1.00
R5068:Wdr24 UTSW 17 25,825,779 (GRCm38) missense possibly damaging 0.77
R5088:Wdr24 UTSW 17 25,828,207 (GRCm38) splice site probably null
R5104:Wdr24 UTSW 17 25,824,591 (GRCm38) missense probably damaging 1.00
R5498:Wdr24 UTSW 17 25,824,561 (GRCm38) missense probably damaging 1.00
R5719:Wdr24 UTSW 17 25,828,340 (GRCm38) critical splice donor site probably null
R5892:Wdr24 UTSW 17 25,827,986 (GRCm38) missense probably benign 0.00
R5975:Wdr24 UTSW 17 25,827,128 (GRCm38) missense probably benign 0.37
R6106:Wdr24 UTSW 17 25,824,605 (GRCm38) missense probably benign
R6114:Wdr24 UTSW 17 25,824,605 (GRCm38) missense probably benign
R6116:Wdr24 UTSW 17 25,824,605 (GRCm38) missense probably benign
R6165:Wdr24 UTSW 17 25,826,421 (GRCm38) missense probably benign 0.18
R6175:Wdr24 UTSW 17 25,826,578 (GRCm38) missense probably damaging 1.00
R6331:Wdr24 UTSW 17 25,825,676 (GRCm38) missense possibly damaging 0.61
R6548:Wdr24 UTSW 17 25,827,925 (GRCm38) missense probably damaging 0.99
R6984:Wdr24 UTSW 17 25,828,235 (GRCm38) missense possibly damaging 0.93
R7485:Wdr24 UTSW 17 25,826,127 (GRCm38) missense probably damaging 1.00
R7583:Wdr24 UTSW 17 25,825,830 (GRCm38) missense probably null 1.00
R7770:Wdr24 UTSW 17 25,827,096 (GRCm38) missense probably benign 0.04
R8086:Wdr24 UTSW 17 25,826,127 (GRCm38) missense probably damaging 1.00
R8164:Wdr24 UTSW 17 25,825,949 (GRCm38) splice site probably null
R9210:Wdr24 UTSW 17 25,824,498 (GRCm38) missense probably benign 0.00
R9212:Wdr24 UTSW 17 25,824,498 (GRCm38) missense probably benign 0.00
R9567:Wdr24 UTSW 17 25,824,216 (GRCm38) missense probably damaging 0.98
R9667:Wdr24 UTSW 17 25,827,327 (GRCm38) missense possibly damaging 0.55
X0022:Wdr24 UTSW 17 25,824,272 (GRCm38) missense probably damaging 0.99
Z1177:Wdr24 UTSW 17 25,825,687 (GRCm38) missense probably benign 0.29
Predicted Primers PCR Primer
(F):5'- CATTGAGGAGGAGCAGTTCG -3'
(R):5'- CACACATTTCAGCCTGCCTG -3'

Posted On 2017-07-14