Incidental Mutation 'R6086:Cdyl2'
ID 482486
Institutional Source Beutler Lab
Gene Symbol Cdyl2
Ensembl Gene ENSMUSG00000031758
Gene Name chromodomain protein, Y chromosome-like 2
Synonyms 1700029M19Rik, 4930453I21Rik
MMRRC Submission 044427-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.127) question?
Stock # R6086 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 117301139-117459730 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 117316035 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 318 (S318P)
Ref Sequence ENSEMBL: ENSMUSP00000104730 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109102]
AlphaFold Q9D5D8
Predicted Effect probably damaging
Transcript: ENSMUST00000109102
AA Change: S318P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000104730
Gene: ENSMUSG00000031758
AA Change: S318P

DomainStartEndE-ValueType
CHROMO 6 60 1.25e-17 SMART
Pfam:ECH_1 252 499 5e-33 PFAM
Pfam:ECH_2 258 501 1.6e-14 PFAM
Meta Mutation Damage Score 0.0934 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.9%
Validation Efficiency 96% (65/68)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apob G T 12: 8,065,164 (GRCm39) K4044N probably benign Het
Asic4 G A 1: 75,449,887 (GRCm39) V468I possibly damaging Het
Atf4 T A 15: 80,141,654 (GRCm39) V348D probably benign Het
Bcl9 A G 3: 97,112,840 (GRCm39) V1205A possibly damaging Het
Bora A T 14: 99,299,730 (GRCm39) Q234L possibly damaging Het
Cap2 C A 13: 46,789,188 (GRCm39) P131Q probably damaging Het
Ces1a T G 8: 93,753,981 (GRCm39) N341H probably benign Het
Cimap2 T C 4: 106,470,403 (GRCm39) E218G probably damaging Het
Crlf3 C T 11: 79,939,436 (GRCm39) V352M possibly damaging Het
Cybb C G X: 9,316,989 (GRCm39) D246H probably benign Het
Cyren A G 6: 34,851,555 (GRCm39) S127P probably damaging Het
Dnah2 T C 11: 69,406,834 (GRCm39) T529A probably benign Het
Dnah9 C T 11: 65,880,741 (GRCm39) D2619N probably damaging Het
Dnah9 A C 11: 65,976,000 (GRCm39) S1350A probably benign Het
Dnajc6 C T 4: 101,455,004 (GRCm39) S65L probably benign Het
Dnm3 C A 1: 162,148,602 (GRCm39) R256S probably damaging Het
Enpp2 T C 15: 54,709,230 (GRCm39) D795G probably damaging Het
Fah A T 7: 84,238,120 (GRCm39) W367R probably damaging Het
Fam220a T A 5: 143,548,796 (GRCm39) H69Q probably benign Het
Fgd3 T A 13: 49,440,772 (GRCm39) T220S probably benign Het
Furin G T 7: 80,045,179 (GRCm39) H248Q probably damaging Het
Gabrg1 A T 5: 70,911,396 (GRCm39) L410Q probably damaging Het
Gm10801 AAGT AAGTAGT 2: 98,494,148 (GRCm39) probably null Het
Gm9742 T C 13: 8,080,069 (GRCm39) noncoding transcript Het
Gpcpd1 A G 2: 132,380,034 (GRCm39) S252P probably damaging Het
Hnrnpdl C T 5: 100,184,340 (GRCm39) G398S probably null Het
Hspa1l T C 17: 35,197,131 (GRCm39) V390A possibly damaging Het
Htr3b T C 9: 48,858,598 (GRCm39) S94G probably benign Het
Klf10 G T 15: 38,297,181 (GRCm39) S271R probably benign Het
Klk1b3 T A 7: 43,851,158 (GRCm39) L197Q probably damaging Het
Knl1 A G 2: 118,924,549 (GRCm39) R1861G probably damaging Het
Myo9a C T 9: 59,697,340 (GRCm39) Q374* probably null Het
Myt1l G A 12: 29,882,331 (GRCm39) G509R unknown Het
Ncapg T C 5: 45,850,578 (GRCm39) L728P probably damaging Het
Nfxl1 A C 5: 72,698,362 (GRCm39) F228V probably benign Het
Ntaq1 C A 15: 58,014,024 (GRCm39) A71E probably damaging Het
Oc90 A G 15: 65,761,560 (GRCm39) S153P probably damaging Het
Or4c123 A G 2: 89,127,198 (GRCm39) C139R probably damaging Het
Or5b105 A G 19: 13,079,745 (GRCm39) *308Q probably null Het
Pbk A T 14: 66,052,702 (GRCm39) K182* probably null Het
Piezo1 A G 8: 123,228,396 (GRCm39) F296S possibly damaging Het
