Incidental Mutation 'R6074:Or10j5'
ID 482620
Institutional Source Beutler Lab
Gene Symbol Or10j5
Ensembl Gene ENSMUSG00000037924
Gene Name olfactory receptor family 10 subfamily J member 5
Synonyms Olfr16, MOR267-13, GA_x6K02T2R7CC-893157-892228, MOR23
MMRRC Submission 044235-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # R6074 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 172784335-172785384 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 172784945 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 194 (N194K)
Ref Sequence ENSEMBL: ENSMUSP00000149249 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038432] [ENSMUST00000215254]
AlphaFold Q62007
Predicted Effect probably benign
Transcript: ENSMUST00000038432
AA Change: N194K

PolyPhen 2 Score 0.105 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000041524
Gene: ENSMUSG00000037924
AA Change: N194K

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 7.5e-51 PFAM
Pfam:7tm_1 41 289 3.4e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215254
AA Change: N194K

PolyPhen 2 Score 0.105 (Sensitivity: 0.93; Specificity: 0.86)
Meta Mutation Damage Score 0.1443 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.1%
Validation Efficiency 97% (61/63)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Amigo1 T A 3: 108,099,009 (GRCm39) C189* probably null Het
Auts2 G T 5: 131,505,828 (GRCm39) probably benign Het
Cadps2 C A 6: 23,626,670 (GRCm39) W177L probably damaging Het
Camk2b G T 11: 5,939,635 (GRCm39) P223Q probably damaging Het
Ccdc74a C A 16: 17,464,591 (GRCm39) S9* probably null Het
Ccnt1 A C 15: 98,441,205 (GRCm39) Y688D probably damaging Het
Cdhr1 T C 14: 36,801,600 (GRCm39) N781S probably benign Het
Ceacam3 C T 7: 16,885,484 (GRCm39) T29I probably benign Het
Cep170b T C 12: 112,710,589 (GRCm39) S1473P probably damaging Het
Col19a1 T A 1: 24,565,564 (GRCm39) T256S unknown Het
Eif2d T A 1: 131,094,079 (GRCm39) D423E probably damaging Het
Fam13a A G 6: 58,966,723 (GRCm39) probably null Het
Gaa G A 11: 119,175,012 (GRCm39) R871H probably benign Het
Galnt12 T A 4: 47,112,405 (GRCm39) V37D probably damaging Het
Glp2r A G 11: 67,637,640 (GRCm39) S13P unknown Het
Gnptab C T 10: 88,268,940 (GRCm39) L548F probably damaging Het
Heg1 C T 16: 33,547,573 (GRCm39) P787S possibly damaging Het
Hivep2 T A 10: 14,007,485 (GRCm39) M1361K probably benign Het
Hivep3 T C 4: 119,954,891 (GRCm39) I1069T possibly damaging Het
Hspg2 A G 4: 137,268,046 (GRCm39) D2121G probably benign Het
Htatip2 A G 7: 49,422,322 (GRCm39) probably null Het
Ighv1-75 T C 12: 115,798,007 (GRCm39) S4G probably benign Het
Ip6k1 A G 9: 107,901,308 (GRCm39) probably benign Het
Kcna6 A G 6: 126,716,242 (GRCm39) S216P probably benign Het
Kif21a T A 15: 90,865,095 (GRCm39) T526S probably benign Het
Kng2 C T 16: 22,819,346 (GRCm39) G230D probably benign Het
Lgi2 A T 5: 52,703,984 (GRCm39) F216I probably benign Het
Lratd1 G A 12: 14,200,512 (GRCm39) H72Y probably benign Het
Lss T A 10: 76,379,693 (GRCm39) N383K probably damaging Het
Mical1 T C 10: 41,362,061 (GRCm39) M929T probably benign Het
Mroh2a A G 1: 88,186,386 (GRCm39) S64G probably benign Het
Nat8f4 A G 6: 85,878,169 (GRCm39) V118A probably damaging Het
Or4p23 A C 2: 88,576,566 (GRCm39) L222R probably damaging Het
Or6b2 G A 1: 92,407,497 (GRCm39) T282M probably benign Het
Osbpl11 T A 16: 33,030,335 (GRCm39) S188T probably benign Het
Pea15a C T 1: 172,026,752 (GRCm39) R85H possibly damaging Het
Ppp1r13b A G 12: 111,798,836 (GRCm39) I919T probably damaging Het
Rasgrf1 A G 9: 89,835,968 (GRCm39) D232G probably benign Het