Psmg1 T A 16: 95,781,244 (GRCm39) Y288F probably damaging Het
Rab11fip4 G A 11: 79,574,306 (GRCm39) D132N probably damaging Het
Recql4 T C 15: 76,588,787 (GRCm39) D1051G probably damaging Het
Reep5 A C 18: 34,490,184 (GRCm39) D104E probably damaging Het
Rnpepl1 T C 1: 92,845,403 (GRCm39) Y441H probably damaging Het
Scnm1 T C 3: 95,037,596 (GRCm39) I157V probably benign Het
Sema3b T C 9: 107,478,047 (GRCm39) D446G probably damaging Het
Sema4d C T 13: 51,867,781 (GRCm39) R190Q probably damaging Het
Slco3a1 G A 7: 73,968,338 (GRCm39) R461C possibly damaging Het
Spmap2l T A 5: 77,209,152 (GRCm39) V458E probably benign Het
Tenm2 T A 11: 35,899,473 (GRCm39) I2562F possibly damaging Het
Tmem40 G T 6: 115,710,628 (GRCm39) N120K possibly damaging Het
Tmod3 T C 9: 75,407,405 (GRCm39) H351R probably benign Het
Tnn C T 1: 159,913,690 (GRCm39) V1268M probably damaging Het
Tpmt T A 13: 47,188,506 (GRCm39) D132V probably damaging Het
Trgc3 T C 13: 19,447,454 (GRCm39) S136P probably damaging Het
Trib1 G A 15: 59,526,324 (GRCm39) R298H probably damaging Het
Tsen2 A G 6: 115,537,036 (GRCm39) E264G probably benign Het
Urah A G 7: 140,416,711 (GRCm39) I60M probably benign Het
Vmn2r26 T A 6: 124,016,519 (GRCm39) S328T possibly damaging Het
Vmn2r27 G C 6: 124,168,958 (GRCm39) T724R probably damaging Het
Washc2 A G 6: 116,233,177 (GRCm39) probably null Het
Zfp955b T A 17: 33,521,478 (GRCm39) W316R probably benign Het
Zranb2 T C 3: 157,248,883 (GRCm39) probably null Het
Other mutations in Cdyl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00953:Cdyl2 APN 8 117,321,928 (GRCm39) splice site probably benign
IGL01670:Cdyl2 APN 8 117,351,092 (GRCm39) missense probably damaging 1.00
IGL01964:Cdyl2 APN 8 117,350,768 (GRCm39) missense probably benign 0.00
IGL02148:Cdyl2 APN 8 117,315,983 (GRCm39) splice site probably benign
IGL02186:Cdyl2 APN 8 117,306,025 (GRCm39) missense possibly damaging 0.78
Allein UTSW 8 117,305,935 (GRCm39) missense probably damaging 1.00
R0449:Cdyl2 UTSW 8 117,309,931 (GRCm39) missense probably damaging 1.00
R0630:Cdyl2 UTSW 8 117,350,774 (GRCm39) missense probably benign 0.03
R1430:Cdyl2 UTSW 8 117,306,056 (GRCm39) splice site probably benign
R1883:Cdyl2 UTSW 8 117,321,902 (GRCm39) missense probably damaging 1.00
R2326:Cdyl2 UTSW 8 117,350,537 (GRCm39) missense probably benign
R4194:Cdyl2 UTSW 8 117,305,903 (GRCm39) splice site probably null
R4916:Cdyl2 UTSW 8 117,305,926 (GRCm39) missense probably damaging 1.00
R4977:Cdyl2 UTSW 8 117,302,008 (GRCm39) missense probably damaging 0.99
R5092:Cdyl2 UTSW 8 117,350,679 (GRCm39) missense possibly damaging 0.50
R5320:Cdyl2 UTSW 8 117,321,794 (GRCm39) nonsense probably null
R5727:Cdyl2 UTSW 8 117,309,907 (GRCm39) missense probably damaging 1.00
R5830:Cdyl2 UTSW 8 117,321,823 (GRCm39) missense probably benign 0.23
R6077:Cdyl2 UTSW 8 117,316,129 (GRCm39) missense probably damaging 1.00
R6145:Cdyl2 UTSW 8 117,321,717 (GRCm39) missense probably damaging 1.00
R6380:Cdyl2 UTSW 8 117,309,923 (GRCm39) missense probably damaging 1.00
R7152:Cdyl2 UTSW 8 117,351,066 (GRCm39) missense probably damaging 1.00
R7193:Cdyl2 UTSW 8 117,350,733 (GRCm39) missense probably benign 0.09
R7244:Cdyl2 UTSW 8 117,301,999 (GRCm39) nonsense probably null
R7394:Cdyl2 UTSW 8 117,350,790 (GRCm39) missense not run
R7457:Cdyl2 UTSW 8 117,305,935 (GRCm39) missense probably damaging 1.00
R8770:Cdyl2 UTSW 8 117,321,822 (GRCm39) missense probably damaging 1.00
R9574:Cdyl2 UTSW 8 117,350,669 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ACCTATGGAGAGCAAAGCCTG -3'
(R):5'- CTCAGACATTCAAAGCTCTGC -3'

Posted On 2017-07-14