Rp1 A G 1: 4,415,602 (GRCm39) S1837P probably benign Het
Samd5 T A 10: 9,550,334 (GRCm39) Y125F possibly damaging Het
Skint5 T C 4: 113,662,397 (GRCm39) T597A unknown Het
Slc25a12 A G 2: 71,106,798 (GRCm39) F605L probably benign Het
Slc39a12 C T 2: 14,412,290 (GRCm39) Q321* probably null Het
Slc6a19 T C 13: 73,837,882 (GRCm39) S206G probably benign Het
Tacc2 T A 7: 130,227,165 (GRCm39) H1283Q possibly damaging Het
Thumpd3 A G 6: 113,036,971 (GRCm39) E290G possibly damaging Het
Timd2 C T 11: 46,577,999 (GRCm39) G44D possibly damaging Het
Tmem74 A G 15: 43,730,134 (GRCm39) V303A possibly damaging Het
Tpo A G 12: 30,128,186 (GRCm39) V785A probably benign Het
Tpra1 T A 6: 88,888,919 (GRCm39) I367N possibly damaging Het
Txnrd2 T C 16: 18,256,297 (GRCm39) I95T probably damaging Het
Usp32 A G 11: 84,885,399 (GRCm39) V1216A probably benign Het
Usp54 C A 14: 20,602,167 (GRCm39) M1394I probably benign Het
Vmn2r13 A G 5: 109,322,167 (GRCm39) F177L probably benign Het
Vmn2r82 T A 10: 79,232,377 (GRCm39) V792E probably damaging Het
Wdfy4 C T 14: 32,805,596 (GRCm39) probably null Het
Wnk2 A T 13: 49,204,875 (GRCm39) C458S probably damaging Het
Xkr6 T G 14: 63,844,519 (GRCm39) F181V possibly damaging Het
Zfp212 T A 6: 47,903,986 (GRCm39) C149* probably null Het
Zfp647 G A 15: 76,796,285 (GRCm39) P125L probably damaging Het
Zfp661 A G 2: 127,419,793 (GRCm39) S116P probably benign Het
Zfp770 A G 2: 114,026,870 (GRCm39) Y400H possibly damaging Het
Other mutations in Or10j5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00334:Or10j5 APN 1 172,785,158 (GRCm39) missense possibly damaging 0.66
IGL00336:Or10j5 APN 1 172,785,045 (GRCm39) missense probably benign 0.30
IGL01155:Or10j5 APN 1 172,784,491 (GRCm39) missense probably benign 0.43
IGL01549:Or10j5 APN 1 172,784,541 (GRCm39) missense probably damaging 1.00
IGL02679:Or10j5 APN 1 172,784,743 (GRCm39) missense probably damaging 1.00
IGL03071:Or10j5 APN 1 172,784,502 (GRCm39) missense probably benign 0.01
IGL03352:Or10j5 APN 1 172,784,850 (GRCm39) missense probably benign 0.00
R0449:Or10j5 UTSW 1 172,784,965 (GRCm39) missense probably damaging 1.00
R1725:Or10j5 UTSW 1 172,784,908 (GRCm39) missense possibly damaging 0.90
R1726:Or10j5 UTSW 1 172,784,658 (GRCm39) missense probably benign 0.00
R1735:Or10j5 UTSW 1 172,784,374 (GRCm39) missense probably benign
R1928:Or10j5 UTSW 1 172,784,881 (GRCm39) missense probably damaging 0.98
R4258:Or10j5 UTSW 1 172,785,205 (GRCm39) missense possibly damaging 0.88
R4359:Or10j5 UTSW 1 172,784,647 (GRCm39) missense probably benign
R4434:Or10j5 UTSW 1 172,785,111 (GRCm39) missense probably damaging 1.00
R4666:Or10j5 UTSW 1 172,785,157 (GRCm39) missense probably benign
R4874:Or10j5 UTSW 1 172,785,166 (GRCm39) missense probably benign 0.00
R5063:Or10j5 UTSW 1 172,785,009 (GRCm39) missense possibly damaging 0.48
R5988:Or10j5 UTSW 1 172,784,723 (GRCm39) nonsense probably null
R7021:Or10j5 UTSW 1 172,784,494 (GRCm39) missense probably benign 0.01
R7234:Or10j5 UTSW 1 172,784,673 (GRCm39) missense probably damaging 0.96
R7527:Or10j5 UTSW 1 172,784,511 (GRCm39) missense probably benign 0.00
R8271:Or10j5 UTSW 1 172,784,744 (GRCm39) nonsense probably null
R8890:Or10j5 UTSW 1 172,785,045 (GRCm39) missense probably benign 0.30
R8906:Or10j5 UTSW 1 172,784,186 (GRCm39) start gained probably benign
R9048:Or10j5 UTSW 1 172,784,929 (GRCm39) missense probably benign
R9583:Or10j5 UTSW 1 172,784,893 (GRCm39) missense probably damaging 1.00
Z1088:Or10j5 UTSW 1 172,784,891 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTCACAGCAATGGGTTATGATCG -3'
(R):5'- TGGACAATGACCACAGTGAG -3'

Posted On 2017-07-14